Category: 79-07-2

On November 30, 2020, Zhang, Nan; Hu, Xiaoling; Guan, Ping; Xu, Yarong; Liu, Zhuangjian; Cheng, Yuan published an article.Application of 79-07-2 The title of the article was Effect of surface functionality of molecularly imprinted composite nanospheres on specific recognition of proteins. And the article contained the following:

The surface functionality of biomaterial plays a primary role in determining its application in biorecognition and drug delivery. In our work, three types of synthetic tailoring polymer nanospheres with hierarchical architecture were constructed to obtain functional polymer layer with disparate chem. motifs for protein adsorption via surface imprinting and grafting copolymerization In this polymerization system, the structure stability of template protein bovine serum albumin (BSA) is well maintained within a certain range, which facilitated the accurate imprinting and precise identification. A comprehensive protocol for screening different functional layer is proposed through comparing the adsorption behavior, selectivity, identification and responsiveness to medium pH of three functional layers. Our study demonstrates that surface functionality greatly influences the adsorption capacity and selectivity of adsorption material. The functional layer with ionic liquid structure that could only provide multiple non-covalent binding sites is beneficial to the proteins aggregation and extraction, while the anti-nonspecific binding functional layer of biomaterial with zwitterionic structure for specific protein capture is promising to serve as a preferable antigen-antibody communication network, which shows great potential for protein recognition and separation In summary, our proposed strategy provides a systematic selection criterion of biomaterials for effective application in biosensors. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Application of 79-07-2

The Article related to molecularly imprinted polymer nanocomposite nanosphere surface functionalization, composite nanospheres, molecularly imprinted nanospheres, specific recognition and separation, surface functionality and other aspects.Application of 79-07-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On February 5, 2022, Han, Lingxi; Liu, Tong; Fang, Kuan; Li, Xianxu; You, Xiangwei; Li, Yiqiang; Wang, Xiuguo; Wang, Jun published an article.Electric Literature of 79-07-2 The title of the article was Indigenous functional microbial communities for the preferential degradation of chloroacetamide herbicide S-enantiomers in soil. And the article contained the following:

This study investigated indigenous functional microbial communities associated with the degradation of chloroacetamide herbicides acetochlor (ACE), S-metolachlor (S-MET) and their enantiomers in repeatedly treated soils. The results showed that biodegradation was the main process for the degradation of ACE, S-MET and their enantiomers. Eight dominant bacterial genera associated with the degradation were found: Amycolatopsis, Saccharomonospora, Mycoplasma, Myroides, Mycobacterium, Burkholderia, Afipia, and Kribbella. The S-enantiomers of ACE and S-MET were preferentially degraded, which mainly relied on Amycolatopsis, Saccharomonospora and Kribbella for the ACE S-enantiomer and Amycolatopsis and Saccharomonospora for the S-MET S-enantiomer. Importantly, the relative abundances of Amycolatopsis and Saccharomonospora increased by 146.3%-4467.2% in the S-enantiomer treatments of ACE and S-MET compared with the control, which were significantly higher than that in the corresponding R-enantiomer treatments (25.3%-4168.2%). Both metagenomic and qPCR analyses demonstrated that four genes, ppah, alkb, benA, and P 450, were the dominant biodegradation genes (BDGs) potentially involved in the preferential degradation of the S-enantiomers of ACE and S-MET. Furthermore, network anal. suggested that Amycolatopsis, Saccharomonospora, Mycoplasma, Myroides, and Mycobacterium were the potential hosts of these four BDGs. Our findings indicated that Amycolatopsis and Saccharomonospora might play pivotal roles in the preferential degradation of the S-enantiomers of ACE and S-MET. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Electric Literature of 79-07-2

The Article related to chloroacetamide enantiomer microbial community biodegradation wastewater treatment china, chloroacetamide herbicides, degradation, enantiomers, functional microbial communities, network analysis and other aspects.Electric Literature of 79-07-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On January 10, 2022, Xu, Xiaolei; Gujarati, Priyansh D.; Okwor, Neechi; Sivey, John D.; Reber, Keith P.; Xu, Wenqing published an article.Reference of 2-Chloroacetamide The title of the article was Reactivity of chloroacetamides toward sulfide + black carbon: Insights from structural analogues and dynamic NMR spectroscopy. And the article contained the following:

Chloroacetamides are commonly used in herbicide formulations, and their occurrence has been reported in soils and groundwater. However, how their chem. structures affect transformation kinetics and pathways in the presence of environmental reagents such as hydrogen sulfide species and black carbon has not been investigated. In this work, we assessed the impact of increasing Cl substituents on reaction kinetics and pathways of six chloroacetamides. The contribution of individual pathways (reductive dechlorination vs. nucleophilic substitution) to the overall decay of selected chloroacetamides was differentiated using various exptl. setups; both the transformation rates and product distributions were characterized. Our results suggest that the number of Cl substituents affected reaction pathways and kinetics: trichloroacetamides predominantly underwent reductive dechlorination whereas mono- and dichloroacetamides transformed via nucleophilic substitution. Furthermore, we synthesized eight dichloroacetamide analogs (Cl2CHC(=O)NRR′) with differing R groups and characterized their transformation kinetics. Dynamic NMR spectroscopy was employed to quantify the rotational energy barriers of dichloroacetamides. Our results suggest that adsorption of dichloroacetamides on black carbon constrained R groups from approaching the dichloromethyl carbon and subsequently favored nucleophilic attack. This study provides new insights to better predict the fate of chloroacetamides in subsurface environments by linking their structural characteristics to transformation kinetics and pathways. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Reference of 2-Chloroacetamide

The Article related to black carbon chloroacetamide transformation kinetics structural analog dynamic nmr, dechlorination, dynamic nmr spectroscopy, halogenated agrochemical fate, polysulfides, subsurface environments and other aspects.Reference of 2-Chloroacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On June 30, 2022, Liu, Junwei; Bao, Yixuan; Zhang, Xuan; Zhao, Shiyu; Qiu, Jiguo; Li, Na; He, Jian published an article.Reference of 2-Chloroacetamide The title of the article was Anaerobic biodegradation and detoxification of chloroacetamide herbicides by a novel Proteiniclasticum sediminis BAD-10T. And the article contained the following:

Chloroacetamide herbicides (CAAHs) are important herbicides that were widely used to control agricultural weeds. However, their mass applications have seriously contaminated environment, and they are toxic to living beings. CAAHs are easy to enter anoxic environments such as subsoil, wetland sediment, and groundwater, where CAAHs are mainly degraded by anaerobic organisms. To date, there are no research on the anaerobic degradation of CAAHs by pure isolate and toxicity of anaerobic metabolites of CAAHs. In this study, the anaerobic degradation kinetics and metabolites of CAAHs by an anaerobic isolate BAD-10T and the toxicity of anaerobic metabolites were studied. Isolate BAD-10T could degrade alachlor, acetochlor, propisochlor, butachlor, pretilachlor and metolachlor with the degradation kinetics fitting the pseudo-first-order kinetics equation. The degradation rates of CAAHs were significantly affected by the length of N-alkoxyalkyl groups, the shorter the N-alkoxyalkyl groups, the higher the degradation rates. Four metabolites 2-ethyl-6-methyl-N-(ethoxymethyl)-acetanilide (EMEMA), N-(2-methyl-6-ethylphenyl)-acetamide (MEPA), N-2-ethylphenyl acetamide and 2-ethyl-N-carboxyl aniline were identified during acetochlor degradation, and an anaerobic catabolic pathway of acetochlor was proposed. The toxicity of EMEMA and EMPA for zebrafish, Arabidopsis and Chlorella ellipsoidea were obviously lower than that of acetochlor, indicating that the anaerobic degradation of acetochlor by isolate BAD-10T is a detoxification process. The work reveals the anaerobic degradation kinetics and catabolic pathway of CAAHs and highlights a potential application of Proteiniclasticum sediminis BAD-10T for bioremediation of CAAHs residue-contaminated environment. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Reference of 2-Chloroacetamide

The Article related to chloroacetamide herbicide anaerobic biodegradation detoxification, acetochlor, anaerobic biodegradation, catabolic pathway, chloroacetamide herbicides, detoxification, proteiniclasticum sediminis bad-10(t) and other aspects.Reference of 2-Chloroacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On December 1, 2020, Verdugo, Edgard M.; Gifford, Mac; Glover, Caitlin; Cuthbertson, Amy A.; Trenholm, Rebecca A.; Kimura, Susana Y.; Liberatore, Hannah K.; Richardson, Susan D.; Stanford, Benjamin D.; Summers, R. Scott; Dickenson, Eric R. V. published an article.Application of 79-07-2 The title of the article was Controlling disinfection byproducts from treated wastewater using adsorption with granular activated carbon: Impact of pre-ozonation and pre-chlorination. And the article contained the following:

This study measured chlorine- and chloramine-reactive precursors using formation potential (FP) tests of nine U. S. Environmental Protection Agency (EPA) regulated and 57 unregulated disinfection byproducts (DBPs) in tertiary-filtered wastewater before and after pilot-scale granular activated carbon (GAC) adsorption. Using breakthrough of precursor concentration and of concentration associated calculated cytotoxicity and genotoxicity (by correlating known lethal concentrations reported elsewhere), the performance of three parallel GAC treatment trains were compared against tertiary-filtered wastewater: ozone/GAC, chlorine/GAC, and GAC alone. Results show GAC alone was the primary process, vs. ozone or chlorine alone, to remove the largest fraction of total chlorine- and chloramine-reactive DBP precursors and calculated cytotoxicity and genotoxicity potencies. GAC with pre-ozonation removed the most chlorine- and chloramine-reactive DBP precursors followed by GAC with pre-chlorination and lastly GAC without pre-treatment. GAC with pre-ozonation produced an effluent with cytotoxicity and genotoxicity of DBPs from FP that generally matched that of GAC without pre-oxidation; meanwhile removal of toxicity was greater by GAC with pre-chlorination. The cytotoxicity and genotoxicity of DBPs from FP tests did not scale with DBP concentration; for example, more than 90% of the calculated cytotoxicity resulted from 20% of the DBPs, principally from haloacetaldehydes, haloacetamides, and haloacetonitriles. The calculated cytotoxicity and genotoxicity from DBPs associated with FP-chloramination were at times higher than with FP-chlorination though the concentration of DBPs was five times higher with FP-chlorination. The removal of DBP precursors using GAC based treatment was at least as effective as removal of DOC (except for halonitromethanes for GAC without pre-oxidation and with pre-chlorination), indicating DOC can be used as an indicator for DBP precursor adsorption efficacy. However, the DOC was not a good surrogate for total cytotoxicity and genotoxicity breakthrough behavior, therefore, unregulated DBPs could have neg. health implications that are disconnected from general water quality parameters, such as DOC, and regulated classes of DBPs. Instead, cytotoxicity and genotoxicity correlate with the concentration of specific classes of unregulated DBPs. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Application of 79-07-2

The Article related to carbon pre ozonation chlorination cytotoxicity adsorption, chlorine and chloramine disinfection byproducts, cytotoxicity, genotoxicity, granular activated carbon adsorption, potable reuse, preoxidation and other aspects.Application of 79-07-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On August 20, 2020, Vinogradova, Ekaterina V.; Zhang, Xiaoyu; Remillard, David; Lazar, Daniel C.; Suciu, Radu M.; Wang, Yujia; Bianco, Giulia; Yamashita, Yu; Crowley, Vincent M.; Schafroth, Michael A.; Yokoyama, Minoru; Konrad, David B.; Lum, Kenneth M.; Simon, Gabriel M.; Kemper, Esther K.; Lazear, Michael R.; Yin, Sifei; Blewett, Megan M.; Dix, Melissa M.; Nguyen, Nhan; Shokhirev, Maxim N.; Chin, Emily N.; Lairson, Luke L.; Melillo, Bruno; Schreiber, Stuart L.; Forli, Stefano; Teijaro, John R.; Cravatt, Benjamin F. published an article.Application of 79-07-2 The title of the article was An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. And the article contained the following:

Electrophilic compounds originating from nature or chem. synthesis have profound effects on immune cells. These compounds are thought to act by cysteine modification to alter the functions of immune-relevant proteins; however, our understanding of electrophile-sensitive cysteines in the human immune proteome remains limited. Here, we present a global map of cysteines in primary human T cells that are susceptible to covalent modification by electrophilic small mols. More than 3,000 covalently liganded cysteines were found on functionally and structurally diverse proteins, including many that play fundamental roles in immunol. We further show that electrophilic compounds can impair T cell activation by distinct mechanisms involving the direct functional perturbation and/or degradation of proteins. Our findings reveal a rich content of ligandable cysteines in human T cells and point to electrophilic small mols. as a fertile source for chem. probes and ultimately therapeutics that modulate immunol. processes and their associated disorders. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Application of 79-07-2

The Article related to electrophile cysteine interaction primary human t cell immunol, birc3, itk, t cells, activity-based protein profiling, chemical proteomics, covalent, cysteine, electrophiles, human, protein degradation and other aspects.Application of 79-07-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On August 31, 2020, Sanad, Sherif M. H.; Mekky, Ahmed E. M. published an article.Recommanded Product: 2-Chloroacetamide The title of the article was Piperazine-mediated tandem synthesis of bis(thieno[2,3-b]pyridines): Versatile precursors for related fused [1,2,4]triazolo[4,3-a]pyrimidines. And the article contained the following:

In this study, the utility of bis(cyanoacetamides) as versatile precursors to the piperazine-mediated synthesis of a wide spectrum of bis(thieno[2,3-b]pyridine) derivatives, linked to aliphatic spacers via thioethers was reported. The proposed tandem protocol involved the reaction of bis(cyanoacetamides) with two equivalent of the appropriate cinnamonitriles in dioxane in the presence of six equivalent of piperazine was refluxed for 4 h which on further addition of halogen-containing reagents afforded bis(thieno[2,3-b]pyridine) derivatives I [Ar = 4-MeOC6H4, 4-ClC6H4; Y = CN, C(O)Me, C(O)NH2, etc.; Z = CH2, (CH2)3]. Compounds I were taken as a key intermediates and reacted with formic acid/acetic anhydride/carbon disulfide afforded bis(oxopyrido[3′,2′:4,5]thieno[3,2-d]pyrimidine) derivatives II [R = H, Me; R1 = CH2, (CH2)3; Ar1 = 4-MeOC6H4, 4-ClC6H4] and III [R2 = CH2, (CH2)3]. Compounds III were reacted with the appropriate hydrazonyl chloride derivatives in dioxane in the presence of triethylamine afforded the corresponding bis([1,2,4]triazoles) with related fused pyridothienopyrimidine moiety IV [R3 = CH2, (CH2)3; Ar2 = Ph, 4-MeC6H4, 4-ClC6H4]. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Recommanded Product: 2-Chloroacetamide

The Article related to bis thienopyridine preparation, cyanoacetamide cinnamonitrile halogen reagent tandem four component piperazine mediated, oxopyridothienopyrimidine bis preparation, acetyl pyridothienotriazolopyrimidine bis preparation and other aspects.Recommanded Product: 2-Chloroacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On August 16, 2022, Liang, Chao; Zhang, Shan; Robinson, David; Ploeg, Matthew Vander; Wilson, Rebecca; Nah, Jiemin; Taylor, Dale; Beh, Sheryl; Lim, Radiance; Sun, Lei; Muoio, Deborah M.; Stroud, David A.; Ho, Lena published an article.Product Details of 79-07-2 The title of the article was Mitochondrial microproteins link metabolic cues to respiratory chain biogenesis. And the article contained the following:

Electron transport chain (ETC) biogenesis is tightly coupled to energy levels and availability of ETC subunits. Complex III (CIII), controlling ubiquinol:ubiquinone ratio in ETC, is an attractive node for modulating ETC levels during metabolic stress. Here, we report the discovery of mammalian Co-ordinator of mitochondrial CYTB (COM) complexes that regulate the stepwise CIII biogenesis in response to nutrient and nuclear-encoded ETC subunit availability. The COMA complex, consisting of UQCC1/2 and membrane anchor C16ORF91, facilitates translation of CIII enzymic core subunit CYTB. Subsequently, microproteins SMIM4 and BRAWNIN together with COMA subunits form the COMB complex to stabilize nascent CYTB. Finally, UQCC3-containing COMC facilitates CYTB hemylation and association with downstream CIII subunits. Furthermore, when nuclear CIII subunits are limiting, COMB is required to chaperone nascent CYTB to prevent OXPHOS collapse. Our studies highlight CYTB synthesis as a key regulatory node of ETC biogenesis and uncover the roles of microproteins in maintaining mitochondrial homeostasis. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Product Details of 79-07-2

The Article related to respiratory chain biogenesis mitochondrial microprotein homeostasis, cp: metabolism, cytb, seps, smim4, uqcc1, uqcc2, complex iii, electron transport chain, microproteins, nuclear-mitochondrial coordination, smorfs and other aspects.Product Details of 79-07-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On June 20, 2022, Wang, Zheng; Liao, Yufeng; Li, Xiuwen; Shuang, Chendong; Pan, Yang; Li, Yan; Li, Aimin published an article.Recommanded Product: 2-Chloroacetamide The title of the article was Effect of ammonia on acute toxicity and disinfection byproducts formation during chlorination of secondary wastewater effluents. And the article contained the following:

Ammonia nitrogen (NH3-N) significantly affects the occurrence of disinfection byproducts (DBPs) and residual chlorine in chlorinated wastewater, thereby affecting the acute toxicity to aquatic organisms. In this paper, the formation of thirty-five halogenated DBPs and the changes in acute toxicity of luminescent bacteria and zebrafish embryos were evaluated after chlorination of seven secondary wastewater effluents with different NH3-N concentrations Results showed that NH3-N significantly reduced the formation of most DBPs by 82-100%. The acute toxicity was enhanced after chlorination and increased linearly with increasing NH3-N concentration for luminescent bacteria (r = 0.986, p < 0.05) and zebrafish embryos (r = 0.972, p < 0.05) due to the coexistence of DBPs and monochloramine. According to the toxicity classification system of wastewater, the fitting results indicated that the toxicity level was acceptable for chlorinated wastewater with NH3-N concentration below 1.00 mg-N/L. DBPs might be the main toxicant to luminescent bacteria in the wastewater with low NH3-N concentrations (0.06-0.31 mg-N/L), which accounted for 68-97% of the toxicity contribution. By contrast, monochloramine contributed over 80% to the toxicity of luminescent bacteria and zebrafish embryos in the wastewater with high NH3-N concentrations (2.66-7.17 mg-N/L). Compared to chlorination, chlorine dioxide and UV disinfection unaffected by NH3-N could reduce acute toxicity by nearly 100%, primarily due to the lack of residual disinfectant. In view of the high toxicity caused by chlorination, chlorination-dechlorination or chlorine dioxide and UV disinfection are highly recommended for the treatment of wastewater with high NH3-N concentration The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Recommanded Product: 2-Chloroacetamide

The Article related to ammonia acute toxicity disinfection byproduct secondary wastewater effluent chlorination, alternative disinfection process, ammonia-containing wastewater, dechlorination, residual chlorine, toxicity contribution and other aspects.Recommanded Product: 2-Chloroacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On November 1, 2020, Qian, Yunkun; Hu, Yue; Chen, Yanan; An, Dong; Westerhoff, Paul; Hanigan, David; Chu, Wenhai published an article.SDS of cas: 79-07-2 The title of the article was Haloacetonitriles and haloacetamides precursors in filter backwash and sedimentation sludge water during drinking water treatment. And the article contained the following:

Haloacetonitriles (HANs) and haloacetamides (HAMs) are nitrogenous disinfection byproducts that are present in filter backwash water (FBW) and sedimentation sludge water (SSW). In many cases FBW and SSW are recycled to the head of drinking water treatment plants. HAN and HAM concentrations in FBW and SSW, without addnl. oxidants, ranged from 6.8 to 11.6 nM and 2.9 to 3.6 nM of three HANs and four HAMs, resp. Upon oxidant addition to FBW and SSW under formation potential conditions, concentrations for six HANs and six HAMs ranged from 92.2 to 190.4 nM and 42.2 to 95.5 nM, resp. Therefore, at common FBW and SSW recycle rates (2 to 10% of treated water flows), the precursor levels in these recycle waters should not be ignored because they are comparable to levels present in finished water. Brominated HAN and chlorinated HAM were the dominant species in FBW and SSW, resp. The lowest mol. weight ultrafiltration fraction (< 3 kDa) contributed the most to HAN and HAM formations. The hydrophilic (HPI) organic fraction contributed the greatest to HAN precursors in sand-FBW and SSW and were the most reactive HAM precursors in both sand- or carbon-FBWs. Fluorescence revealed that aromatic protein-like compounds were dominant HAN and HAM precursors. Therefore, strategies that remove low mol. weight hydrophilic organic matter and aromatic protein-like compounds will minimize HAN and HAM formations in recycled FBW and SSW. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).SDS of cas: 79-07-2

The Article related to haloacetonitrile haloacetamide filter backwash sedimentation sludge water, drinking water treatment, filter backwash water, haloacetamides, disinfection byproducts, haloacetonitriles, sedimentation sludge water and other aspects.SDS of cas: 79-07-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics