Category: 78191-00-1

《Formation of Aryl [1-Cyano-4-(dialkylamino)butadienyl] Ketones from Pyridines》 was written by Gim, Hyo Jin; Jung, Michael E.. Safety of N-Methoxy-N-methylacetamideThis research focused onWeinreb amide chloropyridine dialkylamine ring opening addition reaction; carbonyl dialkylamino pentadienenitrile preparation. The article conveys some information:

Treatment of 2-chloropyridine with LDA and the Weinreb amide of benzoic acid afforded three unusual products, namely N-methylbenzamide, 2-chloropyridine-3-methanol and the ring-opened addition product. This same final product could also be obtained from 2-chloro-3-benzoylpyridine on treatment with LDA. Mechanistic insight for the formation of these products is provided. In the part of experimental materials, we found many familiar compounds, such as N-Methoxy-N-methylacetamide(cas: 78191-00-1Safety of N-Methoxy-N-methylacetamide)

N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.Safety of N-Methoxy-N-methylacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In 2017,Suna, Yuki; Himeda, Yuichiro; Fujita, Etsuko; Muckerman, James T.; Ertem, Mehmed Z. published 《Iridium Complexes with Proton-Responsive Azole-Type Ligands as Effective Catalysts for CO2 Hydrogenation》.ChemSusChem published the findings.COA of Formula: C4H9NO2 The information in the text is summarized as follows:

Pentamethylcyclopentadienyl Ir (Cp*Ir) complexes with bidentate ligands consisting of a pyridine ring and an electron-rich diazole ring were prepared Their catalytic activity toward CO2 hydrogenation in 2.0 M KHCO3 aqueous solutions (pH 8.5) at 50°, under 1.0 MPa CO2/H2 (1:1) are reported as an alternative to photo- and electrochem. CO2 reduction Bidentate ligands incorporating an electron-rich diazole ring improved the catalytic performance of the Ir complexes compared to the bipyridine ligand. Complexes 2, 4, and 6, possessing both a hydroxy group and an uncoordinated NH group, which are proton-responsive and capable of generating pendent bases in basic media, recorded high initial turnover frequency values of 1300, 1550, and 2000 h-1, resp. Spectroscopic and computational studies revealed that the reversible deprotonation changes the electronic properties of the complexes and causes interactions between pendent base and substrate and/or solvent H2O mols., resulting in high catalytic performance in basic media. In the experiment, the researchers used N-Methoxy-N-methylacetamide(cas: 78191-00-1COA of Formula: C4H9NO2)

N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. Left-handed and right-handed forms (mirror-image configurations, known as optical isomers or enantiomers) are possible when all the substituents on the central nitrogen atom are different (i.e., the nitrogen is chiral). With amines, there is extremely rapid inversion in which the two configurations are interconverted.COA of Formula: C4H9NO2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

The author of 《Heterosubstituted 4-vinylimidazoles – preparation and diels-alder reactions》 were Ray, Abhisek; Mukherjee, Sabuj; Das, Jayanta; Bhandari, Manoj; Herath, Apsara; Yousufuddin, Muhammed; Lovely, Carl J.. And the article was published in Heterocycles in 2019. Synthetic Route of C4H9NO2 The author mentioned the following in the article:

The Diels-Alder reactions of vinylimidazole derivatives provide an expedient stereocontrolled entry into polysubstituted tetrahydrobenzimidazole derivatives Prior studies have described methods for postcycloaddn. functionalization of these adducts, however, in several cases unable to achieve appropriate elaboration of cycloadducts and have sought alternatives. To circumvent this problem, pre-cycloaddition functionalization through the preparation of vinyl-substituted derivs was investigated . Initial studies with vinyl halides or silyl enol ethers were compromised either by poor yields or postcycloaddn. elimination. However, vinylsilanes and vinylstannanes participate in Diels-Alder reactions with retention of the heterosubstituent and provide a means for further elaboration, for example through Fleming-Tamao oxidation After reading the article, we found that the author used N-Methoxy-N-methylacetamide(cas: 78191-00-1Synthetic Route of C4H9NO2)

N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. Acylation is one of the most important reactions of primary and secondary amines; a hydrogen atom is replaced by an acyl group (a group derived from an acid, such as RCOOH or RSO3H, by removal of ―OH, such as RC(=O)―, RS(O)2―, and so on). Reagents may be acid chlorides (RCOC1, RSO2C1), anhydrides ((RCO)2O), or even esters (RCOOR′); the products are amides of the corresponding acids.Synthetic Route of C4H9NO2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

《Comparative studies on polysaccharides, triterpenoids, and essential oil from fermented mycelia and cultivated sclerotium of a medicinal and edible mushroom, Poria cocos》 was written by Wang, Dongdong; Huang, Chonggui; Zhao, Ye; Wang, Lin; Yang, Yongcheng; Wang, Anhua; Zhang, Yang; Hu, Gaosheng; Jia, Jingming. Product Details of 78191-00-1 And the article was included in Molecules in 2020. The article conveys some information:

Poria cocos, an important medicinal and edible fungus, is well known in East Asia. The main active components are water-soluble polysaccharides (WPS) and triterpenoids. Due to the growing market demand, long cultivation period, and consumption of pine trunk during cultivation, alternative methods for producing P. cocos or its active components should be investigated. In this study, WPS, triterpenoids, monosaccharide composition, and essential oil in fermented mycelia and cultivated sclerotium were analyzed using UV spectrophotometry, HPLC, pre-column derivatization, and HS-GC/MS, resp. Our results showed that the WPS and triterpenoids in mycelia are several times higher than those in sclerotium. Among the 62 compounds identified by HS-GC/MS anal. from the essential oil obtained from the fermentation media and a fresh external layer, the two main fragrances in common were linalool and Me phenylacetate. Our results suggested that it is applicable to produce polysaccharides and triterpenoids by the fermentation of P. cocos, and a strategy to improve triterpenoid production in the fermentation process was proposed. The experimental process involved the reaction of N-Methoxy-N-methylacetamide(cas: 78191-00-1Product Details of 78191-00-1)

N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. Amine, any member of a family of nitrogen-containing organic compounds that is derived, either in principle or in practice, from ammonia (NH3). Naturally occurring amines include the alkaloids, which are present in certain plants; the catecholamine neurotransmitters (i.e., dopamine, epinephrine, and norepinephrine); and a local chemical mediator, histamine, that occurs in most animal tissues.Product Details of 78191-00-1

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

《Gold-Catalyzed Synthesis of Chiral Cyclopentadienyl Esters via Chirality Transfer》 was written by Zhao, Ke; Hsu, Yu-Chen; Yang, Ziguang; Liu, Rai-Shung; Zhang, Liming. Application In Synthesis of N-Methoxy-N-methylacetamide And the article was included in Organic Letters in 2020. The article conveys some information:

Efficient access to chiral cyclopentadienyl esters from readily accessible chiral enynyl ester substrates is developed. Typically high levels of chirality transfer realized in this homogeneous gold catalysis are attributed to the intermediacy of a chiral bent allene gold complex. Cyclopentadienyl esters can be prepared in good yields and with excellent enantiomeric excesses. The synthetic utilities of the chiral cyclopentadienyl esters are demonstrated by the Diels-Alder reactions, fluorination, alkylation, and epoxidation without any notable erosion of enantiopurity. The experimental process involved the reaction of N-Methoxy-N-methylacetamide(cas: 78191-00-1Application In Synthesis of N-Methoxy-N-methylacetamide)

N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 → R2N―NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.Application In Synthesis of N-Methoxy-N-methylacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

《Palladium-catalyzed carbene coupling of N-tosylhydrazones and arylbromides to synthesize cross-conjugated polymers》 was written by Zhou, Qi; Gao, Yunpeng; Xiao, Yiyang; Yu, Lefei; Fu, Zihao; Li, Zichen; Wang, Jianbo. Formula: C4H9NO2This research focused ontosylhydrazone arylbromide palladium carbene coupling cross conjugated polymer. The article conveys some information:

Carbene-involving cross-coupling reactions of N-tosylhydrazones and arylbromides have been introduced into polymer chem. for the first time, providing a novel method to access a new type of cross-conjugated polymer, poly(arylene-1,1-vinylidene)s (iso-PAVs). The pendant double bonds of these cross-conjugated polymers allow for further post-polymerization functionalization. The good thermal stability and remarkable optical properties of these cross-conjugated polymers reveal their potential for applications. In the part of experimental materials, we found many familiar compounds, such as N-Methoxy-N-methylacetamide(cas: 78191-00-1Formula: C4H9NO2)

N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. Hydrogen peroxide (H2O2) and peroxy acids generally add an oxygen atom to the nitrogen of amines. With primary amines, this step is normally followed by further oxidation, leading to nitroso compounds, RNO, or nitro compounds, RNO2. Secondary amines are converted to hydroxylamines, R2NOH, and tertiary amines to amine oxides, R3NO.Formula: C4H9NO2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

《Design, Synthesis, Biological Evaluation, and X-ray Studies of HIV-1 Protease Inhibitors with Modified P2′ Ligands of Darunavir》 was written by Ghosh, Arun K.; Fyvie, W. Sean; Brindisi, Margherita; Steffey, Melinda; Agniswamy, Johnson; Wang, Yuan-Fang; Aoki, Manabu; Amano, Masayuki; Weber, Irene T.; Mitsuya, Hiroaki. Product Details of 78191-00-1This research focused onxray HIV1 protease inhibitor darunavir; crystal structure; HIV-1 protease inhibitors; P2′ ligands; drug resistance; pharmacokinetics; structure-based design. The article conveys some information:

The structure-based design, synthesis, and biol. evaluation of a series of nonpeptidic HIV-1 protease inhibitors with rationally designed P2′ ligands are described. The inhibitors are designed to enhance backbone binding interactions, particularly at the S2′ subsite. Synthesis of inhibitors was carried out efficiently. The stereochem. of alc. functionalities of the P2′ ligands was set by asym. reduction of the corresponding ketone using (R,R)- or (S,S)-Noyori catalysts. A number of inhibitors displayed very potent enzyme inhibitory and antiviral activity. Inhibitors I and II showed enzyme Ki values of 27.9 and 49.7 pM and antiviral activity of 6.2 and 3.9 nM, resp. These inhibitors also remained quite potent against darunavir-resistant HIV-1 variants. An x-ray structure of inhibitor I in complex with HIV-1 protease revealed key interactions in the S2′ subsite.N-Methoxy-N-methylacetamide(cas: 78191-00-1Product Details of 78191-00-1) was used in this study.

N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. Aniline, ethanolamines, and several other amines are major industrial commodities used in making rubber, dyes, pharmaceuticals, and synthetic resins and fibres and for a host of other applications. Most of the numerous methods for the preparation of amines may be broadly divided into two groups: (1) chemical reduction (replacement of oxygen with hydrogen atoms in the molecule) of members of several other classes of organic nitrogen compounds and (2) reactions of ammonia or amines with organic compounds.Product Details of 78191-00-1

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In 2019,Heterocycles included an article by Tanimoto, Iku; Kawai, Kentaro; Sato, Akane; Yoshino, Tatsuhiko; Matsunaga, Shigeki. Recommanded Product: N-Methoxy-N-methylacetamide. The article was titled 《One-step synthesis of 4H-3,1-benzoxazin-4-ones from Weinreb amides and 1,4,2-dioxazol-5-ones via cobalt-catalyzed C-H bond activation》. The information in the text is summarized as follows:

A one-step synthesis of 4H-3,1-benzoxazin-4-ones e.g., 2-phenyl-4H-benzo[d][1,3]oxazin-4-one from readily available Weinreb amides I (R = t-Bu, Ph, thiophen-2-yl, etc.) and 1,4,2-dioxazol-5-ones e.g., N-methoxy-N-methylbenzamide under Cp*Co(III) catalysis is described. The reactions proceeded in moderate to good yields with high functional group compatibility. After reading the article, we found that the author used N-Methoxy-N-methylacetamide(cas: 78191-00-1Recommanded Product: N-Methoxy-N-methylacetamide)

N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. Aniline, ethanolamines, and several other amines are major industrial commodities used in making rubber, dyes, pharmaceuticals, and synthetic resins and fibres and for a host of other applications. Most of the numerous methods for the preparation of amines may be broadly divided into two groups: (1) chemical reduction (replacement of oxygen with hydrogen atoms in the molecule) of members of several other classes of organic nitrogen compounds and (2) reactions of ammonia or amines with organic compounds.Recommanded Product: N-Methoxy-N-methylacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In 2016,Ge, Jing-Jie; Yao, Chuan-Zhi; Wang, Mei-Mei; Zheng, Hong-Xing; Kang, Yan-Biao; Li, Yadong published 《Transition-Metal-Free Deacylative Cleavage of Unstrained C(sp3)-C(sp2) Bonds: Cyanide-Free Access to Aryl and Aliphatic Nitriles from Ketones and Aldehydes》.Organic Letters published the findings.Formula: C4H9NO2 The information in the text is summarized as follows:

A transition-metal-free deacylative C(sp3)-C(sp2) bond cleavage for the synthetically practical oxidative amination of ketones and aldehydes to nitriles is first described, using cheap and com. abundant NaNO2 as the oxidant and the nitrogen source. Various nitriles bearing aryl, heteroaryl, alkyl, and alkenyl groups could be smoothly obtained from ketones and aldehydes in high yields, avoiding highly toxic cyanides or transition metals. In the experiment, the researchers used many compounds, for example, N-Methoxy-N-methylacetamide(cas: 78191-00-1Formula: C4H9NO2)

N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. Left-handed and right-handed forms (mirror-image configurations, known as optical isomers or enantiomers) are possible when all the substituents on the central nitrogen atom are different (i.e., the nitrogen is chiral). With amines, there is extremely rapid inversion in which the two configurations are interconverted.Formula: C4H9NO2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

《Cobalt-Catalyzed Defluorosilylation of Aryl Fluorides via Grignard Reagent Formation》 was published in Organic Letters in 2020. These research results belong to Lim, Soobin; Cho, Hyungdo; Jeong, Jongheon; Jang, Minjae; Kim, Hyunseok; Cho, Seung Hwan; Lee, Eunsung. Formula: C4H9NO2 The article mentions the following:

Transition-metal-catalyzed transformations of the C-F bond not only tackle an interesting problem of challenging bond activation but also offer new synthetic strategies where the relatively inert C-F bond is converted to versatile functional groups. Herein the authors report a practical Co-catalyzed silylation of aryl fluorides that uses a cheap electrophilic Si source with Mg. This method is compatible with various Si sources and can be operated under aerobic conditions. Mechanistic studies support the in situ formation of a Grignard reagent, which is captured by the electrophilic Si source. The experimental part of the paper was very detailed, including the reaction process of N-Methoxy-N-methylacetamide(cas: 78191-00-1Formula: C4H9NO2)

N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.Formula: C4H9NO2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics