Category: 79-07-2

Nguyen, Vu Thanh published the artcileOne-pot three-component synthesis of 1-amidoalkyl naphthols and polyhydroquinolines using a deep eutectic solvent: A green method and mechanistic insight, Name: 2-Chloroacetamide, the publication is New Journal of Chemistry (2021), 45(4), 2053-2059, database is CAplus.

The multicomponent synthesis of 1-amidoalkyl naphthols I [R¹ = n-Pr, Ph, 4-MeC₆H₄, 2-furyl, etc., R² = Ph, CH₂Cl] and polyhydroquinolines II [R = furan-2-yl, Ph, 2-ClC₆H₄, etc.] was developed as an atom-economic procedure catalyzed by a deep eutectic solvent ([CholineCl][ZnCl₂]₃). The reactions proceeded smoothly at low temperatures for a short reaction time without the use of toxic and volatile organic solvents. Deep eutectic solvents were capable of not only allowing multicomponent reactions to proceed in high yield but also controlling the selectivity towards desired products. Mechanistic insights were examined by HRMS (ESI) to propose a plausible mechanism. Furthermore, [CholineCl][ZnCl₂]₃ could be recycled up to three consecutive cycles with an insignificant loss of catalytic activity under the optimized conditions.

New Journal of Chemistry published new progress about 79-07-2. 79-07-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Aliphatic hydrocarbon chain,Amide,Inhibitor, name is 2-Chloroacetamide, and the molecular formula is C2H4ClNO, Name: 2-Chloroacetamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Tung, Truong Thanh published the artcileAmide bond formation in aqueous solution: direct coupling of metal carboxylate salts with ammonium salts at room temperature, Quality Control of 79-07-2, the publication is Organic & Biomolecular Chemistry (2021), 19(46), 10073-10080, database is CAplus and MEDLINE.

A green, expeditious and practically simple protocol for direct coupling of carboxylate salts such as sodium benzoate, sodium nicotinate, sodium acrylate, etc. and ammonium salts such as methoxyamine hydrochloride, ammonium chloride, dimethylamine hydrochloride, etc. under ACN/H₂O conditions at room temperature without the addition of tertiary amine bases was reported. The water-soluble coupling reagent EDC·HCl is a key component in the reaction. The reaction runs smoothly with unsubstituted/substituted ammonium salts and provides a clean products e.g., N-methoxybenzamide without column chromatog. This reaction tolerates both carboxylate (which are unstable in other forms) and amine salts (which are unstable/volatile when present in free form). It was believed that the reported method could be used as an alternative and suitable method at the laboratory and industrial scales.

Organic & Biomolecular Chemistry published new progress about 79-07-2. 79-07-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Aliphatic hydrocarbon chain,Amide,Inhibitor, name is 2-Chloroacetamide, and the molecular formula is C5H5BrN2, Quality Control of 79-07-2.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Zhao, Mi-Na published the artcileIron-Catalyzed Cycloaddition of Amides and 2,3-Diaryl-2H-azirines To Access Oxazoles via C-N Bond Cleavage, Application In Synthesis of 79-07-2, the publication is Journal of Organic Chemistry (2021), 86(3), 2957-2964, database is CAplus and MEDLINE.

A novel and efficient iron-catalyzed cycloaddition reaction using readily available 2,3-diaryl-2H-azirines and primary amides is reported. A wide range of trisubstituted oxazoles could be achieved in good yields with good functional group compatibility. In this transformation, two C-N bonds were cleaved and new C-N and C-O bonds were formed.

Journal of Organic Chemistry published new progress about 79-07-2. 79-07-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Aliphatic hydrocarbon chain,Amide,Inhibitor, name is 2-Chloroacetamide, and the molecular formula is C6H8O3, Application In Synthesis of 79-07-2.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Duarte-Restrepo, Edisson published the artcileSpatial distribution of pesticides, organochlorine compounds, PBDEs, and metals in surface marine sediments from Cartagena Bay, Colombia, Safety of 2-Chloroacetamide, the publication is Environmental Science and Pollution Research (2021), 28(12), 14632-14653, database is CAplus and MEDLINE.

Cartagena Bay is an estuarine system located in the Caribbean Sea (Colombia, South America), that receives fresh water from Canal del Dique, which is connected to the Magdalena River, the most important river of Colombia, with some of the most prominent Colombian cities located in its watershed, which has a high sediment yield. An anal. of persistent organic pollutants and heavy metals was carried out on marine sediments from Cartagena Bay. Cartagena Bay sediments deployed the occurrence of total levels of pesticides (thiocarbamates, bromacil, triazines, organochlorines, and organophosphorus), polybrominated di-Ph ethers (PBDEs), and polychlorinated biphenyls (PCBs), in sediments ranging from 0.83-33.67 ng/g dry-weight, 0.05-0.34 ng/g dry-weight, and 0.06-19.58 ng/g dry-weight, resp. Their concentrations were lower than those reported in NOAA Screening Quick Reference Tables. DDTs and PCBs are banned organochlorine compounds, since, even at low levels, their presence in sediments represents a threat to aquatic organisms and, therefore, to human health through the trophic chain. Sediments showed high concentrations of strontium (50-959.6 mg/kg). All metals evaluated in the marine sediments were found in the S6 sampling point; this was near tannery and hydrocarbon industries (Pb 37.1 mg/kg, Cr 137.2 mg/kg, Cd 1.7 mg/kg, Cu 64.4 mg/kg, As 13.1 mg/kg, Sr 318.9 mg/kg); these results exceeded the accepted values of threshold effect levels (TEL) used as an indicator of their potential risk on marine life.

Environmental Science and Pollution Research published new progress about 79-07-2. 79-07-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Aliphatic hydrocarbon chain,Amide,Inhibitor, name is 2-Chloroacetamide, and the molecular formula is C2H4ClNO, Safety of 2-Chloroacetamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Gilani, Saeedeh published the artcileEvaluation of the extraction process parameters on bioactive compounds of cinnamon bark: A comparative study, Related Products of amides-buliding-blocks, the publication is Process Biochemistry (Oxford, United Kingdom) (2022), 93-101, database is CAplus.

In recent times, there has been special attention to the antidiabetic properties of herbal medicine like cinnamon, because of its major compounds such as cinnamic acid and cinnamaldehyde. This study optimizes an effective technique for the extraction of cinnamic acid and cinnamaldehyde from cinnamon bark. The effective parameters of both microwave and ultrasound methods were considered and then compared with the soxhlet extraction method. The impact of different solvent types, temperature and process time, solid: solvent portion, particle size, on the yield of cinnamic acid and cinnamaldehyde extraction were investigated. In addition, all the obtained extraction samples were analyzed by the newly developed HPLC method via UV detector. Finally, the optimized extraction factors were obtained 85 % aqueous ethanol; solid: solvent portion, 1:40 g/mL; particle size of 0.18 mm; for both microwave and ultrasound extraction methods. The maximum yield of cinnamic acid and cinnamaldehyde in microwave extraction were gained 3.9 and 49.4 mg/g, resp. Both advanced extraction techniques with our obtained optimized conditions are suggested for cinnamon bark.

Process Biochemistry (Oxford, United Kingdom) published new progress about 79-07-2. 79-07-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Aliphatic hydrocarbon chain,Amide,Inhibitor, name is 2-Chloroacetamide, and the molecular formula is C2H4ClNO, Related Products of amides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Alam, Mohammad Mahboob published the artcileNaproxen Based 1,3,4-Oxadiazole Derivatives as EGFR Inhibitors: Design, Synthesis, Anticancer, and Computational Studies, Application of 2-Chloroacetamide, the publication is Pharmaceuticals (2021), 14(9), 870, database is CAplus and MEDLINE.

A library of novel naproxen based 1,3,4-oxadiazole derivatives (8-16 and 19-26) has been synthesized and screened for cytotoxicity as EGFR inhibitors. Among the synthesized hybrids, compound2-(4-((5-((S)-1-(2-methoxynaphthalen-6-yl)ethyl)-1,3,4-oxadiazol-2-ylthio)methyl)-1H-1,2,3-triazol-1-yl)phenol(15) was the most potent compound against MCF-7 and HepG2cancer cells with IC₅₀ of 2.13 and 1.63 μg/mL, resp., and was equipotent to doxorubicin (IC₅₀ 1.62 μg/mL) towards HepG2. Furthermore, compound 15 inhibited EGFR kinase with IC₅₀ 0.41 μM compared to standard drug Erlotinib (IC₅₀ 0.30 μM). The active compound induces a high percentage of necrosis towards MCF-7, HePG2 and HCT 116 cells. The docking studies, DFT and MEP also supported the biol. data. These results demonstrated that these synthesized naproxen hybrids have EGFR inhibition effects and can be used as leads for cancer therapy.

Pharmaceuticals published new progress about 79-07-2. 79-07-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Aliphatic hydrocarbon chain,Amide,Inhibitor, name is 2-Chloroacetamide, and the molecular formula is C2H4ClNO, Application of 2-Chloroacetamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Goudarziafshar, Hamid published the artcileNano-[Mn-PSMP]Cl₂ as a new Schiff base complex and catalyst for the synthesis of N,N’-alkylidene bisamides, Recommanded Product: 2-Chloroacetamide, the publication is Research on Chemical Intermediates (2022), 48(4), 1423-1437, database is CAplus.

Nano-Mn-[phenyl-salicylaldimine-methyl-pyranopyrimidinedione]Cl₂ {Nano-[Mn-PSMP]Cl₂} as a new Schiff base complex was prepared and characterized by various analyses such as FTIR spectroscopy (FTIR), energy-dispersive x-ray spectroscopy (EDX), TGA, differential TGA (DTA), mass spectroscopy (MASS), SEM. Nano-[Mn-PSMP]Cl₂ was used as an efficient catalyst for the synthesis of N,N’-alkylidene bisamides.

Research on Chemical Intermediates published new progress about 79-07-2. 79-07-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Aliphatic hydrocarbon chain,Amide,Inhibitor, name is 2-Chloroacetamide, and the molecular formula is C2H4ClNO, Recommanded Product: 2-Chloroacetamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Lv, Xue-Jiao published the artcileBronsted acid-catalyzed dynamic kinetic resolution of in situ formed acyclic N,O-hemiaminals: cascade synthesis of chiral cyclic N,O-aminals, Name: 2-Chloroacetamide, the publication is Organic Chemistry Frontiers (2021), 8(22), 6309-6316, database is CAplus.

A Bronsted acid-catalyzed cascade acyclic N,O-hemiaminal formation/oxa-Michael reaction is developed for the synthesis of cis-2,6-disubstituted tetrahydropyrans bearing an exo amide group, i.e., cyclic N,O-aminals. By using TsOH, various different amides including carboxyamides, carbamates, sulfonamides and even phosphoramides were applicable for the designed reaction sequence. By using chiral phosphoric acid, a wide range of enantioenriched cyclic N,O-aminal scaffolds were obtained. Detailed mechanistic investigations revealed that the good enantioselectivity can be attributed to a H₂O controlled dynamic kinetic resolution of the in situ formed acyclic N,O-hemiaminal intermediate during the reaction process. Furthermore, a number of divergent transformations of the obtained products were investigated, leading to various synthetically useful heterocyclic architectures.

Organic Chemistry Frontiers published new progress about 79-07-2. 79-07-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Aliphatic hydrocarbon chain,Amide,Inhibitor, name is 2-Chloroacetamide, and the molecular formula is C2H4ClNO, Name: 2-Chloroacetamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Kuljanin, Miljan published the artcileReimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries, Related Products of amides-buliding-blocks, the publication is Nature Biotechnology (2021), 39(5), 630-641, database is CAplus and MEDLINE.

Current methods used for measuring amino acid side-chain reactivity lack the throughput needed to screen large chem. libraries for interactions across the proteome. Here we redesigned the work flow for activity-based protein profiling of reactive cysteine residues by using a smaller desthiobiotin-based probe, sample multiplexing, reduced protein starting amounts and software to boost data acquisition in real time on the mass spectrometer. Our method, streamlined cysteine activity-based protein profiling (SLC-ABPP), achieved a 42-fold improvement in sample throughput, corresponding to profiling library members at a depth of >8,000 reactive cysteine sites at 18 min per compound We applied it to identify proteome-wide targets of covalent inhibitors to mutant Kirsten rat sarcoma (KRAS)^G12C and Bruton’s tyrosine kinase (BTK). In addition, we created a resource of cysteine reactivity to 285 electrophiles in three human cell lines, which includes >20,000 cysteines from >6,000 proteins per line. The goal of proteome-wide profiling of cysteine reactivity across thousand-member libraries under several cellular contexts is now within reach.

Nature Biotechnology published new progress about 79-07-2. 79-07-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Aliphatic hydrocarbon chain,Amide,Inhibitor, name is 2-Chloroacetamide, and the molecular formula is C2H4ClNO, Related Products of amides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Ahmed, Ahmed A. M. published the artcileNew piperazine-based bis(thieno[2,3-b]pyridine) and bis(pyrazolo[3,4-b]pyridine) hybrids linked to benzofuran units: Synthesis and in vitro screening of potential acetylcholinesterase inhibitors, Related Products of amides-buliding-blocks, the publication is Synthetic Communications (2022), 52(6), 912-925, database is CAplus.

Two series of piperazine-based bis(thieno[2,3-b]pyridines) I (Y = CN, COMe, CONH₂, COOEt, COPh) and bis(pyrazolo[3,4-b]pyridines) II (Z = H, Me, OMe, Cl, COOEt) were prepared in good yields, utilizing the appropriate bis(pyridinethione). The first series was obtained by reacting the previous synthon with different α-halogenated reagents, whereas the second series was produced by reacting the synthon with various hydrazonyl chlorides, and then cyclizing the resulting bis(hydrazonothioates). At 50 and 100μM concentrations, the two series were screened as potential acetylcholinesterase inhibitors. The reference donepezil had inhibition percentages of 90.7 and 93.5 at the tested concentrations Generally, bis(thieno[2,3-b]pyridine) series was found to be more effective than the other series of bis(pyrazolo[3,4-b]pyridine). Bis(thieno[2,3-b]pyridine-2-carbonitrile) inhibited acetylcholinesterase the best, with inhibition percentages of 55.2 and 88.4 at 50 and 100μM concentrations, resp. Furthermore, when tested at a concentration of 25μg/mL, the prior hybrid demonstrated the best DPPH antioxidant activity, with an inhibition percentage of 81.5 when compared to the reference ascorbic acid (inhibition percentage of 88.7).

Synthetic Communications published new progress about 79-07-2. 79-07-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Aliphatic hydrocarbon chain,Amide,Inhibitor, name is 2-Chloroacetamide, and the molecular formula is C2H4ClNO, Related Products of amides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics