Category: 885-70-1

Related Products of 885-70-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 885-70-1, name is 5,11-Dihydropyrido[2,3-b][1,4]benzodiazepin-6-one belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Preparation 1 11-Acryloyl-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one and a mixture thereof with the corresponding 11-(3-chloro-propionyl) compound STR35 Solutions of 3-chloropropionyl chloride (6.3 g) in dioxane (60 ml) and triethylamine (8.4 g) in dioxane (60 ml) were added simultaneously to a refluxing suspension of 5,11-dihydro-6H-pyrido [2,3-b][1,4]benzodiazepin-6-one (9.45 g – see DT-PS 1179943) in dioxane (300 ml) and the mixture was heated under reflux for 6 hours and evaporated to give a mixture of the two title compounds in which the acryloyl compound predominated. Crude mixtures of the 11-acryloyl and 11-(3-chloropropionyl) compounds prepared using this procedure were used in Examples 22-30. The residue was purified by chromatography on silica using dichloromethane plus 0-2% methanol as eluant. Appropriate fractions were combined and evaporated to give the title 11-acryloyl compound as a colourless solid, 3.2 g, (27%) which was used directly in Examples 11-21.

The synthetic route of 5,11-Dihydropyrido[2,3-b][1,4]benzodiazepin-6-one has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Alker; David; Cross; Peter E.; US5418229; (1995); A;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Related Products of 885-70-1, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 885-70-1, name is 5,11-Dihydropyrido[2,3-b][1,4]benzodiazepin-6-one, This compound has unique chemical properties. The synthetic route is as follows.

EXAMPLE 20 L-5,11-Dihydro-11-[[6-methyl-2,6-diazabicyclo[3.3.0]oct-2-yl]carbonyl]-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one 2.6 g (0.021 mole) of L-2-methyl-2,6-diazabicyclo [3.3.0]octane were added dropwise to a mixture consisting of 11.2 ml of a 20% strength solution of phosgene in toluene, 50 ml of acetonitrile and 2.4 g (0.023 mole) of anhydrous sodium carbonate while externally cooling with ice. After 60 minutes, 4.5 g (0.021 mole) of 5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one were added and the mixture was heated under reflux for 4 hours. The hot mixture was filtered, the precipitate was washed three times using 10 ml of hot acetonitrile each time and the combined filtrates were concentrated in vacuo to a total volume of 15 ml. The solution was cooled in an ice bath and the resulting crystal paste was filtered under suction. Recrystallisation from acetonitrile produced 2.1 g (27% of theory) of colourless crystals of m.p. 220-222 C., identical to the preparation made as in Example 6c according to mixed melting point and spectroscopic data. 5,11-Dihydro-11-[[7-methyl-3,7-diazabicyclo[3.3.0]oct-3-yl]carbonyl]-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one of m.p. 157-159 C. (acetonitrile) 5,11-dihydro-11-[[10-methyl-4,10-diazatricyclo[5.2.1.02,6 ]dec-4- yl]carbonyl]-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one of m.p. 218-220 C. (ethyl acetate) were obtained in corresponding manner.

The chemical industry reduces the impact on the environment during synthesis 5,11-Dihydropyrido[2,3-b][1,4]benzodiazepin-6-one. I believe this compound will play a more active role in future production and life.

Reference:
Patent; Rudolf; Klaus; Engel; Wolfhard; Eberlein; Wolfgang; Trummlitz; Gunter; Mihm; Gerhard; Doods; Henri; Mayer; Norbert; US5179090; (1993); A;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Related Products of 885-70-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 885-70-1, name is 5,11-Dihydropyrido[2,3-b][1,4]benzodiazepin-6-one belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

EXAMPLE 6 5,11-Dihydro-11-[6-(1-piperidinyl)hexyl]-6H-pyrido-[2,3-b][1,4]benzodiazepin-6-one To a suspension of 33.2 g (0.157 mol) of 5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one in 875 ml of anhydrous dioxan, 173 ml (approx. 0.45 mol) of a 2.6 molar solution of n-butyl-lithium in n-hexane was added dropwise at ambient temperature and the resulting mixture was then stirred for another hour at the same temperature. It was then heated to 70 C. and at a reaction temperature of not more than 75 C. 83.0 g (0.034 mol) of 1-bromo6-(1-piperidinyl)hexane were added dropwise, then to complete the reaction the mixture was stirred for a further 4 hours at 80 C. After cooling, the solvent was distilled off in a water jet vacuum, the residue was adjusted to pH 7 with dilute aqueous hydrochloric acid and the mixture was then filtered. The filtrate was made alkaline with concentrated aqueous potassium hydroxide solution and extracted exhaustively with dichloromethane. The dichloromethane extracts were dried over sodium sulphate and then evaporated down and the residue remaining was digested with 100 ml of boiling diethyl ether and filtered while hot. The residue remaining after the ether had been removed was purified by chromatography on silica gel (Macherey-Nagel, 0.2-0.5 mm) using dichloromethane/methanol/cyclohexane/ethyl acetate/conc. ammonia 59/7.5/7.5/25/1 (v/v/v/v/v) as eluant. By evaporating the desired fractions and subsequently recrystallising from acetonitrile, a colourless crystalline product with a m.p. of 131 to 132 C. was obtained in a yield of 11.29 g (19% of theory). The hydrochloride melted at 223 C. (ethanol).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5,11-Dihydropyrido[2,3-b][1,4]benzodiazepin-6-one, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Karl Thomae GmbH; US5006522; (1991); A;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 885-70-1 as follows. Recommanded Product: 5,11-Dihydropyrido[2,3-b][1,4]benzodiazepin-6-one

(a) 5,11-Dihydro-11-(prop-2-ynyl)-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one To a suspension of 7.4 g (0.035 mol) of 5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one in 150 ml of anhydrous tetrahydrofuran, 44.8 ml (approx. 0.07 mol) of a 15% solution of n-butyl-lithium in n-hexane was added dropwise with stirring at a reaction temperature of from 0 to +10 C. After it had all been added, the mixture was stirred for 30 minutes at ambient temperature before a solution of 4.16 g (0.035 mol) of 3-bromo-prop-1-yne in 25 ml of anhydrous tetrahydrofuran was added dropwise. The resulting mixture was stirred for a further 2 hours at ambient temperature, added to 1 liter of saturated aqueous saline solution and the resulting mixture was extracted exhaustively with ethylacetate. The combined ethylacetate extracts were washed twice more with 100 ml of saturated saline solution, dried over sodium sulphate with the addition of 1 g of activated charcoal and evaporated down in vacuo. The residue was purified on silica gel by chromatography using dichloromethane/ethyl acetate 95/5 (v/v) as eluant. 8.5 g (97% of theory) of colourless crystals were obtained, m.p. 199 C. (decomposition).

According to the analysis of related databases, 885-70-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Karl Thomae GmbH; US5006522; (1991); A;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics