79-07-2 Archives - Page 9 of 16 - Amides-buliding-blocks

Dyachenko, I. V.’s team published research in Russian Chemical Bulletin in 70 | CAS: 79-07-2

Russian Chemical Bulletin published new progress about 79-07-2. 79-07-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Aliphatic hydrocarbon chain,Amide,Inhibitor, name is 2-Chloroacetamide, and the molecular formula is C2H4ClNO, SDS of cas: 79-07-2.

Dyachenko, I. V. published the artcileSynthesis of functionalized tetrahydropyridones by the tandem Knoevenagel-Michael-intramolecular ammonolysis-alkylation reaction, SDS of cas: 79-07-2, the publication is Russian Chemical Bulletin (2021), 70(11), 2145-2155, database is CAplus.

The tandem Knoevenagel-Michael-intramol. ammonolysis-alkylation reaction was used to synthesize functionalized tetrahydropyridones. The mol. and crystal structures of four pyridone derivatives were studied by X-ray diffraction.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Dyachenko, Ivan V.’s team published research in Chemistry of Heterocyclic Compounds (New York, NY, United States) in 56 | CAS: 79-07-2

Chemistry of Heterocyclic Compounds (New York, NY, United States) published new progress about 79-07-2. 79-07-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Aliphatic hydrocarbon chain,Amide,Inhibitor, name is 2-Chloroacetamide, and the molecular formula is C2H4ClNO, Formula: C2H4ClNO.

Dyachenko, Ivan V. published the artcileNovel multicomponent synthesis of 6,7-dihydro-5H-cyclopenta[b]pyridine derivatives, Formula: C2H4ClNO, the publication is Chemistry of Heterocyclic Compounds (New York, NY, United States) (2020), 56(12), 1592-1598, database is CAplus.

The multicomponent condensation of malononitrile, hydrogen sulfide, aldehydes RCHO (R = Et, cyclohex-3-en-1-yl, Ph, 4-hydroxyphenyl, etc.), 1-(cyclopent-1-en-1-yl)pyrrolidine, and alkylating agents XCH₂Z (X = Br, Cl, I; Z = H, ethoxycarbonyl, CN, Ph, etc.) leads to the formation of 6,7-dihydro-5H-cyclopenta[b]pyridine derivatives, e.g., I.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Abulkhair, Hamada S.’s team published research in Archiv der Pharmazie (Weinheim, Germany) in 354 | CAS: 79-07-2

Archiv der Pharmazie (Weinheim, Germany) published new progress about 79-07-2. 79-07-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Aliphatic hydrocarbon chain,Amide,Inhibitor, name is 2-Chloroacetamide, and the molecular formula is C2H4ClNO, Recommanded Product: 2-Chloroacetamide.

Abulkhair, Hamada S. published the artcileIn vivo- and in silico-driven identification of novel synthetic quinoxalines as anticonvulsants and AMPA inhibitors, Recommanded Product: 2-Chloroacetamide, the publication is Archiv der Pharmazie (Weinheim, Germany) (2021), 354(5), 2000449, database is CAplus and MEDLINE.

The lack of effective therapies for epileptic patients and the potentially harmful consequences of untreated seizure incidents have made epileptic disorders in humans a major health concern. Therefore, new and more potent anticonvulsant drugs are continually sought after, to combat epilepsy. On the basis of the pharmacophoric structural specifications of effective α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) antagonists with an efficient anticonvulsant activity, the present work reports the design and synthesis of two novel sets of quinoxaline derivatives The anticonvulsant activity of the synthesized compounds was evaluated in vivo according to the pentylenetetrazol-induced seizure protocol, and the results were compared with those of perampanel as a reference drug. Among the synthesized compounds, four showed promising activities with ED₅₀ values of 37.50, 23.02, 29.16, and 23.86 mg/kg. Docking studies of these compounds suggested that AMPA binding could be the mechanism of action of these derivatives Overall, the pharmacophore-based structural optimization, in vivo and in silico docking, and druglikeness studies indicated that the designed compounds could serve as promising candidates for the development of effective anticonvulsant agents with good pharmacokinetic profiles.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Hassan, Aisha Y.’s team published research in Journal of Molecular Structure in 1230 | CAS: 79-07-2

Journal of Molecular Structure published new progress about 79-07-2. 79-07-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Aliphatic hydrocarbon chain,Amide,Inhibitor, name is 2-Chloroacetamide, and the molecular formula is C2H4ClNO, Application of 2-Chloroacetamide.

Hassan, Aisha Y. published the artcilePotential antiviral and anticancer effect of imidazoles and bridgehead imidazoles generated by HPV-Induced cervical carcinomas via reactivating the P53/pRb pathway and inhibition of CA IX, Application of 2-Chloroacetamide, the publication is Journal of Molecular Structure (2021), 129865, database is CAplus.

Human papillomaviruses E6 and E7 oncoproteins are crucial to viral-induced cervical cancers and targeting E6/E7 leads to safer and better treatment for cervical cancer. Hence, a simple and green solvent-free protocol was applied for the synthesis of novel imidazoles e.g., I, and bridgehead imidazoles (purine analogs), e.g., II, via versatile straightforward synthetic routes. All the synthesized compounds have been characterized by IR, ¹H NMR, ¹³C NMR, mass spectroscopy, and elemental analyses and then have been examined for their in vitro antiviral activity against HPV, genotype 18. Two compounds, I and II, were the most promising HR-HPV inhibitors with a percentage of 95.00 and 96.84%, resp. Both compounds demonstrated a substantial down-regulation of HPV oncoproteins E6 and E7 with up-regulation of tumor suppressor proteins, p53, and pRb, resp. using western blot technique. Furthermore, the cytotoxicity of compounds I and II against the cervical cancer Hela cell line was further examined Compound I exhibited strong anticancer activity with IC₅₀ 0.08μM, which is equivalent to 5-FU (IC₅₀ 0.09μM). The cell cycle anal. was performed for investigating the potential mechanism of compound I, resulting in a significant accumulation of the cell population in both pre-G1 and G0-G1 phases and arrest the cell cycle at G1 phase. Addnl., compound I induced apoptosis, triggering cell death via increasing the early and late apoptotic rates by approx. 16 and 188 folds compared with the control. The most cytotoxic agent, I, revealed a remarkable inhibition of the targeted carbonic anhydrase IX enzyme with an IC₅₀ value of 0.12μM comparable to the standard drug. In addition, the ADME profiles of the most highly successful derivatives have been studied in order to determine their ability to be produced as good drug candidates.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Zhang, Di’s team published research in Science of the Total Environment in 801 | CAS: 79-07-2

Science of the Total Environment published new progress about 79-07-2. 79-07-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Aliphatic hydrocarbon chain,Amide,Inhibitor, name is 2-Chloroacetamide, and the molecular formula is C10H11NO4, HPLC of Formula: 79-07-2.

Zhang, Di published the artcileCatalytic hydrolysis: A novel role of zero-valent iron in haloacetonitrile degradation and transformation in unbuffered systems, HPLC of Formula: 79-07-2, the publication is Science of the Total Environment (2021), 149537, database is CAplus and MEDLINE.

Efforts to remove highly toxic haloacetonitriles (HANs) is an important step to reduce health risks associated with disinfection by product exposure. Zero valent iron (ZVI) is a versatile material, whose reductant, sorbent and coagulant role has been well understood. However, their catalytic role is less known. In this study, the degradation and transformation of HANs in ZVI system were investigated. Significant decreases of the four HANs in ZVI system were observed, and haloacetamides and haloacetic acids (hydrolysis products of HANs) were the dominant transformation products of HANs. However dehalogenated HANs, Fe (II) and Fe (III) were rarely detected after reaction, indicating that the ZVI acted as a catalyst to promote the hydrolysis of HANs, rather than other previously reported causes (dehalogenation or redox reaction). The HAN degradation rates were dramatically affected by the initial pH, ZVI doses and initial HAN concentration Kinetic anal. indicated that HAN removal was enhanced with the increase of initial pH (5-9), ZVI doses (1-10 g/L), and initial HAN concentration (25-200μg/L). ZVI induced the transformation of HANs to haloacetamides, haloacetic acids and other de-halogenated compounds, which reduced the cytotoxicity and genotoxicity by 88% and 85%, resp. This study helped to understand the fate of HAN during the transmission in cast iron pipes, and provided a theor. foundation for future HAN control and monitoring efforts.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Krivokolysko, D. S.’s team published research in Russian Journal of General Chemistry in 91 | CAS: 79-07-2

Russian Journal of General Chemistry published new progress about 79-07-2. 79-07-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Aliphatic hydrocarbon chain,Amide,Inhibitor, name is 2-Chloroacetamide, and the molecular formula is C2H4ClNO, Synthetic Route of 79-07-2.

Krivokolysko, D. S. published the artcileSynthesis, Structure, and Analgesic Activity of 4-(5-Cyano-{4-(fur-2-yl)-1,4-dihydropyridin-3-yl}carboxamido)benzoic Acids Ethyl Esters, Synthetic Route of 79-07-2, the publication is Russian Journal of General Chemistry (2021), 91(12), 2588-2605, database is CAplus.

A series of new hybrid mols. containing fragments of anesthesin and 4-(2-furyl)-1,4-dihydronicotinonitrile have been obtained starting from diketene, Et 4-aminobenzoate, cyanothioacetamide, and furfural. The obtained compounds have been investigated for the analgesic activity in vivo (rats) in the orofacial trigeminal pain and acetic acid induced writhing tests. The compounds exhibiting analgesic effect superior to that of the reference drug (metamizole sodium) have been revealed. Mol. docking has been performed for the considered compounds with respect to a wide range of protein targets, including cyclooxygenases COX-1 and COX-2.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Cuthbertson, Amy A. et al. published their research in Analytical Chemistry (Washington, DC, United States) in 2020 |CAS: 79-07-2

The Article related to trace halo disinfection byproduct part per trillion drinking water, Water: Analysis and other aspects.Recommanded Product: 2-Chloroacetamide

On February 18, 2020, Cuthbertson, Amy A.; Liberatore, Hannah K.; Kimura, Susana Y.; Allen, Joshua M.; Bensussan, Alena V.; Richardson, Susan D. published an article.Recommanded Product: 2-Chloroacetamide The title of the article was Trace Analysis of 61 Emerging Br-, Cl-, and I-DBPs: New Methods to Achieve Part-Per-Trillion Quantification in Drinking Water. And the article contained the following:

Disinfection byproducts (DBPs) are a ubiquitous source of chem. exposure in drinking H2O and were associated with serious health impacts in human epidemiol. studies. While toxicol. studies have pinpointed DBPs with the greatest toxic potency, anal. methods were lacking for quantifying complete classes of most toxic DBPs at sufficiently low quantification limits (ng/L). This new method reports the parts-per-trillion quantification for 61 toxicol. significant DBPs from 7 different chem. classes, including unregulated iodinated haloacetic acids (HAAs) and trihalomethanes (THMs), haloacetaldehydes, haloketones, haloacetonitriles, halonitromethanes, and haloacetamides, in addition to regulated HAAs and THMs. The final optimized method uses salt-assisted liquid-liquid extraction in a single extraction method for a wide range of DBPs, producing the lowest method detection limits to-date for many compounds, including highly toxic iodinated, brominated, and N-containing DBPs. Extracts were divided for the anal. of the HAAs (including iodinated HAAs) by diazomethane derivatization and anal. using a GC-triple quadrupole mass spectrometer with multiple reaction monitoring, resulting in higher signal-to-noise ratios, greater selectivity, and improved detection of these compounds The remaining DBPs were analyzed using a GC-single quadrupole mass spectrometer with selected ion monitoring, using a multimode inlet allowed for lower injection temperatures to allow the anal. of thermally labile DBPs. Finally, the use of a specialty-phase GC column (Restek Rtx-200) significantly improved peak shapes, which improved separations and lowered detection limits. Method detection limits for most DBPs were 15-100 ng/L, and relative standard deviations in tap H2O samples were mostly between 0.2 and 30%. DBP concentrations in real samples ranged from 40 to 17,760 ng/L for this study. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Recommanded Product: 2-Chloroacetamide

The Article related to trace halo disinfection byproduct part per trillion drinking water, Water: Analysis and other aspects.Recommanded Product: 2-Chloroacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Bogdanovic, Aleksandra et al. published their research in Arhiv za Higijenu Rada i Toksikologiju in 2021 |CAS: 79-07-2

The Article related to n-substituted amides, antimicrobial potential, quantitative analysis of chemical structure and activity relationship, and other aspects.Safety of 2-Chloroacetamide

On March 31, 2021, Bogdanovic, Aleksandra; Lazic, Anita; Grujic, Slavica; Dimkic, Ivica; Stankovic, Slavisa; Petrovic, Slobodan published an article.Safety of 2-Chloroacetamide The title of the article was Characterisation of twelve newly synthesised N-(substituted phenyl)-2-chloroacetamides with QSAR analysis and antimicrobial activity tests. And the article contained the following:

In this study we screened twelve newly synthesized N-(substituted phenyl)-2-chloroacetamides for antimicrobial potential relying on quant. structure-activity relationship (QSAR) anal. based on the available cheminformatics prediction models (Molinspiration, SwissADME, PreADMET, and PkcSM) and verified it through standard antimicrobial testing against Escherichia coli, Staphylococcus aureus, methicillin-resistant S. aureus (MRSA), and Candida albicans. Our compounds met all the screening criteria of Lipinski’s rule of five (Ro5) as well as Veber’s and Egan’s methods for predicting biol. activity. In antimicrobial activity tests, all chloroacetamides were effective against Gram-pos. S. aureus and MRSA, less effective against the Gram-neg. E. coli, and moderately effective against the yeast C. albicans. Our study confirmed that the biol. activity of chloroacetamides varied with the position of substituents bound to the Ph ring, which explains why some mols. were more effective against Gram-neg. than Gram-pos. bacteria or C. albicans. Bearing the halogenated p-substituted Ph ring, N-(4-chlorophenyl), N-(4-fluorophenyl), and N-(3-bromophenyl) chloroacetamides were among the most active thanks to high lipophilicity, which allows them to pass rapidly through the phospholipid bilayer of the cell membrane. They are the most promising compounds for further investigation, particularly against Gram-pos. bacteria and pathogenic yeasts. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Safety of 2-Chloroacetamide

The Article related to n-substituted amides, antimicrobial potential, quantitative analysis of chemical structure and activity relationship, and other aspects.Safety of 2-Chloroacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Prothiwa, Michaela et al. published their research in Methods in Enzymology in 2020 |CAS: 79-07-2

The Article related to acetamides: chemistry, bacterial proteins: antagonists & inhibitors, bacterial proteins: biosynthesis, bacterial proteins: genetics, binding, competitive, catalytic domain, click chemistry: methods, electrophoresis, polyacrylamide gel: methods, enzyme inhibitors: chemistry, enzyme inhibitors: pharmacology and other aspects.Name: 2-Chloroacetamide

Prothiwa, Michaela; Bottcher, Thomas published an article in 2020, the title of the article was Competitive profiling for enzyme inhibitors using chemical probes.Name: 2-Chloroacetamide And the article contains the following content:

Enzyme inhibitors are central tools for chem. biol. In this chapter we will discuss the application of chem. probes for competitive profiling of inhibitors of the quinolone biosynthesis enzyme PqsD of Pseudomonas aeruginosa. The human pathogen P. aeruginosa produces a large diversity of 2-alkyl-4(JH)-quinolones and their derivatives as metabolites with major roles in quorum sensing, virulence, and interspecies competition. PqsD is a central enzyme in the biosynthesis of all ofthese quinolones and hence an interesting target for inhibitor discovery. Aaivity-based probes with an elearophilic warhead bind covalently to aaive site nucleophiles like cysteine or serine. An α-chloroacetamide probe with terminal alkyne tag allowed to selectively label the aaive site cysteine of PqsD and was demonstrated to be a useful tool for inhibitor discovery using competition experiments Potent inhibitors bind to the aaive site and thereby prevent labeling ofthe enzyme by the probe. Labeling intensity is quantified. on polyacrylamide gels by the fluorescence of a reporter tag appended by bioorthogonal click chem. The competitive inhibitor profiling strategy has many advantages over traditional screening approaches and is applicable in vitro as well as in live cells. Here we describe the synthesis of an activity-based probe and provide our detailed protocols for target enzyme labeling as well as its application for the screening for potent enzyme inhibitors of PqsD by a competitive profiling strategy. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Name: 2-Chloroacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Murphy, EmmaRae L. et al. published their research in Analytical Biochemistry in 2021 |CAS: 79-07-2

The Article related to alkylation, kinetics, liquid chromatography and quadrupole-orbitrap mass spectrometer, protein, acetamides: chemistry, alkylation, chromatography, liquid, cysteine: chemistry, iodoacetamide: chemistry, proteins: chemistry, tandem mass spectrometry and other aspects.Formula: C2H4ClNO

On April 15, 2021, Murphy, EmmaRae L.; Joy, Andrew P.; Ouellette, Rodney J.; Barnett, David A. published an article.Formula: C2H4ClNO The title of the article was Optimization of cysteine residue alkylation using an on-line LC-MS strategy: Benefits of using a cocktail of haloacetamide reagents. And the article contained the following:

Several common reagents for the alkylation of cysteine residues of model intact proteins were evaluated for reaction speed, yield of alkylated product and degree of over-alkylation using an online LC-MS platform. The efficiency of the alkylation reaction is found to be dependent on the (1) reagent, (2) peptide/protein, (3) reagent concentration and (4) reaction time. At high reagent concentrations, iodoacetic acid was found to produce significant levels of over-alkylation products wherein methionine residues become modified. For optimal performance of the alkylation reaction, we found the use of a cocktail of chloroacetamide, bromoacetamide and iodoacetamide worked best. The alkylating efficiency of each haloacetamide is a balance between the characteristics of the halogen leaving group and the steric hindrance of the alkylation site on the peptide or protein. A key aspect of using a cocktail of haloacetamides is that they all produce the same modification (+57.0209 Da) to the cysteine residues of the protein while the alkylation efficiency of each site may differ for each of the three reagents. Over-alkylation effects appear to be lower with the cocktail due to a lower concentration of each reagent. The haloacetamide cocktail could be useful when considering complex mixtures of proteins. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Formula: C2H4ClNO

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics