Category: 79-07-2

Ong-Artborirak, Parichat; Boonchieng, Waraporn; Juntarawijit, Yuwayong; Juntarawijit, Chudchawal published an article in 2022, the title of the article was Potential Effects on Mental Health Status Associated with Occupational Exposure to Pesticides among Thai Farmers.Application In Synthesis of 2-Chloroacetamide And the article contains the following content:

Pesticide-related mental health issues in Thailand, an upper-middle-income country, are not well known. This study aimed to investigate the association between the history of occupational exposure to pesticides and the mental health of Thai farmers. A cross-sectional study was carried out in the areas around Chiang Mai, a large city in Northern Thailand, between June 2020 and Jan. 2021. A total of 6974 farmers from six districts were interviewed to determine whether they regularly experienced symptoms related to mental health by the Self-Reporting Questionnaire (SRQ-20) as well as their lifetime history of agricultural pesticide exposure from 31 active ingredients and five functional categories: insecticides, herbicides, fungicides, rodenticides, and molluscicides. The cut-off of 6 was used to evaluate probable mental disorder. Most of the farmers under investigation were men (53.8%), with a mean age of 55.2 (11.7) years, and were involved mainly in the planting of rice, fruit, and vegetables. About 86.7% reported having used pesticides on their crops at some point in their lives-mostly glyphosate, paraquat, 2,4-D, methomyl, and carbofuran. All functional groups, as well as pesticide classes like organochlorines, organophosphates, and carbamates, were significantly associated with a higher risk of probable mental disorder based on exposure duration, frequency, personal protective equipment usage, and hygienic behavior. In a model with multiple pesticides, there was an association between mental disorder and exposure to endosulfan (AOR = 2.27, 95%CI = 1.26-4.08) and methyl parathion (AOR = 2.26, 95%CI = 1.26-4.06). Having previously reported pesticide poisoning symptoms was related to mental disorder (AOR = 7.97, 95%CI = 5.16-12.31), the findings provided evidence of pesticide exposure posing a risk to farmers′ mental health, particularly long-term and high-intensity exposure. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Application In Synthesis of 2-Chloroacetamide

The Article related to glyphosate organochlorine occupational exposure mental health risk assessment population, farmer, mental health, pesticide, psychiatric disorder, symptom, Placeholder for records without volume info and other aspects.Application In Synthesis of 2-Chloroacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Abdul, Shiraazkhan; Dekkers, Dick H. W.; Ariens, Robert A. S.; Leebeek, Frank W. G.; Rijken, Dingeman C.; Uitte de Willige, Shirley published an article in 2020, the title of the article was On the localization of the cleavage site in human alpha-2-antiplasmin, involved in the generation of the non-plasminogen binding form.COA of Formula: C2H4ClNO And the article contains the following content:

The C-terminus of α2AP is crucial for the initial interaction with plasmin(ogen) and the rapid inhibitory mechanism. Approx. 35% of circulating α2AP has lost its C-terminus (non-plasminogen binding α2AP/NPB-α2AP) and thereby its rapid inhibitory capacity. The C-terminal cleavage site of α2AP is still unknown. A com. available monoclonal antibody against α2AP (TC 3AP) detects intact but not NPB-α2AP, suggesting that the cleavage site is located N-terminally from the epitope of TC 3AP. For epitope mapping of TC 3AP, com. available plasma purified α2AP was enzymically digested with Asp-N, Glu-C, or Lys-N. The resulting peptides were immunoprecipitated using TC 3AP-loaded Dynabeads Protein G. Bound peptides were eluted and analyzed by liquid chromatog.-tandem mass spectometry (LC-MS/MS). To localize the C-terminal cleavage site precisely, α2AP (intact and NPB) was purified from plasma and analyzed by LC-MS/MS after enzymic digestion with Arg-C. LC-MS/MS data from plasma purified α2AP showed that NPB-α2AP results from cleavage at Gln421-Asp422 as preferred site, but also after Leu417, Glu419, Gln420, or Asp422. The C-terminal cleavage site of human α2AP is located N-terminally from the TC 3AP epitope. Because C-terminal cleavage of α2AP can occur after multiple residues, different proteases may be responsible for the generation of NPB-α2AP. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).COA of Formula: C2H4ClNO

The Article related to alpha 2 antiplasmin amino acid proteolysis protein localization, alpha-2-antiplasmin, epitope mapping, mass spectrometry, proteolysis, western blot, Placeholder for records without volume info and other aspects.COA of Formula: C2H4ClNO

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Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On August 31, 2022, Sobh, Eman A.; Khalil, Nadia A.; Faggal, Samar I.; Hassan, Marwa S. A. published an article.Application of 79-07-2 The title of the article was New benzothienopyrimidine derivatives as dual EGFR/ARO inhibitors: Design, synthesis, and their cytotoxic effect on MCF-7 breast cancer cell line. And the article contained the following:

New cytotoxic agents based on benzothienopyrimidine scaffold were designed, synthesized, and evaluated against the MCF-7 breast cancer line in comparison to erlotinib and letrozole as reference drugs. Eight compounds demonstrated up to 20-fold higher anticancer activity than erlotinib, and five of these compounds were up to 11-fold more potent than letrozole in MTT assay. The most promising compounds were evaluated for their inhibitory activity against EGFR and ARO enzymes. Compound 12, which demonstrated potent dual EGFR and ARO inhibitory activity with IC50 of 0.045 and 0.146 μM, resp., was further evaluated for caspase-9 activation, cell cycle anal., and apoptosis. The results revealed that the tested compound 12 remarkably induced caspase-9 activation (IC50 = 16.29 ng/mL) caused cell cycle arrest at the pre-G1/G1 phase and significantly increased the concentration of cells at both early and late stage of apoptosis. In addition, it showed a higher safety profile on normal MCF-10A cells, and higher antiproliferative activity on cancer cells (IC50 = 8.15 μM) in comparison to normal cells (IC50 = 41.20 μM). It also revealed a fivefold higher selectivity index than erlotinib towards MCF-7 cancer cells. Docking studies were performed to rationalize the dual inhibitory activity of compound 12. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Application of 79-07-2

The Article related to benzothienopyrimidine derivative preparation aromatase egfr inhibitor antitumor activity, aro and egfr inhibitors, benzothienopyrimidine, cytotoxic, Placeholder for records without volume info and other aspects.Application of 79-07-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On March 18, 2021, Peng, Guibin; Zhu, Chengzhen; Liao, Junbin; Gao, Xing; Hao, Liang; Sotto, Arcadio; Shen, Jiangnan published an article.Application In Synthesis of 2-Chloroacetamide The title of the article was A two-step strategy for the preparation of anion-exchange membranes based on poly(vinylidenefluoride-co-hexafluoropropylene) for electrodialysis desalination. And the article contained the following:

The development of a facile approach to fabricate anion exchange membranes (AEMs) with efficient ionic transport and desirable stabilities (mech. and dimensional) for various applications is meaningful. In this work, a two-step strategy for the preparation of AEMs with 3D network structure, via crosslinking reaction between 2-chloroacetamide (CAA) modified poly (vinylidene fluoride-co-hexafluoropropylene) (PVDF-HFP) and N,N,N’,N’-tetramethyl-1,4-diaminobutane (TMDAB) has been reported. The as-prepared AEMs with ion-exchange capacity (IEC) in the range of 1.38-1.84 mmol g-1, exhibit the much lower water uptake (13.14-22.45%, 80°C) relative to the un-crosslinked AEM (35.89%, 80°C). In addition, due to the presence of fluorine-based 3D network structure, the as-prepared AEMs show much enhanced mech. and thermal stability in comparison with the un-crosslinked AEM. In the electrodialysis (ED) application, the optimized AEM shows the higher current efficiency (78.6%) and lower energy consumption (2.01 kWh kg-1 NaCl) than those of com. AEM AEM-Type II (76.4%; 2.26 kWh kg-1), resp., within 150 min of operation interval. The proposed facile fabrication protocol and the better-performance of optimized PVDF-HFP -based AEM demonstrate the potential ED application. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Application In Synthesis of 2-Chloroacetamide

The Article related to strategy anion exchange membrane polyvinylidene hexafluoropropylene electrodialysis desalination, Plastics Fabrication and Uses: Plastic Product Uses and other aspects.Application In Synthesis of 2-Chloroacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On March 31, 2020, Kim, Da-Hye; Park, Chang Gyun; Kim, Young Jun published an article.Formula: C2H4ClNO The title of the article was Characterizing the potential estrogenic and androgenic activities of two disinfection byproducts, mono-haloacetic acids and haloacetamides, using in vitro bioassays. And the article contained the following:

Exposure to disinfection byproducts (DBPs) is potentially related to cytotoxic, genotoxic, mutagenic, and tumorigenic effects in humans, in addition to their adverse effects on the environment. However, their impacts on endocrine disruption, especially reproductive toxicity, remain largely unknown. In this study, the estrogenic and androgenic activities of DBPs and corresponding antagonistic activities were investigated using a yeast-based reporter assay, focusing on haloacetic acids and haloacetamides. We also examined the cytotoxicity of DBPs and mechanisms of antagonistic activities. Of the DBPs assayed, iodoacetamide (IAM) and bromoacetamide (BAM) were the most cytotoxic, with LC50 values of 0.0462 and 0.0537 mM, resp., followed by chloroacetic acid (CAA; LC50 = 4.87 mM) and chloroacetamide (CAM; LC50 = 5.28 mM). Iodoacetic acid (IAA) and bromoacetic acid (BAA) were the least cytotoxic, with LC50 values of 5.52 and 6.35 mM, resp. IAA (EC10 = 0.00573 mM; EC50 = 0.0215 mM) exhibited most potent estrogenic activity, and CAA (EC10 = 0.0434 mM) and BAM (EC10 = 0.0150 mM) showed weak estrogenic and androgenic activities, resp. By contrast, IAM exhibited anti-estrogenic effects. These results suggest that DBPs interact with hormone receptors. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Formula: C2H4ClNO

The Article related to pituitary cell iodoacetamide bromoacetamide cytotoxicity estrogenic androgenic, cytotoxicity, disinfection byproducts, endocrine disrupting potency, yes/yas assay, Toxicology: Carcinogens, Mutagens, and Teratogens and other aspects.Formula: C2H4ClNO

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On March 18, 2021, Peng, Guibin; Zhu, Chengzhen; Liao, Junbin; Gao, Xing; Hao, Liang; Sotto, Arcadio; Shen, Jiangnan published an article.Application In Synthesis of 2-Chloroacetamide The title of the article was A two-step strategy for the preparation of anion-exchange membranes based on poly(vinylidenefluoride-co-hexafluoropropylene) for electrodialysis desalination. And the article contained the following:

The development of a facile approach to fabricate anion exchange membranes (AEMs) with efficient ionic transport and desirable stabilities (mech. and dimensional) for various applications is meaningful. In this work, a two-step strategy for the preparation of AEMs with 3D network structure, via crosslinking reaction between 2-chloroacetamide (CAA) modified poly (vinylidene fluoride-co-hexafluoropropylene) (PVDF-HFP) and N,N,N’,N’-tetramethyl-1,4-diaminobutane (TMDAB) has been reported. The as-prepared AEMs with ion-exchange capacity (IEC) in the range of 1.38-1.84 mmol g-1, exhibit the much lower water uptake (13.14-22.45%, 80°C) relative to the un-crosslinked AEM (35.89%, 80°C). In addition, due to the presence of fluorine-based 3D network structure, the as-prepared AEMs show much enhanced mech. and thermal stability in comparison with the un-crosslinked AEM. In the electrodialysis (ED) application, the optimized AEM shows the higher current efficiency (78.6%) and lower energy consumption (2.01 kWh kg-1 NaCl) than those of com. AEM AEM-Type II (76.4%; 2.26 kWh kg-1), resp., within 150 min of operation interval. The proposed facile fabrication protocol and the better-performance of optimized PVDF-HFP -based AEM demonstrate the potential ED application. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Application In Synthesis of 2-Chloroacetamide

The Article related to strategy anion exchange membrane polyvinylidene hexafluoropropylene electrodialysis desalination, Plastics Fabrication and Uses: Plastic Product Uses and other aspects.Application In Synthesis of 2-Chloroacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On March 31, 2020, Kim, Da-Hye; Park, Chang Gyun; Kim, Young Jun published an article.Formula: C2H4ClNO The title of the article was Characterizing the potential estrogenic and androgenic activities of two disinfection byproducts, mono-haloacetic acids and haloacetamides, using in vitro bioassays. And the article contained the following:

Exposure to disinfection byproducts (DBPs) is potentially related to cytotoxic, genotoxic, mutagenic, and tumorigenic effects in humans, in addition to their adverse effects on the environment. However, their impacts on endocrine disruption, especially reproductive toxicity, remain largely unknown. In this study, the estrogenic and androgenic activities of DBPs and corresponding antagonistic activities were investigated using a yeast-based reporter assay, focusing on haloacetic acids and haloacetamides. We also examined the cytotoxicity of DBPs and mechanisms of antagonistic activities. Of the DBPs assayed, iodoacetamide (IAM) and bromoacetamide (BAM) were the most cytotoxic, with LC50 values of 0.0462 and 0.0537 mM, resp., followed by chloroacetic acid (CAA; LC50 = 4.87 mM) and chloroacetamide (CAM; LC50 = 5.28 mM). Iodoacetic acid (IAA) and bromoacetic acid (BAA) were the least cytotoxic, with LC50 values of 5.52 and 6.35 mM, resp. IAA (EC10 = 0.00573 mM; EC50 = 0.0215 mM) exhibited most potent estrogenic activity, and CAA (EC10 = 0.0434 mM) and BAM (EC10 = 0.0150 mM) showed weak estrogenic and androgenic activities, resp. By contrast, IAM exhibited anti-estrogenic effects. These results suggest that DBPs interact with hormone receptors. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Formula: C2H4ClNO

The Article related to pituitary cell iodoacetamide bromoacetamide cytotoxicity estrogenic androgenic, cytotoxicity, disinfection byproducts, endocrine disrupting potency, yes/yas assay, Toxicology: Carcinogens, Mutagens, and Teratogens and other aspects.Formula: C2H4ClNO

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Chau, Nguyen Dang Giang; Van Hop, Nguyen; Long, Hoang Thai; Duyen, Ngo Thi My; Raber, Georg published an article in 2020, the title of the article was Multi-residue analytical method for trace detection of new-generation pesticides in vegetables using gas chromatography-tandem mass spectrometry.Formula: C2H4ClNO And the article contains the following content:

A GC-MS/MS method with low solvent consumption and easy operation was developed to simultaneously determine ten new-generation pesticides, namely fenobucarb, acetochlor, pretilachlor, fipronil, trifloxystrobin, fluazifop-p-Bu, isoprothiolane, tebuconazole, cypermethrin and difenoconazole in leafy vegetables. Influences from ultrasonic sample extraction and the clean-up steps to reduce matrix effects were investigated. Under suitable conditions, good linearity (deviation of back calculated concentration from true concentration lower than 20%) was achieved for all studied pesticides; the method detection limits (MDLs) ranged from 1.4 to 3.6 ng g-1 wet weight For mustard green and green onion the method yielded good recoveries at two spiking levels (201 and 100 ng g-1) ranging from 80% to 111% (n = 5). The repeatability, expressed as relative standard deviation (RSD), was lower than 11% (n = 5). The method was successfully used to quantify pesticide residues in 207 vegetable samples (green onions, mustard greens, and lettuce) collected in Thua Thien Hue and Quang Binh Provinces, Central Vietnam. The insecticide cypermethrin was found at critical levels in 98% of the vegetable samples. Green onions had high pesticide residues with a significant number of samples containing pesticides at concentrations exceeding the maximum residue levels (MRLs). The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Formula: C2H4ClNO

The Article related to onion mustard green lettuce pesticide gas chromatog mass spectrometry, gc-ms/ms, method development, pesticides residues, solid phase extraction, ultrasonic extraction, Food and Feed Chemistry: Fruits, Vegetables, Legumes, and Nuts and other aspects.Formula: C2H4ClNO

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Mohareri, Mohammad Moein; Ghaffari, Mehdi; Sattarzadeh, Elham; Kakaei, Saeed published an article in 2021, the title of the article was Preparation and application of Fe3O4@Acetamidoxanthate as a unique nanosorbent in heavy metal removing.Computed Properties of 79-07-2 And the article contains the following content:

Chelating agents are one of the most important substances in metal extraction, but separation is the main problem in the use of these agents as an adsorbent. After the adsorption of metals by an external magnet, magnetic NPs provide the possibility of easy collecting and isolating the adsorbent nanomaterial for many applications. Given the immense importance of magnetic NPs, there has been widespread interest in accessing the above adsorbent. In the present study, an attempt was made to synthesize acetamido xanthate which was coupled to NPs and has the potential to be used as a nano-adsorbent for the removal of heavy metals. This novel nano sorbent was characterized by SEM (SEM), Fourier transforms IR (FT-IR), and NMR (NMR) spectroscopy. The effect of some parameters such as temperature, time, pH, and the amount of adsorbent on the extraction reaction was investigated. The optimized condition for extraction of cerium was temperature of 30°C, pH=8, reaction time of 45 min using 7.5mg of the prepared nanosorbent, that in such condition the yield of reaction achieved up to 97%. The prepared adsorbent showed high efficiency in the adsorption of heavy metals specifically. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Computed Properties of 79-07-2

The Article related to iron oxide acetamidoxanthate nanosorbent heavy metal removing, Waste Treatment and Disposal: Physical Treatment Of Aqueous Wastes and other aspects.Computed Properties of 79-07-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On April 30, 2022, Tong, Ruoming; Fu, Rui; Yang, Zhe; Jiang, Yuanxing; Jiang, Kun; Sun, Xuhui published an article.Computed Properties of 79-07-2 The title of the article was Efficient degradation of sulfachloropyridazine by sulfite activation with CuO-Al2O3 composites under neutral pH conditions: Radical and non-radical. And the article contained the following:

In this work, CuO-Al2O3 composites were synthesized at higher temperatures to control the leaching of metal ions, which can activate sulfite (S(IV)) to degrade organic contaminants by generating reactive oxygen species (ROSs). The synthesized catalysts were characterized by X-ray diffraction, SEM, high-resolution transmission electron microscopy, Brunauer-Emmett-Teller, Raman spectroscopy, and Fourier transform IR spectrophotometry. Sulfachloropyridazine (SCP) was almost completely removed (>99%) at pH 6.8, and the leaching amount of Cu accounted for 0.027% of the total amount of Cu after the reaction. Notably, singlet oxygen (1O2) was found for the first time in the activated sulfite system, which removed organic pollutants together with sulfate (SO4·- ) and hydroxyl (·OH) radicals. And Al2O3 plays an important role in the catalyst, including anti-sintering, reducing the leaching of copper ions, and promoting the generation of oxygen vacancies. Based on the types of ROSs and XPS results, a possible ROSs generation mechanism was proposed. In addition, the stability of the catalyst and the effect of different factors on the degradation of SCP, including operating parameters and water quality, were further investigated. The intermediates were detected by using gas chromatog.-mass spectrometry and a developmental toxicity assessment of the intermediates was defined based on the Toxicity Estimation Software Tool (TEST). Overall, this paper not only provides a new strategy for sulfite activation but also promotes more attention to non-radical processes in activated sulfite systems. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Computed Properties of 79-07-2

The Article related to copper aluminum oxide sulfachloropyridazine degradation, Waste Treatment and Disposal: Physical Treatment Of Aqueous Wastes and other aspects.Computed Properties of 79-07-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics