Reference of 79-16-3, A common heterocyclic compound, 79-16-3, name is N-methylacetamide, molecular formula is C3H7NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: A Schlenk tube was charged with amide (1.2 mmol), aryl iodides (1 mmol), CuI (0.1 mmol), N,N-dimethylglycine (0.2 mmol), and potassium phosphate (2 mmol). The tube was evacuated and backfilled with argon at room temperature. DMF (0.5 mL) was added under argon via syringe. The Schlenk tube was immersed in a preheated oil bath and the reaction mixture was stirred for the specified time at the indicated temperature. The cooled mixture was partitioned between water and ethyl acetate. The organic layer was separated and the aqueous layer was extracted with ethyl acetate. The combined organic layers were washed with brine, dried over Na2SO4, and concentrated in vacuo. The residue was purified by column chromatography on silica gel (eluting with 1:8 to 1:2 ethylacetate/petroleum ether) to give the the desired N-aryl amides.
The synthetic route of 79-16-3 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Jiang, Liqin; Molecules; vol. 19; 9; (2014); p. 13448 – 13460;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics