Category: 79-07-2

On August 31, 2020, Pokhodylo, N. T.; Savka, R. D.; Obushak, M. D. published an article.Product Details of 79-07-2 The title of the article was Synthesis of (1H-1,2,3-Triazol-1-yl)acetic Acid Derivatives. And the article contained the following:

A convenient synthetic approach to (1H-1,2,3-triazol-1-yl)acetic acid derivatives via the reaction of azidoacetamides with β-ketoesters and acetylacetone is proposed. Based on this strategy, 1,5-disubstituted 1,2,3-triazoles were prepared from available reagents under metal-free conditions. A one-pot protocol for the synthesis of (5-methyl-1H-1,2,3-triazol-1-yl)acetamides derived from N-substituted chloroacetamides is developed. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Product Details of 79-07-2

The Article related to triazolyl acetic acid preparation acetamide, azidoacetamide ketoester acetylacetone alk hydrolysis cyclocondensation, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Product Details of 79-07-2

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Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Ahmed, Ahmed A. M.; Mekky, Ahmed E. M.; Sanad, Sherif M. H. published an article in 2022, the title of the article was New piperazine-based bis(thieno[2,3-b]pyridine) and bis(pyrazolo[3,4-b]pyridine) hybrids linked to benzofuran units: Synthesis and in vitro screening of potential acetylcholinesterase inhibitors.Category: amides-buliding-blocks And the article contains the following content:

Two series of piperazine-based bis(thieno[2,3-b]pyridines) I (Y = CN, COMe, CONH2, COOEt, COPh) and bis(pyrazolo[3,4-b]pyridines) II (Z = H, Me, OMe, Cl, COOEt) were prepared in good yields, utilizing the appropriate bis(pyridinethione). The first series was obtained by reacting the previous synthon with different α-halogenated reagents, whereas the second series was produced by reacting the synthon with various hydrazonyl chlorides, and then cyclizing the resulting bis(hydrazonothioates). At 50 and 100μM concentrations, the two series were screened as potential acetylcholinesterase inhibitors. The reference donepezil had inhibition percentages of 90.7 and 93.5 at the tested concentrations Generally, bis(thieno[2,3-b]pyridine) series was found to be more effective than the other series of bis(pyrazolo[3,4-b]pyridine). Bis(thieno[2,3-b]pyridine-2-carbonitrile) inhibited acetylcholinesterase the best, with inhibition percentages of 55.2 and 88.4 at 50 and 100μM concentrations, resp. Furthermore, when tested at a concentration of 25μg/mL, the prior hybrid demonstrated the best DPPH antioxidant activity, with an inhibition percentage of 81.5 when compared to the reference ascorbic acid (inhibition percentage of 88.7). The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Category: amides-buliding-blocks

The Article related to piperazine thienopyridine pyrazolopyridine benzofuran preparation acetylcholinesterase inhibitor antioxidant, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Category: amides-buliding-blocks

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On July 13, 2020, Sanad, Sherif M. H.; Mekky, Ahmed E. M. published an article.Synthetic Route of 79-07-2 The title of the article was Novel Nicotinonitriles and Thieno[2,3-b]pyridines as Potent Biofilm and COX-2 Inhibitors: Synthesis, In Vitro and In Silico Studies. And the article contained the following:

(Cyano)diaryl-substituted pyridine-2(1H)-thiones were used to prepare two novel series of nicotinonitriles I (R1 = 2-thienyl, R2 = 4-ClC6H4; R1 = 1,3-benzodioxol-5-yl, R2 = 2-thienyl; R1 = 3,5-dibromo-4-ethoxyphenyl, R2 = 4-MeC6H4; R3 = MeCO, CN, H2NCO, 4-ClC6H4CO) and thieno[2,3-b]pyridines II (R1-R3 as above) using piperazine as an eco-friendly catalyst under ultrasonic irradiation The in vitro antibacterial activities of both series were estimated against different Gram-pos. and neg. bacterial strains. Moreover, the most potent antibacterial derivatives were subjected to further evaluation of their cytotoxic activity against HEPG2 and MCF-7 cell lines as well as their capability to inhibit COX-2 enzyme. The compound I (R1 = 1,3-benzodioxol-5-yl; R2 = 2-thienyl; R3 = H2NCO) gave the least MIC/MBC values of 4.8/9.6, 4.8/9.6 and 9.6/19.7μM against each of Staphylococcus aureus, Escherichia coli and Streptococcus mutans, resp., when compared with Ciprofloxacin. This compound I also showed the best biofilm inhibition activities with IC50 values in the range of 5.2-7.3μM against S. aureus, S. mutans and E. coli bacterial strains when compared with Ciprofloxacin, the best cytotoxic activity against HEPG2 and MCF-7 cell lines with IC50 of 23.9 and 29.8μM, resp., when compared with Doxorubicin and revealed nearly inhibition activity equipotent to Celecoxib with IC50 of 0.12μM. The in silico study was performed to predict the capability of the novel nicotinonitriles and thienopyridines as potent inhibitors of COX-2 enzyme. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Synthetic Route of 79-07-2

The Article related to nicotinonitrile thienopyridine preparation antibacterial antitumor antibiofilm cox2 inhibitor human, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.Synthetic Route of 79-07-2

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Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Mekky, Ahmed E. M.; Sanad, Sherif M. H.; Said, Ahmed Y.; Elneairy, Mohamed A. A. published an article in 2020, the title of the article was Synthesis, cytotoxicity, in-vitro antibacterial screening and in-silico study of novel thieno[2,3-b]pyridines as potential pim-1 inhibitors.Quality Control of 2-Chloroacetamide And the article contains the following content:

A novel series of thieno[2,3-b]pyridines I [R = Me, MeO; R1 = acetyl, ethoxycarbonyl, aminocarbonyl, etc.] was prepared via an one-step protocol in excellent yields. The protocol involved the reaction of pyridine-2(1H)-thiones I with the appropriate halogen containing reagents in ethanolic sodium ethoxide solution under stirring at 80°C for 2 h. The new thienopyridines were screened against different bacterial and fungal strains. Thieno[2,3-b]pyridine-2-carboxylate I [R = Me; R1 = ethoxycarbonyl] showed the most effective antibacterial activities against each of Staphylococcus aureus and Escherichia coli with MIC/MBC values of 9.9/19.8 and 19.8/39.5μM, resp., when compared with Ciprofloxacin. I [R = Me; R1 = ethoxycarbonyl] was the most effective compound against MRSA with inhibition zone of 16.2 ± 0.6 mm, when compared with Gentamicin. Moreover, I [R = Me; R1 = ethoxycarbonyl] exhibited the best cytotoxic activity against each of HEPG2 and MCF-7 cell lines with IC50 values of 25.7 and 30.53μM, resp., when compared with Doxorubicin. The in-silico study was performed to predict the capability of new thienopyridines as potential inhibitors of pim-1 kinase. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Quality Control of 2-Chloroacetamide

The Article related to thienopyridine preparation antibacterial activity antitumor pim kinase inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.Quality Control of 2-Chloroacetamide

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Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On January 31, 2022, Ratanaphain, Chatkrita; Viboonratanasri, Duangkamon; Prompinit, Panida; Krajangpan, Sita; Khan, Eakalak; Punyapalakul, Patiparn published an article.Product Details of 79-07-2 The title of the article was Reactivity characterization of SiO2-coated nano zero-valent iron for iodoacetamide degradation: The effects of SiO2 thickness, and the roles of dehalogenation, hydrolysis and adsorption. And the article contained the following:

The effect of SiO2-layer thickness in SiO2-coated nano zero-valent iron (nZVI) particles on the reactivity characteristics of iodoacetamide (IAcAm) degradation was evaluated. SiO2-layer thicknesses ranging from 3.6 to 27.3 nm were obtained through varying tetra-Et orthosilicate dosages of 0.001-1 M. The crystallinity, surface chem. composition, and physicochem. properties were evaluated for their effects on synergetic degradation mechanisms, dehalogenation, hydrolysis, and adsorption. At a thickness of 3.6 nm, the SiO2 layer offered the highest observed pseudo-first-order rate (kobs) and higher rates of IAcAm degradation were maintained under pH fluctuations (pH 5-7) and aerobic conditions compared to pristine nZVI. At this SiO2-layer thickness (3.6 nm), the rate of iron oxide-layer formation was reduced and the migration of reactive iron species (Fe0 and Fe2+) for the dehalogenation and hydrolysis reactions was enabled. In a single-solute solution, IAcAm elimination was greater than bromoacetamide and chloroacetamide elimination due to the weak ionic I-C bond. In mixed solute conditions, the hydrophobicity of chloroacetamide played a more significant role in competitive degradation through greater adsorption. The proportion of dehalogenation relative to hydrolysis during IAcAm degradation by pristine nZVI and SiO2-coated nZVI was approx. 0.6:0.4. Iodoacetic acid and acetic acid were detected as intermediates in the degradation pathway of IAcAm by pristine nZVI. In contrast, the SiO2 layer on nZVI can accelerate the transformation of IAcAm to acetamide and iodoacetic acid. The electrolyte background of tap water exhibited a slight inhibitory effect on the degradation of IAcAm for both nZVI and SiO2-coated nZVI. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Product Details of 79-07-2

The Article related to silica iron iodoacetamide dehalogenation hydrolysis adsorptive wastewater treatment, adsorption, dehalogenation, haloacetamide, hydrolysis, sio(2)-coated nano zero-valent iron and other aspects.Product Details of 79-07-2

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Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On March 9, 2020, Yamashita, Yu; Vinogradova, Ekaterina V.; Zhang, Xiaoyu; Suciu, Radu M.; Cravatt, Benjamin F. published an article.Formula: C2H4ClNO The title of the article was A Chemical Proteomic Probe for the Mitochondrial Pyruvate Carrier Complex. And the article contained the following:

Target engagement assays are crucial for establishing the mechanism-of-action of small mols. in living systems. Integral membrane transporters can present a challenging protein class for assessing cellular engagement by small mols. The chem. proteomic discovery of alpha-chloroacetamide (αCA) compounds that covalently modify cysteine-54 (C54) of the MPC2 subunit of the mitochondrial pyruvate carrier (MPC) is presented. This finding is used to create an alkyne-modified αCA, YY4-yne, that serves as a cellular engagement probe for MPC2 in click chem.-enabled western blotting or global mass spectrometry-based proteomic experiments Studies with YY4-yne revealed that UK-5099, an alpha-cyanocinnamate inhibitor of the MPC complex, engages MPC2 with remarkable selectivity in human cells. These findings support a model where UK-5099 inhibits the MPC complex by binding to C54 of MPC2 in a covalent reversible manner that can be quantified in cells using the YY4-yne probe. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Formula: C2H4ClNO

The Article related to chem proteomic probe mitochondrial pyruvate carrier complex mcp2 uk5099, chemical proteomics, cysteine, mitochondrial pyruvate complex, target engagement, α-chloroacetamide and other aspects.Formula: C2H4ClNO

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Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On November 8, 2020, Lajin, Bassam; Goessler, Walter published an article.Recommanded Product: 79-07-2 The title of the article was Fluorinated carboxylic acids as “ion repelling agents” in reversed-phase chromatography. And the article contained the following:

Fluorinated carboxylic acids have been in use as ion-pairing reagents for over three decades. It has been observed that ion-pairing reagents not only increase the retention of oppositely charged analytes on reversed-phase HPLC columns but also decrease the retention of similarly charged analytes; these latter effects, however, have not been thoroughly investigated for the fluorinated carboxylic acids, and the application of these reagents has been rather restricted to their ion-pairing capacity to sep. basic analytes. In the present study, we report a systematic investigation about the effects of three fluorinated carboxylic acids (trifluoroacetic acid (TFA), pentafluoropropionic acid (PFPA), and heptafluorobutyric acid (HFBA)) on the retention and selectivity of the separation of halogenated carboxylic acids and sulfonic acids by reversed-phase chromatog. with an inductively coupled plasma mass spectrometry detector (ICPMS). Several eluents were tested and compared at different concentrations (0-100 mM) and pH values, including sulfate, nitrate, phosphate, oxalate, TFA, PFPA, and HFBA. The fluorinated carboxylic acids resulted in a consistent decrease in the retention factors (up to ca. 9-fold with HFBA) in a concentration dependent manner, which plateaued at around 50 mM. Significant improvement of the peak symmetry of the chromatographed acids was also observed We highlight the advantages of incorporating the fluorinated carboxylic acids in modifying the selectivity and retention of organic acids in reversed phase chromatog. in general, and particularly when employing chromatog. detectors with limited compatibility with organic mobile phases such as the ICPMS. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Recommanded Product: 79-07-2

The Article related to fluorinated carboxylic acid ion repelling agent reversed phase chromatog, alkyl sulfonate, fluorinated acetic acids, heptafluorobutyric acid, icpms, ion-pair chromatography and other aspects.Recommanded Product: 79-07-2

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Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On September 30, 2022, Liman, Recep; Ali, Muhammad Muddassir; Istifli, Erman Salih; Cigerci, Ibrahim Hakki; Bonciu, Elena published an article.Formula: C2H4ClNO The title of the article was Genotoxic and cytotoxic effects of pethoxamid herbicide on Allium cepa cells and its molecular docking studies to unravel genotoxicity mechanism. And the article contained the following:

Pethoxamid is chloroacetamide herbicide. Pethoxamid is commonly used to kill different weeds in various crops. Pethoxamid can leach in the water and soil and can cause toxic effects to other non-target species. Current study is therefore aimed to perform the investigation of the cytotoxic and genotoxic effects of pethoxamid on Allium cepa cells. The root growth, mitotic index (MI), chromosomal aberrations (CAs), and DNA damage were assessed through root growth inhibition, A. cepa ana-telophase, and alk. comet assays, resp. Furthermore, mol. docking was performed to evaluate binding affinity of pethoxamid on DNA and very-long-chain fatty acid (VLCFA) synthases. In root growth inhibition test, onion root length was statistically significantly decreased in a concentration dependent manner. Concentration- and time-dependent decreases in MI were observed, whereas increase in CAs such as disturbed ana-telophase, chromosome laggards, stickiness, anaphase bridges, and DNA damage was caused by the pethoxamid on A. cepa root cells. Mol. docking revealed that pethoxamid binds selectively to GC-rich regions in the minor groove of the DNA structure and showed remarkable binding affinity against all synthases taking part in the sequential biosynthesis of VLCFAs. It was concluded that the pethoxamid-induced genotoxicity and cytotoxicity may be through multiple binding ability of this herbicide with DNA and VLCFA synthases. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Formula: C2H4ClNO

The Article related to pethoxamid herbicide allium cepa cell mol docking genotoxicity, binding affinity, chromosomal aberrations, dna damage, long-chain fatty acids, mitotic index, molecular docking, pethoxamid and other aspects.Formula: C2H4ClNO

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Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On November 30, 2021, Yang, Jing; Chen, Xiaoqian; Yin, Daqiang; Yin, Haowen; Zhang, Ying; Liu, Min; Zhao, Weigang; Zhang, Lu; Liu, Yanan; Yang, Xichen; Zhong, Zhijie published an article.Quality Control of 2-Chloroacetamide The title of the article was Applicability of Enchytraeus bulbosus as a model species in ecotoxicology and risk assessment. And the article contained the following:

Enchytraeus bulbosus is listed in the ISO and OECD standard guidelines as a possible test species of enchytraeid. However, in contrast to other listed species, its applicability in ecotoxicol. studies as well as its sensitivity is widely unknown. Therefore, copper, pentachlorophenol(PCP), carbendazim, and chloroacetamide have been investigated by performing two-generation studies with multiple endpoints. Comparable toxicity trends to the existing studies were shown for copper and PCP in the two-generation studies of E. bulbosus. Dose-related abnormal swelling of clitella were found for the first time with PCP and chloroacetamide treatments. Sensitivity comparisons of E. bulbosus to other terrestrial test species were also conducted. E. bulbosus showed high sensitivity, it has comparable sensitivity as other sensitive species of genus Enchytraeus ( E. albidus or E. luxuriosus)to different chems., and was more sensitive than E. crypticus and earthworm species ( Eisenia fetida or Eisenia andrei). Combined with the phylogenetic and biol. characterization, the results lead to the conclusion that E.bulbosus is a suitable model species in ecotoxicol. and the chem. risk assessment (especially in multi-generation) because it has a short generation time, comparatively moderate fecundity, ideal and reasonable sensitivity. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Quality Control of 2-Chloroacetamide

The Article related to copper pentachlorophenol carbendazim chloroacetamide enchytraeus ecotoxicol risk assessment, carbendazim, chloroacetamide, copper, enchytraeus bulbosus, pentachlorophenol, two generations and other aspects.Quality Control of 2-Chloroacetamide

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Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On March 31, 2020, Paronikyan, Ervand G.; Dashyan, Shushanik Sh.; Mamyan, Suren S. published an article.HPLC of Formula: 79-07-2 The title of the article was Synthesis of pyrano[3,4-c]thieno[3,2-e][1,2,4]triazolo[4,3-a]pyridines, representatives of a new fused heterocyclic system. And the article contained the following:

New effective synthesis of functionalized pyrano[3,4-c]thieno-[3,2-e][1,2,4]triazolo[4,3-a]pyridines I (Y = COOEt, C(O)NH2, CN) is described. The synthesis comprises nucleophilic substitution of 8-morpholino-6-thioxopyrano[3,4-c]pyridine-5-carbonitrile with hydrazine hydrate followed by sequential heterocyclization with formic acid and chloroacetic acid derivatives The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).HPLC of Formula: 79-07-2

The Article related to pyranothienotriazolopyridine preparation, morpholino thioxopyranopyridine carbonitrile hydrazine hydrate nucleophilic substitution, formic chloroacetic acid derivative heterocyclization and other aspects.HPLC of Formula: 79-07-2

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Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics