Category: 88-96-0

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 88-96-0, name is Phthalamide, A new synthetic method of this compound is introduced below., Computed Properties of C8H8N2O2

To a solution of (S)-tert-butyl 4-(3-(l-hydroxyethyl)benzyl)piperazine-l- carboxylate (480 mg, 1.50 mmol) in 10 mL of anhydrous THF at 00C under a positive pressure of N2 were added phthalimde (330 mg, 2.25 mmol), triphenyl phosphine (590 mg, 2.25 mmol) and DIAD (440 DL, 2.25 mmol). The solution was warmed up to ambient temperature and stirred 1 h. The solvent was removed at reduced pressure and the residue was purified by reverse-phase HPLC to afford (S)-rerr-butyl 4-(3-(l-(l,3-dioxoisoindolin-2- yl)ethyl)benzyl)piperazine-l-carboxylate as 490 mg of a white solid.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; CYTOKINETICS, INC.; WO2007/89336; (2007); A2;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Reference of 88-96-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 88-96-0 name is Phthalamide, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

1) Synthesis of phthalimide potassium A round-bottom flask containing 3200 mL dehydrated alcohol was added with 160.0 g phthalamide, and heated and refluxed for 0.5 h, until only a small amount of raw materials was not dissolved. The resulted hot solution was added into 61.0 g potassium hydroxide solution (including 60 mL water and 180 mL alcohol) by decantation, by which a white precipitate was formed immediately. Then the solution was cooled and filtered to obtain filtered residue, and alcohol was recycled. The filtered residue was washed with 400 mL acetone, 196.0 g phthalimide potassium was obtained, and the yield was 98.0%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Phthalamide, and friends who are interested can also refer to it.

Reference:
Patent; Institue of Transfusion Medicine, Academy of Military Medical Sciences, People’s Liberation Army of China; PEI, Xuetao; LI, Yanhua; WANG, Sihan; ZHANG, Jing; YAO, Hailei; SHI, Wei; YUE, Wen; EP2949323; (2015); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

A common heterocyclic compound, 88-96-0, name is Phthalamide, molecular formula is C8H8N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 88-96-0.

Example 20B (404 mg, 1.13 mmol), triphenylphosphine (455 mg, 1.6 eq.) and phthalamide (222 mg, 1.4 eq.) were mixed in 3.5 mL of toluene. Then, di-tert-butylazodicarboxylate (DBAD, 398 mg, 1.6 eq.) was added. The reaction flask was flushed with argon and then heated to 90 C. After stirring overnight at 90 C., the mixture was cooled to room temperature, concentrated and the resulting oil was purified by column chromatography (eluding with 20% to 40% ethyl acetate in hexane) to give the title compound (684 mg).

The synthetic route of Phthalamide has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Pei, Zhonghua; Geldern, Thomas von; Madar, David J.; Li, Xiaofeng; Basha, Fatima; Yong, Hong; Longenecker, Kenton L.; Backes, Bradley J.; Judd, Andrew S.; Mulhern, Matthew M.; Stewart, Kent D.; US2007/49596; (2007); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics