In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 88612-71-9, name is Ethyl 4-oxo-4H-quinolizine-3-carboxylate belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Quality Control of Ethyl 4-oxo-4H-quinolizine-3-carboxylate
EXAMPLE 1 To a solution of 3-ethoxycarbonyl-4H-quinolizin-4-one (2.17 g) in methanol (65.2 ml) was added dropwise 6 N aqueous sodium hydroxide (6.5 ml) at room temperature. After stirring for 20 minutes, water (10 ml) was added. After stirring for 20 minutes, water (30 ml) was also added. After stirring for an hour, the reaction mixture was acidified to pH 3 with 4N aqueous hydrochloric acid. The precipitate was filtered and washed with water to give 4H-quinolizin-4-one-3-carboxylic acid (1.75 g) as pale yellow crystal. mp 233 C. IR (Nujol): 1730, 1610, 1585, 1320 cm-1 NMR (DMSO-d6) delta: 7.26 (d, 1H, J=9 Hz), 7.50-7.95 (m, 1H), 8.00-8.20 (m, 2H), 8.41 (d, 1H, J=9 Hz), 9.20-9.40 (m, 1H)
The synthetic route of 88612-71-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Fujisawa Pharmaceutical Co., Ltd.; US4698349; (1987); A;,
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