Category: 79-07-2

Liu, Xiao published the artcileExploring the genotoxicity triggers in the MP UV/H₂O₂-chloramination treatment of bisphenol A through bioassay coupled with non-targeted analysis, Computed Properties of 79-07-2, the publication is Science of the Total Environment (2021), 145218, database is CAplus and MEDLINE.

Bisphenol A (BPA) is a well-known xenoestrogen, and UV/H2O2 advanced oxidation process (AOP) is one of the most effective technologies to remove BPA from water. Using BPA spiked tap water, a batch-scale photochem. experiment was conducted to investigate whether BPA can pose a genotoxicity concern during the medium pressure (MP) UV/H2O2 treatment and the post-chloramination. Samples at different UV exposure and post-chloramination durations were collected and analyzed by CALUX gene reporter assays regarding estrogen receptor α (ERα) and p53 transcriptional activity. MP UV/H2O2 process did not cause extra estrogenic effects from the degradation of BPA, whereas genotoxicity occurred when the treated water was exposed with monochloramine. Seven frequently reported nitrogenous disinfection byproducts (N-DBPs) were detected, but none of them were responsible for the observed genotoxicity. Employed with gas chromatog.-quadrupole time-of-flight mass spectrometry (GC-QTOF-MS), four compounds possibly contributed to the genotoxicity were tentatively identified and two of them with aminooxy- or cyano- group were considered as “new” N-DBPs. This study demonstrated that byproducts differ from their parent compounds in toxicity can be formed in the UV oxidation with post-disinfection process, which should become a cause for concern.

Science of the Total Environment published new progress about 79-07-2. 79-07-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Aliphatic hydrocarbon chain,Amide,Inhibitor, name is 2-Chloroacetamide, and the molecular formula is C2H4ClNO, Computed Properties of 79-07-2.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Mustafayev, Nazim published the artcileSynthesis and Study of Novel Derivatives of 1,3-Dioxolane as Anti-Seizing Additives to Lubricating Oils, Recommanded Product: 2-Chloroacetamide, the publication is Chemistry Africa (2022), 5(4), 821-826, database is CAplus.

The paper is focused on synthesis and study of novel derivatives of 1,3-dioxolane as anti-seizing additives to lubricating oils. By reacting 23, 2-dimethyl-4-hydroxymethyl-1,3-dioxolane with -chlorohydroxymethylchloroacetamide, 2,2-dimethyl-4-chloromethylcarbamoylmethyl-1,3-dioxolane was synthesized by reacting it with potassium S-butylxanthate and N,N-sodium diethylcarbamate synthesized 2,2-dimethyl-4-xantogenatomethylcarbamoylmethyloxymethyl-1,3-dioxolane and 2,2-dimethyl-4-N,N-diethylcarbamatomethylcarbamoylmethyloxymethyl-1,3-dioxolane, resp. The structure of all synthesized compounds was proved by studying their physicochem. properties including the defermination of refractive indexes, sp. gr. and the calculation on their basis of mol. refraction (MRD calculate and MRD found.) with their subsequent comparison, elemental composition and IR spectroscopy. The anti-seize properties of the synthesized compounds were studied using a four-ball friction machine (FFM-1). It was found that the synthesized compounds have high extreme pressure properties in synthetic (penta erythritol ether – PEE) and compounded (SN-1200 gear oil and PEE synthetic oil taken 1:1) oils and can be used to make prototypes of synthetic gear oils used in various gears. Using 2,2-dimethyl-4-xantogenatomethylcarbamoylmethyloxymethyl-1,3-dioxolane as an example, the advantage of using a compounded oil to achieve higher extreme properties is shown. The dependence of the efficiency of the lubricating properties of the synthesized compounds on their structure was revealed.

Chemistry Africa published new progress about 79-07-2. 79-07-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Aliphatic hydrocarbon chain,Amide,Inhibitor, name is 2-Chloroacetamide, and the molecular formula is C2H4ClNO, Recommanded Product: 2-Chloroacetamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Bogdanovic, Aleksandra published the artcileCharacterisation of twelve newly synthesised N-(substituted phenyl)-2-chloroacetamides with QSAR analysis and antimicrobial activity tests, Safety of 2-Chloroacetamide, the publication is Arhiv za Higijenu Rada i Toksikologiju (2021), 72(1), 70-79, database is CAplus and MEDLINE.

In this study we screened twelve newly synthesized N-(substituted phenyl)-2-chloroacetamides for antimicrobial potential relying on quant. structure-activity relationship (QSAR) anal. based on the available cheminformatics prediction models (Molinspiration, SwissADME, PreADMET, and PkcSM) and verified it through standard antimicrobial testing against Escherichia coli, Staphylococcus aureus, methicillin-resistant S. aureus (MRSA), and Candida albicans. Our compounds met all the screening criteria of Lipinski’s rule of five (Ro5) as well as Veber’s and Egan’s methods for predicting biol. activity. In antimicrobial activity tests, all chloroacetamides were effective against Gram-pos. S. aureus and MRSA, less effective against the Gram-neg. E. coli, and moderately effective against the yeast C. albicans. Our study confirmed that the biol. activity of chloroacetamides varied with the position of substituents bound to the Ph ring, which explains why some mols. were more effective against Gram-neg. than Gram-pos. bacteria or C. albicans. Bearing the halogenated p-substituted Ph ring, N-(4-chlorophenyl), N-(4-fluorophenyl), and N-(3-bromophenyl) chloroacetamides were among the most active thanks to high lipophilicity, which allows them to pass rapidly through the phospholipid bilayer of the cell membrane. They are the most promising compounds for further investigation, particularly against Gram-pos. bacteria and pathogenic yeasts.

Arhiv za Higijenu Rada i Toksikologiju published new progress about 79-07-2. 79-07-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Aliphatic hydrocarbon chain,Amide,Inhibitor, name is 2-Chloroacetamide, and the molecular formula is C2H4ClNO, Safety of 2-Chloroacetamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Fernandez-Perez, Hector published the artcileAccess to α-Aminophosphonic Acid Derivatives and Phosphonopeptides by [Rh(P-OP)]-Catalyzed Stereoselective Hydrogenation, Formula: C2H4ClNO, the publication is Journal of Organic Chemistry (2020), 85(22), 14779-14784, database is CAplus and MEDLINE.

The hydrogenation of N-substituted vinylphosphonates using rhodium complexes derived from P-OP ligands L1, ent-L1 or (R,R)-Me-DuPHOS as catalysts has been successfully accomplished, achieving very high levels of stereoselectivity (up to 99% ee or de). The described synthetic strategy allowed for the efficient preparation of alpha-aminophosphonic acid derivatives, e.g. I, and phosphonopeptides, e.g. II, which are valuable building blocks for the preparation of biol. relevant mols.

Journal of Organic Chemistry published new progress about 79-07-2. 79-07-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Aliphatic hydrocarbon chain,Amide,Inhibitor, name is 2-Chloroacetamide, and the molecular formula is C2H4ClNO, Formula: C2H4ClNO.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Kuznetsova, Ksenia G. published the artcileCysteine alkylation methods in shotgun proteomics and their possible effects on methionine residues, Category: amides-buliding-blocks, the publication is Journal of Proteomics (2021), 104022, database is CAplus and MEDLINE.

In order to optimize sample preparation for shotgun proteomics, we compared four cysteine alkylating agents: iodoacetamide, chloroacetamide, 4-vinylpyridine and Me methanethiosulfonate, and estimated their effects on the results of proteome anal. Because alkylation may result in methionine modification in vitro, proteomics data were searched for methionine to isothreonine conversions, which may mimic genomic methionine to threonine substitutions found in proteogenomic analyses. We found that chloroacetamide was superior to the other reagents in terms of the number of identified peptides and undesirable off-site reactions. Among the reagents evaluated, iodoacetamide increased the rate of methionine-to-isothreonine conversion, especially if the sample was prepared in gel. The presence of proline following methionine in a protein sequence increased the modification rate as well. Generally, the methionine-to-isothreonine conversion events were relatively rare, but should be taken into account in proteogenomic studies when searching for single nucleotide polymorphism events at the protein level. Addnl., we have evaluated other methionine modifications, such as oxidation and carbamidomethylation. We found that carbamidomethylation may affect up to 80% of peptides containing methionine under the condition of iodoacetamide alkylation. In this case, carbamidomethylation of methionine is more common than oxidation and should be accounted for as a variable modification during proteomic search. One of the most trending questions in bottom-up proteomics is the depth of proteome profiling, in other words, the coverage of proteins by identified tryptic peptides. In proteogenomics, where the identification of a single peptide, e.g. bearing an amino acid substitution, may be of interest, high sequence coverage is especially important. Chem. modifications during sample preparation may mimic biol. significant coding mutations at the proteome level. A typical example of such modification is methionine to isothreonine conversion during alkylation, which mimics methionine to threonine substitution in protein sequences due to resp. genomic mutations. Therefore, the studies on the proper selection of alkylating reagents which balance the cysteine alkylation efficiency and the extent of methionine conversion upon conventional proteomic sample preparation workflow are crucial for the outcome of proteogenomic analyses and should present a general interest for the proteomic community.

Journal of Proteomics published new progress about 79-07-2. 79-07-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Aliphatic hydrocarbon chain,Amide,Inhibitor, name is 2-Chloroacetamide, and the molecular formula is C2H4ClNO, Category: amides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Baulina, T. V. published the artcileSynthesis, Molecular, and Crystal Structure of Tris(2-carbamoylmethoxyphenyl)phosphine Oxide, Synthetic Route of 79-07-2, the publication is Russian Journal of General Chemistry (2020), 90(10), 1840-1844, database is CAplus.

New tripodal ligand, tris(2-carbamoylmethoxyphenyl)phosphine oxide (I), has been synthesized via the alkylation of tris(2-hydroxyphenyl)phosphine oxide with chloroacetamide. The ligand structure has been studied by means of IR and NMR (¹H, ³¹P) spectroscopy as well as X-ray diffraction.

Russian Journal of General Chemistry published new progress about 79-07-2. 79-07-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Aliphatic hydrocarbon chain,Amide,Inhibitor, name is 2-Chloroacetamide, and the molecular formula is C2H4ClNO, Synthetic Route of 79-07-2.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Masulovic, Aleksandra D. published the artcileCharge assisted assembly of zwitterionic pyridone hydrates, Product Details of C2H4ClNO, the publication is Journal of Molecular Structure (2021), 130419, database is CAplus.

Two pyridone derivatives, bearing the pyridinium moiety (1), or dimethylpyridinium moiety (2) I and II, have been synthesized and their crystal structures have been determined The compounds crystalize in hydrated zwitterionic forms with either two (1·2H₂O) or four (2·4H₂O) water mols. The zwitterionic networks contain different types of water clusters, generated into channels, incorporating them into the network by sandwiching. The type of channel depends on the crystal lattice and the nature of non-covalent interactions established between zwitterions as well as the number of water mols. incorporated into the architecture. 1 affords tubes filled in with water channels formed by water tetramers, contrary to 2, which affords a layered network altering the zwitterionic layer and the layer formed by water tetramers and hexamers. A detailed study of intermol. interactions of both crystal structures and a quantification of interaction energies has been performed using PIXEL lattice energy calculations, giving an insight to a quant. evaluation of interactions through Coulombic, disperse, repulsion and polarization energies. The strongest pairwise, in both structures, is found to be a dipole-dipole interaction between oppositely charged heterocyclic rings. The differences in the crystal packings of these hydrates have been elucidated by the fingerplot anal. The comparative studies between exptl. and calculated (DFT) data of mols. 1·H₂O and 2·4H₂O for systems of different complexity are performed. Furthermore, correlations of exptl. and calculated bond lengths and the simulation of compound solvation with the CPCM model are done.

Journal of Molecular Structure published new progress about 79-07-2. 79-07-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Aliphatic hydrocarbon chain,Amide,Inhibitor, name is 2-Chloroacetamide, and the molecular formula is C2H4ClNO, Product Details of C2H4ClNO.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Chikineva, T. Yu. published the artcileYtterbium and Europium Complexes with Naphtho[1,2]thiazole-2-carboxylic and Naphtho[2,1]thiazole-2-carboxylic Acid Anions for Organic Light-Emitting Diodes (OLED), Recommanded Product: 2-Chloroacetamide, the publication is Russian Journal of Inorganic Chemistry (2021), 66(2), 170-178, database is CAplus.

An approach to the directed synthesis of aromatic lanthanide carboxylates as promising candidates for various luminescent applications, first of all, as emitting layers in light-emitting diodes, by varying the conjugation length with the introduction of a heteroatom and a neutral ligand was proposed. This approach enabled the synthesis of new europium and ytterbium complexes with naphtho[1,2]thiazole-2-carboxylic and naphtho[2,1]thiazole-2-carboxylic acid anions, which were successfully used in light-emitting diodes.

Russian Journal of Inorganic Chemistry published new progress about 79-07-2. 79-07-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Aliphatic hydrocarbon chain,Amide,Inhibitor, name is 2-Chloroacetamide, and the molecular formula is C2H4ClNO, Recommanded Product: 2-Chloroacetamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Sobh, Eman A. published the artcileNew benzothienopyrimidine derivatives as dual EGFR/ARO inhibitors: Design, synthesis, and their cytotoxic effect on MCF-7 breast cancer cell line, Application of 2-Chloroacetamide, the publication is Drug Development Research, database is CAplus and MEDLINE.

New cytotoxic agents based on benzothienopyrimidine scaffold were designed, synthesized, and evaluated against the MCF-7 breast cancer line in comparison to erlotinib and letrozole as reference drugs. Eight compounds demonstrated up to 20-fold higher anticancer activity than erlotinib, and five of these compounds were up to 11-fold more potent than letrozole in MTT assay. The most promising compounds were evaluated for their inhibitory activity against EGFR and ARO enzymes. Compound 12, which demonstrated potent dual EGFR and ARO inhibitory activity with IC₅₀ of 0.045 and 0.146 μM, resp., was further evaluated for caspase-9 activation, cell cycle anal., and apoptosis. The results revealed that the tested compound 12 remarkably induced caspase-9 activation (IC₅₀ = 16.29 ng/mL) caused cell cycle arrest at the pre-G₁/G₁ phase and significantly increased the concentration of cells at both early and late stage of apoptosis. In addition, it showed a higher safety profile on normal MCF-10A cells, and higher antiproliferative activity on cancer cells (IC₅₀ = 8.15 μM) in comparison to normal cells (IC₅₀ = 41.20 μM). It also revealed a fivefold higher selectivity index than erlotinib towards MCF-7 cancer cells. Docking studies were performed to rationalize the dual inhibitory activity of compound 12.

Drug Development Research published new progress about 79-07-2. 79-07-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Aliphatic hydrocarbon chain,Amide,Inhibitor, name is 2-Chloroacetamide, and the molecular formula is C5H10Cl3O3P, Application of 2-Chloroacetamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Fuhrimann, Samuel published the artcileQualitative assessment of 27 current-use pesticides in air at 20 sampling sites across Africa, Application In Synthesis of 79-07-2, the publication is Chemosphere (2020), 127333, database is CAplus and MEDLINE.

Increasing use of current-use pesticides (CUPs) in Africa raises environmental and public health concerns. But there is a large uncertainty about their occurrence and the composition of pesticide mixtures on this continent. This paper investigates the presence of 27 CUPs in air across 20 sampling sites in Africa. 166 passive air samples, consisting of polyurethane foam (PUF), were collected in 12 African countries between 2010 and 2018. Samples were extracted with methanol and analyzed via high-performance liquid chromatog. coupled with tandem mass spectrometry. The detection frequencies of CUPs per site were compared to land use patterns and sampling years, while their similarities were assessed using hierarchical cluster anal. Atrazine and chlorpyrifos were detected in 19 out of 20 sampling sites. Carbaryl, metazachlor, simazine, tebuconazole and terbuthylazine had the highest detection frequencies at sampling sites dominated by croplands. Across all the sampling years, 16 CUPs were present. Seven CUPs were newly detected from 2016 onwards (azinfos-Me, dimetachlor, chlorsulfuron, chlortoluron, isoproturon, prochloraz and pyrazon), while metamitron was only present before 2012. Sites within a radius of about 200 km showed similarities in detected CUP mixtures across all samples. Our results show the presence of CUP mixtures across multiple agricultural and urban locations in Africa which requires further investigation of related environmental and human health risks.

Chemosphere published new progress about 79-07-2. 79-07-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Aliphatic hydrocarbon chain,Amide,Inhibitor, name is 2-Chloroacetamide, and the molecular formula is C2H4ClNO, Application In Synthesis of 79-07-2.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics