847361-67-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 847361-67-5, name is 1-(4-Bromophenyl)cyclopropanecarboxamide belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
A solution of the bromide from Step 4 (1.0 g, 4.16 mmol), commercially available 4-(dihydroxyboranyl)benzoic acid (0.73 g, 4.37 mmol), sodium carbonate (2 M aq. solution, 5.2 mL, 10.4 mmol), tetrakis(triphenylphosphine)palladium(0) (20 mg, 0.017 mmol) in water (8 mL) and acetontrile (12 mL) was heated to 60C and stirred overnight. The reaction mixture was cooled, filter and the mother liquors were concentrated. The residual aqueous mixture was acidified with 1 N HCl. The resultant milky suspension was filtered to provide a pale grey solid which was further dried under high vacuum to provide the title compound (1.1 g).
The synthetic route of 1-(4-Bromophenyl)cyclopropanecarboxamide has been constantly updated, and we look forward to future research findings.
Reference:
Patent; MERCK FROSST CANADA LTD.; BLACK, Cameron; BEAULIEU, Christian; WO2010/148488; (2010); A1;,
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