Category: 849833-86-9

Guo, Chuangxing published the artcileDesign of oxobenzimidazoles and oxindoles as novel androgen receptor antagonists, Formula: C8H9BFNO3, the publication is Bioorganic & Medicinal Chemistry Letters (2012), 22(7), 2572-2578, database is CAplus and MEDLINE.

Oxobenzimidazoles (e.g., 1), a novel series of androgen receptor (AR) antagonists, were discovered through de novo design guided by structure-based drug design. The compounds in this series were reasonably permeable and metabolically stable, but suffered from poor solubility The incorporation of three dimensional structural features led to improved solubility In addition, the observation of a ‘flipped’ binding mode of an oxobenzimidazole analog in an AR ligand binding domain (LBD) model, led to the design and discovery of the novel oxindole series (e.g., 2, I) that is a potent full antagonist of AR.

Bioorganic & Medicinal Chemistry Letters published new progress about 849833-86-9. 849833-86-9 belongs to amides-buliding-blocks, auxiliary class Fluoride,Boronic acid and ester,Amine,Benzene,Amide,Boronic Acids,Boronic Acids,Boronic acid and ester, name is (3-Fluoro-4-(methylcarbamoyl)phenyl)boronic acid, and the molecular formula is C8H9BFNO3, Formula: C8H9BFNO3.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Liu, Yang published the artcilePyridazinone derivatives displaying highly potent and selective inhibitory activities against c-Met tyrosine kinase, Application In Synthesis of 849833-86-9, the publication is European Journal of Medicinal Chemistry (2016), 322-333, database is CAplus and MEDLINE.

Over activation of c-Met tyrosine kinase is known to promote tumorigenesis and metastasis, as well as therapeutic resistance. Herein the authors describe the design, synthesis and biol. activities of novel, ATP-competitive, c-Met tyrosine kinase inhibitors that are members of the 6-aryl-2-(3-(heteroarylamino)benzyl)pyridazinone family. A structure-activity relationship (SAR) study of these substances led to identification of a pyridazinone derivative as a highly selective and potent c-Met tyrosine inhibitor, which displays favorable pharmacokinetic properties in mice and significant antitumor activity against a c-Met driven EBC-1 tumor xenograft. The synthesis of the target compounds was achieved using [(3-iodophenyl)methyl]-3-pyridazinone derivatives as key intermediates.

European Journal of Medicinal Chemistry published new progress about 849833-86-9. 849833-86-9 belongs to amides-buliding-blocks, auxiliary class Fluoride,Boronic acid and ester,Amine,Benzene,Amide,Boronic Acids,Boronic Acids,Boronic acid and ester, name is (3-Fluoro-4-(methylcarbamoyl)phenyl)boronic acid, and the molecular formula is C8H9BFNO3, Application In Synthesis of 849833-86-9.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Albrecht, Brian K. published the artcileDiscovery and Optimization of Triazolopyridazines as Potent and Selective Inhibitors of the c-Met Kinase, Product Details of C8H9BFNO3, the publication is Journal of Medicinal Chemistry (2008), 51(10), 2879-2882, database is CAplus and MEDLINE.

Tumorigenesis is a multistep process in which oncogenes play a key role in tumor formation, growth, and maintenance. MET was discovered as an oncogene that is activated by its ligand, hepatocyte growth factor. Deregulated signaling in the c-Met pathway has been observed in multiple tumor types. Herein we report the discovery of potent and selective triazolopyridazine small mols. that inhibit c-Met activity.

Journal of Medicinal Chemistry published new progress about 849833-86-9. 849833-86-9 belongs to amides-buliding-blocks, auxiliary class Fluoride,Boronic acid and ester,Amine,Benzene,Amide,Boronic Acids,Boronic Acids,Boronic acid and ester, name is (3-Fluoro-4-(methylcarbamoyl)phenyl)boronic acid, and the molecular formula is C8H9BFNO3, Product Details of C8H9BFNO3.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Alexeev, Vladimir L. published the artcilePhotonic crystal glucose-sensing material for noninvasive monitoring of glucose in tear fluid, Name: (3-Fluoro-4-(methylcarbamoyl)phenyl)boronic acid, the publication is Clinical Chemistry (Washington, DC, United States) (2004), 50(12), 2353-2360, database is CAplus and MEDLINE.

Background: We recently developed a photonic crystal glucose-sensing material, which consists of a crystalline colloidal array embedded within a polymer network of a polyacrylamide-poly(ethylene glycol) hydrogel with pendent phenylboronic acid groups. The aim of the present work was to improve this approach for application to noninvasive or minimally invasive monitoring of glucose. Methods: We used new boronic acid derivatives such as 4-amino-3-fluorophenylboronic acid and 4-carboxy-3-fluorophenylboronic acid as the mol. recognition elements to achieve sensing at physiol. pH values. Results: The improved photonic glucose-sensing material sensed glucose in the range of the 100 μmol/L concentrations found in tear fluid. The detection limits were ∼1 μmol/L in synthetic tear fluid. The visually evident diffraction color shifted across the entire visible spectral region from red to blue over the physiol. relevant tear-fluid glucose concentrations This sensing material is selective for glucose over galactose, mannose, and fructose. Conclusions: These new glucose sensors have properties appropriate for use in such glucose-sensing applications as ocular inserts or diagnostic contact lenses for patients with diabetes mellitus.

Clinical Chemistry (Washington, DC, United States) published new progress about 849833-86-9. 849833-86-9 belongs to amides-buliding-blocks, auxiliary class Fluoride,Boronic acid and ester,Amine,Benzene,Amide,Boronic Acids,Boronic Acids,Boronic acid and ester, name is (3-Fluoro-4-(methylcarbamoyl)phenyl)boronic acid, and the molecular formula is C8H9BFNO3, Name: (3-Fluoro-4-(methylcarbamoyl)phenyl)boronic acid.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics