Category: 86499-96-9

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 86499-96-9, name is 3-Bromo-4,5-dihydro-1H-benzo[b]azepin-2(3H)-one, A new synthetic method of this compound is introduced below., Quality Control of 3-Bromo-4,5-dihydro-1H-benzo[b]azepin-2(3H)-one

To a suspension of 3-bromo-1,3,4,5-tetrahydro-1-benzazepin-2-one (9.56 g, 40 mmol) in acetic acid (40 mL) was added bromine (12.8 g, 80 mmol) dropwise. The resulting mixture was stirred at rt for 14 h. The resulting precipitate was collected by filtration, washed with HOAc, and dried to give 72A as a white solid (11.54 g, 91percent). LC/MS m/z 317 (M+H)+.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Bristol-Myers Squibb Company; US2007/93470; (2007); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

86499-96-9, Adding some certain compound to certain chemical reactions, such as: 86499-96-9, name is 3-Bromo-4,5-dihydro-1H-benzo[b]azepin-2(3H)-one, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 86499-96-9.

3-Bromo-2,3,4,5-tetrahydro-1H-[1]-benzazepin-2-one (300 mg) was added in one portion to a stirred suspension of potassium hydroxide (90 mg) and tetrabutylammonium bromide (40 mg) in tetrahydrofuran (10 ml) maintained at 0¡ã under a nitrogen atmosphere. Stirring was continued for 5 minutes, then ethyl bromoacetate (200 mg) was added in one portion. The reaction mixture was allowed to warm to room temperature while stirring for an additional 3 hours. The tetrahydrofuran was removed under reduced pressure and the residue partitioned between water (5 ml) and ether (25 ml). The organic phase was washed with 2N hydrochloric acid (5 ml), dried over magnesium sulfate, and the solvent removed under reduced pressure to give 3-bromo-1-ethoxycarbonylmethyl-2,3,4,5-tetrahydro-1H-[1]-benzazepin-2-one, m.p. 114¡ã-116¡ã. 3-Chloro-1-ethoxycarbonylmethyl-2,3,4,5-tetrahydro-1H-[1]-benzazepin-2-one was similarly prepared.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 86499-96-9.

Reference:
Patent; Ciba-Geigy Corporation; US4575503; (1986); A;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics