Category: 79-07-2

Wang, Xuan published the artcilePerformance assessment of capsaicin derivatives containing amide groups used as active substances for antifouling coatings, Application of 2-Chloroacetamide, the publication is Progress in Organic Coatings (2021), 106515, database is CAplus.

The culprit of biofouling is the formation and reproduction of viable microbial biofilms. For many years, biofouling is a critical issue in marine pollution treatment and has drawn great attention. Herein, eight capsaicin (CAP) derivatives were prepared using aromatic hydrocarbons and amides as raw materials, thereinto, compounds A1, A2, A3, A4, and B1 has not been reported, being considered some new compounds Meanwhile, the antifouling (AF) property of CAP derivatives were characterized for the first time. The inhibition rates of these CAP derivatives (20μg·mL^-1) against Escherichia coli and Staphylococcus aureus exceed 80% and 92%, resp. The anti-algal activity of the CAP derivatives is time and concentration dependent. Compounds A3 and A4 exhibit excellent anti-algal activity (> 77.30% against Nitzschia closterium and > 82.50% against C. vulgaris), and their toxicity is lower than that of currently used antifoulants, such as TBT and SeaNine 211. Most importantly, AF coatings with CAP derivatives show excellent AF effects in marine environments for 180 days; moreover, as auxiliary AF agents, CAP derivatives further enhance the AF performance of cuprous oxide-containing coatings, which are widely used as antifoulants. The phenolic hydroxyl group, benzene ring, amide group and chlorine atom in the CAP derivatives are supposed to be the main active groups contributing to the AF performance. This study may provide a promising method to solve marine pollution.

Progress in Organic Coatings published new progress about 79-07-2. 79-07-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Aliphatic hydrocarbon chain,Amide,Inhibitor, name is 2-Chloroacetamide, and the molecular formula is C6H8O4, Application of 2-Chloroacetamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Wang, Xuan published the artcilePreparation and evaluation of polyphenol derivatives as potent antifouling agents: addition of a side chain affects the biological activity of polyphenols, Application of 2-Chloroacetamide, the publication is Biofouling (2022), 38(1), 29-41, database is CAplus and MEDLINE.

In this study, eight polyphenol derivatives were prepared to serve as green antifoulants. Polyphenol derivatives, which can hinder the growth of bacteria and algae and decrease the adhesion of some marine organisms, showed good AF activity; in particular, the activities of these derivatives were much higher than those of the corresponding polyphenols. The antibacterial rates of the products (20μg ml-1) exceeded 88%. Moreover, the anti-algal rates of compounds a3, b1, b2, b3 and b4 (15μg ml-1) were over 57% at 240 h, but these compounds showed low toxicity, and the 120 h EC50 values were > 6.60μg ml-1. In addition, there were fewer marine microorganisms on the test panel than on the control. The above results show that some polyphenol derivatives possess relatively high antibacterial, anti-algal, and AF activity; more notably, the addition of chlorine atoms and amide groups can further increase the activity of these derivatives

Biofouling published new progress about 79-07-2. 79-07-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Aliphatic hydrocarbon chain,Amide,Inhibitor, name is 2-Chloroacetamide, and the molecular formula is C7H8BFO2, Application of 2-Chloroacetamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Murphy, EmmaRae L. published the artcileOptimization of cysteine residue alkylation using an on-line LC-MS strategy: Benefits of using a cocktail of haloacetamide reagents, SDS of cas: 79-07-2, the publication is Analytical Biochemistry (2021), 114137, database is CAplus and MEDLINE.

Several common reagents for the alkylation of cysteine residues of model intact proteins were evaluated for reaction speed, yield of alkylated product and degree of over-alkylation using an online LC-MS platform. The efficiency of the alkylation reaction is found to be dependent on the (1) reagent, (2) peptide/protein, (3) reagent concentration and (4) reaction time. At high reagent concentrations, iodoacetic acid was found to produce significant levels of over-alkylation products wherein methionine residues become modified. For optimal performance of the alkylation reaction, we found the use of a cocktail of chloroacetamide, bromoacetamide and iodoacetamide worked best. The alkylating efficiency of each haloacetamide is a balance between the characteristics of the halogen leaving group and the steric hindrance of the alkylation site on the peptide or protein. A key aspect of using a cocktail of haloacetamides is that they all produce the same modification (+57.0209 Da) to the cysteine residues of the protein while the alkylation efficiency of each site may differ for each of the three reagents. Over-alkylation effects appear to be lower with the cocktail due to a lower concentration of each reagent. The haloacetamide cocktail could be useful when considering complex mixtures of proteins.

Analytical Biochemistry published new progress about 79-07-2. 79-07-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Aliphatic hydrocarbon chain,Amide,Inhibitor, name is 2-Chloroacetamide, and the molecular formula is C2H4ClNO, SDS of cas: 79-07-2.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Mokariya, Jaydeep A. published the artcileSimultaneous ultrasound- and microwave-assisted one-pot ‘click’ synthesis of 3-formyl-indole clubbed 1,2,3-triazole derivatives and their biological evaluation, Name: 2-Chloroacetamide, the publication is Molecular Diversity (2022), 26(2), 963-979, database is CAplus and MEDLINE.

An environment friendly, high yielding, promising one-pot protocol for the click reaction of N-propargyl-3-formylindoles, chloroacetic acid/ester and sodium azide, leading to the formation of 3-formyl-indole clubbed 1,4-disubstituted-1,2,3-triazole derivatives I [R = OH, OEt, Ph, etc.; R¹ = H, Me] aided by CuI catalyst accomplished under acceleration of simultaneous ultrasound and microwave irradiation in a very short reaction time was described. Further, acid derivatives I [R = OH; R¹ = H, Me] were subjected to acid-amine coupling reaction with secondary amines in the presence of HATU to afford triazoles II [R² = 4-methylpiperidin-1-yl, 2-morpholino, 1,2,3-triazol-1-yl, etc.]. The perspective of this protocol was to get rid of the hectic preparation and handling of organic azide which are generated in situ. Consequently, this protocol blossomed the click process by making it environment benign, user-friendly, safe and clean technique. All the synthesized compounds were preliminarily screened for their in vitro antimicrobial activity against a panel of pathogenic strains. The majority of compounds possessed noticeably inhibitory action against E. Coli, S. Typhi, P. Aeruginosa, C. tetani, S. aureus and B. subtillis. Among all compounds, I [R¹ = H, R² = 4-methylpiperidin-1-yl; R¹ = Me, R² = 4-methylpiperazin-1-yl] exhibited excellent inhibitory action against E.Coli and P. Aeruginosa strain, resp., as compared to standard drug. One compound I [R = Me, R¹ = OEt] showed remarkable potency against fungal strain. Mol. docking study was carried out to understand binding of compound with protein. In silico ADME prediction was carried out to check physicochem. properties of synthesized compound

Molecular Diversity published new progress about 79-07-2. 79-07-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Aliphatic hydrocarbon chain,Amide,Inhibitor, name is 2-Chloroacetamide, and the molecular formula is C2H4ClNO, Name: 2-Chloroacetamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Novotorzhina, Nelya N. published the artcileSynthesis of new derivatives of N,N-diethyldithiocarbamine acid and study of their anti-seize properties, Name: 2-Chloroacetamide, the publication is Neft Kimyasi va Neft E’mali Proseslari (2021), 22(1), 41-49, database is CAplus.

By the reaction of sodium N,N-diethyldithiocarbamate and chloroacetamide, S-carbamoylmethyldiethyldithiocarbamate was obtained. The conditions of two different methods for producing S(N-2,2-dimethyl-4-methyloxymethyl-1,3 dioxolane) carbamoylmethyldiethyldithiocarbamate were proposed. One of which was based on the homocondensation of hydroxylmethylcarbamoyldiethyldithiocarbamate and 2,2-dimethyl-4-hydroxymethyl-1,3-dioxolane, the other on the interaction of 2,2-dimethyl-4- chloromethylcarbamoylmethyloxymethyl-1,3-dioxolane and sodium N,N-diethyldithiocarbamate. At the first stage of the study, 4 starting reagents were synthesized, 2 of which were not previously described in the literature: 2,2-dimethyl-4-chloromethylcarbamoylmethoxymethyi-1,3-dioxolane and S-hydroxymethylcarbamoylethyldithiocarbamate. The structure of the synthesized compounds was proved by determining their elemental compositions, calculating mol. refractions based on refractive indexes and specific gravities, as well as recording IR absorption spectra on a spectrophotometer. The presence of comparatively high extreme pressure properties of the synthesized compounds in the mineral oil SN-1200 and synthetic oil consisting of penta erythritol of fatty acids was revealed and it was shown that they are superior to the known additives in the literature of tricresyl phosphate and N-allyl-5-hexyloxycarbocarbonylmethyl-1,3-thiazolidin-4-one-2-thione.

Neft Kimyasi va Neft E’mali Proseslari published new progress about 79-07-2. 79-07-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Aliphatic hydrocarbon chain,Amide,Inhibitor, name is 2-Chloroacetamide, and the molecular formula is C2H4ClNO, Name: 2-Chloroacetamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Klimochkin, Yu. N. published the artcileSynthesis and Chemical Transformations of N-Adamantylated Amides, Formula: C2H4ClNO, the publication is Russian Journal of Organic Chemistry (2022), 58(5), 669-678, database is CAplus.

N-Adamantylated amides, e.g., I were synthesized from 1-adamantyl nitrate. The reactions were carried out in the sulfuric acid media. The proposed method was usefulness for the preparation of antiviral drug tromantadine. A number of new cage aminoamides were synthesized by reactions of N-(1-adamantyl)-2-chloroacetamide with nitrogen-containing nucleophiles with potential biol. activity.

Russian Journal of Organic Chemistry published new progress about 79-07-2. 79-07-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Aliphatic hydrocarbon chain,Amide,Inhibitor, name is 2-Chloroacetamide, and the molecular formula is C2H4ClNO, Formula: C2H4ClNO.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Marae, Islam S. published the artcileSynthesis, characterization and crystal structure of some novel partially hydrogenated isoquinolines and their fused heterocyclic systems, Application of 2-Chloroacetamide, the publication is Journal of Heterocyclic Chemistry (2022), 59(7), 1230-1240, database is CAplus.

Ketonic hydrolysis of 7-acetyl-4-cyano-1,6-dimethyl-6-hydroxy-8-phenyl-5,6,7,8-tetrahydro-isoquinoline-3(2H)-thione via heating with aqueous solution of potassium hydroxide resulted in both deacetylation and dehydration affording new 7,8-dihydroisoquinoline scaffold (7,8-DHISQ) I. Two simple mechanistic approaches are postulated for this synthesis. One of them was supported by converting II into I via heating with aqueous solution of potassium hydroxide. I was used as a key intermediate for synthesizing other 7,8-DHISQ’s III and IV, as well as 7,8-dihydrothienoisoquinoline. Reaction of compound II with 2-chloroacetamide by refluxing in ethanol containing sodium acetate gave 7-acetyl-1-amino-5,8-dimethyl-6-phenyl-6,7-dihydrothieno[2,3-c] isoquinoline-2-carboxamide which was converted into full aromatized pyrimidothienoisoquinoline on treatment with tri-Et orthoformate. Reaction of II with both hydrazine hydrate and hydroxylamine hydrochloride afforded tetrahydropyrazolo-isoquinoline and tetrahydroisoxazoloisoquinoline, resp. Reaction of tetrahydroisoxazoloisoquinoline with N-(4-chlorophenyl)-2-chloroacetamide produced (N-phenylcarbamoylmethylthio)tetra-hydroisoxazoloisoquinoline which was converted into tetrahydroisoxazolothieno-isoquinoline upon heating with sodium ethoxide. Also, crystal structures of compounds III and another tetrahydropyrazoloisoquinoline were determined via X-rays diffraction anal.

Journal of Heterocyclic Chemistry published new progress about 79-07-2. 79-07-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Aliphatic hydrocarbon chain,Amide,Inhibitor, name is 2-Chloroacetamide, and the molecular formula is C2H4ClNO, Application of 2-Chloroacetamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Zhang, Nan published the artcileEffect of surface functionality of molecularly imprinted composite nanospheres on specific recognition of proteins, Related Products of amides-buliding-blocks, the publication is Materials Science & Engineering, C: Materials for Biological Applications (2020), 111076, database is CAplus and MEDLINE.

The surface functionality of biomaterial plays a primary role in determining its application in biorecognition and drug delivery. In our work, three types of synthetic tailoring polymer nanospheres with hierarchical architecture were constructed to obtain functional polymer layer with disparate chem. motifs for protein adsorption via surface imprinting and grafting copolymerization In this polymerization system, the structure stability of template protein bovine serum albumin (BSA) is well maintained within a certain range, which facilitated the accurate imprinting and precise identification. A comprehensive protocol for screening different functional layer is proposed through comparing the adsorption behavior, selectivity, identification and responsiveness to medium pH of three functional layers. Our study demonstrates that surface functionality greatly influences the adsorption capacity and selectivity of adsorption material. The functional layer with ionic liquid structure that could only provide multiple non-covalent binding sites is beneficial to the proteins aggregation and extraction, while the anti-nonspecific binding functional layer of biomaterial with zwitterionic structure for specific protein capture is promising to serve as a preferable antigen-antibody communication network, which shows great potential for protein recognition and separation In summary, our proposed strategy provides a systematic selection criterion of biomaterials for effective application in biosensors.

Materials Science & Engineering, C: Materials for Biological Applications published new progress about 79-07-2. 79-07-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Aliphatic hydrocarbon chain,Amide,Inhibitor, name is 2-Chloroacetamide, and the molecular formula is C11H12O4, Related Products of amides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Qian, Yunkun published the artcileHaloacetonitriles and haloacetamides precursors in filter backwash and sedimentation sludge water during drinking water treatment, Name: 2-Chloroacetamide, the publication is Water Research (2020), 116346, database is CAplus and MEDLINE.

Haloacetonitriles (HANs) and haloacetamides (HAMs) are nitrogenous disinfection byproducts that are present in filter backwash water (FBW) and sedimentation sludge water (SSW). In many cases FBW and SSW are recycled to the head of drinking water treatment plants. HAN and HAM concentrations in FBW and SSW, without addnl. oxidants, ranged from 6.8 to 11.6 nM and 2.9 to 3.6 nM of three HANs and four HAMs, resp. Upon oxidant addition to FBW and SSW under formation potential conditions, concentrations for six HANs and six HAMs ranged from 92.2 to 190.4 nM and 42.2 to 95.5 nM, resp. Therefore, at common FBW and SSW recycle rates (2 to 10% of treated water flows), the precursor levels in these recycle waters should not be ignored because they are comparable to levels present in finished water. Brominated HAN and chlorinated HAM were the dominant species in FBW and SSW, resp. The lowest mol. weight ultrafiltration fraction (< 3 kDa) contributed the most to HAN and HAM formations. The hydrophilic (HPI) organic fraction contributed the greatest to HAN precursors in sand-FBW and SSW and were the most reactive HAM precursors in both sand- or carbon-FBWs. Fluorescence revealed that aromatic protein-like compounds were dominant HAN and HAM precursors. Therefore, strategies that remove low mol. weight hydrophilic organic matter and aromatic protein-like compounds will minimize HAN and HAM formations in recycled FBW and SSW.

Water Research published new progress about 79-07-2. 79-07-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Aliphatic hydrocarbon chain,Amide,Inhibitor, name is 2-Chloroacetamide, and the molecular formula is C2H4ClNO, Name: 2-Chloroacetamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Sayed, Eman M. published the artcileNitrophenyl-Group-Containing Heterocycles. I. Synthesis, Characterization, Crystal Structure, Anticancer Activity, and Antioxidant Properties of Some New 5,6,7,8-Tetrahydroisoquinolines Bearing 3(4)-Nitrophenyl Group, Synthetic Route of 79-07-2, the publication is ACS Omega (2022), 7(10), 8767-8776, database is CAplus and MEDLINE.

Regioselective cyclocondensation of 2,4-diacetyl-5-hydroxy-5-methyl-3-(3-nitrophenyl/4-nitrophenyl)cyclohexanones with cyano-thioacetamide afforded the corresponding 7-acetyl-4-cyano-1,6-dimethyl-6-hydroxy-8-(3- and -4-nitrophenyl)-5,6,7,8-tetrahydrosoquinoline-3(2H)-thiones. Reaction of above compounds with Et iodide, 2-chloro-acetamide , or its N-aryl derivatives in the presence of sodium acetate trihydrate gave 3-ethylthio-5,6,7,8-tetrahydroisoquinoline and (5,6,7,8-tetrahydroisoquinolin-3-ylthio)acetamides, i.e., I. Cyclization of (5,6,7,8-tetrahydroisoquinolin-3-ylthio)acetamides into their isomeric 1-amino-6,7,8,9-tetrahydrothieno[2,3-c]isoquinoline-2-carboxamides was achieved by heating in ethanol containing a catalytic amount of sodium carbonate. Structures of all synthesized compounds were characterized on the basis of their elemental analyses and spectroscopic data. The crystal structure of 5,6,7,8-tetrahydroisoquinoline I was determined by X-ray diffraction anal. In addition, the biol. evaluation of some synthesized compounds as anticancer agents was performed, and only six compounds showed moderate to strong activity against PACA2 (pancreatic cancer cell line) and A549 (lung carcinoma cell line). Moreover, the antioxidant properties of most synthesized compounds were examined The results revealed high antioxidant activity for the most tested compounds

ACS Omega published new progress about 79-07-2. 79-07-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Aliphatic hydrocarbon chain,Amide,Inhibitor, name is 2-Chloroacetamide, and the molecular formula is C2H4ClNO, Synthetic Route of 79-07-2.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics