Category: 78191-00-1

In 2017,Diehl, Julian; Brueckner, Reinhard published 《Synthesis of Enantiomerically Pure β-Hydroxy Ketones via β-Keto Weinreb Amides by a Condensation/Asymmetric-Hydrogenation/Acylation Sequence》.European Journal of Organic Chemistry published the findings.Product Details of 78191-00-1 The information in the text is summarized as follows:

An established route to enantiomerically pure β-hydroxy ketones proceeds through the asym. hydrogenation of β-keto esters, an ester/amide exchange, and the use of the resulting β-hydroxy amide for the acylation of an organometallic compound The authors shortened this route by showing that β-keto Weinreb amides are hydrogenated with up to 99% ee in the presence of [Me2NH2]+{[RuCl(S)-BINAP]2(μ-Cl)3}- (0.5 mol-%) at room temperature/5 bar. These Weinreb amides were prepared by seemingly obvious yet unprecedented condensations of lithiated N-methoxy-N-methylacetamide with carboxylic chlorides (51-87% yield). The resulting β-hydroxy Weinreb amides were used for the acylation of organolithium and Grignard reagents. They thus gave enantiomerically pure β-hydroxy ketones (28 examples). A selection of these compounds gave anti-1,3-diols after another C:O bond hydrogenation, or syn-1,3-diols by a Narasaka-Prasad reduction In the experiment, the researchers used N-Methoxy-N-methylacetamide(cas: 78191-00-1Product Details of 78191-00-1)

N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. Amine, any member of a family of nitrogen-containing organic compounds that is derived, either in principle or in practice, from ammonia (NH3). Naturally occurring amines include the alkaloids, which are present in certain plants; the catecholamine neurotransmitters (i.e., dopamine, epinephrine, and norepinephrine); and a local chemical mediator, histamine, that occurs in most animal tissues.Product Details of 78191-00-1

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In 2018,Journal of Medicinal Chemistry included an article by Helal, Christopher J.; Arnold, Eric; Boyden, Tracey; Chang, Cheng; Chappie, Thomas A.; Fisher, Ethan; Hajos, Mihaly; Harms, John F.; Hoffman, William E.; Humphrey, John M.; Pandit, Jayvardhan; Kang, Zhijun; Kleiman, Robin J.; Kormos, Bethany L.; Lee, Che-Wah; Lu, Jiemin; Maklad, Noha; McDowell, Laura; McGinnis, Dina; OConnor, Rebecca E.; ODonnell, Christopher J.; Ogden, Adam; Piotrowski, Mary; Schmidt, Christopher J.; Seymour, Patricia A.; Ueno, Hirokazu; Vansell, Nichole; Verhoest, Patrick R.; Yang, Edward X.. Recommanded Product: N-Methoxy-N-methylacetamide. The article was titled 《Identification of a Potent, Highly Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor Clinical Candidate》. The information in the text is summarized as follows:

Computational modeling was used to direct the synthesis of analogs of previously reported phosphodiesterase 2A (PDE2A) inhibitor (I) with an imidazotriazine core to yield compounds of significantly enhanced potency. The analog PF-05180999 (30) was subsequently identified as a preclin. candidate targeting cognitive impairment associated with schizophrenia. Compound 30 demonstrated potent binding to PDE2A in brain tissue, dose responsive mouse brain cGMP increases, and reversal of N-methyl-D-aspartate (NMDA) antagonist-induced (MK-801, ketamine) effects in electrophysiol. and working memory models in rats. Preclin. pharmacokinetics revealed unbound brain/unbound plasma levels approaching unity and good oral bioavailability resulting in an average concentration at steady state (Cav,ss) predicted human dose of 30 mg once daily (q.d.). Modeling of a modified release formulation suggested that 25 mg twice daily (b.i.d.) could maintain plasma levels of 30 at or above targeted efficacious plasma levels for 24 h, which became part of the human clin. plan. In the experimental materials used by the author, we found N-Methoxy-N-methylacetamide(cas: 78191-00-1Recommanded Product: N-Methoxy-N-methylacetamide)

N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. To avoid the problem of multiple alkylation, methods have been devised for “blocking” substitution so that only one alkyl group is introduced. The Gabriel synthesis is one such method; it utilizes phthalimide, C6H4(CO)2NH, whose one acidic hydrogen atom has been removed upon the addition of a base such as KOH to form a salt.Recommanded Product: N-Methoxy-N-methylacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In 2018,Journal of Medicinal Chemistry included an article by Gerasyuto, Aleksey I.; Arnold, Michael A.; Wang, Jiashi; Chen, Guangming; Zhang, Xiaoyan; Smith, Sean; Woll, Matthew G.; Baird, John; Zhang, Nanjing; Almstead, Neil G.; Narasimhan, Jana; Peddi, Srinivasa; Dumble, Melissa; Sheedy, Josephine; Weetall, Marla; Branstrom, Arthur A.; Prasad, J. V. N.; Karp, Gary M.. Computed Properties of C4H9NO2. The article was titled 《Discovery and Optimization of Indolyl-Containing 4-Hydroxy-2-Pyridone Type II DNA Topoisomerase Inhibitors Active against Multidrug Resistant Gram-negative Bacteria》. The information in the text is summarized as follows:

There exists an urgent medical need to identify new chem. entities (NCEs) targeting multidrug resistant (MDR) bacterial infections, particularly those caused by Gram-neg. pathogens. 4-Hydroxy-2-pyridones represent a novel class of nonfluoroquinolone inhibitors of bacterial type II topoisomerases active against MDR Gram-neg. bacteria. Herein, authors report on the discovery and structure-activity relationships of a series of fused indolyl-containing 4-hydroxy-2-pyridones with improved in vitro antibacterial activity against fluoroquinolone resistant strains. Compounds 10-((sec-butylamino)methyl)-4-hydroxy-9-methyl-2-oxo-2,5,6,9-tetrahydro-1H-pyrido[2′,3′:4,5]oxepino[3,2-f]indole-3-carboxylic acid hydrochloride (6o) and 4-hydroxy-9-methyl-2-oxo-10-(pyrrolidin-1-ylmethyl)-1,2,5,6,7,9-hexahydropyrido[3′,2′:6,7]cyclohepta[1,2-f]indole-3-carboxylic acid hydrochloride (6v) are representative of this class, targeting both bacterial DNA gyrase and topoisomerase IV (Topo IV). In an abbreviated susceptibility screen, compounds 6o and 6v showed improved MIC90 values against Escherichia coli (0.5-1 μg/mL) and Acinetobacter baumannii (8-16 μg/mL) compared to the precursor compounds In a murine septicemia model, both compounds showed complete protection in mice infected with a LD of E. coli. In the experimental materials used by the author, we found N-Methoxy-N-methylacetamide(cas: 78191-00-1Computed Properties of C4H9NO2)

N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 → R2N―NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.Computed Properties of C4H9NO2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In 2017,Ganiek, Maximilian A.; Becker, Matthias R.; Berionni, Guillaume; Zipse, Hendrik; Knochel, Paul published 《Barbier Continuous Flow Preparation and Reactions of Carbamoyllithiums for Nucleophilic Amidation》.Chemistry – A European Journal published the findings.Application of 78191-00-1 The information in the text is summarized as follows:

An ambient temperature continuous flow method for nucleophilic amidation and thioamidation was described. Deprotonation of formamides e.g., N,N-diethylformamide by lithium diisopropylamine (LDA) affords carbamoyllithium intermediates that are quenched in situ with various electrophiles such as ketones e.g., cyclohexanone, allyl bromides, Weinreb amides e.g., N-methoxy-N-methylacetamide and morpholino amides RC(O)R1 [R = C6H5, 4-FC6H4, CH(OC2H5)2, etc.; R1 = morpholin-4-yl]. The nature of the reactive lithium intermediates and the thermodn. of the metalation were further investigated by ab initio calculations and kinetic experiments In the experiment, the researchers used many compounds, for example, N-Methoxy-N-methylacetamide(cas: 78191-00-1Application of 78191-00-1)

N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. Milder oxidation, using reagents such as NaOCl, can remove four hydrogen atoms from primary amines of the type RCH2NH2 to form nitriles (R―C≡N), and oxidation with reagents such as MnO2 can remove two hydrogen atoms from secondary amines (R2CH―NHR′) to form imines (R2C=NR′). Tertiary amines can be oxidized to enamines (R2C=CHNR2) by a variety of reagents.Application of 78191-00-1

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In 2022,Thangavelu, Sangeetha; Balasubramanian, Balamuralikrishnan; Palanisamy, Sampathkumar; Shanmugam, Velayuthaprabhu; Natchiappan, Senthilkumar; Kalibulla, Syed Ibrahim; Rathinasamy, Baskaran; Arumugam, Vijaya Anand published an article in South African Journal of Botany. The title of the article was 《Characterization and phytoconstituents of Petroselinum crispum (Mill) and Coriandrum sativum (Linn) and their impacts on inflammation-An in vitro analysis against human adenocarcinoma cells with molecular docking》.Application In Synthesis of N-Methoxy-N-methylacetamide The author mentioned the following in the article:

Petroselinum crispum (Mill) and Coriandrum sativum (Linn) are common culinary herbs enriched with a wide range of nutrients and minerals. The phytochems. found in these plants as secondary metabolites are useful against a variety of clin. diseases such as inflammation, diabetes, and cancer. The current study used in vitro studies on adenocarcinoma human alveolar basal epithelial (A549) cells to identify the phytochem. compounds present in the petroleum ether, methanol, and aqueous extracts of P. crispum and C. sativum leaves, as well as to depict the influence of these herbs in wound healing and inflammation. In all, 1761 compounds have been found in the leaf extracts of P. crispum and C. sativum, and the identified compounds have been tested in silico against binding receptors such as CD36 and antitrypsin receptors to determine their binding affinity. The extracts had lower IC50 values on A549 cells, suggesting lower toxicity, as well as substantially faster cell migration after treatment with P. crispum and C. sativum extracts, compared to untreated cells, implying that the extracts have high anti-inflammatory activity. Among P. crispum and C. sativum extracts, the healing of the wound was faster when treated with the extracts of P. crispum. The experimental part of the paper was very detailed, including the reaction process of N-Methoxy-N-methylacetamide(cas: 78191-00-1Application In Synthesis of N-Methoxy-N-methylacetamide)

N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. Amines can be classified according to the nature and number of substituents on nitrogen. Aliphatic amines contain only H and alkyl substituents. Aromatic amines have the nitrogen atom connected to an aromatic ring.Important amines include amino acids, biogenic amines, trimethylamine, and aniline. Inorganic derivatives of ammonia are also called amines, such as monochloramine (NClH2).Application In Synthesis of N-Methoxy-N-methylacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

The author of 《Internal Nucleophilic Catalyst Mediated Cyclisation/Ring Expansion Cascades for the Synthesis of Medium-Sized Lactones and Lactams》 were Lawer, Aggie; Rossi-Ashton, James A.; Stephens, Thomas C.; Challis, Bradley J.; Epton, Ryan G.; Lynam, Jason M.; Unsworth, William P.. And the article was published in Angewandte Chemie, International Edition in 2019. Application In Synthesis of N-Methoxy-N-methylacetamide The author mentioned the following in the article:

A strategy for the synthesis of medium-sized lactones and lactams from linear precursors is described in which an amine acts as an internal nucleophilic catalyst to facilitate a novel cyclisation/ring expansion cascade sequence. This method obviates the need for the high-dilution conditions usually associated with medium-ring cyclisation protocols, as the reactions operate exclusively via kinetically favorable “”normal””-sized cyclic transition states. This same feature also enables biaryl-containing medium-sized rings to be prepared with complete atroposelectivity by point-to-axial chirality transfer. In the part of experimental materials, we found many familiar compounds, such as N-Methoxy-N-methylacetamide(cas: 78191-00-1Application In Synthesis of N-Methoxy-N-methylacetamide)

N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. Aniline, ethanolamines, and several other amines are major industrial commodities used in making rubber, dyes, pharmaceuticals, and synthetic resins and fibres and for a host of other applications. Most of the numerous methods for the preparation of amines may be broadly divided into two groups: (1) chemical reduction (replacement of oxygen with hydrogen atoms in the molecule) of members of several other classes of organic nitrogen compounds and (2) reactions of ammonia or amines with organic compounds.Application In Synthesis of N-Methoxy-N-methylacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In 2016,Wang, Shitao; Sawada, Tomohisa; Ohara, Kazuaki; Yamaguchi, Kentaro; Fujita, Makoto published 《Capsule-Capsule Conversion by Guest Encapsulation》.Angewandte Chemie, International Edition published the findings.Recommanded Product: 78191-00-1 The information in the text is summarized as follows:

Guest-induced M18L6-M24L8 capsule-capsule conversion is reported. Both capsules are composed of PdII ethylenediamine units (M) and 1,3,5-tris(3,5-pyrimidyl)pyrimidine (L), and form trigonal bipyramidal (M18L6) and octahedral (M24L8) closed-shell structures with huge hydrophobic inner spaces. The M18L6 trigonal bipyramid is converted to the M24L8 octahedron through encapsulation of large aromatic guests, with the latter capsule possessing a cavity volume three times larger than the former. Despite the dynamic properties of the capsule host, the encapsulated guests are difficult to extract and were thus isolated from the external environment. In the part of experimental materials, we found many familiar compounds, such as N-Methoxy-N-methylacetamide(cas: 78191-00-1Recommanded Product: 78191-00-1)

N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. Reduction of nitro compounds, RNO2, by hydrogen or other reducing agents produces primary amines cleanly (i.e., without a mixture of products), but the method is mostly used for aromatic amines because of the limited availability of aliphatic nitro compounds. Reduction of nitriles and oximes (R2C=NOH) also yields primary amines.Recommanded Product: 78191-00-1

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

The author of 《Nickel-Catalyzed Carbofluoroalkylation of 1,3-Enynes to Access Structurally Diverse Fluoroalkylated Allenes》 were Zhang, Kai-Fan; Bian, Kang-Jie; Li, Chao; Sheng, Jie; Li, Yan; Wang, Xi-Sheng. And the article was published in Angewandte Chemie, International Edition in 2019. Safety of N-Methoxy-N-methylacetamide The author mentioned the following in the article:

A nickel-catalyzed 1,4-carbofluoroalkylation of 1,3-enynes R1CCC(R2)=CH2 [R1 = H, heptyl, cyclohexyl, Ph, thiophen-3-yl, etc.; R2 = Me, H, Ph, (CH2)2OC(O)CH3] to access structurally diverse fluoroalkylated allenes R3C(R1)=C=C(R2)CH2R4 [R3 = Ph, naphthalen-2-yl, 2-methylphenyl, etc.; R4 = CF2C(O)OCH2CH3, CF3, CF2C6H5, etc.;] has been established. This method has demonstrated high catalytic reactivity, mild reaction conditions, broad substrate scope, and excellent functional-group tolerance. The key to success is the use of a nickel catalyst to generate different fluoroalkyl radicals from readily available and structurally diverse fluoroalkyl halides R4X (X = Br, I) to access 1,4-difunctionalization of 1,3-enynes by a radical relay. This strategy provides facile synthesis of structurally diverse multisubstituted allenes, and offers a solution for batch production of various fluorinated bioactive mols. for drug discovery by further transformations. After reading the article, we found that the author used N-Methoxy-N-methylacetamide(cas: 78191-00-1Safety of N-Methoxy-N-methylacetamide)

N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. Halogenation, in which one or more hydrogen atoms of an amine is replaced by a halogen atom, occurs with chlorine, bromine, and iodine, as well as with some other reagents, notably hypochlorous acid (HClO). With primary amines the reaction proceeds in two stages, producing N-chloro- and N,N-dichloro-amines, RNHCl and RNCl2, respectively. With tertiary amines, an alkyl group may be displaced by a halogen.Safety of N-Methoxy-N-methylacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In 2018,Science (Washington, DC, United States) included an article by Trost, Barry M.; Huang, Zhongxing; Murhade, Ganesh M.. HPLC of Formula: 78191-00-1. The article was titled 《Catalytic palladium-oxyallyl cycloaddition》. The information in the text is summarized as follows:

Exploration of intermediates that enable chemoselective cycloaddition reactions and expeditious construction of fused- or bridged-ring systems is a continuous challenge for organic synthesis. As an intermediate of interest, the oxyallyl cation was harnessed to synthesize architectures containing seven-membered rings via (4+3) cycloaddition However, its potential to access five-membered skeletons is underdeveloped, largely due to the thermally forbidden (3+2) pathway. Here, the combination of a tailored precursor and a Pd(0) catalyst generates a Pd-oxyallyl intermediate that cyclizes with conjugated dienes to produce a diverse array of THF skeletons. The cycloaddition overrides conventional (4+3) selectivity by proceeding through a stepwise pathway involving a Pd-allyl transfer and ring closure sequence. Subsequent treatment of the (3+2) adducts with a palladium catalyst converts the heterocycles to the carbocyclic cyclopentanones. In the experiment, the researchers used many compounds, for example, N-Methoxy-N-methylacetamide(cas: 78191-00-1HPLC of Formula: 78191-00-1)

N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.HPLC of Formula: 78191-00-1

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Ren, Zhiqiang; Sun, Zhongliu; Li, Yifei; Fan, Xin; Dai, Mingda; Wang, Yunxia; Hu, Xiangdong published their research in Angewandte Chemie, International Edition in 2021. The article was titled 《Total Synthesis of (+)-3-Deoxyfortalpinoid F, (+)-Fortalpinoid A, and (+)-Cephinoid H》.Category: amides-buliding-blocks The article contains the following contents:

3-Deoxyfortalpinoid F, fortalpinoid A, and cephinoid H are members of the Cephalotaxus diterpenoids class of natural products, which feature diverse chem. structures and valuable biol. activities. We report herein the development of a diastereoselective Pauson-Khand reaction as an effective pathway to access the core tetracyclic skeleton, which is found widely in Cephalotaxus diterpenoids. Furthermore, we enabled the construction of the tropone moiety through a ring-closing metathesis/elimination protocol. Based on the developed strategy, asym. synthesis of the title compounds has been achieved for the first time. In the experiment, the researchers used N-Methoxy-N-methylacetamide(cas: 78191-00-1Category: amides-buliding-blocks)

N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. Large quantities of aliphatic amines are made synthetically. The most widely used industrial method is the reaction of alcohols with ammonia at a high temperature, catalyzed by metals or metal oxide catalysts (e.g., nickel or copper). Mixtures of primary, secondary, and tertiary amines are thereby produced.Category: amides-buliding-blocks

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics