Category: 84547-64-8

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Kim, Hyo-Jeong; Park, Il-Hyun researched the compound: 3-(Chloromethyl)-1-methyl-1H-pyrazole( cas:84547-64-8 ).Recommanded Product: 3-(Chloromethyl)-1-methyl-1H-pyrazole.They published the article 《Synthesis of new proton-pump inhibitors》 about this compound( cas:84547-64-8 ) in Chungnam Kwahak Yonguchi. Keywords: antiulcer agent pyrazole derivative preparation. We’ll tell you more about this compound (cas:84547-64-8).

For development new anti-ulcer agents, we synthesized omeprazole analogs, in which pyridine group was replaced by pyrazole moiety, to increase pharmacol. activity and to decrease side effects, and also synthesize substituted benzimidazole rings.

This compound(3-(Chloromethyl)-1-methyl-1H-pyrazole)Recommanded Product: 3-(Chloromethyl)-1-methyl-1H-pyrazole was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 84547-64-8, is researched, SMILESS is CN1N=C(CCl)C=C1, Molecular C5H7ClN2Journal, Chungnam Kwahak Yonguchi called Synthesis of new proton-pump inhibitors, Author is Kim, Hyo-Jeong; Park, Il-Hyun, the main research direction is antiulcer agent pyrazole derivative preparation.Recommanded Product: 3-(Chloromethyl)-1-methyl-1H-pyrazole.

For development new anti-ulcer agents, we synthesized omeprazole analogs, in which pyridine group was replaced by pyrazole moiety, to increase pharmacol. activity and to decrease side effects, and also synthesize substituted benzimidazole rings.

This compound(3-(Chloromethyl)-1-methyl-1H-pyrazole)Recommanded Product: 3-(Chloromethyl)-1-methyl-1H-pyrazole was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Gardinier, Kevin M.; Gernert, Douglas L.; Porter, Warren J.; Reel, Jon K.; Ornstein, Paul L.; Spinazze, Patrick; Stevens, F. Craig; Hahn, Patric; Hollinshead, Sean P.; Mayhugh, Daniel; Schkeryantz, Jeff; Khilevich, Albert; De Frutos, Oscar; Gleason, Scott D.; Kato, Akihiko S.; Luffer-Atlas, Debra; Desai, Prashant V.; Swanson, Steven; Burris, Kevin D.; Ding, Chunjin; Heinz, Beverly A.; Need, Anne B.; Barth, Vanessa N.; Stephenson, Gregory A.; Diseroad, Benjamin A.; Woods, Tim A.; Yu, Hong; Bredt, David; Witkin, Jeffrey M. researched the compound: 3-(Chloromethyl)-1-methyl-1H-pyrazole( cas:84547-64-8 ).Recommanded Product: 84547-64-8.They published the article 《Discovery of the First α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Antagonist Dependent upon Transmembrane AMPA Receptor Regulatory Protein (TARP) γ-8》 about this compound( cas:84547-64-8 ) in Journal of Medicinal Chemistry. Keywords: LY3130481 preparation AMPA receptor antagonist TARP gamma8 anticonvulsant epilepsy. We’ll tell you more about this compound (cas:84547-64-8).

Transmembrane AMPA receptor regulatory proteins (TARPs) are a family of scaffolding proteins that regulate AMPA receptor trafficking and function. TARP γ-8 is one member of this family and is highly expressed within the hippocampus relative to the cerebellum. A selective TARP γ-8-dependent AMPA receptor antagonist (TDAA) is an innovative approach to modulate AMPA receptors in specific brain regions to potentially increase the therapeutic index relative to known non-TARP-dependent AMPA antagonists. We describe here, for the first time, the discovery of a noncompetitive AMPA receptor antagonist that is dependent on the presence of TARP γ-8. Three major iteration cycles were employed to improve upon potency, CYP1A2-dependent challenges, and in vivo clearance. An optimized mol., compound (-)-25 (LY3130481), was fully protective against pentylenetetrazole-induced convulsions in rats without the motor impairment associated with non-TARP-dependent AMPA receptor antagonists. Compound (-)-25 could be utilized to provide proof of concept for antiepileptic efficacy with reduced motor side effects in patients.

This compound(3-(Chloromethyl)-1-methyl-1H-pyrazole)Recommanded Product: 84547-64-8 was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

SDS of cas: 84547-64-8. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 3-(Chloromethyl)-1-methyl-1H-pyrazole, is researched, Molecular C5H7ClN2, CAS is 84547-64-8, about Discovery of the First α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Antagonist Dependent upon Transmembrane AMPA Receptor Regulatory Protein (TARP) γ-8. Author is Gardinier, Kevin M.; Gernert, Douglas L.; Porter, Warren J.; Reel, Jon K.; Ornstein, Paul L.; Spinazze, Patrick; Stevens, F. Craig; Hahn, Patric; Hollinshead, Sean P.; Mayhugh, Daniel; Schkeryantz, Jeff; Khilevich, Albert; De Frutos, Oscar; Gleason, Scott D.; Kato, Akihiko S.; Luffer-Atlas, Debra; Desai, Prashant V.; Swanson, Steven; Burris, Kevin D.; Ding, Chunjin; Heinz, Beverly A.; Need, Anne B.; Barth, Vanessa N.; Stephenson, Gregory A.; Diseroad, Benjamin A.; Woods, Tim A.; Yu, Hong; Bredt, David; Witkin, Jeffrey M..

Transmembrane AMPA receptor regulatory proteins (TARPs) are a family of scaffolding proteins that regulate AMPA receptor trafficking and function. TARP γ-8 is one member of this family and is highly expressed within the hippocampus relative to the cerebellum. A selective TARP γ-8-dependent AMPA receptor antagonist (TDAA) is an innovative approach to modulate AMPA receptors in specific brain regions to potentially increase the therapeutic index relative to known non-TARP-dependent AMPA antagonists. We describe here, for the first time, the discovery of a noncompetitive AMPA receptor antagonist that is dependent on the presence of TARP γ-8. Three major iteration cycles were employed to improve upon potency, CYP1A2-dependent challenges, and in vivo clearance. An optimized mol., compound (-)-25 (LY3130481), was fully protective against pentylenetetrazole-induced convulsions in rats without the motor impairment associated with non-TARP-dependent AMPA receptor antagonists. Compound (-)-25 could be utilized to provide proof of concept for antiepileptic efficacy with reduced motor side effects in patients.

Different reactions of this compound(3-(Chloromethyl)-1-methyl-1H-pyrazole)SDS of cas: 84547-64-8 require different conditions, so the reaction conditions are very important.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Chungnam Kwahak Yonguchi called Synthesis of new proton-pump inhibitors (2) and tests for it’s biological activity, Author is Kim, Hyo-Jeong; Kwon, Tae-Ik; Park, Il-Hyun, which mentions a compound: 84547-64-8, SMILESS is CN1N=C(CCl)C=C1, Molecular C5H7ClN2, Application of 84547-64-8.

For development new anti-ulcer agents, we synthesized proton-pump (H+/K+-ATPase) inhibitors which inhibit gastric acid secretion at the last step in the parietal cell. These are omeprazole analogs, in which pyridine group is replaced by pyrazole moiety, to increase pharmacol. activity and to decrease side effects, and we also synthesized substituted benzimidazole rings. The structure of the compounds was identified with 1H-NMR, M.S. and I.R. The compounds with 5-substituted benzimidazoles showed good activity in the following order MeO > Cl > H, and also, 1-benzyl group of pyrazole substituted compounds has enhanced activity.

Different reactions of this compound(3-(Chloromethyl)-1-methyl-1H-pyrazole)Application of 84547-64-8 require different conditions, so the reaction conditions are very important.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Synthesis of new proton-pump inhibitors, published in 1996-06-30, which mentions a compound: 84547-64-8, mainly applied to antiulcer agent pyrazole derivative preparation, Computed Properties of C5H7ClN2.

For development new anti-ulcer agents, we synthesized omeprazole analogs, in which pyridine group was replaced by pyrazole moiety, to increase pharmacol. activity and to decrease side effects, and also synthesize substituted benzimidazole rings.

Different reactions of this compound(3-(Chloromethyl)-1-methyl-1H-pyrazole)Computed Properties of C5H7ClN2 require different conditions, so the reaction conditions are very important.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

COA of Formula: C5H7ClN2. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 3-(Chloromethyl)-1-methyl-1H-pyrazole, is researched, Molecular C5H7ClN2, CAS is 84547-64-8, about Synthesis of new proton-pump inhibitors.

For development new anti-ulcer agents, we synthesized omeprazole analogs, in which pyridine group was replaced by pyrazole moiety, to increase pharmacol. activity and to decrease side effects, and also synthesize substituted benzimidazole rings.

Different reactions of this compound(3-(Chloromethyl)-1-methyl-1H-pyrazole)COA of Formula: C5H7ClN2 require different conditions, so the reaction conditions are very important.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 3-(Chloromethyl)-1-methyl-1H-pyrazole, is researched, Molecular C5H7ClN2, CAS is 84547-64-8, about Synthesis of pyrazole derivatives from 1,1-dimethylhydrazine and chlorovinyl ketones.Application In Synthesis of 3-(Chloromethyl)-1-methyl-1H-pyrazole.

The reaction of accessible 2-chlorovinyl Me ketones with 1,1-dimethylhydrazine gave pyrazole derivatives in high yields. 1,1,1-Trimethylhydrazinium chloride was isolated as second product of this reaction in high yield.

Different reactions of this compound(3-(Chloromethyl)-1-methyl-1H-pyrazole)Application In Synthesis of 3-(Chloromethyl)-1-methyl-1H-pyrazole require different conditions, so the reaction conditions are very important.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Levkovskaya, G. G.; Bozhenkov, G. V.; Malyushenko, R. N.; Mirskova, A. N. researched the compound: 3-(Chloromethyl)-1-methyl-1H-pyrazole( cas:84547-64-8 ).Name: 3-(Chloromethyl)-1-methyl-1H-pyrazole.They published the article 《Synthesis of pyrazole derivatives from 1,1-dimethylhydrazine and chlorovinyl ketones》 about this compound( cas:84547-64-8 ) in Russian Journal of Organic Chemistry (Translation of Zhurnal Organicheskoi Khimii). Keywords: chlorovinyl ketone cyclization methylhydrazine; pyrazol preparation; hydrazinium methyl chloride preparation. We’ll tell you more about this compound (cas:84547-64-8).

The reaction of accessible 2-chlorovinyl Me ketones with 1,1-dimethylhydrazine gave pyrazole derivatives in high yields. 1,1,1-Trimethylhydrazinium chloride was isolated as second product of this reaction in high yield.

Different reactions of this compound(3-(Chloromethyl)-1-methyl-1H-pyrazole)Name: 3-(Chloromethyl)-1-methyl-1H-pyrazole require different conditions, so the reaction conditions are very important.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Safety of 3-(Chloromethyl)-1-methyl-1H-pyrazole. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 3-(Chloromethyl)-1-methyl-1H-pyrazole, is researched, Molecular C5H7ClN2, CAS is 84547-64-8, about 1-Alkylpyrazoles and 1-alkyl-5-chloropyrazoles from halovinyl ketones and 1,1-dialkylhydrazines. Author is Bozhenkov, G. V.; Savosik, V. A.; Klyba, L. V.; Zhanchipova, E. R.; Mirskova, A. N.; Levkovskaya, G. G..

Regioselective heterocyclization of chlorovinyl ketones R1COCH:C(R2)Cl (R1 = Me, R2 = H; R1 = n-Pr, R2 = H, Cl; R1 = CH2Cl, R2 = H) with 1,1-dialkyl-hydrazines NH2N(R3)2 (R3 = Me, n-Bu) to pyrazoles I involved intermediate formation of the corresponding dialkylhydrazones II. The mass spectrum fragmentation pattern of chlorine-containing pyrazoles I (R1 = CH2Cl, R2 = H, R3 = Me; R1 = n-Pr, R2 = Cl, R3 = Me) depended on the position of the halogen atom.

Different reactions of this compound(3-(Chloromethyl)-1-methyl-1H-pyrazole)Safety of 3-(Chloromethyl)-1-methyl-1H-pyrazole require different conditions, so the reaction conditions are very important.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics