Category: 91-00-9

SDS of cas: 91-00-9. In 2019 NAT CATAL published article about AQUEOUS AMMONIA; SELECTIVE HYDROGENATION; IRON CATALYSTS; ALKYLATION; ALCOHOLS; KETONES; ACIDS; FURFURYLAMINE; NANOPARTICLES; NITROARENES in [Hahn, G.; Kempe, R.] Univ Bayreuth, Chair Inorgan Chem II Catalyst Design, Bayreuth, Germany; [Kunnas, P.; de Jonge, N.] INM Leibniz Inst New Mat, Saarbrucken, Germany; [de Jonge, N.] Saarland Univ, Dept Phys, Saarbrucken, Germany in 2019, Cited 54. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9.

Reusable catalysts based on earth-abundant metals with a broad applicability in organic synthesis are a key to a more sustainable production of fine chemicals, pharmaceuticals and agrochemicals. Herein, we report on a nanostructured nickel catalyst for the general and selective synthesis of primary amines via reductive amination, employing ammonia dissolved in water. Our catalyst, which operates at low temperature and pressure, is highly active, reusable and easy to handle. The synthesis from a specific nickel complex and gamma-Al2O3 is straightforward, with the ligand-metal combination of this complex being crucial. Aldehydes (including purely aliphatic ones), aryl-alkyl, dialkyl and diaryl ketones can all be converted smoothly into primary amines. In addition, the amination of pharmaceuticals, bioactive compounds and natural products is demonstrated. Many functional groups-including hydrogenation-sensitive examples-are tolerated. We expect that our findings will inspire others to develop reusable and nanostructured earth-abundant metal catalysts for complex organic transformations.

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Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Authors Linciano, P; Pozzi, C; dello Iacono, L; di Pisa, F; Landi, G; Bonucci, A; Gul, S; Kuzikov, M; Ellinger, B; Witt, G; Santarem, N; Baptista, C; Franco, C; Moraes, CB; Muller, W; Wittig, U; Luciani, R; Sesenna, A; Quotadamo, A; Ferrari, S; Pohner, I; Cordeiro-Da-Silva, A; Mangani, S; Costantino, L; Costi, MP in AMER CHEMICAL SOC published article about DIHYDROFOLATE-REDUCTASE; THYMIDYLATE SYNTHASE; BINDING MODES; LEISHMANIA; IDENTIFICATION; ASSAY; DERIVATIVES; VALIDATION; SOLUBILITY; RESISTANCE in [Linciano, Pasquale; Luciani, Rosaria; Sesenna, Antony; Quotadamo, Antonio; Costantino, Luca; Costi, Maria Paola] Univ Modena & Reggio Emilia, Dipartimento Sci Vita, Via Campi 103, I-41125 Modena, Italy; [Pozzi, Cecilia; dello Iacono, Lucia; di Pisa, Flavio; Landi, Giacomo; Bonucci, Alessio; Mangani, Stefano] Univ Siena, Dipartimento Biotecnol Chim & Farm, Via Aldo Moro 2, I-53100 Siena, Italy; [Gul, Sheraz; Kuzikov, Maria; Ellinger, Bernhard; Witt, Gesa] Fraunhofer Inst Mol Biol & Appl Ecol Screening Po, D-22525 Hamburg, Germany; [Santarem, Nuno; Baptista, Catarina] Inst Mol & Cell Biol, P-4150180 Porto, Portugal; [Santarem, Nuno; Baptista, Catarina] Univ Porto, Inst Invest & Inovacao Saude, P-4150180 Porto, Portugal; [Franco, Caio; Moraes, Carolina B.] CNPEM, Lab Nacl Biociencias LNBio, BR-13083100 Campinas, SP, Brazil; [Mueller, Wolfgang; Wittig, Ulrike] HITS, Sci Databases & Visualizat Grp, D-69118 Heidelberg, Germany; [Wittig, Ulrike] HITS, Mol & Cellular Modeling Grp, D-69118 Heidelberg, Germany; [Franco, Caio; Moraes, Carolina B.] Univ Sao Paulo, Dept Microbiol, Inst Biomed Sci, BR-05508900 Sao Paulo, SP, Brazil in 2019.0, Cited 57.0. Recommanded Product: Diphenylmethanamine. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9

2-Amino-benzo[d]thiazole was identified as a new scaffold for the development of improved pteridine reductase-1 (PTR1) inhibitors and anti-trypanosomatidic agents. Molecular docking and crystallography guided the design and synthesis of 42 new benzothiazoles. The compounds were assessed for Trypanosoma brucei and Leishmania major PTR1 inhibition and in vitro activity against T. brucei and amastigote Leishmania infantum. We identified several 2-amino-benzo[d]thiazoles with improved enzymatic activity (TbPTR1 IC50 = 0.35 mu M; LmPTR1 IC50 = 1.9 mu M) and low mu M antiparasitic activity against T. brucei. The ten most active compounds against TbPTR1 were able to potentiate the antiparasitic activity of methotrexate when evaluated in combination against T. brucei, with a potentiating index between 1.2 and 2.7. The compound library was profiled for early ADME toxicity, and 2-amino-N-benzylbenzo[d]thiazole-6-carboxamide (4c) was finally identified as a novel potent, safe, and selective anti-trypanocydal agent (EC50 = 7.0 mu M). Formulation of 4c with hydroxypropyl-beta-cyclodextrin yielded good oral bioavailability, encouraging progression to in vivo studies.

Recommanded Product: Diphenylmethanamine. Welcome to talk about 91-00-9, If you have any questions, you can contact Linciano, P; Pozzi, C; dello Iacono, L; di Pisa, F; Landi, G; Bonucci, A; Gul, S; Kuzikov, M; Ellinger, B; Witt, G; Santarem, N; Baptista, C; Franco, C; Moraes, CB; Muller, W; Wittig, U; Luciani, R; Sesenna, A; Quotadamo, A; Ferrari, S; Pohner, I; Cordeiro-Da-Silva, A; Mangani, S; Costantino, L; Costi, MP or send Email.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Application In Synthesis of Diphenylmethanamine. Authors Sun, WN; Chen, XL; Huang, SZ; Li, WP; Tian, CY; Yang, SY; Li, LL in PERGAMON-ELSEVIER SCIENCE LTD published article about in [Sun, Weining; Tian, Chenyu; Li, Linli] Sichuan Univ, West China Sch Pharm, Key Lab Drug Targeting & Drug Delivery Syst, Minist Educ, Chengdu 610041, Sichuan, Peoples R China; [Chen, Xiuli; Huang, Shenzhen; Li, Wenpei; Yang, Shengyong] Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Chengdu 610041, Sichuan, Peoples R China; [Chen, Xiuli; Huang, Shenzhen; Li, Wenpei; Yang, Shengyong] Sichuan Univ, West China Hosp, Canc Ctr, Chengdu 610041, Sichuan, Peoples R China in 2020, Cited 14. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9

SIRT6 is a deacetylase of histone H3 and inhibitors of SIRT6 have been thought as potential agents for treatment of diabetes. Herein we report the discovery of a series of new SIRT6 inhibitors containing the skeleton 1-phenylpiperazine. Among them, compound 5-(4-methylpiperazin-1-yl)-2-nitroaniline (6d) is the most potent one, which showed an IC50 value of 4.93 mu M against SIRT6 in the Fluor de Lys (FDL) assay. It displayed K-D values of 9.76 mu M and 10 mu M in surface plasmon resonance (SPR) and isothermal titration calorimetry (ITC) assays, respectively. In selectivity assay, 6d showed no activity against other members of the HDAC family (SIRT1-3 and HDAC1-11) at concentrations up to 200 mu M. In a mouse model of type 2 diabetes, 6d could significantly increase the level of glucose transporter GLUT-1, thereby reducing blood glucose. Overall, this study provides a promising lead compound for subsequent drug discovery targeting SIRT6.

Application In Synthesis of Diphenylmethanamine. Bye, fridends, I hope you can learn more about C13H13N, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Quality Control of Diphenylmethanamine. I found the field of Chemistry; Science & Technology – Other Topics very interesting. Saw the article Environmentally benign decarboxylative N-, O-, and S-acetylations and acylations published in 2020.0, Reprint Addresses Jana, CK (corresponding author), Indian Inst Technol Guwahati, Dept Chem, Gauhati 781039, India.. The CAS is 91-00-9. Through research, I have a further understanding and discovery of Diphenylmethanamine.

An operationally simple and general method for acetylation and acylation of a wide variety of substrates (amines, alcohols, phenols, thiols, and hydrazones) has been reported. Meldrum’s acid and its derivatives have been used as an air-stable, non-volatile, cost-effective, and easy to handle acetylating/acylating agent. Easily separable byproducts (CO2 and acetone) allowed the isolation of analytically pure acetylated products without the requirement of work-up and any chromatography.

Welcome to talk about 91-00-9, If you have any questions, you can contact Ghosh, S; Purkait, A; Jana, CK or send Email.. Quality Control of Diphenylmethanamine

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

In 2020.0 RUSS J GEN CHEM+ published article about CYCLIC AMINOMETHYLPHOSPHINES; COMPLEXES in [Musina, E. I.; Musin, L. I.; Litvinov, I. A.; Karasik, A. A.] Russian Acad Sci, Kazan Sci Ctr, Fed Res Ctr, AE Arbuzov Inst Organ & Phys Chem, Kazan 420088, Russia in 2020.0, Cited 25.0. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9. Category: amides-buliding-blocks

New 1-aza-3,5-diphosphorinanes have been synthesized as a mixture of RR/SS- and RS-isomers via the reaction of bis(phenylphosphanyl)methane, paraformaldehyde, isopropylamine, of benzhydrylamine.

Category: amides-buliding-blocks. About Diphenylmethanamine, If you have any questions, you can contact Musina, EI; Musin, LI; Litvinov, IA; Karasik, AA or concate me.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

HPLC of Formula: C13H13N. In 2019.0 BIOORG CHEM published article about HUMAN SERUM-ALBUMIN; MOLECULAR-DYNAMICS SIMULATION; MULTIFUNCTIONAL AGENTS; FLAVONOID DERIVATIVES; COUMARIN DERIVATIVES; BETULINIC ACID; DESIGN; INHIBITORS; DISEASE; SERIES in [Shaik, Jeelan Basha; Kandrakonda, Yelamanda Rao; Penumala, Mohan; Zinka, Raveendra Babu; Amooru, Damu Gangaiah] Yogi Vemana Univ, Dept Chem, Kadapa, Andhra Pradesh, India; [Yeggoni, Daniel Pushparaju; Subramanyam, Rajagopal] Univ Hyderabad, Sch Life Sci, Dept Plant Sci, Hyderabad, India; [Kotapati, Kasi Viswanath; Ampasala, Dinakara Rao] Pondicherry Cent Univ, Ctr Bioinformat, Sch Life Sci, Pondicherry, India; [Darla, Mark Manidhar] Sri Venkateswara Univ, Dept Chem, Tirupati, Andhra Pradesh, India in 2019.0, Cited 56.0. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9.

In a search for novel multifunctional anti-Alzheimer agents, a congeneric set of seventeen flavone-8-acrylamide derivatives (8a-q) were synthesized and evaluated for their cholinesterase inhibitory, antioxidant, neuroprotective and modulation of A beta aggregation activities. The target compounds showed effective and selective inhibitory activity against the AChE over BuChE. In addition, the target compounds also showed moderate antioxidant activity and strong neuroprotective capacities, and accelerated dosage-dependently the A beta aggregation. Also, we presented here a complete study on the interaction of 8a, 8d, 8e, 8h and 8i with AChE. Through fluorescence emission studies, the binding sites number found to be 1, binding constants were calculated as 2.04 x 10(4), 2.22 x 10(4), 1.18 x 10(4), 9.8 x 10(3) and 3.2 x 10(4) M-1 and free energy change as -5.83, -5.91, -5.51, -5.41 and -6.12 kcal M-1 at 25 degrees C which were well agreed with the computational calculations indicating a strong binding affinity of flavones and AChE. Furthermore, the CD studies revealed that the secondary structure of AChE became partly unfolded upon binding with 8a, 8d, 8e, 8h and 8i.

HPLC of Formula: C13H13N. Bye, fridends, I hope you can learn more about C13H13N, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

An article Photochemical C-H Amination of Ethers and Geminal Difunctionalization Reactions in One Pot WOS:000479138600001 published article about INTERMOLECULAR ADDITION-REACTIONS; SULFONYL AZIDES; FUNCTIONALIZATION; SULFONAMIDES; DERIVATIVES; OXIDATION; BONDS; ACID in [Hernandez-Guerra, Daniel; Hlavackova, Anna; Pramthaisong, Chiranan; Vespoli, Ilaria; Pohl, Radek; Slanina, Tomas; Jahn, Ullrich] Czech Acad Sci, Inst Organ Chem & Biochem, Flemingovo Namesti 2, Prague 16610 6, Czech Republic in 2019, Cited 54. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9. Safety of Diphenylmethanamine

A mild, atom-economic, and metal-free alpha-C-H amination of ethers using relatively stable nonafluorobutanesulfonyl (nonaflyl, Nf) azide as the aminating reagent to give N-sulfonyl hemiaminals is reported. This enables unprecedented C(sp(3)) difunctionalization reactions, leading to diverse functionalized amino group containing compounds starting from simple ethers in one pot.

Safety of Diphenylmethanamine. Welcome to talk about 91-00-9, If you have any questions, you can contact Hernndez-Guerra, D; Hlavackov, A; Pramthaisong, C; Vespoli, I; Pohl, R; Slanina, T; Jahn, U or send Email.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

An article Hexacoordinated nickel catalysts containing salicylaldbenzhydrylimine ligand and tetrahydrofuran heterocycle: High catalytic activity and high 1-hexene insert ratios for norbornene (Co)polymerization WOS:000525896700008 published article about RING-OPENING METATHESIS; PALLADIUM COMPLEXES; POLYMERIZATION; COPOLYMERIZATION; ETHYLENE; 1-ALKENE in [He, Xiaohui; Duan, Yapeng; Guo, Yan; Wang, Kai; Wu, Bin; Wen, Yufei; Zou, Jianhua; Zhu, Chuanyi; Huang, Shengmei] Nanchang Univ, Sch Mat Sci & Engn, 999 Xuefu Ave, Nanchang 330031, Jiangxi, Peoples R China; [Chen, Defu] Nanchang Univ, Sch Civil Engn & Architecture, 999 Xuefu Ave, Nanchang 330031, Jiangxi, Peoples R China; [Huang, Shengmei] Nanchang Hangkong Univ, Sch Mat Sci & Engn, Nanchang 330063, Jiangxi, Peoples R China in 2020.0, Cited 34.0. Application In Synthesis of Diphenylmethanamine. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9

Three novel hexacoordinated nickel catalysts containing salicylaldbenzhydrylimine ligand and tetrahydrofuran heterocycle, Ni{(THF) (3-R-1) (5-R-2)C6H2(O)CHNCH(C6H5)(2)}(2), (R-1 = Br, R-2 = H, Ni1; R-1 = Br, R-2 = Br, Ni2; R-1 = Cl, R-2 = Cl, Ni3.), were synthesized and their molecular structures were confirmed by X-ray crystallography. Ni1-Ni3 catalysts exhibited high activities (0.53-2.11 x 10(6) g(polymer)/mol(Ni).h) toward norbornene homopolymerization and high activity (0.29-2.62 x 10(5) g(polymer)/mol(Ni).h) to copolymerization of norbornene and 1-hexene. When the 1-hexene feed ratio was changed from 10 to 70%, the 1-hexene content in the obtained copolymers could be controlled to 8.23-26.58%. The Ni3 with R-1 and R-2 were both electron withdrawing groups (-Cl) on the aromatic ring of salicylaldehyde, showed the highest activity as well as the highest 1-hexene insert ratios. At the same time, only a small amount of B(C6F5)(3) cocatalyst (5 x 10(-5) mol) need to be consumed in the copolymerization process. In addition, the obtained copolymers had a high thermal decomposition temperature (T-d > 386 degrees C) and a low glass transition temperature (T-g = 208.67-237.42 degrees C), which showed that the processability of these polymers was improved while the high thermal decomposition temperature was kept. The copolymers also exhibited good solubility in general organic solvents and high optical transparency in the visible region. (C) 2020 Elsevier B.V. All rights reserved.

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Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Quality Control of Diphenylmethanamine. Wang, Y; Cao, XY; Zhao, LY; Pi, C; Ji, JF; Cui, XL; Wu, YJ in [Wang, Yong; Pi, Chao; Cui, Xiuling; Wu, Yangjie] Zhengzhou Univ, Key Lab Appl Chem Henan Univ, Green Catalysis Ctr, Henan Key Lab Chem Biol & Organ Chem, Zhengzhou 450052, Peoples R China; [Wang, Yong; Pi, Chao; Cui, Xiuling; Wu, Yangjie] Zhengzhou Univ, Coll Chem, Zhengzhou 450052, Peoples R China; [Cao, Xinyi; Zhao, Leyao; Ji, Jingfei] Zhengzhou Univ, Int Coll, Zhengzhou 450052, Peoples R China published Generalized Chemoselective Transfer Hydrogenation/Hydrodeuteration in 2020, Cited 156. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9.

A generalized, simple and efficient transfer hydrogenation of unsaturated bonds has been developed using HBP in and various proton reagents as hydrogen sources. The substrates, including alkenes, alkynes, aromatic heterocycles, aldehydes, ketones, imines, azo, nitro, epoxy and nitrile compounds, are all applied to this catalytic system. Various groups, which cannot survive under the Pd/C/H-2 combination, are tolerated. The activity of the reactants was studied and the trends are as follows:styrene>diphenylmethanimine>benzaldehyde>azobenzene>nitrobenzene>quinoline>acetophenone>benzonitrile. Substrates bearing two or more different unsaturated bonds were also investigated and transfer hydrogenation occurred with excellent chemoselectivity. Nano-palladium catalystin situgenerated from Pd(OAc)(2) and HBP in extremely improved the TH efficiency. Furthermore, chemoselective anti-Markovnikov hydrodeuteration of terminal aromatic olefins was achieved using D2O and HBP in via in situ HD generation and discrimination.

Quality Control of Diphenylmethanamine. Bye, fridends, I hope you can learn more about C13H13N, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Hernndez-Guerra, D; Hlavackov, A; Pramthaisong, C; Vespoli, I; Pohl, R; Slanina, T; Jahn, U in [Hernandez-Guerra, Daniel; Hlavackova, Anna; Pramthaisong, Chiranan; Vespoli, Ilaria; Pohl, Radek; Slanina, Tomas; Jahn, Ullrich] Czech Acad Sci, Inst Organ Chem & Biochem, Flemingovo Namesti 2, Prague 16610 6, Czech Republic published Photochemical C-H Amination of Ethers and Geminal Difunctionalization Reactions in One Pot in 2019, Cited 54. Quality Control of Diphenylmethanamine. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9.

A mild, atom-economic, and metal-free alpha-C-H amination of ethers using relatively stable nonafluorobutanesulfonyl (nonaflyl, Nf) azide as the aminating reagent to give N-sulfonyl hemiaminals is reported. This enables unprecedented C(sp(3)) difunctionalization reactions, leading to diverse functionalized amino group containing compounds starting from simple ethers in one pot.

Bye, fridends, I hope you can learn more about C13H13N, If you have any questions, you can browse other blog as well. See you lster.. Quality Control of Diphenylmethanamine

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics