Related Products of 92748-09-9,Some common heterocyclic compound, 92748-09-9, name is 2-Bromobenzenesulfonamide, molecular formula is C6H6BrNO2S, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
STR28 (Process (b)) 2.5 g (10 mmol) of 2-bromo-benzolsulphonamide are dissolved in 40 ml acetonitrile, and 3.2 g (10 mmol) of 4-methyl-2-phenoxycarbonyl-5-(3-tetrahydrofuryl-oxy)-2,4-dihydro-3H-1,2,4-triazol-3-one and 1.6 g (10 mmol) of diazabicycloundecene (DBU) are added with strirring. The mixture is stirred at 20 C. for 12 hours and then concentrated under a water pump vacuum. The residue is taken up in methylene chloride and the mixture is washed with 10% strength hydrochloric acid, dried over sodium sulphate and filtered. The filtrate is concentrated under a water pump vacuum, the residue is digested with isopropanol/petroleum ether (1/5) and the crystalline product obtained is isolated by filtration with suction. 3.5 g (78% of theory) of 2-(2-bromo-phenylsulphonyl-aminocarbonyl)-4-methyl-5-(3-tetrahydrofuryl-oxy)-2,4-dihydro-3H-1,2,4-triazol-3-one are obtained of melting point 191 C. In analogy to Example 1 or 2 and in accordance with the general description of the preparation processes according to the invention it is also possible, for example, to prepare the compounds of the formula (I) which are listed in Table I below. STR29
The synthetic route of 92748-09-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Bayer Aktiengesellschaft; US6001776; (1999); A;,
Amide – Wikipedia,
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