Category: 84547-64-8

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Bozhenkov, G. V.; Savosik, V. A.; Klyba, L. V.; Zhanchipova, E. R.; Mirskova, A. N.; Levkovskaya, G. G. researched the compound: 3-(Chloromethyl)-1-methyl-1H-pyrazole( cas:84547-64-8 ).Computed Properties of C5H7ClN2.They published the article 《1-Alkylpyrazoles and 1-alkyl-5-chloropyrazoles from halovinyl ketones and 1,1-dialkylhydrazines》 about this compound( cas:84547-64-8 ) in Russian Journal of Organic Chemistry. Keywords: ketone chloro vinyl heterocyclization hydrazine dialkyl; pyrazole alkyl chloro preparation. We’ll tell you more about this compound (cas:84547-64-8).

Regioselective heterocyclization of chlorovinyl ketones R1COCH:C(R2)Cl (R1 = Me, R2 = H; R1 = n-Pr, R2 = H, Cl; R1 = CH2Cl, R2 = H) with 1,1-dialkyl-hydrazines NH2N(R3)2 (R3 = Me, n-Bu) to pyrazoles I involved intermediate formation of the corresponding dialkylhydrazones II. The mass spectrum fragmentation pattern of chlorine-containing pyrazoles I (R1 = CH2Cl, R2 = H, R3 = Me; R1 = n-Pr, R2 = Cl, R3 = Me) depended on the position of the halogen atom.

Different reactions of this compound(3-(Chloromethyl)-1-methyl-1H-pyrazole)Computed Properties of C5H7ClN2 require different conditions, so the reaction conditions are very important.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 3-(Chloromethyl)-1-methyl-1H-pyrazole( cas:84547-64-8 ) is researched.Recommanded Product: 84547-64-8.Kim, Hyo-Jeong; Kwon, Tae-Ik; Park, Il-Hyun published the article 《Synthesis of new proton-pump inhibitors (2) and tests for it’s biological activity》 about this compound( cas:84547-64-8 ) in Chungnam Kwahak Yonguchi. Keywords: antiulcer agent omeprazole analog preparation. Let’s learn more about this compound (cas:84547-64-8).

For development new anti-ulcer agents, we synthesized proton-pump (H+/K+-ATPase) inhibitors which inhibit gastric acid secretion at the last step in the parietal cell. These are omeprazole analogs, in which pyridine group is replaced by pyrazole moiety, to increase pharmacol. activity and to decrease side effects, and we also synthesized substituted benzimidazole rings. The structure of the compounds was identified with 1H-NMR, M.S. and I.R. The compounds with 5-substituted benzimidazoles showed good activity in the following order MeO > Cl > H, and also, 1-benzyl group of pyrazole substituted compounds has enhanced activity.

Different reactions of this compound(3-(Chloromethyl)-1-methyl-1H-pyrazole)Recommanded Product: 84547-64-8 require different conditions, so the reaction conditions are very important.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 3-(Chloromethyl)-1-methyl-1H-pyrazole( cas:84547-64-8 ) is researched.Category: amides-buliding-blocks.Kim, Hyo-Jeong; Park, Il-Hyun published the article 《Synthesis of new proton-pump inhibitors》 about this compound( cas:84547-64-8 ) in Chungnam Kwahak Yonguchi. Keywords: antiulcer agent pyrazole derivative preparation. Let’s learn more about this compound (cas:84547-64-8).

For development new anti-ulcer agents, we synthesized omeprazole analogs, in which pyridine group was replaced by pyrazole moiety, to increase pharmacol. activity and to decrease side effects, and also synthesize substituted benzimidazole rings.

Different reactions of this compound(3-(Chloromethyl)-1-methyl-1H-pyrazole)Category: amides-buliding-blocks require different conditions, so the reaction conditions are very important.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Application In Synthesis of 3-(Chloromethyl)-1-methyl-1H-pyrazole. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 3-(Chloromethyl)-1-methyl-1H-pyrazole, is researched, Molecular C5H7ClN2, CAS is 84547-64-8, about Synthesis of pyrazole derivatives from 1,1-dimethylhydrazine and chlorovinyl ketones.

The reaction of accessible 2-chlorovinyl Me ketones with 1,1-dimethylhydrazine gave pyrazole derivatives in high yields. 1,1,1-Trimethylhydrazinium chloride was isolated as second product of this reaction in high yield.

Different reactions of this compound(3-(Chloromethyl)-1-methyl-1H-pyrazole)Application In Synthesis of 3-(Chloromethyl)-1-methyl-1H-pyrazole require different conditions, so the reaction conditions are very important.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Synthesis of new proton-pump inhibitors, published in 1996-06-30, which mentions a compound: 84547-64-8, mainly applied to antiulcer agent pyrazole derivative preparation, Synthetic Route of C5H7ClN2.

For development new anti-ulcer agents, we synthesized omeprazole analogs, in which pyridine group was replaced by pyrazole moiety, to increase pharmacol. activity and to decrease side effects, and also synthesize substituted benzimidazole rings.

Different reactions of this compound(3-(Chloromethyl)-1-methyl-1H-pyrazole)Synthetic Route of C5H7ClN2 require different conditions, so the reaction conditions are very important.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Related Products of 84547-64-8. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 3-(Chloromethyl)-1-methyl-1H-pyrazole, is researched, Molecular C5H7ClN2, CAS is 84547-64-8, about Synthesis of new proton-pump inhibitors (2) and tests for it’s biological activity. Author is Kim, Hyo-Jeong; Kwon, Tae-Ik; Park, Il-Hyun.

For development new anti-ulcer agents, we synthesized proton-pump (H+/K+-ATPase) inhibitors which inhibit gastric acid secretion at the last step in the parietal cell. These are omeprazole analogs, in which pyridine group is replaced by pyrazole moiety, to increase pharmacol. activity and to decrease side effects, and we also synthesized substituted benzimidazole rings. The structure of the compounds was identified with 1H-NMR, M.S. and I.R. The compounds with 5-substituted benzimidazoles showed good activity in the following order MeO > Cl > H, and also, 1-benzyl group of pyrazole substituted compounds has enhanced activity.

The article 《Synthesis of new proton-pump inhibitors (2) and tests for it’s biological activity》 also mentions many details about this compound(84547-64-8)Related Products of 84547-64-8, you can pay attention to it, because details determine success or failure

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

SDS of cas: 84547-64-8. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 3-(Chloromethyl)-1-methyl-1H-pyrazole, is researched, Molecular C5H7ClN2, CAS is 84547-64-8, about 1-Alkylpyrazoles and 1-alkyl-5-chloropyrazoles from halovinyl ketones and 1,1-dialkylhydrazines. Author is Bozhenkov, G. V.; Savosik, V. A.; Klyba, L. V.; Zhanchipova, E. R.; Mirskova, A. N.; Levkovskaya, G. G..

Regioselective heterocyclization of chlorovinyl ketones R1COCH:C(R2)Cl (R1 = Me, R2 = H; R1 = n-Pr, R2 = H, Cl; R1 = CH2Cl, R2 = H) with 1,1-dialkyl-hydrazines NH2N(R3)2 (R3 = Me, n-Bu) to pyrazoles I involved intermediate formation of the corresponding dialkylhydrazones II. The mass spectrum fragmentation pattern of chlorine-containing pyrazoles I (R1 = CH2Cl, R2 = H, R3 = Me; R1 = n-Pr, R2 = Cl, R3 = Me) depended on the position of the halogen atom.

The article 《1-Alkylpyrazoles and 1-alkyl-5-chloropyrazoles from halovinyl ketones and 1,1-dialkylhydrazines》 also mentions many details about this compound(84547-64-8)SDS of cas: 84547-64-8, you can pay attention to it, because details determine success or failure

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Levkovskaya, G. G.; Bozhenkov, G. V.; Larina, L. I.; Mirskova, A. N. published an article about the compound: 3-(Chloromethyl)-1-methyl-1H-pyrazole( cas:84547-64-8,SMILESS:CN1N=C(CCl)C=C1 ).COA of Formula: C5H7ClN2. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:84547-64-8) through the article.

A new regioselective heterocyclization was revealed in the reaction of 2-chloro- and 2,2-dichloro(bromo)vinyl ketones with N,N-dimethylhydrazine to afford 3-substituted 1-methyl-5-halopyrazoles. The reaction is accompanied by elimination of Me halide and formation of up to 90% of N,N,N-trimethylhydrazinium halide as the second product.

The article 《New synthesis and properties of 3-alkyl-, 3-chloroalkyl-, 3-perfluoroalkyl-, and 3-aryl-1-methyl-5-halopyrazoles from chloro(bromo)vinyl ketones and N,N-dimethylhydrazine》 also mentions many details about this compound(84547-64-8)COA of Formula: C5H7ClN2, you can pay attention to it, because details determine success or failure

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called 1-Alkylpyrazoles and 1-alkyl-5-chloropyrazoles from halovinyl ketones and 1,1-dialkylhydrazines, published in 2008-08-31, which mentions a compound: 84547-64-8, mainly applied to ketone chloro vinyl heterocyclization hydrazine dialkyl; pyrazole alkyl chloro preparation, Electric Literature of C5H7ClN2.

Regioselective heterocyclization of chlorovinyl ketones R1COCH:C(R2)Cl (R1 = Me, R2 = H; R1 = n-Pr, R2 = H, Cl; R1 = CH2Cl, R2 = H) with 1,1-dialkyl-hydrazines NH2N(R3)2 (R3 = Me, n-Bu) to pyrazoles I involved intermediate formation of the corresponding dialkylhydrazones II. The mass spectrum fragmentation pattern of chlorine-containing pyrazoles I (R1 = CH2Cl, R2 = H, R3 = Me; R1 = n-Pr, R2 = Cl, R3 = Me) depended on the position of the halogen atom.

The article 《1-Alkylpyrazoles and 1-alkyl-5-chloropyrazoles from halovinyl ketones and 1,1-dialkylhydrazines》 also mentions many details about this compound(84547-64-8)Electric Literature of C5H7ClN2, you can pay attention to it, because details determine success or failure

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Levkovskaya, G. G.; Bozhenkov, G. V.; Larina, L. I.; Mirskova, A. N. published the article 《New synthesis and properties of 3-alkyl-, 3-chloroalkyl-, 3-perfluoroalkyl-, and 3-aryl-1-methyl-5-halopyrazoles from chloro(bromo)vinyl ketones and N,N-dimethylhydrazine》. Keywords: regioselective heterocyclization halovinyl ketone dimethylhydrazine; halopyrazole preparation; pyrazole halo preparation.They researched the compound: 3-(Chloromethyl)-1-methyl-1H-pyrazole( cas:84547-64-8 ).SDS of cas: 84547-64-8. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:84547-64-8) here.

A new regioselective heterocyclization was revealed in the reaction of 2-chloro- and 2,2-dichloro(bromo)vinyl ketones with N,N-dimethylhydrazine to afford 3-substituted 1-methyl-5-halopyrazoles. The reaction is accompanied by elimination of Me halide and formation of up to 90% of N,N,N-trimethylhydrazinium halide as the second product.

The article 《New synthesis and properties of 3-alkyl-, 3-chloroalkyl-, 3-perfluoroalkyl-, and 3-aryl-1-methyl-5-halopyrazoles from chloro(bromo)vinyl ketones and N,N-dimethylhydrazine》 also mentions many details about this compound(84547-64-8)SDS of cas: 84547-64-8, you can pay attention to it, because details determine success or failure

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics