Category: 79-07-2

Yengoyan, Aleksandr P. published the artcileSynthesis of 4,6-Dimethylpyrimidine 2-Thiosubstituted Derivatives and Their Preliminary Biological Evaluation, COA of Formula: C2H4ClNO, the publication is Letters in Organic Chemistry (2021), 18(4), 311-317, database is CAplus.

Based on 4,6-dimethylpyrimidine-2-thiol hydrochloride a series of its novel S-substituted derivatives including bi- and tricyclic heterosystems with a combination of azines and pyrazole cycles I (R = H, Me; R¹ = H, Ph, 3,4-dichlorophenyl, etc.), were synthesized. The preliminary biol. screening has shown that the obtained compounds have a pronounced plants growth-stimulating activity, which is a new property for these heterosystems. This fact indicates the prospectivity of further development of synthesized systems for the search for new plants growth stimulators.

Letters in Organic Chemistry published new progress about 79-07-2. 79-07-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Aliphatic hydrocarbon chain,Amide,Inhibitor, name is 2-Chloroacetamide, and the molecular formula is C6H12Br2, COA of Formula: C2H4ClNO.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Bhukya, Bhadru published the artcileSynthesis and anticancer activity of novel oxadiazole functionalized pyrazolo[3,4-b]pyridine derivatives, Recommanded Product: 2-Chloroacetamide, the publication is Asian Journal of Chemistry (2021), 33(6), 1331-1335, database is CAplus.

A series of novel oxadiazole functionalized pyrazolo[3,4-b]pyridine derivatives I (R = Ph, thien-2-yl; R¹ = C₆H₅, 3-CH₃C₆H₄, 3-FC₆H₄, etc.) was synthesized using 6-thiophenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-3-amine through reaction with 2-bromoethyl acetate, followed by hydrazine hydrate to afford hydrazide derivatives II (R = Ph, thien-2-yl). These compounds were further treated with aromatic acids in the presence of phosphoryl chloride and obtained oxadiazole functionalized pyrazolo[3,4-b]pyridine derivatives I. All the synthesized compounds I were screened for anticancer activity against four cancer cell lines such as HeLa – cervical cancer (CCL-2); COLO 205-colon cancer (CCL-222); HepG2-liver cancer (HB-8065); MCF7-breast cancer (HTB-22). Compounds I (R = thien-2-yl; R¹ = 3-FC₆H₄), I (R = thien-2-yl; R¹ = 3-MeOC₆H₄) and I (R = thien-2-yl; R¹ = 3-F₃CC₆H₄) were found to have more prominent anticancer activity at micromolar concentration

Asian Journal of Chemistry published new progress about 79-07-2. 79-07-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Aliphatic hydrocarbon chain,Amide,Inhibitor, name is 2-Chloroacetamide, and the molecular formula is C2H4ClNO, Recommanded Product: 2-Chloroacetamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Xu, Xiaolei published the artcileReactivity of chloroacetamides toward sulfide + black carbon: Insights from structural analogues and dynamic NMR spectroscopy, Recommanded Product: 2-Chloroacetamide, the publication is Science of the Total Environment (2022), 150064, database is CAplus and MEDLINE.

Chloroacetamides are commonly used in herbicide formulations, and their occurrence has been reported in soils and groundwater. However, how their chem. structures affect transformation kinetics and pathways in the presence of environmental reagents such as hydrogen sulfide species and black carbon has not been investigated. In this work, we assessed the impact of increasing Cl substituents on reaction kinetics and pathways of six chloroacetamides. The contribution of individual pathways (reductive dechlorination vs. nucleophilic substitution) to the overall decay of selected chloroacetamides was differentiated using various exptl. setups; both the transformation rates and product distributions were characterized. Our results suggest that the number of Cl substituents affected reaction pathways and kinetics: trichloroacetamides predominantly underwent reductive dechlorination whereas mono- and dichloroacetamides transformed via nucleophilic substitution. Furthermore, we synthesized eight dichloroacetamide analogs (Cl2CHC(=O)NRR′) with differing R groups and characterized their transformation kinetics. Dynamic NMR spectroscopy was employed to quantify the rotational energy barriers of dichloroacetamides. Our results suggest that adsorption of dichloroacetamides on black carbon constrained R groups from approaching the dichloromethyl carbon and subsequently favored nucleophilic attack. This study provides new insights to better predict the fate of chloroacetamides in subsurface environments by linking their structural characteristics to transformation kinetics and pathways.

Science of the Total Environment published new progress about 79-07-2. 79-07-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Aliphatic hydrocarbon chain,Amide,Inhibitor, name is 2-Chloroacetamide, and the molecular formula is C19H17N2NaO4S, Recommanded Product: 2-Chloroacetamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Verdugo, Edgard M. published the artcileControlling disinfection byproducts from treated wastewater using adsorption with granular activated carbon: Impact of pre-ozonation and pre-chlorination, Category: amides-buliding-blocks, the publication is Water Research: X (2020), 100068, database is CAplus and MEDLINE.

This study measured chlorine- and chloramine-reactive precursors using formation potential (FP) tests of nine U. S. Environmental Protection Agency (EPA) regulated and 57 unregulated disinfection byproducts (DBPs) in tertiary-filtered wastewater before and after pilot-scale granular activated carbon (GAC) adsorption. Using breakthrough of precursor concentration and of concentration associated calculated cytotoxicity and genotoxicity (by correlating known lethal concentrations reported elsewhere), the performance of three parallel GAC treatment trains were compared against tertiary-filtered wastewater: ozone/GAC, chlorine/GAC, and GAC alone. Results show GAC alone was the primary process, vs. ozone or chlorine alone, to remove the largest fraction of total chlorine- and chloramine-reactive DBP precursors and calculated cytotoxicity and genotoxicity potencies. GAC with pre-ozonation removed the most chlorine- and chloramine-reactive DBP precursors followed by GAC with pre-chlorination and lastly GAC without pre-treatment. GAC with pre-ozonation produced an effluent with cytotoxicity and genotoxicity of DBPs from FP that generally matched that of GAC without pre-oxidation; meanwhile removal of toxicity was greater by GAC with pre-chlorination. The cytotoxicity and genotoxicity of DBPs from FP tests did not scale with DBP concentration; for example, more than 90% of the calculated cytotoxicity resulted from 20% of the DBPs, principally from haloacetaldehydes, haloacetamides, and haloacetonitriles. The calculated cytotoxicity and genotoxicity from DBPs associated with FP-chloramination were at times higher than with FP-chlorination though the concentration of DBPs was five times higher with FP-chlorination. The removal of DBP precursors using GAC based treatment was at least as effective as removal of DOC (except for halonitromethanes for GAC without pre-oxidation and with pre-chlorination), indicating DOC can be used as an indicator for DBP precursor adsorption efficacy. However, the DOC was not a good surrogate for total cytotoxicity and genotoxicity breakthrough behavior, therefore, unregulated DBPs could have neg. health implications that are disconnected from general water quality parameters, such as DOC, and regulated classes of DBPs. Instead, cytotoxicity and genotoxicity correlate with the concentration of specific classes of unregulated DBPs.

Water Research: X published new progress about 79-07-2. 79-07-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Aliphatic hydrocarbon chain,Amide,Inhibitor, name is 2-Chloroacetamide, and the molecular formula is C22H18Cl2N2, Category: amides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Lajin, Bassam published the artcileFluorinated carboxylic acids as “ion repelling agents” in reversed-phase chromatography, Application of 2-Chloroacetamide, the publication is Journal of Chromatography A (2020), 461575, database is CAplus and MEDLINE.

Fluorinated carboxylic acids have been in use as ion-pairing reagents for over three decades. It has been observed that ion-pairing reagents not only increase the retention of oppositely charged analytes on reversed-phase HPLC columns but also decrease the retention of similarly charged analytes; these latter effects, however, have not been thoroughly investigated for the fluorinated carboxylic acids, and the application of these reagents has been rather restricted to their ion-pairing capacity to sep. basic analytes. In the present study, we report a systematic investigation about the effects of three fluorinated carboxylic acids (trifluoroacetic acid (TFA), pentafluoropropionic acid (PFPA), and heptafluorobutyric acid (HFBA)) on the retention and selectivity of the separation of halogenated carboxylic acids and sulfonic acids by reversed-phase chromatog. with an inductively coupled plasma mass spectrometry detector (ICPMS). Several eluents were tested and compared at different concentrations (0-100 mM) and pH values, including sulfate, nitrate, phosphate, oxalate, TFA, PFPA, and HFBA. The fluorinated carboxylic acids resulted in a consistent decrease in the retention factors (up to ca. 9-fold with HFBA) in a concentration dependent manner, which plateaued at around 50 mM. Significant improvement of the peak symmetry of the chromatographed acids was also observed We highlight the advantages of incorporating the fluorinated carboxylic acids in modifying the selectivity and retention of organic acids in reversed phase chromatog. in general, and particularly when employing chromatog. detectors with limited compatibility with organic mobile phases such as the ICPMS.

Journal of Chromatography A published new progress about 79-07-2. 79-07-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Aliphatic hydrocarbon chain,Amide,Inhibitor, name is 2-Chloroacetamide, and the molecular formula is C2H4ClNO, Application of 2-Chloroacetamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Kaur, Ravneet published the artcileBiodegradation of Butachlor by Bacillus altitudinis and Identification of Metabolites, Name: 2-Chloroacetamide, the publication is Current Microbiology (2020), 77(10), 2602-2612, database is CAplus and MEDLINE.

Butachlor is a chloroacetamide pre-emergence herbicide, with a half-life of 1.6 to 29 days. It is a suspected carcinogen, genotoxin, neurotoxin and persists in the environment having toxic effect on living systems. Butachlor degrading bacterial strain A16 was isolated from coal tar contaminated soil, which showed 99.38% similarity with Bacillus altitudinis 41KF2b^T as revealed by 16S rRNA anal. B. altitudinis strain A16 utilized butachlor as a sole source of carbon and degraded 90% of 50 mg L^-1 butachlor in 5 days at a rate constant and half-life (t_1/2) of 0.02 h^-1 and 34.65 h, resp., following the first-order reaction kinetics. Five metabolites (N-(butoxymethyl)-N-(2-chloroethyl)-2,6-diethylaniline, (N-(butoxymethyl))-2-chloro-N-(2-ethylphenyl) acetamide, N-(butoxymethyl)-2,6-diethyl-N-propylaniline, 2-chloro-N-(2,6-diethylphenyl) acetamide and 2,6-diethylaniline) were produced during the breakdown of butachlor by B. altitudinis A16 as identified by GC-MS anal., which are further mineralized to carbon dioxide and water. A metabolic pathway is proposed and compared with other bacteria. The findings have immense beneficial application since such microbes can be used on large scale for faster soil bioremediation and minimizing neg. impact of pesticide butachlor on health and environment.

Current Microbiology published new progress about 79-07-2. 79-07-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Aliphatic hydrocarbon chain,Amide,Inhibitor, name is 2-Chloroacetamide, and the molecular formula is C2H4ClNO, Name: 2-Chloroacetamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Adel M. Kamal El-Dean published the artcileNovel Synthesis, Reactions, and Biological Study of New Morpholino-Thieno[2,3-c][2,7]Naphthyridines as Anti-Cancer and Anti-Microbial Agents, COA of Formula: C2H4ClNO, the publication is Russian Journal of Bioorganic Chemistry, database is CAplus.

The biol. uses of 2,7-naphthyridines have sparked great attention in recent years. For this reason, a series of novel 2,7-naphthyridines derivatives was synthesized and explored their spectrum and biol. properties in this study. Compound I was prepared by the reaction of 1-Me piperidin-4-one with CS₂, malononitrile, and triethylamine. The condensed I be converted to II by reaction with morpholine. Composite II was used as a starter in heterocyclic compound a series, such as the thieno[2,3-c][2,7]naphthyridines III (R = CN, COOEt, COPh, etc.). Authors used III (R = COOEt), III (R = CONH₂) and III (R = CHO) as a precursor to create original heterocyclic moieties, namely: pyrimidothienonaphthyridino and pyridothieno naphthyridino in compounds A number of compounds for antimicrobial activity were examined against a variety of bacterial and fungal strains. In addition, some of these compounds showed anticancer activity in liver and cells of breast cancer.

Russian Journal of Bioorganic Chemistry published new progress about 79-07-2. 79-07-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Aliphatic hydrocarbon chain,Amide,Inhibitor, name is 2-Chloroacetamide, and the molecular formula is C2H4ClNO, COA of Formula: C2H4ClNO.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Mohareri, Mohammad Moein published the artcilePreparation and application of Fe₃O₄@Acetamidoxanthate as a unique nanosorbent in heavy metal removing, Synthetic Route of 79-07-2, the publication is Main Group Chemistry (2021), 20(4), 633-643, database is CAplus.

Chelating agents are one of the most important substances in metal extraction, but separation is the main problem in the use of these agents as an adsorbent. After the adsorption of metals by an external magnet, magnetic NPs provide the possibility of easy collecting and isolating the adsorbent nanomaterial for many applications. Given the immense importance of magnetic NPs, there has been widespread interest in accessing the above adsorbent. In the present study, an attempt was made to synthesize acetamido xanthate which was coupled to NPs and has the potential to be used as a nano-adsorbent for the removal of heavy metals. This novel nano sorbent was characterized by SEM (SEM), Fourier transforms IR (FT-IR), and NMR (NMR) spectroscopy. The effect of some parameters such as temperature, time, pH, and the amount of adsorbent on the extraction reaction was investigated. The optimized condition for extraction of cerium was temperature of 30°C, pH=8, reaction time of 45 min using 7.5mg of the prepared nanosorbent, that in such condition the yield of reaction achieved up to 97%. The prepared adsorbent showed high efficiency in the adsorption of heavy metals specifically.

Main Group Chemistry published new progress about 79-07-2. 79-07-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Aliphatic hydrocarbon chain,Amide,Inhibitor, name is 2-Chloroacetamide, and the molecular formula is C2H4ClNO, Synthetic Route of 79-07-2.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Tong, Ruoming published the artcileEfficient degradation of sulfachloropyridazine by sulfite activation with CuO-Al₂O₃ composites under neutral pH conditions: Radical and non-radical, Formula: C2H4ClNO, the publication is Journal of Environmental Chemical Engineering (2022), 10(2), 107276, database is CAplus.

In this work, CuO-Al₂O₃ composites were synthesized at higher temperatures to control the leaching of metal ions, which can activate sulfite (S(IV)) to degrade organic contaminants by generating reactive oxygen species (ROSs). The synthesized catalysts were characterized by X-ray diffraction, SEM, high-resolution transmission electron microscopy, Brunauer-Emmett-Teller, Raman spectroscopy, and Fourier transform IR spectrophotometry. Sulfachloropyridazine (SCP) was almost completely removed (>99%) at pH 6.8, and the leaching amount of Cu accounted for 0.027% of the total amount of Cu after the reaction. Notably, singlet oxygen (¹O₂) was found for the first time in the activated sulfite system, which removed organic pollutants together with sulfate (SO₄^·- ) and hydroxyl (·OH) radicals. And Al₂O₃ plays an important role in the catalyst, including anti-sintering, reducing the leaching of copper ions, and promoting the generation of oxygen vacancies. Based on the types of ROSs and XPS results, a possible ROSs generation mechanism was proposed. In addition, the stability of the catalyst and the effect of different factors on the degradation of SCP, including operating parameters and water quality, were further investigated. The intermediates were detected by using gas chromatog.-mass spectrometry and a developmental toxicity assessment of the intermediates was defined based on the Toxicity Estimation Software Tool (TEST). Overall, this paper not only provides a new strategy for sulfite activation but also promotes more attention to non-radical processes in activated sulfite systems.

Journal of Environmental Chemical Engineering published new progress about 79-07-2. 79-07-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Aliphatic hydrocarbon chain,Amide,Inhibitor, name is 2-Chloroacetamide, and the molecular formula is C7H8BFO2, Formula: C2H4ClNO.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Yahya, Rana published the artcileRecycling Oryza sativa wastes into poly-imidazolium acetic acid-tagged nanocellulose Schiff base supported Pd nanoparticles for applications in cross-coupling reactions, Name: 2-Chloroacetamide, the publication is Reactive & Functional Polymers (2022), 105137, database is CAplus.

A green and sustainable heterogeneous nanocatalyst for the Suzuki reaction was fabricated by refining rice straw to ionic nanocellulose Schiff base (NCESB) which was employed for bio-reduction of Pd(II) into Pd nanoparticles (Pd NPs) and immobilization of these NPs to fabricate the desired nanocatalyst (NCESB@Pd). The TEM image revealed well-dispersed PdNPs with sizes of 5-23 nm. The new nanocatalyst displayed amazing activity in catalyzing coupling reactions of a wide range of halobenzenes with phenylboronic acid at 50°C (reaction time 15-60 min) and even at room temperature (reaction time 120 min). The NCESB@Pd nanocatalyst exhibited excellent recyclability (up to five catalytic runs) without a significant loss of its activity or identity. Therefore, the new ionic nanocatalyst may open a new window for a novel generation of ionic low-cost green and highly effective nanocatalysts for organic transformation reactions.

Reactive & Functional Polymers published new progress about 79-07-2. 79-07-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Aliphatic hydrocarbon chain,Amide,Inhibitor, name is 2-Chloroacetamide, and the molecular formula is C10H15NS, Name: 2-Chloroacetamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics