Category: 79-07-2

Sanad, Sherif M. H.; Ahmed, Ahmed A. M.; Mekky, Ahmed E. M. published an article in 2020, the title of the article was Efficient synthesis and molecular docking of novel antibacterial pyrimidines and their related fused heterocyclic derivatives.Product Details of 79-07-2 And the article contains the following content:

3-(Benzo[d][1,3]dioxol-5-yl)-1-(thiophen-2-yl)prop-2-en-1-one (chalcone) reacted with thiourea and 6-amino-2-thioxo-2,3-dihydropyrimidin-4(1H)-one to give the corresponding 3,4-dihydro-1H-pyrimidine-2-thione and 2-thioxo-1H-pyrido[2,3-d]pyrimidin-4-one. Then, these compounds reacted with the appropriate hydrazonyl chlorides 4-R1C6H4NHN=C(Cl)R [R = C(O)Me, CO2Et; R1 = H, Me] in dioxane in presence of triethylamine to afford corresponding 1,5-dihydro-[1,2,4]triazolo[4,3-a]pyrimidines I [R = C(O)Me, CO2Et; R1 = H, Me] and their related fused pyridines II. Moreover, chalcone was cyclocondensed with 2-cyanothioacetamide to give corresponding 2-thioxo-1H-pyridine-3-carbonitrile, which was used as key synthon to synthesize fused heterocyclic compounds III [R2 = C(O)NH2, R3 = NH2; R2R3 = C(O)NHC(S)NH, C(O)NHC(O)NH, C(O)NHCH=N, C(O)NHC(Me)=N, C(O)NHC(SMe)=N]. The compound III [R2R3 = C(O)NHC(SMe)=N] reacted with appropriate hydrazonyl chlorides in dioxane in presence of triethylamine to yield corresponding pyrido[3′,2′:4,5]thieno[3,2-d][1,2,4]triazolo[4,3-a]pyrimidines IV [R = C(O)Me, CO2Et; R1 = H, Me]. Study of the in vitro antimicrobial activities of newly synthesized pyrimidines against different pathogenic bacterial and fungal strains were performed. The compound III [R2R3 = C(O)NHCH=N] showed the highest inhibitory activity against all bacteria with MIC values of 3.9, 7.81, 7.81, and 15.62μg/mL, resp., against Escherichia coli, Klebsiella pneumonia, Staphylococcus aureus and Streptococcus mutans, resp., as compared to reference drugs. Mol. docking was studied to predict the optimized conformation of pyrimidines as active ligands against Escherichia coli alk. phosphatase. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Product Details of 79-07-2

The Article related to pyrimidine preparation antibacterial antifungal docking pharmacokinetic cytotoxicity human, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Product Details of 79-07-2

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Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On February 13, 2020, Cai, Yingjun; von Solms, Nicolas; Zhang, Suojiang; Thomsen, Kaj published an article.Related Products of 79-07-2 The title of the article was Density, Viscosity, and Conductivity of [VAIM][TFSI] in Mixtures for Lithium-Ion Battery Electrolytes. And the article contained the following:

A novel unsaturated and amide-based ionic liquid, [VAIM][TFSI] (3-(2-amino-2-oxoethyl)-1-vinylimidazolium bis(trifluoromethylsulfonyl)amide), was synthesized using a two-step method. Its structure was confirmed by NMR, and its water content was determined by Karl Fischer titration to be below 0.03 wt %. The d., viscosity, and conductivity of the pure ionic liquid and its binary mixtures with acetonitrile were measured at various temperatures and at ambient pressure. Both the d. and viscosity increase with the mole fraction of the ionic liquid and decrease with decreasing temperature Excess molar volumes and viscosity deviations were calculated from the exptl. results. The elec. conductivities in mixtures with different contents of the ionic liquid were investigated at different temperatures The highest conductivity of binary mixtures is achieved at 0.07 mol fraction, with a value of ∼3.32 S·m-1 at 298.15 K. The conductivity of an electrolyte consisting of acetonitrile, LiTFSI, and the ionic liquid was measured to determine the optimal ionic liquid content. The suggested concentration is 3 wt% ionic liquid in this electrolyte, giving a conductivity of ∼4.11 S·m-1 at 298.15 K. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Related Products of 79-07-2

The Article related to density viscosity conductivity vaimtfsi ionic liquid lithium battery electrolyte, Phase Equilibriums, Chemical Equilibriums, and Solutions: Electrolytic Solutions and other aspects.Related Products of 79-07-2

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Amide – an overview | ScienceDirect Topics

Zaki, Remon M.; El-Ossaily, Yasser A.; Geies, Ahmed A. published an article in 2020, the title of the article was A convenient green synthetic approach to the synthesis of novel bioactive selenolo[2,3-c]pyrazoles as antibacterial and antifungal agents.Application of 79-07-2 And the article contains the following content:

A series of new pyrimidine, triazine, and isoindole heterocycles fused to the selenolopyrazole ring system, e.g., I, was synthesized by various condensation reactions of selenolopyrazole II, which was prepared by a new green methodol. The fused pyrimidinone compound I was used as a versatile precursor for several aromatic nucleophilic substitution reactions to produce sulfanyl- and amino-substituted pyrimidines. Furthermore, some of the compounds were screened against various pathogenic bacterial and fungal strains. Their results demonstrated that some of them revealed remarkable antimicrobial activities. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Application of 79-07-2

The Article related to selenolopyrazole green preparation antibacterial antifungal activity sar, pyrazoloselenolopyrimidine green preparation antibacterial antifungal activity sar, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Application of 79-07-2

Referemce:
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Amide – an overview | ScienceDirect Topics

On February 1, 2020, Khalil, Nadia A.; Ahmed, Eman M.; Zaher, Ashraf F.; El-Zoghbi, Mona S.; Sobh, Eman A. published an article.Recommanded Product: 2-Chloroacetamide The title of the article was Synthesis of certain benzothieno[3,2-d]pyrimidine derivatives as a selective SIRT2 inhibitors. And the article contained the following:

A series of new benzothieno[3,2-d]pyrimidine derivatives were designed and synthesized. The National Cancer Institute (NCI, USA) evaluated all synthesized compounds against 60 human tumor cell lines. Most of the compounds showed good cytotoxicity against MCF-7 breast cancer cell line and UO-31 renal cancer cell line (growth inhibitory range: 17.88%-68.65%). IC50 of twelve most active compounds was determined against MCF-7 and UO-31 cell lines. IC50 against SIRT2 enzyme was evaluated for the most active compounds to explore the mechanism of antiproliferative activity. The best activity was displayed by compound I (IC50 = 2.10μg/mL), which is 6.6 more potent than cambinol as a reference Moreover, compound I displayed high selectivity against SIRT1 and SIRT2 over SIRT3 in the selectivity studies and displayed twice activity of cambinol in hyperacetylation of α-tubulin protein with IC50 = 32.05μg/mL. Mol. docking study of the synthesized compounds into SIRT2 active site was performed to rationalize the remarkable SIRT2 inhibitory activity. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Recommanded Product: 2-Chloroacetamide

The Article related to benzothienopyrimidine preparation antitumor sirutin inhibition mol docking sar, benzothieno[3,2-d]pyrimidines, cytotoxic activity, sirt2 inhibitors, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Recommanded Product: 2-Chloroacetamide

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Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On May 3, 2022, Younis, Osama; Sayed, Mostafa; Mohammed, Ahmed A. K.; Tolba, Mahmoud S.; Hassanien, Reda; Kamal El-Dean, Adel M.; Tsutsumi, Osamu; Ahmed, Mostafa published an article.Recommanded Product: 79-07-2 The title of the article was Solid-State Luminescent Materials Containing Both Indole and Pyrimidine Moieties: Design, Synthesis, and Density Functional Theory Calculations. And the article contained the following:

Heterocyclic compounds with effective solid-state luminescence offer a wide range of uses. It has been observed that combining pyrimidine and indole moieties in a single mol. can enhance material behavior dramatically. Here, different heterocyclic compounds with indole and pyrimidine moieties have been synthesized effectively, and their structures have been validated using NMR, IR, and mass spectroscopy. The photoluminescence behavior of two substances was investigated in powder form and solutions of varying concentrations After aggregation, one mol. displayed a red shifted luminescence spectrum, whereas another homolog showed a blueshift. Thus, d. functional theory calculations were carried out to establish that introducing a terminal group allows modifying of the luminescence behavior by altering the mol. packing. Because of the non-planarity, intermol. interactions, and tiny intermol. distances within the dimers, the materials demonstrated a good emission quantum yield (Φem) in the solid state (ex. 25.6%). At high temperatures, the compounds also demonstrated a stable emission characteristic. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Recommanded Product: 79-07-2

The Article related to design synthesis luminescence dft indole pyrimidine derivative, solid state luminescent material aggregation indole pyrimidine derivative, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Recommanded Product: 79-07-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On August 31, 2022, Adel M. Kamal El-Dean; Geies, Ahmed A.; Hassanien, Reda; Abdel-Wadood, Fatma K.; El-Naeem, Eman E. Abd published an article.Formula: C2H4ClNO The title of the article was Novel Synthesis, Reactions, and Biological Study of New Morpholino-Thieno[2,3-c][2,7]Naphthyridines as Anti-Cancer and Anti-Microbial Agents. And the article contained the following:

The biol. uses of 2,7-naphthyridines have sparked great attention in recent years. For this reason, a series of novel 2,7-naphthyridines derivatives was synthesized and explored their spectrum and biol. properties in this study. Compound I was prepared by the reaction of 1-Me piperidin-4-one with CS2, malononitrile, and triethylamine. The condensed I be converted to II by reaction with morpholine. Composite II was used as a starter in heterocyclic compound a series, such as the thieno[2,3-c][2,7]naphthyridines III (R = CN, COOEt, COPh, etc.). Authors used III (R = COOEt), III (R = CONH2) and III (R = CHO) as a precursor to create original heterocyclic moieties, namely: pyrimidothienonaphthyridino and pyridothieno naphthyridino in compounds A number of compounds for antimicrobial activity were examined against a variety of bacterial and fungal strains. In addition, some of these compounds showed anticancer activity in liver and cells of breast cancer. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Formula: C2H4ClNO

The Article related to morpholinothieno naphthyridine preparation antitumor antibacterial antifungal human, Heterocyclic Compounds (More Than One Hetero Atom): Oxazines (Including Morpholine) and other aspects.Formula: C2H4ClNO

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Amide – an overview | ScienceDirect Topics

Novotorzhina, Nelya N.; Ismailova, Gunay G.; Musayeva, Bella I.; Safarova, Mekhpara R.; Ismailov, Ingilab P. published an article in 2021, the title of the article was Synthesis of new derivatives of N,N-diethyldithiocarbamine acid and study of their anti-seize properties.Application In Synthesis of 2-Chloroacetamide And the article contains the following content:

By the reaction of sodium N,N-diethyldithiocarbamate and chloroacetamide, S-carbamoylmethyldiethyldithiocarbamate was obtained. The conditions of two different methods for producing S(N-2,2-dimethyl-4-methyloxymethyl-1,3 dioxolane) carbamoylmethyldiethyldithiocarbamate were proposed. One of which was based on the homocondensation of hydroxylmethylcarbamoyldiethyldithiocarbamate and 2,2-dimethyl-4-hydroxymethyl-1,3-dioxolane, the other on the interaction of 2,2-dimethyl-4- chloromethylcarbamoylmethyloxymethyl-1,3-dioxolane and sodium N,N-diethyldithiocarbamate. At the first stage of the study, 4 starting reagents were synthesized, 2 of which were not previously described in the literature: 2,2-dimethyl-4-chloromethylcarbamoylmethoxymethyi-1,3-dioxolane and S-hydroxymethylcarbamoylethyldithiocarbamate. The structure of the synthesized compounds was proved by determining their elemental compositions, calculating mol. refractions based on refractive indexes and specific gravities, as well as recording IR absorption spectra on a spectrophotometer. The presence of comparatively high extreme pressure properties of the synthesized compounds in the mineral oil SN-1200 and synthetic oil consisting of penta erythritol of fatty acids was revealed and it was shown that they are superior to the known additives in the literature of tricresyl phosphate and N-allyl-5-hexyloxycarbocarbonylmethyl-1,3-thiazolidin-4-one-2-thione. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Application In Synthesis of 2-Chloroacetamide

The Article related to diethyl carbamothioyl sulfanyl acetamide preparation antiwear, Heterocyclic Compounds (More Than One Hetero Atom): Dioxoles, Oxathioles, Dithioles and other aspects.Application In Synthesis of 2-Chloroacetamide

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Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On May 31, 2022, Klimochkin, Yu. N.; Ivleva, E. A. published an article.COA of Formula: C2H4ClNO The title of the article was Synthesis and Chemical Transformations of N-Adamantylated Amides. And the article contained the following:

N-Adamantylated amides, e.g., I were synthesized from 1-adamantyl nitrate. The reactions were carried out in the sulfuric acid media. The proposed method was usefulness for the preparation of antiviral drug tromantadine. A number of new cage aminoamides were synthesized by reactions of N-(1-adamantyl)-2-chloroacetamide with nitrogen-containing nucleophiles with potential biol. activity. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).COA of Formula: C2H4ClNO

The Article related to adamantylated amide preparation, Alicyclic Compounds: Tricyclic Compounds and Higher Analogs, Including Adamantanes, Fullerenes and other aspects.COA of Formula: C2H4ClNO

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Amide – an overview | ScienceDirect Topics

On December 31, 2021, Medo, Juraj; Makova, Jana; Medova, Janka; Lipkova, Nikola; Cinkocki, Renata; Omelka, Radoslav; Javorekova, Sona published an article.Name: 2-Chloroacetamide The title of the article was Changes in soil microbial community and activity caused by application of dimethachlor and linuron. And the article contained the following:

Soil microorganisms and their activities are essential for maintaining soil health and fertility. Microorganisms can be neg. affected by application of herbicides. Although effects of herbicides on microorganisms are widely studied, there is a lack of information for chloroacetamide herbicide dimethachlor. Thus, dimethachlor and well known linuron were applied to silty-loam luvisol and their effects on microorganisms were evaluated during112 days long laboratory assay. Dimethachlor and linuron were applied in doses 1.0 kg ha-1 and 0.8 kg ha-1 corresponding to 3.33 mg kg-1 and 2.66 mg kg-1 resp. Also 100-fold doses were used for magnification of impacts. Linuron in 100-fold dose caused minor increase of respiration, temporal increase of soil microbial biomass, decrease of soil dehydrogenase activity, and altered microbial community. Dimethachlor in 100-fold dose significantly increased respiration; microbial biomass and decreased soil enzymic activities. Microbial composition changed significantly, Proteobacteria abundance, particularly Pseudomonas and Achromobacter genera increased from 7 to 28th day. In-silico prediction of microbial gene expression by PICRUSt2 software revealed increased expression of genes related to xenobiotic degradation pathways. Evaluated characteristics of microbial community and activity were not affected by herbicides in recommended doses and the responsible use of both herbicides will not harm soil microbial community. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Name: 2-Chloroacetamide

The Article related to dimethachlor linuron soil microbial community activity, Fertilizers, Soils, and Plant Nutrition: Fertilizer-Soil Relations, Including Amendments and other aspects.Name: 2-Chloroacetamide

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Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On March 31, 2021, Simonov, A. Yu.; Panov, A. A.; Trenin, A. S.; Korolev, A. M.; Lavrenov, S. N. published an article.Product Details of 79-07-2 The title of the article was Optimization of the Synthesis of New Antibacterial Compounds with Tris(1-Alkylindol-3-yl)Methylium Fragments. And the article contained the following:

A new optimal synthetic scheme for new antibacterial compounds I (R = H, Me) combining tris-(1-alkyindol-3-yl)methylium and 3-(indol-1-yl)maleimide in their structures was developed. The proposed method provided a significant increase in the product yield, reduced the labor intensiveness and number of steps, and used readily accessible starting reagents. A good yield was achieved for 3-(formylindol-1-yl)-4-chloromaleimide, a universal precursor enabling two-step syntheses of target tri(indolyl)methanes II (R1 = H, NH2, NMe2) and production of an extensive library of analogous potentially active compounds from other 1-alkylindoles and various amines and thiols. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Product Details of 79-07-2

The Article related to aminomaleimido trisindolylmethylium chloride preparation antibacterial, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Product Details of 79-07-2

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Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics