Hong, W. David published the artcileAWZ1066S, a highly specific anti-Wolbachia drug candidate for a short-course treatment of filariasis, COA of Formula: C7H5F3N2O, the main research area is AWZ1066S antibacterial antifilarial pharmacokinetics toxicity Wolbachia filariasis; anti-Wolbachia; drug discovery; lymphatic filariasis; macrofilaricide; onchocerciasis.
Onchocerciasis and lymphatic filariasis are two neglected tropical diseases that together affect ∼ 157 million people and inflict severe disability. Both diseases are caused by parasitic filarial nematodes with elimination efforts constrained by the lack of a safe drug that can kill the adult filaria (macrofilaricide). Previous proof-of-concept human trials have demonstrated that depleting > 90% of the essential nematode endosymbiont bacterium, Wolbachia, using antibiotics, can lead to permanent sterilization of adult female parasites and a safe macrofilaricidal outcome. AWZ1066S is a highly specific anti-Wolbachia candidate selected through a lead optimization program focused on balancing efficacy, safety and drug metabolism/pharmacokinetic (DMPK) features of a thienopyrimidine/quinazoline scaffold derived from phenotypic screening. AWZ1066S shows superior efficacy to existing anti-Wolbachia therapies in validated preclin. models of infection and has DMPK characteristics that are compatible with a short therapeutic regimen of 7 days or less. This candidate mol. is well-positioned for onward development and has the potential to make a significant impact on communities affected by filariasis.
Proceedings of the National Academy of Sciences of the United States of America published new progress about Anthelmintics. 959108-47-5 belongs to class amides-buliding-blocks, name is 2-(Trifluoromethyl)nicotinamide, and the molecular formula is C7H5F3N2O, COA of Formula: C7H5F3N2O.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics