Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 869640-41-5, name is 7-Benzyl-5,6,7,8-tetrahydro-1,7-naphthyridin-2(1H)-one, A new synthetic method of this compound is introduced below., Recommanded Product: 7-Benzyl-5,6,7,8-tetrahydro-1,7-naphthyridin-2(1H)-one
To a solution of the product of preparation 26 (620mg, 2.22mmol) in toluene (30mL) was added the product of preparation 4 (344mg, 2.64mmol), tri-n-butylphosphine (0.66mL, 2.64mmol) and 1,1′-azobis(N,N-dimethylformamide) (458mg, 2.24mmol) and the reaction mixture was stirred at 85C for 18 hours. The solvent was then evaporated under reduced pressure and the residue was purified by column chromatography on silica gel, eluting with dichloromethane:methanol:0.88 ammonia, 90:10:0.5. The crude product was dissolved in dichloromethane (20mL), washed with 2M sodium hydroxide, dried over magnesium sulfate and concentrated in vacuo to afford the title compound in 33% yield, 255mg. 1HNMR(CDCl3, 400MHz) delta: 1.79(m, 4H), 1.94(m, 2H), 2.55(m, 4H), 2.61(m, 2H), 2.76(m, 4H) 3.51 (s, 2H), 3.70(s, 2H), 4.21 (m, 2H), 6.55(d, 1H), 7.25-7.41 (brm, 6H) MS APCl+ m/z 352 [MH]+
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Pfizer Limited; EP1595881; (2005); A1;,
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