Category: 78191-00-1

Siddiki, S. M. A. Hakim; Rashed, Nurnobi Md.; Touchy, Abeda Sultana; Jamil, A. R. Md.; Jing, Yuan; Toyao, Takashi; Maeno, Zen; Shimizu, Ken-ichi published their research in Catalysis Science & Technology in 2021. The article was titled 《Hydrolysis of amides to carboxylic acids catalyzed by Nb2O5》.Reference of N-Methoxy-N-methylacetamide The article contains the following contents:

Hydrolysis of amides RC(O)N(R1)R2 (R = Me, cyclohexyl, Ph, Bn, furan-2-yl, etc.; R1 = H, Me, Et, OMe; R2 = H, Me, Et, Ph, Bn) to carboxylic acids RC(O)OH is an industrially important reaction but is challenging due to the difficulty of cleaving the resonance stabilized amidic C-N bond. Twenty-three heterogeneous and homogenous catalysts were examined in the hydrolysis of acetamide. Results showed that Nb2O5 was the most effective heterogeneous catalyst with the greatest yield of acetic acid. A series of Nb2O5 catalysts calcined at various temperatures were characterized and tested in the hydrolysis of acetamide to determine the effects of crystal phase and surface properties of Nb2O5 on catalytic performance. The high catalytic performance observed was attributed mainly to the facile activation of the carbonyl bond by Lewis acid sites that function even in the presence of basic inhibitors (NH3 and H2O). The catalytic studies showed the synthetic advantages of the present method, such as simple operation, catalyst recyclability, additive free, solvent-free, and wide substrate scope (>40 examples; up to 95% isolated yield). In the experimental materials used by the author, we found N-Methoxy-N-methylacetamide(cas: 78191-00-1Reference of N-Methoxy-N-methylacetamide)

N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. Halogenation, in which one or more hydrogen atoms of an amine is replaced by a halogen atom, occurs with chlorine, bromine, and iodine, as well as with some other reagents, notably hypochlorous acid (HClO). With primary amines the reaction proceeds in two stages, producing N-chloro- and N,N-dichloro-amines, RNHCl and RNCl2, respectively. With tertiary amines, an alkyl group may be displaced by a halogen.Reference of N-Methoxy-N-methylacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In 2018,Xiao, Peihong; Cao, Yanjun; Gui, Yingying; Gao, Lu; Song, Zhenlei published 《Me3Si-SiMe2[oCON(iPr)2-C6H4]: An Unsymmetrical Disilane Reagent for Regio- and Stereoselective Bis-Silylation of Alkynes》.Angewandte Chemie, International Edition published the findings.Application In Synthesis of N-Methoxy-N-methylacetamide The information in the text is summarized as follows:

The air-stable unsym. disilane Me3Si-SiMe2[o-CON(iPr)2C6H4] was developed for bis-silylation of alkynes. This reagent tolerates a range of functional groups, providing Z-vinyl disilanes in high yields. It is proposed that the phenyl-ring-tethered amide group directs oxidative addition of Pd0 into the Si-Si bond, which might facilitate formation of a six-membered Pd cycle, generating products with good to excellent regioselectivity. In the experimental materials used by the author, we found N-Methoxy-N-methylacetamide(cas: 78191-00-1Application In Synthesis of N-Methoxy-N-methylacetamide)

N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. Halogenation, in which one or more hydrogen atoms of an amine is replaced by a halogen atom, occurs with chlorine, bromine, and iodine, as well as with some other reagents, notably hypochlorous acid (HClO). With primary amines the reaction proceeds in two stages, producing N-chloro- and N,N-dichloro-amines, RNHCl and RNCl2, respectively. With tertiary amines, an alkyl group may be displaced by a halogen.Application In Synthesis of N-Methoxy-N-methylacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In 2018,Nowak, Monika; Fornal, Emilia; Kontek, Renata; Sroczynski, Dariusz; Jozwiak, Andrzej; Augustowska, Ewelina; Warpas, Anna; Adamczyk, Marta; Malinowski, Zbigniew published 《Synthesis of acylnaphthylamines and their applications in the formation of benzoquinazolines》.ARKIVOC (Gainesville, FL, United States) published the findings.SDS of cas: 78191-00-1 The information in the text is summarized as follows:

The synthesis of acyl N-Boc-1-naphthylamines I (R1 = Me, t-Bu) and N-Boc-2-naphthylamines II (R2 = Me, i-Pr) and their transformation into alkyl substituted benzoquinazolines III (R3 = Me, t-Bu; X = H, Br) and alkyl substituted benzoquinazolinones IV (R4 = Me, i-Pr), V (R5 = Me, t-Bu) through the reaction with formamide or potassium cyanate in the presence of ammonium acetate is described. Presented acyl derivatives were obtained from the reactions of the corresponding lithiated N-Boc naphthylamines with various acetylating agents like AcCl, Ac2O, AcOEt, PivCl, i-PrCOCl and also Weinreb amides. Biol. screening of the potential cytotoxicity on the HT29 cell line and lymphocytes were demonstrated for some benzoquinazoline derivatives After reading the article, we found that the author used N-Methoxy-N-methylacetamide(cas: 78191-00-1SDS of cas: 78191-00-1)

N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. In organic chemistry, amines are compounds and functional groups that contain a basic nitrogen atom with a lone pair. Amines are formally derivatives of ammonia (NH3), wherein one or more hydrogen atoms have been replaced by a substituent such as an alkyl or aryl group (these may respectively be called alkylamines and arylamines; amines in which both types of substituent are attached to one nitrogen atom may be called alkylarylamines).SDS of cas: 78191-00-1

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

The author of 《Hydrogenative Cyclopropanation and Hydrogenative Metathesis》 were Peil, Sebastian; Guthertz, Alexandre; Biberger, Tobias; Fuerstner, Alois. And the article was published in Angewandte Chemie, International Edition in 2019. Formula: C4H9NO2 The author mentioned the following in the article:

The unusual geminal hydrogenation of a propargyl alc. derivative with [CpXRuCl] as the catalyst entails formation of piano stool ruthenium carbenes in the first place; these reactive intermediates can be intercepted with tethered alkenes to give either cyclopropanes or cyclic olefins as the result of a formal metathesis event. The course of the reaction is critically dependent on the substitution pattern of the alkene trap. The results came from multiple reactions, including the reaction of N-Methoxy-N-methylacetamide(cas: 78191-00-1Formula: C4H9NO2)

N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. Acylation is one of the most important reactions of primary and secondary amines; a hydrogen atom is replaced by an acyl group (a group derived from an acid, such as RCOOH or RSO3H, by removal of ―OH, such as RC(=O)―, RS(O)2―, and so on). Reagents may be acid chlorides (RCOC1, RSO2C1), anhydrides ((RCO)2O), or even esters (RCOOR′); the products are amides of the corresponding acids.Formula: C4H9NO2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In 2022,Zhang, Nanping; Jiang, Huanfeng; Ma, Zhiqiang published an article in Angewandte Chemie, International Edition. The title of the article was 《Concise Synthesis of (±)-Myrioneurinol Enabled by Sequential [2+2] Cycloaddition/Retro-Mannich Fragmentation/Mannich Reaction》.Electric Literature of C4H9NO2 The author mentioned the following in the article:

A concise total synthesis of (±)-myrioneurinol has been achieved in 14 steps. An efficient AgSbF6/t-BuCl-catalyzed intramol. [2+2] cycloaddition reaction of the alkynone-tethered enamine was developed to prepare the highly strained cyclobutene. It was used in combination with a subsequent retro-Mannich fragmentation/Mannich reaction to efficiently construct the tricyclic core of myrioneurinol. After reading the article, we found that the author used N-Methoxy-N-methylacetamide(cas: 78191-00-1Electric Literature of C4H9NO2)

N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. Left-handed and right-handed forms (mirror-image configurations, known as optical isomers or enantiomers) are possible when all the substituents on the central nitrogen atom are different (i.e., the nitrogen is chiral). With amines, there is extremely rapid inversion in which the two configurations are interconverted.Electric Literature of C4H9NO2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Tan, Guangying; Das, Mowpriya; Maisuls, Ivan; Strassert, Cristian A.; Glorius, Frank published their research in Angewandte Chemie, International Edition in 2021. The article was titled 《Rhodium-Catalyzed Dealkenylative Arylation of Alkenes with Arylboronic Compounds》.COA of Formula: C4H9NO2 The article contains the following contents:

Herein, the first example of rhodium-catalyzed dealkenylative arylation of alkenes with arylboronic compounds, thereby providing an unconventional access to biaryls with excellent chemoselectivity was diclosed. In this method, C(aryl)-C(alkenyl) and C(alkenyl)-C(alkenyl) bonds in various alkenes and 1,3-dienes could be cleaved via a hydrometalation and followed by β-carbon elimination pathway for Suzuki-Miyaura reactions. Furthermore, a series of novel organic fluorescent mols. with excellent photophys. properties were efficiently constructed with this protocol. The experimental part of the paper was very detailed, including the reaction process of N-Methoxy-N-methylacetamide(cas: 78191-00-1COA of Formula: C4H9NO2)

N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. Reduction of nitro compounds, RNO2, by hydrogen or other reducing agents produces primary amines cleanly (i.e., without a mixture of products), but the method is mostly used for aromatic amines because of the limited availability of aliphatic nitro compounds. Reduction of nitriles and oximes (R2C=NOH) also yields primary amines.COA of Formula: C4H9NO2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Formula: C4H9NO2In 2018 ,《Discovery of a Stress-Activated Protein Kinase Inhibitor for Lymphatic Filariasis》 appeared in ACS Medicinal Chemistry Letters. The author of the article were Tummalapalli, Sreedhar R.; Bhat, Rohit; Chojnowski, Agnieszka; Prorok, Monika; Kreiss, Tamara; Goldberg, Ronald; Canan, Stacie; Hawryluk, Natalie; Mortensen, Deborah; Khetani, Vikram; Zeldis, Jerome; Siekierka, John J.; Rotella, David P.. The article conveys some information:

Lymphatic filariasis infects over 120 million people worldwide and can lead to significant disfigurement and disease. Resistance is emerging with current treatments, and these therapies have dose limiting adverse events; consequently new targets are needed. One approach to achieve this goal is inhibition of parasitic protein kinases involved in circumventing host defense mechanisms. This report describes structure-activity relationships leading to the identification of a potent, orally bioavailable stress activated protein kinase inhibitor that may be used to investigate this hypothesis.N-Methoxy-N-methylacetamide(cas: 78191-00-1Formula: C4H9NO2) was used in this study.

N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. Amines have a free lone pair with which they can coordinate to metal centers. Amine–metal bonds are weaker because amines are incapable of backbonding, but they are still important for sensing applications.While stronger than hydrogen bonds, amine–metal bonds are still weaker than both covalent and ionic bonds.Formula: C4H9NO2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Category: amides-buliding-blocksIn 2021 ,《Synthesis and Applications of Polysubstituted Bicyclo[1.1.0]butanes》 appeared in Journal of the American Chemical Society. The author of the article were McNamee, Ryan E.; Thompson, Amber L.; Anderson, Edward A.. The article conveys some information:

The synthesis of tri- and tetrasubstituted bicyclo[1.1.0]butanes (BCBs) via directed metalation of readily accessed BCB amides is reported. This straightforward “”late stage”” approach generates a wide variety of bridge-substituted BCBs that was easily converted into other useful small ring building blocks. Access to a monodeuterated BCB provides an unprecedented insight into the mechanism of dihalocarbene insertion into BCBs to afford bicyclo[1.1.1]pentanes. In the experiment, the researchers used N-Methoxy-N-methylacetamide(cas: 78191-00-1Category: amides-buliding-blocks)

N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime.Typically the presence of an amine functional group is deduced by a combination of techniques, including mass spectrometry as well as NMR and IR spectroscopies. 1H NMR signals for amines disappear upon treatment of the sample with D2O. In their infrared spectrum primary amines exhibit two N-H bands, whereas secondary amines exhibit only one.Category: amides-buliding-blocks

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

《Discovery of a novel 2,3-dimethylimidazo[1,2-a]pyrazine-6-carboxamide M4 positive allosteric modulator (PAM) chemotype》 was published in Bioorganic & Medicinal Chemistry Letters in 2020. These research results belong to Temple, Kayla J.; Engers, Julie L.; Long, Madeline F.; Watson, Katherine J.; Chang, Sichen; Luscombe, Vincent B.; Jenkins, Matthew T.; Rodriguez, Alice L.; Niswender, Colleen M.; Bridges, Thomas M.; Jeffrey Conn, P.; Engers, Darren W.; Lindsley, Craig W.. Name: N-Methoxy-N-methylacetamide The article mentions the following:

This Letter details the authors’ efforts to discover structurally unique M4 PAMs containing 5,6-heteroaryl ring systems. In an attempt to improve the DMPK profiles of the 2,3-dimethyl-2H-indazole-5-carboxamide and 1-methyl-1H-benzo[d][1,2,3]triazole-6-carboxamide cores, the authors studied a plethora of core replacements. This exercise identified a novel 2,3-dimethylimidazo[1,2-a]pyrazine-6-carboxamide core that provided improved M4 PAM activity and CNS penetration. In the part of experimental materials, we found many familiar compounds, such as N-Methoxy-N-methylacetamide(cas: 78191-00-1Name: N-Methoxy-N-methylacetamide)

N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. Milder oxidation, using reagents such as NaOCl, can remove four hydrogen atoms from primary amines of the type RCH2NH2 to form nitriles (R―C≡N), and oxidation with reagents such as MnO2 can remove two hydrogen atoms from secondary amines (R2CH―NHR′) to form imines (R2C=NR′). Tertiary amines can be oxidized to enamines (R2C=CHNR2) by a variety of reagents.Name: N-Methoxy-N-methylacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In 2016,Chan, Jessica Z.; Yao, Wenzhi; Hastings, Brian T.; Lok, Charles K.; Wasa, Masayuki published 《Direct Mannich-Type Reactions Promoted by Frustrated Lewis Acid/Bronsted Base Catalysts》.Angewandte Chemie, International Edition published the findings.COA of Formula: C4H9NO2 The information in the text is summarized as follows:

Direct Mannich-type reactions that afford both α- and β-amino esters by the reaction of a broad range of carbonyl compounds and aldimines are disclosed. The transformation is promoted by a sterically frustrated Lewis acid/Bronsted base pair, which is proposed to operate cooperatively: Within the catalyst complex, an enolate is generated that then reacts with a hydrogen-bond-activated imine. Noncovalent interactions between reactants and the catalyst provide selectivity and new opportunities for future catalyst design.N-Methoxy-N-methylacetamide(cas: 78191-00-1COA of Formula: C4H9NO2) was used in this study.

N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. Many important products require amines as part of their syntheses. Methylamine is utilized in the production of the analgesic meperidine (trade name Demerol) and the photographic developer Metol (trademark), and dimethylamine is used in the synthesis of the antihistamine diphenhydramine (trade name Benadryl), the solvent dimethylformamide (DMF), and the rocket propellant 1,1-dimethylhydrazine. The synthesis of the insect repellent N,N-diethyl-m-toluamide (DEET) incorporates diethylamine while that of the synthetic fibre Kevlar requires aromatic amines.COA of Formula: C4H9NO2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics