Category: 78191-00-1

《Trans-Selective hydrocyanation of ynoates, ynones and ynoic acids catalyzed by nucleophilic phosphines》 was written by Schoemberg, Fritz; Peric, Milica; Meyer, Maximilian; Vilotijevic, Ivan. Formula: C4H9NO2This research focused ontrimethylsilyl cyanide phenyl propynoate methyldiphenylphosphine catalyst diastereoselective hydrocyanation; cyano phenyl acrylate regioselective preparation; trimethylsilanecarbonitrile phenyl propynoic acid methyldiphenylphosphine catalyst diastereoselective hydrocyanation; phenyl cyano acrylic acid regioselective preparation. The article conveys some information:

Trans-Selective hydrocyanation of ynoates and ynones in the presence of TMSCN and an alc. additive were catalyzed by nucleophilic phosphines. The trisubstituted E-olefin products of anti-addition of hydrogen cyanide to the alkyne were produced with high regio- and stereoselectivity. The alc. additive reacts with TMSCN to produce hydrogen cyanide in situ. Ynoic acids underwent the phosphine catalyzed hydrocyanation in the presence of TMSCN under aprotic conditions only. In these reactions, TMSCN reacted with the acid to generate hydrogen cyanide and the silyl ester which, unlike the acid, undergoes phosphine catalyzed hydrocyanation and gave the stereo-defined E-2-cyano-acrylic acids after work up.N-Methoxy-N-methylacetamide(cas: 78191-00-1Formula: C4H9NO2) was used in this study.

N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. Amines can be classified according to the nature and number of substituents on nitrogen. Aliphatic amines contain only H and alkyl substituents. Aromatic amines have the nitrogen atom connected to an aromatic ring.Important amines include amino acids, biogenic amines, trimethylamine, and aniline. Inorganic derivatives of ammonia are also called amines, such as monochloramine (NClH2).Formula: C4H9NO2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Zhang, Fuhao; Zeng, Jingwen; Gao, Mohan; Wang, Linzhou; Chen, Gen-Qiang; Lu, Yixin; Zhang, Xumu published their research in Nature Chemistry in 2021. The article was titled 《Concise, scalable and enantioselective total synthesis of prostaglandins》.HPLC of Formula: 78191-00-1 The article contains the following contents:

Prostaglandins are among the most important natural isolates owing to their broad range of bioactivities and unique structures. However, current methods for the synthesis of prostaglandins suffer from low yields and lengthy steps. Here, we report a practicability-oriented synthetic strategy for the enantioselective and divergent synthesis of prostaglandins. In this approach, the multiply substituted five-membered rings in prostaglandins were constructed via the key enyne cycloisomerization with excellent selectivity (>20:1 d.r., 98% e.e.). The crucial chiral center on the scaffold of the prostaglandins was installed using the asym. hydrogenation method (up to 98% yield and 98% e.e.). From our versatile common intermediates, a series of prostaglandins and related drugs could be produced in two steps, and fluprostenol could be prepared on a 20-g scale. In the experiment, the researchers used many compounds, for example, N-Methoxy-N-methylacetamide(cas: 78191-00-1HPLC of Formula: 78191-00-1)

N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. Milder oxidation, using reagents such as NaOCl, can remove four hydrogen atoms from primary amines of the type RCH2NH2 to form nitriles (R―C≡N), and oxidation with reagents such as MnO2 can remove two hydrogen atoms from secondary amines (R2CH―NHR′) to form imines (R2C=NR′). Tertiary amines can be oxidized to enamines (R2C=CHNR2) by a variety of reagents.HPLC of Formula: 78191-00-1

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

The author of 《Making Carbonyls of Amides Nucleophilic and Hydroxyls of Alcohols Electrophilic Mediated by SO2F2 for Synthesis of Esters from Amides》 were Fang, Wan-Yin; Zha, Gao-Feng; Qin, Hua-Li. And the article was published in Organic Letters in 2019. Electric Literature of C4H9NO2 The author mentioned the following in the article:

The promotion of sulfuryl fluoride, the carbonyl groups of amides performed as nucleophiles while the hydroxyl groups of alcs. were activated to functionalize as electrophiles is reported. This study displayed that the amide C-N bonds could be easily cleaved with delicate nucleophiles to form the ester C-O bonds at room temperature without using transition metals. The broad substrate scope and excellent functional group compatibility were proved with 44 examples in up to 99% yields. The experimental part of the paper was very detailed, including the reaction process of N-Methoxy-N-methylacetamide(cas: 78191-00-1Electric Literature of C4H9NO2)

N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. Hydrogen peroxide (H2O2) and peroxy acids generally add an oxygen atom to the nitrogen of amines. With primary amines, this step is normally followed by further oxidation, leading to nitroso compounds, RNO, or nitro compounds, RNO2. Secondary amines are converted to hydroxylamines, R2NOH, and tertiary amines to amine oxides, R3NO.Electric Literature of C4H9NO2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Reference of N-Methoxy-N-methylacetamideIn 2019 ,《Asymmetric synthesis of natural cis-dihydroarenediols using tetrahydroxynaphthalene reductase and its biosynthetic implications》 was published in Organic Letters. The article was written by Saha, Nirmal; Muller, Michael; Husain, Syed Masood. The article contains the following contents:

Asym. reduction of hydroxynaphthoquinones to secondary metabolites, (3S,4R)-3,4,8- and (2S,4R)-2,4,8-trihydroxy-1-tetralone, a putative biosynthetic diketo intermediate and a probable natural analog, (3S,4R)-7-acetyl-3,4,8-trihydroxy-6-methyl-3,4-dihydronaphthalene-1(2H)-one, using NADPH-dependent tetrahydroxynaphthalene reductase (T4HNR) of Magnaporthe grisea is described. This work implies the involvement of T4HNR or related enzymes during the (bio)synthesis of other dihydroarenediols by reduction of the hydroxynaphthoquinone scaffold containing substrates. The experimental part of the paper was very detailed, including the reaction process of N-Methoxy-N-methylacetamide(cas: 78191-00-1Reference of N-Methoxy-N-methylacetamide)

N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. Aniline, ethanolamines, and several other amines are major industrial commodities used in making rubber, dyes, pharmaceuticals, and synthetic resins and fibres and for a host of other applications. Most of the numerous methods for the preparation of amines may be broadly divided into two groups: (1) chemical reduction (replacement of oxygen with hydrogen atoms in the molecule) of members of several other classes of organic nitrogen compounds and (2) reactions of ammonia or amines with organic compounds.Reference of N-Methoxy-N-methylacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Name: N-Methoxy-N-methylacetamideIn 2016 ,《A novel domino reaction for the preparation of substituted non-racemic β-proline derivatives》 appeared in Tetrahedron. The author of the article were Gilbert, Eric J.; Brunskill, Andrew; Cai, Jiaqiang; Cai, Yaxian; Chu, Xin-Jie; Dai, Xing; Hao, Jinsong; Kuethe, Jeffrey T.; Lai, Zhong; Liu, Hong; Mu, Cuizhi; Qi, Yan; Scott, Jack D.; Taoka, Brandon; Truong, Quang; Walsh, Shawn P.; Wu, Wen-Lian; Cumming, Jared N.. The article conveys some information:

A novel domino reaction for the preparation of non-racemic β-proline derivatives is reported. The addition of a Me 2-(oxetan-3-yl)acetate titanium enolate to chiral tert-butanesulfinyl ketimines followed by an intramol. oxetane ring-opening provides the highly-substituted pyrrolidine ring systems with three contiguous stereogenic centers. In the experiment, the researchers used N-Methoxy-N-methylacetamide(cas: 78191-00-1Name: N-Methoxy-N-methylacetamide)

N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. Examples of direct uses of amines and their salts are as corrosion inhibitors in boilers and in lubricating oils (morpholine), as antioxidants for rubber and roofing asphalt (diarylamines), as stabilizers for cellulose nitrate explosives (diphenylamine), as protectants against damage from gamma radiation (diarylamines), as developers in photography (aromatic diamines), as flotation agents in mining, as anticling and waterproofing agents for textiles, as fabric softeners, in paper coating, and for solubilizing herbicides.Name: N-Methoxy-N-methylacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In 2022,Epton, Ryan G.; Unsworth, William P.; Lynam, Jason M. published an article in Organometallics. The title of the article was 《Selectivity, Speciation, and Substrate Control in the Gold-Catalyzed Coupling of Indoles and Alkynes》.SDS of cas: 78191-00-1 The author mentioned the following in the article:

A convenient and mild protocol for the Au-catalyzed intermol. coupling of substituted indoles with carbonyl-functionalized alkynes to give vinyl indoles is reported. This reaction affords 3-substituted indoles in high yield, and in contrast to the analogous reactions with simple alkynes which give bisindolemethanes, only a single indole is added to the alkyne. The protocol is robust and tolerates substitution at a range of positions of the indole and the use of ester-, amide- and ketone-substituted alkynes. The use of 3-substituted indoles as substrates results in the introduction of the vinyl substituent at the 2-position of the ring. A combined exptl. and computational mechanistic study revealed that the Au catalyst has a greater affinity to the indole than the alkyne, despite the C-C bond formation step proceeding through an η2(π)-alkyne complex, which helps to explain the Stark differences between the intra- and intermol. variants of the reaction. Also the addition of a 2nd indole to the carbonyl-containing vinyl indole products is both kinetically and thermodynamically less favored than in the case of more simple alkynes, providing an explanation for the observed selectivity. Finally, a highly unusual Au-promoted alkyne dimerization reaction to form a substituted Au pyrylium salt was identified and studied. In the experiment, the researchers used many compounds, for example, N-Methoxy-N-methylacetamide(cas: 78191-00-1SDS of cas: 78191-00-1)

N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 → R2N―NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.SDS of cas: 78191-00-1

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Hess, Andreas; Prohaska, Jan P.; Doerrich, Sabrina B.; Trauner, Florian; Lutter, Ferdinand H.; Lemaire, Sebastien; Wagschal, Simon; Karaghiosoff, Konstantin; Knochel, Paul published an article in 2021. The article was titled 《Directed regioselective ortho,ortho’-magnesiations of aromatics and heterocycles using sBu2Mg in toluene》, and you may find the article in Chemical Science.Synthetic Route of C4H9NO2 The information in the text is summarized as follows:

The development of a toluene-soluble dialkylmagnesium base sec-Bu2Mg was reported. This new reagent allows mild and regioselective ortho-magnesiations of various N-arylated pyrazoles as well as arenes bearing oxazolines, phosphorodiamidate or amide directing groups e.g., I. The resulting diarylmagnesium reagents e.g., II were further functionalized either by Pd-catalyzed arylation or by trapping reactions with a broad range of electrophiles e.g., allyl bromide. Furthermore, several double ortho,ortho;-magnesiations were realized in the case of aryl oxazolines, N-aryl pyrazoles as well as 2-aryl-2H-1,2,3-triazoles e.g., IIIby simply repeating the magnesiation/electrophile trapping sequence allowing the preparation of valuable 1,2,3-functionalized arenes e.g., IV. In the experiment, the researchers used many compounds, for example, N-Methoxy-N-methylacetamide(cas: 78191-00-1Synthetic Route of C4H9NO2)

N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. Amines characteristically form salts with acids; a hydrogen ion, H+, adds to the nitrogen. With the strong mineral acids (e.g., H2SO4, HNO3, and HCl), the reaction is vigorous. Salt formation is instantly reversed by strong bases such as NaOH. Neutral electrophiles (compounds attracted to regions of negative charge) also react with amines; alkyl halides (R′X) and analogous alkylating agents are important examples of electrophilic reagents.Synthetic Route of C4H9NO2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Formula: C4H9NO2In 2020 ,《Design, synthesis, antitumor activity and theoretical calculation of novel PI3Ka inhibitors》 appeared in Bioorganic Chemistry. The author of the article were Jin, Ru-Yi; Tang, Tian; Zhou, Sha; Long, Xu; Guo, Hui; Zhou, Jing; Yan, Hao; Li, Zhi; Zuo, Zheng-Yu; Xie, Hong-Lei; Tang, Yu-Ping. The article conveys some information:

PI3Kα has been identified as an ideal target to treat with PIK3CA gene mutation disease, including drugs such as Alpelisib and Copanlisib. Five purine analogs and four thiazole analogs were designed and synthesized. Their enzymic activity against PI3Ka/β/γ/δ were tested, resp. All compounds showed excellent selectivity in modulating PI3Ka activity, and parts of the compounds showed good inhibition. Meanwhile, Autodock 4.2 was used to explore the binding mode of I (X = CH2), the most potent compound, with the target protein. In addition, DFT was used to calculate the HOMO-LUMO maps of the compounds I (X = CH2, O)and pos. control. This paper will provide some useful information for further drug design of PI3Kα inhibitors. In addition to this study using N-Methoxy-N-methylacetamide, there are many other studies that have used N-Methoxy-N-methylacetamide(cas: 78191-00-1Formula: C4H9NO2) was used in this study.

N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. Acylation is one of the most important reactions of primary and secondary amines; a hydrogen atom is replaced by an acyl group (a group derived from an acid, such as RCOOH or RSO3H, by removal of ―OH, such as RC(=O)―, RS(O)2―, and so on). Reagents may be acid chlorides (RCOC1, RSO2C1), anhydrides ((RCO)2O), or even esters (RCOOR′); the products are amides of the corresponding acids.Formula: C4H9NO2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

The author of 《Vanadium-Catalyzed Coupling of Allenols with Electrophilic Halide Sources for the Formation of α-Halo-α’,β’-unsaturated Ketones》 were Trost, Barry M.; Tracy, Jacob S.; Yusoontorn, Tas. And the article was published in Organic Letters in 2019. Product Details of 78191-00-1 The author mentioned the following in the article:

In the presence of tris(triarylsiloxy)oxovanadium complexes, allenyl alcs. such as PhCH(OH)CH:C:CHMe underwent chemoselective and diastereoselective fluorination, chlorination, and bromination (coupling reactions) with electrophilic halogen sources to yield α’-halo-α,β-unsaturated ketones such as (E)-PhCH:CHCOCHRMe (R = F, Cl, Br)(I) as single olefin diastereomers. Nucleophilic substitution reactions of I (R = Br) yielded I (R = N3, NC, PhS, I).N-Methoxy-N-methylacetamide(cas: 78191-00-1Product Details of 78191-00-1) was used in this study.

N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. Large quantities of aliphatic amines are made synthetically. The most widely used industrial method is the reaction of alcohols with ammonia at a high temperature, catalyzed by metals or metal oxide catalysts (e.g., nickel or copper). Mixtures of primary, secondary, and tertiary amines are thereby produced.Product Details of 78191-00-1

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

《Expanding Zirconocene Hydride Catalysis: In Situ Generation and Turnover of ZrH Catalysts Enabling Catalytic Carbonyl Reductions》 was written by Kehner, Rebecca A.; Hewitt, Matthew Christian; Bayeh-Romero, Liela. Electric Literature of C4H9NO2This research focused onzirconium hydride in situ preparation zirconocene dichloride hydrosilane; ketone aldehyde enone ynone lactone reduction zirconium hydride catalyst. The article conveys some information:

Despite the wide use and popularity of metal hydride catalysis, methods utilizing zirconium hydride catalysts remain underexplored. Here, authors report the development of a mild method for the in situ prepatation. and use of zirconium hydride catalysts. This robust method requires only 2.5-5 mol % of zirconocene dichloride in combination with a hydrosilane as the stoichiometric reductant and does not necessitate careful air- or moisture-free technique. A key finding of this study concerns an amine-mediated ligand exchange en route to the active zirconocene hydride catalyst. Mechanistic investigation supports the intermediacy of an oxo-bridged dimer precatalyst. The application of this method to the reduction of a wide variety of carbonyl-containing substrates, including ketones, aldehydes, enones, ynones, and lactones is demonstrated with up to 92% yield and exhibiting broad functional group tolerability. These findings open up alternative avenues for the catalytic application of chlorozirconocenes, potentially serving as the foundation for broader applications of zirconium hydride catalysis. In the experimental materials used by the author, we found N-Methoxy-N-methylacetamide(cas: 78191-00-1Electric Literature of C4H9NO2)

N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. Aniline, ethanolamines, and several other amines are major industrial commodities used in making rubber, dyes, pharmaceuticals, and synthetic resins and fibres and for a host of other applications. Most of the numerous methods for the preparation of amines may be broadly divided into two groups: (1) chemical reduction (replacement of oxygen with hydrogen atoms in the molecule) of members of several other classes of organic nitrogen compounds and (2) reactions of ammonia or amines with organic compounds.Electric Literature of C4H9NO2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics