Category: 89281-13-0

Miletin, Miroslav; Hartl, J.; Odlerova, Z.; Machacek, M. published an article in Pharmazie. The title of the article was 《Synthesis of some 2,6-bis(alkylthio)-4-pyridinecarboxamides and -carbothioamides and their antimycobacterial and antialgal activity》.Application of 89281-13-0 The author mentioned the following in the article:

Various 2,6-bis(alkylthio)-4-pyridinecarboxamides were prepared by treatment of 2,6-dichloro-4-pyridinecarboxamide with 1-alkanethiols. Subsequent reaction with Lawesson’s reagent gave the corresponding thioamides. The thioamides especially showed antimycobacterial activity; some of them inhibited chlorophyll production of Chlorella vulgaris. In the experiment, the researchers used 2,6-Dichloroisonicotinamide(cas: 89281-13-0Application of 89281-13-0)

2,6-Dichloroisonicotinamide(cas: 89281-13-0) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.Application of 89281-13-0

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

《Preparation of Primary Amides from Functionalized Organozinc Halides》 was written by Schade, Matthias A.; Manolikakes, Georg; Knochel, Paul. Quality Control of 2,6-Dichloroisonicotinamide And the article was included in Organic Letters on August 20 ,2010. The article conveys some information:

Organozinc halides, which are prepared either by direct zinc insertion or halogen-magnesium exchange and subsequent transmetalation with ZnCl2, react smoothly with com. available trichloroacetyl isocyanate to give, after hydrolysis, the corresponding primary amides. This method is compatible with a variety of functional groups such as an ester or a cyano group. Also heterocyclic-, alkenyl, and acetylenic zinc reagents are converted to the corresponding primary amides under these conditions. In the part of experimental materials, we found many familiar compounds, such as 2,6-Dichloroisonicotinamide(cas: 89281-13-0Quality Control of 2,6-Dichloroisonicotinamide)

2,6-Dichloroisonicotinamide(cas: 89281-13-0) belongs to anime. Reduction of nitro compounds, RNO2, by hydrogen or other reducing agents produces primary amines cleanly (i.e., without a mixture of products), but the method is mostly used for aromatic amines because of the limited availability of aliphatic nitro compounds. Reduction of nitriles and oximes (R2C=NOH) also yields primary amines.Quality Control of 2,6-Dichloroisonicotinamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

SDS of cas: 89281-13-0On May 20, 1999 ,《Design, synthesis and activity of 2,6-diphenoxypyridine-derived factor Xa inhibitors》 appeared in Journal of Medicinal Chemistry. The author of the article were Phillips, Gary; Davey, David D.; Eagen, Keith A.; Koovakkat, Sunil K.; Liang, Amy; Ng, Howard P.; Pinkerton, Michael; Trinh, Lan; Whitlow, Marc; Beatty, Alicia M.; Morrissey, Michael M.. The article conveys some information:

A novel series of 2,6-diphenoxypyridine derivatives I ( R = H, 3,5-Cl2, 4-CO3Et, etc.) and II (X = H, 3,5-Cl2) has been designed to inhibit factor Xa, a serine protease strategically located in the coagulation cascade. The evolution from the photochem. unstable bis(amidine) (Z,Z)-BABCH III to potent bis(amidine) compounds with a pyridine heterocycle as the core scaffold has been achieved. The most potent compound in the series, I (X = 3,5-F2-4-Me) (IV), has a Ki for human factor Xa of 12 nM. The selectivity of IV against bovine trypsin and human thrombin was greater than 90- and 1000-fold, resp. Two proposed modes of binding of IV to factor Xa are made based on the crystal structures of IV by itself and of IV bound to bovine trypsin. After reading the article, we found that the author used 2,6-Dichloroisonicotinamide(cas: 89281-13-0SDS of cas: 89281-13-0)

2,6-Dichloroisonicotinamide(cas: 89281-13-0) belongs to anime. Amine, any member of a family of nitrogen-containing organic compounds that is derived, either in principle or in practice, from ammonia (NH3). Naturally occurring amines include the alkaloids, which are present in certain plants; the catecholamine neurotransmitters (i.e., dopamine, epinephrine, and norepinephrine); and a local chemical mediator, histamine, that occurs in most animal tissues.SDS of cas: 89281-13-0

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Miletin, Miroslav; Dolezal, Martin; Opletalova, Veronika; Hartl, Jiri; Kral’ova, Katarina; Machacek, Milos published an article in Molecules [online computer file]. The title of the article was 《Some anilides of 2-alkylthio- and 2-chloro-6-alkylthio-4-pyridinecarboxylic acids: synthesis and photosynthesis-inhibiting activity》.Computed Properties of C6H4Cl2N2O The author mentioned the following in the article:

Many compounds containing a -CONH- group display photosynthesis-inhibiting activity. Based on this structural feature, a group of anilides of 2-alkylthio- (I) or 2-chloro-6-alkylthio-4-pyridinecarboxylic acids (II) was synthesized. The prepared compounds were tested for their inhibition of the oxygen evolution rate (OER) in spinach chloroplasts. A quasi-parabolic dependence between photosynthesis-inhibiting activity and the lipophilicity of the compounds was determined The inhibitory activity of compounds I was higher than that of II for comparable lipophilicity values. The results came from multiple reactions, including the reaction of 2,6-Dichloroisonicotinamide(cas: 89281-13-0Computed Properties of C6H4Cl2N2O)

2,6-Dichloroisonicotinamide(cas: 89281-13-0) belongs to anime. Acylation is one of the most important reactions of primary and secondary amines; a hydrogen atom is replaced by an acyl group (a group derived from an acid, such as RCOOH or RSO3H, by removal of ―OH, such as RC(=O)―, RS(O)2―, and so on). Reagents may be acid chlorides (RCOC1, RSO2C1), anhydrides ((RCO)2O), or even esters (RCOOR′); the products are amides of the corresponding acids.Computed Properties of C6H4Cl2N2O

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Lawson, Edward C.; Santulli, Rosemary J.; Dyatkin, Alexey B.; Ballentine, Scott A.; Abraham, William M.; Rudman, Sandra; Page, Clive P.; de Garavilla, Lawrence; Damiano, Bruce P.; Kinney, William A.; Maryanoff, Bruce E. published an article in Bioorganic & Medicinal Chemistry. The title of the article was 《Selection of a 2-azabicyclo[2.2.2]octane-based α4β1 integrin antagonist as an inhaled anti-asthmatic agent》.Category: amides-buliding-blocks The author mentioned the following in the article:

The α4β1 integrin, expressed on eosinophils and neutrophils, induces inflammation in the lung by facilitating cellular infiltration and activation. From a number of potent α4β1 antagonists that the authors evaluated for safety and efficacy, compound (I) was selected as a lead candidate for antiasthma therapy by the inhalation route. The authors devised an optimized stereoselective synthesis to facilitate the preparation of a sufficiently large quantity of I for assessment in vivo. Administration of I to allergen-sensitive sheep by inhalation blocked the late-phase response of asthma and abolished airway hyper-responsiveness at 24 h following the antigen challenge. Addnl., the recruitment of inflammatory cells into the lungs was inhibited. Administration of I to ovalbumin-sensitized guinea pigs i.p. blocked airway resistance and inhibited the recruitment of inflammatory cells. The experimental part of the paper was very detailed, including the reaction process of 2,6-Dichloroisonicotinamide(cas: 89281-13-0Category: amides-buliding-blocks)

2,6-Dichloroisonicotinamide(cas: 89281-13-0) belongs to anime. Acylation is one of the most important reactions of primary and secondary amines; a hydrogen atom is replaced by an acyl group (a group derived from an acid, such as RCOOH or RSO3H, by removal of ―OH, such as RC(=O)―, RS(O)2―, and so on). Reagents may be acid chlorides (RCOC1, RSO2C1), anhydrides ((RCO)2O), or even esters (RCOOR′); the products are amides of the corresponding acids.Category: amides-buliding-blocks

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Reference of 2,6-DichloroisonicotinamideOn March 31, 2000, Miletin, Miroslav; Hartl, Jiri; Dolezal, Martin; Odlerova, Z.; Kralova, K.; Machacek, Milos published an article in Molecules [Electronic Publication]. The article was 《Synthesis of some 2,6-disubstituted 4-amidopyridines and -thioamidopyridines, and their antimycobacterial and photosynthesis-inhibiting activity》. The article mentions the following:

A group of 26 new 2-halo-6-alkylthio- and 2,6-bis(alkylthio)-4-carbamoyl- and -thiocsrbamoylpyridines was synthesized. Some of the carbamoylpyridines and all thiocarbamoylpyridines were tested for their antimycobacterial activity against atypical mycobacterial strains. Promising photosynthesis-inhibiting activity was also found for some of the amidopyridines. The experimental part of the paper was very detailed, including the reaction process of 2,6-Dichloroisonicotinamide(cas: 89281-13-0Reference of 2,6-Dichloroisonicotinamide)

2,6-Dichloroisonicotinamide(cas: 89281-13-0) belongs to anime. Aniline, ethanolamines, and several other amines are major industrial commodities used in making rubber, dyes, pharmaceuticals, and synthetic resins and fibres and for a host of other applications. Most of the numerous methods for the preparation of amines may be broadly divided into two groups: (1) chemical reduction (replacement of oxygen with hydrogen atoms in the molecule) of members of several other classes of organic nitrogen compounds and (2) reactions of ammonia or amines with organic compounds.Reference of 2,6-Dichloroisonicotinamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

《Pyrrolamide DNA gyrase inhibitors: Optimization of antibacterial activity and efficacy》 was published in Bioorganic & Medicinal Chemistry Letters in 2011. These research results belong to Sherer, Brian A.; Hull, Kenneth; Green, Oluyinka; Basarab, Gregory; Hauck, Sheila; Hill, Pamela; Loch, James T. III; Mullen, George; Bist, Shanta; Bryant, Joanna; Boriack-Sjodin, Ann; Read, Jon; DeGrace, Nancy; Uria-Nickelsen, Maria; Illingworth, Ruth N.; Eakin, Ann E.. Synthetic Route of C6H4Cl2N2O The article mentions the following:

The pyrrolamides are a new class of antibacterial agents targeting DNA gyrase, an essential enzyme across bacterial species and inhibition results in the disruption of DNA synthesis and subsequently, cell death. The optimization of biochem. activity and other drug-like properties through substitutions to the pyrrole, piperidine, and heterocycle portions of the mol. resulted in pyrrolamides with improved cellular activity and in vivo efficacy.2,6-Dichloroisonicotinamide(cas: 89281-13-0Synthetic Route of C6H4Cl2N2O) was used in this study.

2,6-Dichloroisonicotinamide(cas: 89281-13-0) belongs to anime. The methylamines occur in small amounts in some plants. Many polyfunctional amines (i.e., those having other functional groups in the molecule) occur as alkaloids in plants—for example, mescaline, 2-(3,4,5-trimethoxyphenyl)ethylamine; the cyclic amines nicotine, atropine, morphine, and cocaine; and the quaternary salt choline, N-(2-hydroxyethyl)trimethylammonium chloride, which is present in nerve synapses and in plant and animal cells.Synthetic Route of C6H4Cl2N2O

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

《Synthesis of novel pyridine and pyrimidine derivatives as potential inhibitors of HIV-1 reverse transcriptase using palladium-catalysed C-N cross-coupling and nucleophilic aromatic substitution reactions》 was published in ARKIVOC (Gainesville, FL, United States) in 2020. These research results belong to Changunda, Charles R. K.; Rousseau, Amanda L.; Basson, Adriaan E.; Bode, Moira L.. Electric Literature of C6H4Cl2N2O The article mentions the following:

Palladium-mediated cross-coupling reactions are used in the successful construction of a small library of flexible heteroatom-linked diarylpyridine target compounds I (R = H, cyano, cyclopropylamino; R1 = cyano, aminocarbonyl, cyclopropylamino; R2 = 4-chlorophenoxy, 2-cyano-5-methylphenyl, cyclohexylamino), including pyridines bearing a secondary amide substituent. Heteroatom-linked diarylpyrimidine derivatives II (R3 = 4-Cl, 2,4-Cl2, 3,5-Cl2, 4-F, 3-CF3; R4 = 5-methylpyridin-2-yl, 5-chloropyrimidin-2-yl, 2-cyano-5-methylphenyl) bearing a chlorine substituent are prepared by base-catalyzed nucleophilic aromatic substitution reactions without the need for palladium catalysis.2,6-Dichloroisonicotinamide(cas: 89281-13-0Electric Literature of C6H4Cl2N2O) was used in this study.

2,6-Dichloroisonicotinamide(cas: 89281-13-0) belongs to anime. Examples of direct uses of amines and their salts are as corrosion inhibitors in boilers and in lubricating oils (morpholine), as antioxidants for rubber and roofing asphalt (diarylamines), as stabilizers for cellulose nitrate explosives (diphenylamine), as protectants against damage from gamma radiation (diarylamines), as developers in photography (aromatic diamines), as flotation agents in mining, as anticling and waterproofing agents for textiles, as fabric softeners, in paper coating, and for solubilizing herbicides.Electric Literature of C6H4Cl2N2O

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

《Nicotinamide and structurally related compounds show halting activity against zoospores of the phytopathogenic fungus Aphanomyces cochlioides》 was written by Shimai, Takashi; Islam, Tofazzal Md.; Fukushi, Yukiharu; Hashidoko, Yasuyuki; Yokosawa, Ryozo; Tahara, Satoshi. HPLC of Formula: 89281-13-0 And the article was included in Zeitschrift fuer Naturforschung, C: Journal of Biosciences on April 30 ,2002. The article conveys some information:

In a survey of plant secondary metabolites regulating the behavior of phytopathogenic Aphanomyces cochlioides zoospores, we found that leaf extracts of Amaranthus gangeticus and cotyledon extracts of pea (Pisum sativum) remarkably halted the motility of zoospores. Bioassay-directed fractionation of A. gangeticus and pea constituents revealed that the halting activity was dependent on a single chem. factor (halting factor). The active principle was identified as nicotinamide (1) by comparing its biol. activity and spectroscopic properties with those of the authentic compound Nicotinamide (1) showed potent halting activity toward the zoospores of A. cochlioides and A. euteiches, but it exhibited very less activity against other Oomycetes, Pythium aphanidermatum and Phytophthora infestans zoospores. Interestingly, the zoospores halted by nicotinamide (1) encysted within 10-15 min and then the resulting cystospores regenerated zoospores instead of germination. Nicotinamide (1) and related compounds were subjected to the halting activity bioassay to elucidate the structure-activity relationships. These bioassays revealed that part structures of (A) the aromatic ring containing at least one nitrogen atom, (B) carbonyl-like group adjacent to the aromatic ring and (C) hydrogen atoms on the amide group are responsible for the strong activity. So far, this is the first report of halting activity of nicotinamide (1) against fungal zoospores. In the experiment, the researchers used 2,6-Dichloroisonicotinamide(cas: 89281-13-0HPLC of Formula: 89281-13-0)

2,6-Dichloroisonicotinamide(cas: 89281-13-0) belongs to anime. Reduction of nitro compounds, RNO2, by hydrogen or other reducing agents produces primary amines cleanly (i.e., without a mixture of products), but the method is mostly used for aromatic amines because of the limited availability of aliphatic nitro compounds. Reduction of nitriles and oximes (R2C=NOH) also yields primary amines.HPLC of Formula: 89281-13-0

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics