Category: 83909-69-7

3-Amino-4-aryl-1(2H)-isoquinolones was written by Nemazanyi, A. G.;Volovenko, Y. M.;Silaeva, T. A.;Kornilov, M. Yu.;Babichev, F. S.. And the article was included in Khimiya Geterotsiklicheskikh Soedinenii in 1991.Recommanded Product: 83909-69-7 The following contents are mentioned in the article:

The cyclocondensation of (nitro)halobenzamides I (R = NO₂, H; R¹ = Cl, F; R² = H, Me, CH₂Ph, Ph, 2-pyridyl) with ArCH₂CN (Ar = substituted Ph) in presence of K₂CO₃ gave isoquinolones II in 61-83% yields. The deflection angle of aromatic ring in the 4-position was determined to be 61°. This study involved multiple reactions and reactants, such as N-Benzyl-2-chloro-5-nitrobenzamide (cas: 83909-69-7Recommanded Product: 83909-69-7).

N-Benzyl-2-chloro-5-nitrobenzamide (cas: 83909-69-7) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.Recommanded Product: 83909-69-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Discovery of halo-nitrobenzamides with potential application against human African trypanosomiasis was written by Hwang, Jong Yeon;Smithson, David;Connelly, Michele;Maier, Julie;Zhu, Fangyi;Guy, Kiplin R.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2010.SDS of cas: 83909-69-7 The following contents are mentioned in the article:

A series of halo-nitrobenzamides were synthesized and evaluated for their ability to block proliferation of Trypanosoma brucei brucei. A number of these compounds had significant activity against the parasite, particularly 2-chloro-N-(4-chlorophenyl)-5-nitrobenzamide which exhibited low micromolar inhibitory potency against T. brucei and selectivity towards both malaria and mammalian cells. This study involved multiple reactions and reactants, such as N-Benzyl-2-chloro-5-nitrobenzamide (cas: 83909-69-7SDS of cas: 83909-69-7).

N-Benzyl-2-chloro-5-nitrobenzamide (cas: 83909-69-7) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Amides can be freed from solvent or water by drying below their melting points. These purifications can also be used for sulfonamides and acid hydrazides.SDS of cas: 83909-69-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Synthesis and structure of 3-amino-4-heteroaryl-1(2H)isoquinolones was written by Nemazanyi, A. G.;Volovenko, Y. M.;Silaeva, T. A.;Kornilov, M. Yu.;Babichev, F. S.. And the article was included in Khimiya Geterotsiklicheskikh Soedinenii in 1991.SDS of cas: 83909-69-7 The following contents are mentioned in the article:

A one-step preparation of the title compounds I (R = H, Me, CH₂Ph, Ph, 2-FC₆H₄; Ar = 2-azahetaryl) by a cyclocondensation of 2-Cl,5-(NO₂)C₆H₃CONHR with ArCH₂CN in K₂CO₃/DMF is reported. This study involved multiple reactions and reactants, such as N-Benzyl-2-chloro-5-nitrobenzamide (cas: 83909-69-7SDS of cas: 83909-69-7).

N-Benzyl-2-chloro-5-nitrobenzamide (cas: 83909-69-7) belongs to amides. Compared to amines, amides are very weak bases and do not have clearly defined acid–base properties in water. On the other hand, amides are much stronger bases than esters, aldehydes, and ketones. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.SDS of cas: 83909-69-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Cu-Catalyzed Efficient Synthetic Methodology for Ebselen and Related Se-N Heterocycles was written by Balkrishna, Shah Jaimin;Bhakuni, Bhagat Singh;Chopra, Deepak;Kumar, Sangit. And the article was included in Organic Letters in 2010.Related Products of 83909-69-7 The following contents are mentioned in the article:

An efficient copper-catalyzed method for the synthesis of biol. important ebselen and related analogs containing a Se-N bond has been developed. This is the first report of a catalytic process of selenation and Se-N bond formation reaction. The copper-catalyzed reaction tolerates functional groups such as amides, hydroxyls, ethers, nitro, fluorides, and chlorides. The best results are obtained by using a combination of potassium carbonate as a base, iodo- or bromo-arylamide substrates, selenium powder, and copper iodide catalyst. This study involved multiple reactions and reactants, such as N-Benzyl-2-chloro-5-nitrobenzamide (cas: 83909-69-7Related Products of 83909-69-7).

N-Benzyl-2-chloro-5-nitrobenzamide (cas: 83909-69-7) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.Related Products of 83909-69-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

An efficient copper mediated synthetic methodology for benzo[d]isothiazol-3(2H)-ones and related sulfur-nitrogen heterocycles was written by Bhakuni, Bhagat Singh;Balkrishna, Shah Jaimin;Kumar, Amit;Kumar, Sangit. And the article was included in Tetrahedron Letters in 2012.COA of Formula: C14H11ClN2O3 The following contents are mentioned in the article:

A copper mediated sulfur-nitrogen coupling reaction for the synthesis of benzo[d]isothiazol-3(2H)-ones and related sulfur-nitrogen heterocycles has been presented, which requires 2-halo arylamides, sulfur powder, 25-50 mol % of copper iodide/1,10-phenanthroline, and potassium carbonate as base. E.g., in presence of copper iodide/1,10-phenanthroline and sulfur powder, sulfur-nitrogen coupling reaction of 2-chloro-, 2-bromo-, and 2-iodo-N-benzylbenzamides gave benzo[d]isothiazol-3(2H)-one (I) in 47-89% yields. This study involved multiple reactions and reactants, such as N-Benzyl-2-chloro-5-nitrobenzamide (cas: 83909-69-7COA of Formula: C14H11ClN2O3).

N-Benzyl-2-chloro-5-nitrobenzamide (cas: 83909-69-7) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.COA of Formula: C14H11ClN2O3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Copper-catalyzed one-pot synthesis of N-substituted benzo[d]isothiazol-3(2H)-ones via C-S/N-S bond formation was written by Paul, Rajesh;Punniyamurthy, Tharmalingam. And the article was included in RSC Advances in 2012.Name: N-Benzyl-2-chloro-5-nitrobenzamide The following contents are mentioned in the article:

A one-pot synthesis of N-substituted benzo[d]isothiazol-3(2H)-one derivatives was described using copper-catalysis and N-substituted 2-halobenzamides and sulfur powder by a C-S/N-S bond formation with high yield. The title compounds thus formed included 5-methoxy-2-(phenylmethyl)-1,2-benzisothiazol-3(2H)-one (I) and related substances. The synthesis of the target compound was achieved by a copper chloride (CuCl) catalyzed reaction of sulfur with 2-iodo-5-methoxy-N-(phenylmethyl)benzamide. This study involved multiple reactions and reactants, such as N-Benzyl-2-chloro-5-nitrobenzamide (cas: 83909-69-7Name: N-Benzyl-2-chloro-5-nitrobenzamide).

N-Benzyl-2-chloro-5-nitrobenzamide (cas: 83909-69-7) belongs to amides. Compared to amines, amides are very weak bases and do not have clearly defined acid–base properties in water. On the other hand, amides are much stronger bases than esters, aldehydes, and ketones. The presence of the amide group –C(=O)N– is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cm−1. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.Name: N-Benzyl-2-chloro-5-nitrobenzamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

2-Mercapto-(1H)-1,3,2λ⁵-benzodiazaphosphorine-2,4-dithiones. Part I. Synthesis and spectral studies was written by Shinde, B. R.;Shenoy, S. J.;Pai, N. R.. And the article was included in Indian Journal of Chemistry in 1990.Application In Synthesis of N-Benzyl-2-chloro-5-nitrobenzamide The following contents are mentioned in the article:

The reaction of 2-H₂NC₆H₄CONH₂ with P₂S₅ in boiling pyridine leading to pyridine adduct of title compound I. The synthesis has been extended to a number of substituted anthranilamides to afford the new adducts. Newer adducts in which pyridine mol. is replaced by α- and γ-picolines and Et₃N resp. have also been synthesized. ¹H NMR and mass spectra of the products have been recorded and discussed. This study involved multiple reactions and reactants, such as N-Benzyl-2-chloro-5-nitrobenzamide (cas: 83909-69-7Application In Synthesis of N-Benzyl-2-chloro-5-nitrobenzamide).

N-Benzyl-2-chloro-5-nitrobenzamide (cas: 83909-69-7) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.Application In Synthesis of N-Benzyl-2-chloro-5-nitrobenzamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

New approach to the synthesis of polyfunctional isoquinolones was written by Nemazanyi, A. G.;Volovenko, Yu. M.;Silaeva, T. A.;Babichev, F. S.. And the article was included in Doklady Akademii Nauk Ukrainskoi SSR in 1989.Recommanded Product: 83909-69-7 The following contents are mentioned in the article:

The title isoquinolones I (R¹ = H, R² = NO₂, R³ = H, Me, Ph, PhCH₂, 4-MeOC₆H₄; R¹ = Cl, R² = H, R³ = H, Me; R¹-R³ = H) were prepared in 54-93% yields by treating the corresponding benzamides II (R⁴ = H, Me, X = Cl, F) with CH₂(CN)₂ in DMF containing K₂CO₃. This study involved multiple reactions and reactants, such as N-Benzyl-2-chloro-5-nitrobenzamide (cas: 83909-69-7Recommanded Product: 83909-69-7).

N-Benzyl-2-chloro-5-nitrobenzamide (cas: 83909-69-7) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds. Tertiary amides, with the important exception of N,N-dimethylformamide, exhibit low solubility in water. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.Recommanded Product: 83909-69-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Synthesis and biological activity of 2,5-diaminobenzoic acids stimulating the biosynthesis of prostaglandins was written by Kosary, J.;Szabo, I. K.;Kasztreiner, E.. And the article was included in Pharmazie in 1982.Quality Control of N-Benzyl-2-chloro-5-nitrobenzamide The following contents are mentioned in the article:

Twenty-two diaminobenzoates [I; R = NH₂; R¹ = OH, OMe, OEt, NH₂, cyclopropylamino, PhCH₂NH, Et₂N(CH₂)₂NH; R² = cyclopropyl, Bu, cyclohexyl, aryl, Et₂N(CH₂)₂; R³ = H, Bu; or NR²R³ = morpholino] (II) were prepared by reduction (H, Pd/C) of the corresponding I (R = NO₂). II are potent activators of prostaglandin synthetase (from sheep seminal vesicles) and play an important role in the biosynthesis of prostaglandins. This study involved multiple reactions and reactants, such as N-Benzyl-2-chloro-5-nitrobenzamide (cas: 83909-69-7Quality Control of N-Benzyl-2-chloro-5-nitrobenzamide).

N-Benzyl-2-chloro-5-nitrobenzamide (cas: 83909-69-7) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.Quality Control of N-Benzyl-2-chloro-5-nitrobenzamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

One Pot Regioselective Synthesis of a Small Library of Dibenzo[b,f][1,4]thiazepin-11(10H)-ones via Smiles Rearrangement was written by Zhao, Yongmei;Dai, Qiaoling;Chen, Zhi;Zhang, Qihui;Bai, Yongcheng;Ma, Chen. And the article was included in ACS Combinatorial Science in 2013.Computed Properties of C14H11ClN2O3 The following contents are mentioned in the article:

A facile and efficient method has been developed for the synthesis of a small library of dibenzo[b,f][1,4]thiazepin-11(10H)-ones via Smiles rearrangement. Compounds were obtained in excellent isolated yields (70%-92%) under metal-free conditions. E.g., in presence of KOH in DMF, reaction of 2-chlorobenzamide derivative (I) with 2-BrC₆H₄SH gave 72% dibenzo[b,f][1,4]thiazepin-11(10H)-one derivative (II). More specifically, this transition metal-free process relates to an environmentally friendly, economical, and efficient method for preparing benzoic-fused seven-membered lactams. This study involved multiple reactions and reactants, such as N-Benzyl-2-chloro-5-nitrobenzamide (cas: 83909-69-7Computed Properties of C14H11ClN2O3).

N-Benzyl-2-chloro-5-nitrobenzamide (cas: 83909-69-7) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds. Tertiary amides, with the important exception of N,N-dimethylformamide, exhibit low solubility in water. Amides can be freed from solvent or water by drying below their melting points. These purifications can also be used for sulfonamides and acid hydrazides.Computed Properties of C14H11ClN2O3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics