Adding a certain compound to certain chemical reactions, such as: 918538-04-2, name is Pyrrolo[2,1-f][1,2,4]triazine-2,4(1H,3H)-dione, belongs to amides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 918538-04-2, SDS of cas: 918538-04-2
To a co-solvent of diisopropylethylamine (4.5 mL) and toluene (2OmL) was added intermediate 5? (1.6g, 10.4mmoL) and POC13 (2.94mL). The mixture was heated at 120C in a sealed tube for 20h, then poured into an ice-cooled saturated sodium bicarbonate solution (5OmL). Stirred for 1 5mm. Extracted with CH2C12 (3x5OmL). Combined organic layers were washed with brine (lx5OmL), dried (Mg504) and concentrated. Column chromatography purification (50-100% CH2C12 in hexanes) afforded the desired dichloride 1 as a light brown solid (1.2g, 86% yield). ?H NMR (CDC13): oe 6.98(1H, m), 7.05 (1H, m),7.86 (1H, m); MS: 187 (M+W).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, Pyrrolo[2,1-f][1,2,4]triazine-2,4(1H,3H)-dione, and friends who are interested can also refer to it.
Reference:
Patent; SUZHOU KINTOR PHARMACEUTICALS, INC.; GUO, Chuangxin; TONG, Youzhi; (160 pag.)WO2017/219800; (2017); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics