Category: 89-73-6

Matsuzaki, Yuichi;Uda, Yukie;Kurahashi, Makoto;Iwahashi, Fukumatsu published 《Microtiter plate test using liquid medium is an alternative method for monitoring metyltetraprole sensitivity in Cercospora beticola》. The research results were published in《Pest Management Science》 in 2021.Quality Control of N,2-Dihydroxybenzamide The article conveys some information:

Metyltetraprole is a new quinone outside inhibitor (QoI) fungicide showing potent activity against QoI-resistant fungi that possess the G143A cytochrome b mutation, which confers resistance to existing QoIs such as trifloxystrobin. For its sustainable use, monitoring of metyltetraprole sensitivity is necessary and the establishment of appropriate methodol. is important in each pathogen species. In Cercospora beticola, the causal agent of sugar beet leaf spot, some isolates were less sensitive to metyltetraprole (EC50 > 1 mg L^-1, higher than the saturated concentration) using the common agar plate method, even with 100 mg L^-1 salicylhydroxamic acid, an alternative oxidase inhibitor. However, microtiter tests (EC50 < 0.01 mg L^-1), conidial germination tests (EC50 < 0.01 mg L^-1) and in planta tests (>80% control at 75 mg L^-1 run-off spraying) confirmed that all tested isolates were highly sensitive to metyltetraprole. For trifloxystrobin, G143A mutants were clearly resistant upon microtiter plate tests (median EC50 > 2 mg L^-1) and distinct from wild-type isolates (median EC50 < 0.01 mg L^-1). Notably, mycelium fragments were usable for the microtiter plate tests and the test was applicable for isolates that do not form sufficient conidia. Our monitoring study by microtiter plate tests did not indicate the presence of metyltetraprole-resistant C. beticola isolates in populations in Hokkaido, Japan. The microtiter tests were revealed to be useful for monitoring the sensitivity of C. beticola to metyltetraprole and trifloxystrobin. To complete the study, the researchers used N,2-Dihydroxybenzamide (cas: 89-73-6) .

N,2-Dihydroxybenzamide(cas: 89-73-6) can be used:To prepare phenylboronic acid-based bioconjugates for chromatographic applications;As a ligand to synthesize Fe(III), Cu(II), Ni(II) and Zn(II) complexes.Quality Control of N,2-Dihydroxybenzamide

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Name: N,2-DihydroxybenzamideIn 2021, Dey, Tanmay;Das, Satyajit;Majumdar, Arkajo;Kar, Rup Kumar published 《Apoplastic reactive oxygen species mediated escape growth of root during illumination in Vigna radiata (L.) Wilczek seedlings》. 《Acta Physiologiae Plantarum》published the findings. The article contains the following contents:

Besides gravity, roots are also guided by light to grow deep into the soil and sensitivity of roots to light is evidently due to presence of photoreceptors like phototropins. Such light-induced root growth (light-escape growth) presumably involves reactive oxygen species (ROS). Present study explores the possibility of ROS action in this event during early seedling growth of Vigna radiata based on pharmacol. evidences. Germinated (20 h) seeds were incubated in dark or light in presence of general ROS scavenger (Pr gallate), specific scavengers of O^·₂^– (copper chloride; CuCl₂), H₂O₂ [dimethylthiourea (DMTU) and potassium iodide (KI)] and ^·OH (sodium benzoate) and ROS-producing enzyme inhibitors [zinc chloride (ZnCl₂), inhibitor of NADPH oxidase (NOX); diethyldithiocarbamate (DEDTC), inhibitor of superoxide dismutase (SOD) and salicylhydroxamic acid (SHAM), inhibitor of peroxidase]. Light-induced root growth of 3-day seedlings diminished signifcantly in case of all the treatments suggesting for a pos. role of ROS in light-escape growth. This is supported by elevated level of apoplastic ROS in light grown roots as evident from ROS-specific staining [nitroblue tetrazolium chloride (NBT) for O^·₂^– and 3,3,5,5-tetramethylbenzidine (TMB) for H₂O₂] and spectrophotometric estimation of apoplastic ROS production (O^·₂^– and H₂O₂). In addition, higher activity of membrane bound NOX (producing O^·₂^– ) and apoplastic class III peroxidase (Prx, producing ^·OH) in light grown roots further corroborates the view that apoplastic ROS (initiated with NOX-generated O^·₂^– , which is converted, either spontaneously or by the activity of SOD, to H₂O₂ and further metabolized by Prx to ^·OH that participates in cell wall relaxation required for growth) is instrumental in light-escape growth of roots.N,2-Dihydroxybenzamide (cas: 89-73-6) were involved in the experimental procedure.

N,2-Dihydroxybenzamide(cas: 89-73-6) is a hydroxamic acid that inhibits the activity of p-hydroxybenzoic acid (PHBA) reductase, an enzyme involved in the conversion of PHBA to benzoic acid. Name: N,2-Dihydroxybenzamide The compound has been shown to inhibit mitochondrial membrane potential and mitochondrial functions, leading to cell death.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Barreto, Pedro;Dambire, Charlene;Sharma, Gunjan;Vicente, Jorge;Osborne, Rory;Yassitepe, Juliana;Gibbs, Daniel J.;Maia, Ivan G.;Holdsworth, Michael J.;Arruda, Paulo published 《Mitochondrial retrograde signaling through UCP1-mediated inhibition of the plant oxygen-sensing pathway》 in 2022. The article was appeared in 《Current Biology》. They have made some progress in their research.Formula: C7H7NO3 The article mentions the following:

Mitochondrial retrograde signaling is an important component of intracellular stress signaling in eukaryotes. UNCOUPLING PROTEIN (UCP)1 is an abundant plant inner-mitochondrial membrane protein with multiple functions including uncoupled respiration and amino-acid transport1,2 that influences broad abiotic stress responses. Although the mechanism(s) through which this retrograde function acts is unknown, overexpression of UCP1 activates expression of hypoxia (low oxygen)-associated nuclear genes.3,4 Here we show in Arabidopsis thaliana that UCP1 influences nuclear gene expression and physiol. response by inhibiting the cytoplasmic PLANT CYSTEINE OXIDASE (PCO) branch of the PROTEOLYSIS (PRT)6 N-degron pathway, a major mechanism of oxygen and nitric oxide (NO) sensing.5 Overexpression of UCP1 (UCP1ox) resulted in the stabilization of an artificial PCO N-degron pathway substrate, and stability of this reporter protein was influenced by pharmacol. interventions that control UCP1 activity. Hypoxia and salt-tolerant phenotypes observed in UCP1ox lines resembled those observed for the PRT6 N-recognin E3 ligase mutant prt6-1. Genetic anal. showed that UCP1 regulation of hypoxia responses required the activity of PCO N-degron pathway ETHYLENE RESPONSE FACTOR (ERF)VII substrates. Transcript expression anal. indicated that UCP1 regulation of hypoxia-related gene expression is a normal component of seedling development. Our results show that mitochondrial retrograde signaling represses the PCO N-degron pathway, enhancing substrate function, thus facilitating downstream stress responses. This work reveals a novel mechanism through which mitochondrial retrograde signaling influences nuclear response to hypoxia by inhibition of an ancient cytoplasmic pathway of eukaryotic oxygen sensing. And N,2-Dihydroxybenzamide (cas: 89-73-6) was used in the research process.

N,2-Dihydroxybenzamide(cas: 89-73-6) has also been shown to be active against wild-type strains of Candida glabrata, but not against resistant mutants. Formula: C7H7NO3 This drug may have therapeutic potential for bone cancer and metabolic disorders such as obesity.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Cheng, Xingkai;Man, Xuejing;Wang, Zitong;Liang, Li;Zhang, Fan;Wang, Zhiwen;Liu, Pengfei;Lei, Bin;Hao, Jianjun;Liu, Xili published 《Fungicide SYP-14288 inducing multidrug resistance in Rhizoctonia solani》 in 2020. The article was appeared in 《Plant Disease》. They have made some progress in their research.Application In Synthesis of N,2-Dihydroxybenzamide The article mentions the following:

Rhizoctonia solani is a widely distributed soilborne plant pathogen, and can cause significant economic losses to crop production In chem. controls, SYP-14288 is highly effective against plant pathogens, including R. solani. To examine the sensitivity to SYP-14288, 112 R. solani isolates were collected from infected rice plants. An established baseline sensitivity showed that values of effective concentration for 50% growth inhibition (EC50) ranged from 0.0003 to 0.0138μg/mL, with an average of 0.0055 ± 0.0030μg/mL. The frequency distribution of the EC50 was unimodal and the range of variation factor (the ratio of maximal over minimal EC50) was 46.03, indicating that all wild-type strains were sensitive to SYP-14288. To examine the risk of fungicide resistance, 20 SYP-14288-resistant mutants were generated on agar plates amended with SYP-14288. Eighteen mutants remained resistant after 10 transfers, and their fitness was significantly different from the parental strain. All of the mutants grew more slowly but showed high virulence to rice plants, though lower than the parental strain. A crossresistance assay demonstrated that there was a pos. correlation between SYP-14288 and fungicides having or not having the same mode of action with SYP-14288, including fluazinam, fentin chloride, fludioxonil, difenoconazole, cyazofamid, chlorothalonil, and 2,4-dinitrophen. This result showed a multidrug resistance induced by SYP-14288, which could be a concern in increasing the spectrum of resistance in R. solani to commonly used fungicides. And N,2-Dihydroxybenzamide (cas: 89-73-6) was used in the research process.

N,2-Dihydroxybenzamide(cas: 89-73-6) can be used:To prepare phenylboronic acid-based bioconjugates for chromatographic applications;As a ligand to synthesize Fe(III), Cu(II), Ni(II) and Zn(II) complexes.Application In Synthesis of N,2-Dihydroxybenzamide

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Morosanova, Maria A.;Kovalev, Vitaliy A.;Morosanova, Elena I. published 《Silica Xerogel Doped with Iron(III) as Sensor Material for Salicylhydroxamic Acid Determination in Urine》 in 2021. The article was appeared in 《Gels》. They have made some progress in their research.SDS of cas: 89-73-6 The article mentions the following:

Salicylhydroxamic acid (SHA) is used as antimicrobic medicine and its concentration has to be monitored in urine. For the first time, silica xerogels doped with iron(III) have been proposed as sensor materials for SHA determination in biol. samples. Three xerogels with iron(III) content in the range of 0.04-1.74% wt have been synthesized. BET surface area of these xerogels has varied in the range of 696-529 m2/g and total pore volume has varied in the range of 0.92-0.23 cm3/g. Complex formation between immobilized iron(III) and salicylhydroxamic acid has been investigated with solid phase spectrophotometry and IR spectroscopy. Orange-brown iron(III)-SHA complex with 1:1 stoichiometry is formed at pH 1-4 with half-reaction time of 17 min. Silica xerogel doped with 0.33% wt iron(III)) has been used as sensor material for SHA solid phase spectrophotometric determination (LOD 1.4 mg/L (n = 3), anal. range 4-230 mg/L). Proposed sensor material has been applied for SHA determination in biol. samples of synthetic and human urine. The proposed procedusalicylhydroxamic acid re is characterized by a good level of accuracy (recovery values 97-120%) and precision (RSD values 4-9%) and can be recommended for pharmacokinetic-pharmacodynamic studies of hydroxamic acid-based medications.N,2-Dihydroxybenzamide (cas: 89-73-6) were involved in the experimental procedure.

N,2-Dihydroxybenzamide(cas: 89-73-6) has also been shown to be active against wild-type strains of Candida glabrata, but not against resistant mutants. SDS of cas: 89-73-6 This drug may have therapeutic potential for bone cancer and metabolic disorders such as obesity.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Vegas-Suarez, Sergio;Aristieta, Asier;Requejo, Catalina;Bengoetxea, Harkaitz;Lafuente, Jose Vicente;Miguelez, Cristina;Ugedo, Luisa published 《The effect of 5-HT_1A receptor agonists on the entopeduncular nucleus is modified in 6-hydroxydopamine-lesioned rats》. The research results were published in《British Journal of Pharmacology》 in 2021.Recommanded Product: N,2-Dihydroxybenzamide The article conveys some information:

L-DOPA prolonged treatment leads to disabling motor complications as dyskinesia that could be decreased by drugs acting on 5-HT1A receptors. Since the internal segment of the globus pallidus, homologous to the entopeduncular nucleus in rodents, seems to be involved in the etiopathol. of L-DOPA-induced dyskinesia, we investigated whether the entopeduncular nucleus is modulated by the 5-HT_1A receptor partial and full agonists, buspirone, and 8-hydroxy-2-(di-n-propylamino)-tetralin (8-OH-DPAT) in control and 6-hydroxydopamine (6-OHDA)-lesioned rats with or without long-term L-DOPA treatment. Extracellular single-unit electrocorticogram and local field potential recordings under anesthesia, immunostaining assays and optogenetic manipulation coupled to electrophysiol. recordings were performed. Systemic buspirone reduced the entopeduncular nucleus firing rate in the sham animals and burst activity in the 6-OHDA-lesioned rats (with or without L-DOPA treatment), while local administration reduced entopeduncular nucleus activity in all the groups, regardless of DA integrity. Systemic 8-OH-DPAT also induced inhibitory effects only in the sham animals. Effects triggered by buspirone and 8-OH-DPAT were reversed by the 5-HT_1A receptor antagonist, WAY-100635. Neither buspirone nor 8-OH-DPAT modified the low-frequency oscillatory activity in the entopeduncular nucleus or its synchronization with the motor cortex. Buspirone did not alter the response induced by subthalamic nucleus opto-stimulation in the entopeduncular nucleus. Systemic 5-HT_1A receptor activation elicits different effects on the electrophysiol. properties of the entopeduncular nucleus depending on the integrity of the nigrostriatal pathway and it does not alter the relationship between subthalamic nucleus and entopeduncular nucleus neuron activity. To complete the study, the researchers used N,2-Dihydroxybenzamide (cas: 89-73-6) .

N,2-Dihydroxybenzamide(cas: 89-73-6) is a hydroxamic acid that inhibits the activity of p-hydroxybenzoic acid (PHBA) reductase, an enzyme involved in the conversion of PHBA to benzoic acid. Recommanded Product: N,2-Dihydroxybenzamide The compound has been shown to inhibit mitochondrial membrane potential and mitochondrial functions, leading to cell death.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Recommanded Product: N,2-DihydroxybenzamideIn 2020, Li, Yu-Ting;Liu, Mei-Jun;Li, Ying;Liu, Peng;Zhao, Shi-Jie;Gao, Hui-Yuan;Zhang, Zi-Shan published 《Photoprotection by mitochondrial alternative pathway is enhanced at heat but disabled at chilling》. 《Plant Journal》published the findings. The article contains the following contents:

SUMMARY : The mitochondrial alternative pathway (AP) represents an important photoprotective mechanism for the chloroplast, but the temperature sensitivity of its photoprotective role is unknown. In this study, using the aox1a Arabidopsis mutant, the photoprotective role of the AP was verified under various temperatures, and the mechanism underlying the temperature sensitivity of the AP’s photoprotective role was clarified. It was observed that the photoprotective role of the AP increased with rising temperature but was absent at low temperature The photoprotective role of the AP was severely reduced under non-photorespiratory conditions. Disturbance of the AP inhibited the conversion of glycine to serine in mitochondria, which may restrain upstream photorespiratory metabolism and aggravate photoinhibition. With rising temperatures, photorespiration accelerated and the restraint of photorespiration caused by disturbance of the AP also increased, determining the temperature sensitivity of the AP’s photoprotective role. We also verified that not only the AP but also the cytochrome pathway in mitochondria contributes to photoprotection by maintaining photorespiration.N,2-Dihydroxybenzamide (cas: 89-73-6) were involved in the experimental procedure.

N,2-Dihydroxybenzamide(cas: 89-73-6) is a hydroxamic acid that inhibits the activity of p-hydroxybenzoic acid (PHBA) reductase, an enzyme involved in the conversion of PHBA to benzoic acid. Recommanded Product: N,2-Dihydroxybenzamide The compound has been shown to inhibit mitochondrial membrane potential and mitochondrial functions, leading to cell death.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Related Products of 89-73-6《Synthesis and crystal structure of a heterobimetallic nickel-manganese 12-metallacrown-4 methanol disolvate monohydrate compound》 was published in 2020. The authors were Hall, Abigail J.;Zeller, Matthias;Zaleski, Curtis M., and the article was included in《Acta Crystallographica, Section E: Crystallographic Communications》. The author mentioned the following in the article:

The synthesis and crystal structure of the title compound [systematic name: di-μ-acetato-tetrakis(μ₄-N,2-dioxidobenzene-1-carboximidato)hexamethanoltetramanganese(III)nickel(II) methanol disolvate monohydrate], [Mn₄Ni(C₇H₄NO₃)₄(C₂H₃O₂)₂(CH₄O)₆]·₂CH₄O·H₂O or Ni(OAc)₂[12-MC_{Mn(III)N(shi)}-4](CH₃OH)₆·2CH₃OH·H₂O, where MC is metallacrown,^–OAc is acetate, and shi^3-is salicylhydroximate, are reported. The macrocyclic metallacrown is positioned on an inversion center located on the Ni^II ion that resides in the central MC cavity. The macrocycle consists of an Mn^III-N-O repeat unit that recurs four times to generate an overall square-shaped mol. Both the NiII and Mn^III ions are six-coordinate with an octahedral geometry. In addition, the Mn^III ions possess an elongated Jahn-Teller distortion along the z-axis of the coordination environment. The interstitial water mol. is slightly offset from and disordered about an inversion center. And N,2-Dihydroxybenzamide (cas: 89-73-6) was used in the research process.

N,2-Dihydroxybenzamide(cas: 89-73-6) has also been shown to be active against wild-type strains of Candida glabrata, but not against resistant mutants. Related Products of 89-73-6 This drug may have therapeutic potential for bone cancer and metabolic disorders such as obesity.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Li, Mingyang;Lian, De;Zhao, Fugang;Tong, Xiong;Wu, Chaoyang;Gao, Xiangpeng published 《Structure-activity of chelating depressants for chalcopyrite/pyrite separation: DFT study and flotation experiment》. The research results were published in《Physicochemical Problems of Mineral Processing》 in 2021.Category: amides-buliding-blocks The article conveys some information:

Three types of chelating depressants were studied for chalcopyrite/pyrite separation, including S-S, S-O, and O-O types, via d. functional theory calculations and microflotation. The calculation results indicate that the depressant’s chelating atoms have large coefficient and great activity according to the mol. frontier orbital (HOMO and LUMO) and the orbital coefficients For S-S type of depressant, S atom in both keto or enol forms won’t affect their HOMO and LUMO patterns and the orbital contributions. For S-O type, the presence of N atom in the ring structure of a mol. will increase the reactivity of O-Cu while weak S-Cu. For O-O type, the electron supply capacity of benzene ring is higher than strain chain, and atom N in strain chain increased their electron supply capacity. The microflotation results basically confirmed the prediction based on the calculation The simulation results demonstrate that the interaction of a depressant with metals and minerals are affected obviously by the spatial structure and electronic structure of an atom in its mol.N,2-Dihydroxybenzamide (cas: 89-73-6) were involved in the experimental procedure.

N,2-Dihydroxybenzamide(cas: 89-73-6) can be used:To prepare phenylboronic acid-based bioconjugates for chromatographic applications;As a ligand to synthesize Fe(III), Cu(II), Ni(II) and Zn(II) complexes.Category: amides-buliding-blocks

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Chuan, Libo;Huang, Xin;Fan, Chuming;Wen, Shiyuan;Yang, Xiaohua;Wang, Jingrong;Ren, Jingyu;Ru, Jin;Ding, Li published 《Metformin ameliorates brain damage caused by cardiopulmonary resuscitation via targeting endoplasmic reticulum stress-related proteins GRP78 and XBP1》. The research results were published in《European Journal of Pharmacology》 in 2021.Synthetic Route of C7H7NO3 The article conveys some information:

Cerebral damage after cardiac arrest (CA) and cardiopulmonary resuscitation (CPR) is a primary cause of death. Endoplasmic reticulum stress (ERS) is very important during these situations. This study aimed to explore the role of metformin in protecting brain endoplasmic reticulum post CA/CPR. Male SD rats (n = 132) were treated with 6-min CA-posted asphyxia and sham surgery. Before CA/CPR, metformin (200 mg/kg/day) or a vehicle (0.9% saline) were administered randomly for two weeks. The neurol. deficit scores were assessed 24 h, 48 h, 72 h, and 7 days after CA/CPR, and the rat brains were analyzed by Western blotting and qRT-PCR. Apoptosis was detected by the TUNEL assay according to the mitochondrial membrane potential (MMP). Oxidative stress and ERS-related protein expression were also investigated. The Western blotting and qRT-PCR results revealed that the resuscitated animals had time-dependent elevated GRP78 and XBP1 levels compared with the sham operative rats. Moreover, our results showed that the rats treated with metformin had increased neurol. deficit scores (NDS), an improved seven-day survival rate, decreased cell apoptosis within the hippocampus CA1 area, and less oxidative stress compared with the CA/CPR group. Furthermore, metformin inhibited the mRNA and protein expressions of glucose-regulated protein 78 (GRP78) and X-box binding protein 1 (XBP1) in the CA/CPR rat model. We confirmed that CA/CPR can induce ERS-related apoptosis and oxidative stress in the brain; moreover, inhibiting ERS-related proteins GRP78 and XBP1 with metformin might attenuate cerebral injury post CA/CPR. To complete the study, the researchers used N,2-Dihydroxybenzamide (cas: 89-73-6) .

N,2-Dihydroxybenzamide(cas: 89-73-6) can be used:To prepare phenylboronic acid-based bioconjugates for chromatographic applications;As a ligand to synthesize Fe(III), Cu(II), Ni(II) and Zn(II) complexes.Synthetic Route of C7H7NO3

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics