Electric Literature of 774-67-4, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 774-67-4, name is 4-Amino-N-isopropylbenzamide, This compound has unique chemical properties. The synthetic route is as follows.
Synthesis of compound 178.2. To a solution of 76.4 (0.150 g, 0.35 mmol, 1.0 eq) in 1,4-dioxane (3 mL) was added 178.1 (0.092g, 0.52mmol, l .Oeq) and K2C03 (0.1 lOg, 0.86mmol, 2.5eq). Reaction mixture was degassed for 10 minutes using argon gas, then Pd2(dba)3 (0.03 lg, 0.034mmol, O. leq) and Xantphos (0.042 g, 0.069 mmol, 0.2 eq) were added, and again degassed for 5 minutes. Reaction was stired at 110 C for 2 hours. After completion of the reaction, mixture was poured into water and extracted with EtOAc. Organic layers were combined, dried over Na2S04 and concentrated under reduced pressure to obtain crude which was purified by column chromatography to furnish 178.2 (0.1 lOg, 55.18%). MS (ES): m/z 573.6 [M+H]+.
The chemical industry reduces the impact on the environment during synthesis 4-Amino-N-isopropylbenzamide. I believe this compound will play a more active role in future production and life.
Reference:
Patent; NIMBUS LAKSHMI, INC.; MASSE, Craig E.; GREENWOOD, Jeremy Robert; ROMERO, Donna L.; HARRIMAN, Geraldine C.; WESTER, Ronald T.; SHELLEY, Mee; KENNEDY-SMITH, Joshua Jahmil; DAHLGREN, Markus; WO2015/131080; (2015); A1;,
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