Category: 89-73-6

Name: N,2-Dihydroxybenzamide《Zinc nanoparticles: Mode of action and efficacy against boscalid-resistant Alternaria alternata isolates》 was published in 2022. The authors were Malandrakis, Anastasios A.;Kavroulakis, Nektarios;Chrysikopoulos, Constantinos V., and the article was included in《Science of the Total Environment》. The author mentioned the following in the article:

The antifungal potential of ZnO-NPs against Alternaria alternata isolates with reduced sensitivity to the succinate dehydrogenase inhibitor (SDHI) boscalid, resulting from target site modifications, was evaluated in vitro and in vivo. ZnO-NPs could effectively inhibit mycelial growth in a dose-dependent way in both boscalid (BOSC) sensitive (BOSC-S) and resistant (BOSC-R) isolates. The fungitoxic effect of ZnO-NPs against the pathogen was significantly enhanced when combined with boscalid compared to the individual treatments in all phenotype cases (BOSC-S/R) both in vitro and in vivo. Fungitoxic effect of ZnO-NPs could be, at least partly, attributed to zinc ion release as indicated by the pos. correlation between sensitivities to the nanoparticles and their ionic counterpart ZnSO₄ and the alleviation of the ZnO-NPs fungitoxic action in the presence of the strong chelating agent EDTA. The superior effectiveness of ZnO-NPs against A. alternata, compared to ZnSO_4, could be due to nanoparticle properties interfering with cellular ion homeostasis mechanisms. The observed additive action of the oxidative phosphorylation-uncoupler fluazinam (FM) against all phenotypes indicates a possible role of ATP-dependent ion efflux mechanism in the mode of action of ZnO-NPs. A potential role of ROS production in the fungitoxic action of ZnO-NPs was evident by the additive/synergistic action of salicylhydroxamate (SHAM), which blocks the alternative oxidase antioxidant action. Mixture of ZnO-NPs and boscalid, resulting in a “capping” effect for the nanoparticles and significantly reducing their mean size, probably accounted for the synergistic effect of the mixture against both sensitive and resistant A. alternata isolates. Summarizing, results indicated that ZnO-NPs can be effectively used against A. alternata both alone or in combination with boscalid, providing an effective tool for combating SDHI-resistance and reducing the environmental fingerprint of synthetic fungicides. And N,2-Dihydroxybenzamide (cas: 89-73-6) was used in the research process.

N,2-Dihydroxybenzamide(cas: 89-73-6) is widely used for a variety of roles in biology and medicine as a chelating therapy.Name: N,2-DihydroxybenzamideIt inhibits bacterial or fungi growth by interfering with iron uptake. It is also active as a inhibitor of enzyme involved in tumour growths.

Reference:
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Bai, Yun;Li, Bing;Wang, Sinan;Jiang, Hai;Li, Junlei;Wang, Wenjuan;Wang, Ke;Qin, Lihua;Jia, Jing published 《Effects of estrogen on STIM1/Orai1 in the sublingual gland of ovariectomized rats》. The research results were published in《Histology and Histopathology》 in 2020.SDS of cas: 89-73-6 The article conveys some information:

Background. Studies have shown that estrogen can protect the function of the sublingual gland, but the specific mechanism is still unclear. Besides, the STIM1/Orai1 pathway is important to secretion in the salivary gland. Here, we explore the possible effects of estrogen on sublingual gland function by observing changes of STIM1 and Orai1 levels in the sublingual glands of ovariectomized rats. Methods. 42 adult female Sprague-Dawley rats were randomly divided into three groups: SHAM, OVX, and OVX + E (n = 14 per group). Two weeks after ovariectomy, rats were treated with estrogen (β-estradiol). The expression of STIM1 and Orai1 in the sublingual gland were observed by double label-immunohistochem. and immunofluorescence. Calcium imaging was conducted to observe changes in cellular Ca2+ levels. Results. IHC and IF showed that the levels of both STIM1 and Orai1 decreased following ovariectomy, but increased to SHAM levels after estrogen treatment. By IF, STIM1 and Orai1 exhibited perfect co-localization. Calcium imaging results showed that the Ca2+ in the cells decreased after ovariectomy. Estrogen intervention returned levels of these proteins and Ca2+ to the same as those in the control group. Conclusion. This study demonstrates that low estrogen status significantly reduced the expression of STIM1 and Orai1 in the sublingual gland of rats, along with cellular Ca2+ levels. These data provide insight into the likely mechanisms underlying sublingual gland secretion dysfunction during menopause. To complete the study, the researchers used N,2-Dihydroxybenzamide (cas: 89-73-6) .

N,2-Dihydroxybenzamide(cas: 89-73-6) has also been shown to be active against wild-type strains of Candida glabrata, but not against resistant mutants. SDS of cas: 89-73-6 This drug may have therapeutic potential for bone cancer and metabolic disorders such as obesity.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

SDS of cas: 89-73-6《Cytochrome oxidase and alternative oxidase pathways of mitochondrial electron transport chain are important for the photosynthetic performance of pea plants under salinity stress conditions》 was published in 2020. The authors were Analin, Benedict;Mohanan, Akhil;Bakka, Kavya;Challabathula, Dinakar, and the article was included in《Plant Physiology and Biochemistry (Issy-les-Moulineaux, France)》. The author mentioned the following in the article:

In the current study, importance of COX and AOX pathways for photosynthetic performance of pea plants (Pisum sativum L. Pea Arkel cv) was analyzed by using the mitochondrial electron transport chain inhibitors Antimycin A (AA) and salicylhydroxamic acid (SHAM) which restrict the electron flow through COX and AOX pathways resp. Salinity stress resulted in decreased CO₂ assimilation rates, leaf stomatal conductance, transpiration and leaf intercellular CO₂ concentration in a stress dependent manner. Superimposition of leaves of salt stressed plants with AA and SHAM caused cellular H₂O₂ and O^–2 accumulation along with cell death. Addnl., aggravation in decrease of CO₂ assimilation rates, leaf stomatal conductance, transpiration and leaf intercellular CO₂ concentration upon superimposition with AA and SHAM during salinity stress suggests the importance of mitochondrial oxidative electron transport for photosynthesis. Increased expression of AOX1a and AOX2 transcripts along with AOX protein levels indicated up regulation of AOX pathway in leaves during salinity stress. Chlorophyll fluorescence measurements revealed enhanced damage to Photosystem (PS) II in the presence of AA and SHAM during salinity stress. Results suggested the beneficial role of COX and AOX pathways for optimal photosynthetic performance in pea leaves during salinity stress conditions. To complete the study, the researchers used N,2-Dihydroxybenzamide (cas: 89-73-6) .

N,2-Dihydroxybenzamide(cas: 89-73-6) can be used:To prepare phenylboronic acid-based bioconjugates for chromatographic applications;As a ligand to synthesize Fe(III), Cu(II), Ni(II) and Zn(II) complexes.SDS of cas: 89-73-6

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Termsung, Natthida;Cheewangkoon, Ratchadawan;Kunasakdakul, Kaewalin published 《First report of septoria steviae causing stevia leaf spot in Thailand》 in 2021. The article was appeared in 《Journal of Phytopathology》. They have made some progress in their research.Category: amides-buliding-blocks The article mentions the following:

Stevia leaf spot is present in stevia production fields in Chiang Mai, Thailand. The disease was characterized by distinct lesions with angular chlorotic halos that result in defoliation. Based on morphol. characters and sequence anal. of the rDNA internal transcribed spacers (ITS1-5.8S-ITS2 = ITS), rDNA 28S subunit (LSU) and RNA polymerase II second largest subunit (RPB2) genes, the pathogen was identified as Septoria steviae. Pathogenicity tests proved Koch’s postulates, supporting S. steviae as the causal agent of stevia leaf spot in Stevia rebaudiana Bertoni. Mancozeb, chlorothalonil, difenoconazole and azoxystrobin significantly inhibited mycelial growth of S. steviae under in vitro conditions at label the recommended concentrations To our knowledge, this is the first report of Septoria leaf spot disease on stevia caused by S. steviae in Thailand. And N,2-Dihydroxybenzamide (cas: 89-73-6) was used in the research process.

N,2-Dihydroxybenzamide(cas: 89-73-6) is a hydroxamic acid that inhibits the activity of p-hydroxybenzoic acid (PHBA) reductase, an enzyme involved in the conversion of PHBA to benzoic acid. Category: amides-buliding-blocks The compound has been shown to inhibit mitochondrial membrane potential and mitochondrial functions, leading to cell death.

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Reference of N,2-Dihydroxybenzamide《Bimodal transcranial direct current stimulation reduces alcohol consumption and induces long-term neurochemical changes in rats with neuropathic pain》 was published in 2021. The authors were Santos, Daniela Silva;Medeiros, Liciane Fernandes;Stein, Dirson Joao;De Macedo, Isabel Cristina;Da Silva Rios, Diego Evandro;De Oliveira, Carla;Toledo, Roberta Stroher;Fregni, Felipe;Caumo, Wolnei;Torres, Iraci L. S., and the article was included in《Neuroscience Letters》. The author mentioned the following in the article:

This study aimed to evaluate the effects of repeated bimodal transcranial d.c. stimulation (tDCS) on alc. consumption and immunohistol. and neurochem. parameters in nerve-injured rats. Forty-eight adult male Wistar rats were distributed into six groups: control, neuropathic pain (NP) + sham-tDCS, NP + alc. + sham-tDCS, alc. + sham-tDCS, alc. + tDCS, and NP + alc. + tDCS. NP is induced by chronic sciatic nerve constriction (CCI). The rats were exposed to a 10% alc. solution by voluntary consumption for 14 days. From the 16th day after surgery, bimodal tDCS was applied for 20 min/day for 8 days. Brain structures were collected to evaluate the number of neuropeptide Y (NPY)-pos. neurons, neurites, and argyrophilic grains by immunohistochem., and brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), interleukin (IL)-6, and IL-10 by ELISA. Nerve-injured rats showed a progressive increase in alc. consumption compared to the non-injured rats. In addition, there was a reduction in voluntary alc. consumption over time induced by tDCS. Alc. exposure, chronic pain, and tDCS treatment modulated the central NPY immunoreactivity. tDCS increased the cerebellar levels of IL-6 and IL-10, and CCI and/or tDCS reduced striatal BDNF levels. The current data suggest that tDCS could be a promising non-pharmacol. adjuvant to treat patients with chronic pain who use alc. to relieve their symptoms.N,2-Dihydroxybenzamide (cas: 89-73-6) were involved in the experimental procedure.

N,2-Dihydroxybenzamide(cas: 89-73-6) can be used:To prepare phenylboronic acid-based bioconjugates for chromatographic applications;As a ligand to synthesize Fe(III), Cu(II), Ni(II) and Zn(II) complexes.Reference of N,2-Dihydroxybenzamide

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Hernandez-Esquivel, Alma Alejandra;Castro-Mercado, Elda;Garcia-Pineda, Ernesto published 《Comparative Effects of Azospirillum brasilense Sp245 and Pseudomonas aeruginosa PAO1 Lipopolysaccharides on Wheat Seedling Growth and Peroxidase Activity》 in 2021. The article was appeared in 《Journal of Plant Growth Regulation》. They have made some progress in their research.Electric Literature of C7H7NO3 The article mentions the following:

The effects of lipopolysaccharides (LPS) from Azospirillum brasilense Sp245, a plant growth-promoting rhizobacteria, and Pseudomonas aeruginosa PAO1, a pathogenic bacterium, on plant growth and peroxidase (POD) activity were assessed on wheat seedlings. A. brasilense LPS (100μg/mL) increased total length, and total fresh weight in wheat seedlings 4 days after treatment. P. aeruginosa LPS did not show effect on plant growth. A. brasilense LPS increased root hairs length similar to whole cells, while P. aeruginosa LPS increased root hairs d. and slightly root hairs length. Both LPS increased POD activity and hydrogen peroxide (H2O2) content in root; however, the LPS from the pathogenic bacterium generated higher increments. The peroxidase inhibitor salicylhydroxamic acid (SHAM) inhibited plant growth, which was not recovered by the addition of LPS neither A. brasilense nor P. aeruginosa. POD activity stimulated by LPS was calcium-dependent as confirmed by the addition of the calcium channel blocker LaCl3. The results suggest that plant cells sense differentially LPS from beneficial or pathogenic bacteria and that calcium is needed to respond to the presence of both LPS.N,2-Dihydroxybenzamide (cas: 89-73-6) were involved in the experimental procedure.

N,2-Dihydroxybenzamide(cas: 89-73-6) can be used:To prepare phenylboronic acid-based bioconjugates for chromatographic applications;As a ligand to synthesize Fe(III), Cu(II), Ni(II) and Zn(II) complexes.Electric Literature of C7H7NO3

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Zhao, Wenjuan;Liu, Dianwen;Feng, Qicheng published 《Enhancement of salicylhydroxamic acid adsorption by Pb(II) modified hemimorphite surfaces and its effect on floatability》 in 2020. The article was appeared in 《Minerals Engineering》. They have made some progress in their research.Application In Synthesis of N,2-Dihydroxybenzamide The article mentions the following:

Hemimorphite is an important zinc oxide mineral, but only a few studies have been conducted on the enhanced flotation recovery of hemimorphite with salicylhydroxamic acid (SHA) as the collector. In this study, the effect of Pb(II) on SHA adsorption on the hemimorphite surface with regard to its floatability was systematically studied. XPS anal. showed that the Pb species could interact with O sites on the hemimorphite surface, thus forming -Zn-O-Pb and -Si-O-Pb complexes on the mineral surface and exhibiting strong reactivity toward SHA. Zeta potential measurements indicated that Pb²⁺ and Pb(OH)⁺ adsorbed onto the hemimorphite surfaces via phys. and chem. adsorption within a pH range that was suitable for the flotation, further enhancing SHA adsorption on the activated mineral surface. Adsorption tests showed that more SHA adsorbed on the Pb-treated hemimorphite surface than on the untreated hemimorphite, and Pb-SHA complexes that were generated in the pulp solution could also adsorb on the surface of hemimorphite. Micro-flotation tests confirmed that the floatability of hemimorphite significantly increased after treatment with Pb(II) ions when SHA was used as the collector. Thus, this paper proposes a promising method of improving the flotation recovery of hemimorphite through via surface modification with Pb(II) ions. And N,2-Dihydroxybenzamide (cas: 89-73-6) was used in the research process.

N,2-Dihydroxybenzamide(cas: 89-73-6) is widely used for a variety of roles in biology and medicine as a chelating therapy.Application In Synthesis of N,2-DihydroxybenzamideIt inhibits bacterial or fungi growth by interfering with iron uptake. It is also active as a inhibitor of enzyme involved in tumour growths.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Chen, Zi;Lu, Dongdong;Xie, Hangqing;Yang, Xiaolei;Li, Yang;Bao, Chenhao;Lei, Lei;Xu, Shiqing published 《Triplet Exciton Enhanced Radioluminescence of Ga³⁺/Tb³⁺ Metallacrown Scintillators for X-Ray Detection》. The research results were published in《Advanced Optical Materials》 in 2022.Recommanded Product: N,2-Dihydroxybenzamide The article conveys some information:

The increasing demand for radiation detection in many applications has led to demanding requirements for scintillators. Realizing low-dose, pollution-free, and reliable X-ray detection has become a key tech. challenge. Here, a triplet-enhanced lanthanide radioluminescence (RL) material Ga³⁺/Tb³⁺ metallacrowns (Tb-1) is reported. This Tb-1 crystal emits bright green luminescence under UV light or X-ray excitation, and the emission intensity is 286 and 242 times that of Tb³⁺ in inorganic salt, resp. Tb-1 crystal is further passivated by trioctylphosphine oxide (TOPO), and the enhanced RL intensity is equivalent to that of com. Tl-doped cesium iodide scintillator. In addition, RL of Tb-1-TOPO has an extremely narrow full width at half maximum and an excellent linear response to the X-ray dose rate. The detection limit is calculated to be 0.146μGy s^-1, which is 38 times lower than typical medical imaging doses. Triplet-enhanced lanthanide RL provides new ideas for replacing scintillators that require high temperature synthesis processes such as inorganic phosphors and ceramics, and provides a new alternative scintillator material for flexible X-ray monitoring, bioimaging, radiotherapy, and other applications. To complete the study, the researchers used N,2-Dihydroxybenzamide (cas: 89-73-6) .

N,2-Dihydroxybenzamide(cas: 89-73-6) is widely used for a variety of roles in biology and medicine as a chelating therapy.Recommanded Product: N,2-DihydroxybenzamideIt inhibits bacterial or fungi growth by interfering with iron uptake. It is also active as a inhibitor of enzyme involved in tumour growths.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Guo, Yu-Hua;Yu, You-Zhu;Shen, Yan-Hong;Yang, Li-Guo;Liu, Na-Na;Zhou, Zhong-Yuan;Niu, Yong-Sheng published 《”Three-in-One” Structural-Building-Mode-Based Ti₁₆-Type Titanium Oxo Cluster Entirely Protected by the Ligands Benzoate and Salicylhydroxamate》 in 2022. The article was appeared in 《Inorganic Chemistry》. They have made some progress in their research.Product Details of 89-73-6 The article mentions the following:

Titanium oxo clusters (TOCs) with accurate mol. structures have potential applications in photocatalysis, such as photocatalytic degradation, hydrogen production, and water oxidation The hydrolytic stability and light absorption ability of TOCs have important impacts on photocatalysis, where the selection of peripheral organic ligands plays a significant role. In this regard, salicylhydroxamic acid (abbreviated as H₃L) attracts our attention, acting as a ligand for its multidentate and dye-functional features, which can increase the hydrolytic stability and broaden light absorption for TOCs. Herein, two TOCs were solvothermally synthesized and structurally characterized using H₃L, formulated as [Ti₈(μ₂-O)₂(μ₃-O)₂(OⁱPr)₁₂(L)₄]·2CH₃CN (1) and [Ti₁₆(μ₂-O)₁₀(μ₃-O)₄(PhCOO)₁₄(L)₆(HL)₂]·4CH₃CN·2ⁱPrOH (2). Complex 2 was obtained by adding excessive benzoic acid over the reaction system of 1, resulting in enhanced hydrolytic stability via the replacement of all alkoxy ligands by multidentate ligands for protection. Interestingly, for the first time, the “three-in-one” structural building mode with {Ti₆} + {Ti₄} + {Ti₆} by the common subunits in 2 was observed among all reported TOCs. Moreover, complex 2 can strongly absorb visible light reaching up to 700 nm and exhibit obvious activity for the photodegradation of methyl orange. The experimental procedure involved many compounds, such as N,2-Dihydroxybenzamide (cas: 89-73-6) .

N,2-Dihydroxybenzamide(cas: 89-73-6) has also been shown to be active against wild-type strains of Candida glabrata, but not against resistant mutants. Product Details of 89-73-6 This drug may have therapeutic potential for bone cancer and metabolic disorders such as obesity.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Ma, Siguang;Zhou, Xinpeng;Jahan, Mohammad Shah;Guo, Shirong;Tian, Mimi;Zhou, Ranran;Liu, Hongyun;Feng, Bingjie;Shu, Sheng published 《Putrescine regulates stomatal opening of cucumber leaves under salt stress via the H₂O₂-mediated signaling pathway》 in 2022. The article was appeared in 《Plant Physiology and Biochemistry (Issy-les-Moulineaux, France)》. They have made some progress in their research.SDS of cas: 89-73-6 The article mentions the following:

The stomatal aperture is imperative for photosynthesis in higher plants. The function of polyamines (PAs) in stomatal regulation under a stressful environment has not been fully determined In this study, we demonstrated the mechanism by which putrescine (Put) regulates stomatal changes in cucumber leaves under salt stress. The results showed that foliar application of Put alleviated the decrease of stomatal aperture and photosynthesis caused by salt stress and promoted plant growth. Exogenous Put caused a significant increase in endogenous PAs and hydrogen peroxide (H₂O₂) levels by 105.43% and 27.97%, resp., while decreased abscisic acid (ABA) content by 67.68% under salt stress. However, application of inhibitors of aminoguanidine hydrochloride (AG), 1, 8-diaminooctane (1, 8-DO), diphenyleneiodonium chloride (DPI) and salicylhydroxamic acid (SHAM) upregulated the 9-cis-cyclocarotenoid dioxygenase (NCED) gene and downregulated the reduced glutathione synthetase (GSHS) gene. These inhibitors also decreased the stomatal aperture, levels of H₂O₂ and reduced glutathione (GSH), but increased the ABA content under salt stress and Put treatment conditions. The order of influence is AG > 1, 8-DO > DPI > SHAM. However, Put-induced downregulation of ABA content and upregulation of GSH content under salt stress were effectively blocked by N, N’-dimethylthiourea (DMTU, H₂O₂ scavenger) and 1-chloro-2,4-dinitrobenzene (CDNB, GSH scavenger) treatments. Taken together, these results suggest that Put induced the formation of H₂O₂ signaling mediates the degradation of PAs by diamine oxidase (DAO), increasing GSH content and inhibiting the accumulation of ABA in leaves, thereby promoting stomatal opening in salt-stressed cucumber leaves.N,2-Dihydroxybenzamide (cas: 89-73-6) were involved in the experimental procedure.

N,2-Dihydroxybenzamide(cas: 89-73-6) can be used:To prepare phenylboronic acid-based bioconjugates for chromatographic applications;As a ligand to synthesize Fe(III), Cu(II), Ni(II) and Zn(II) complexes.SDS of cas: 89-73-6

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics