Category: 758-96-3

Synthetic Route of 758-96-3, The chemical industry reduces the impact on the environment during synthesis 758-96-3, name is N,N-Dimethylpropionamide, I believe this compound will play a more active role in future production and life.

General procedure: tert-Butyl acetate (0.14 mL; 1.0 mmol) was added to a solution of LDA (1.0 mmol) in 3 mL of dry THF at -78 C under argon atmosphere with stirring. After the solution was stirred for 10 min, a solution of vinyl sulfoxide 8 (71 mg; 0.2 mmol) in THF (1 mL) was added. The reaction mixture was stirred for 15 min and then reaction was quenched by adding saturated aq. NH4Cl. The whole mixture was extracted with CHCl3. The product was purified by silica gel column chromatography to afford adduct 9 (94 mg; 99%) as colorless oil.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, N,N-Dimethylpropionamide, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Satoh, Tsuyoshi; Awata, Yu; Kato, Yuichi; Ogata, Shingo; Ishigaki, Masashi; Sugiyama, Shimpei; Saitoh, Hideki; Tetrahedron; vol. 67; 6; (2011); p. 1102 – 1113;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 758-96-3, name is N,N-Dimethylpropionamide belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. HPLC of Formula: C5H11NO

General procedure: To a stirred solution of 46 (800 mg, 2.71 mmol) in THF (20 mL) was slowly added n-BuLi (1.58 mol/L in n-hexane; 3.90 mL, 6.16 mmol) at -78 C under an argon atmosphere. After stirring for 1 h at the same temperature, N,N-dimethylpropionamide (0.890 mL, 8.10 mmol) was added in one portion at -78 C and the reaction mixture was allowed to gradually warm to room temperature over 3 h. The reaction was quenched with satd NH4Cl aq and the resulting mixture was extracted with EtOAc. The organic layer was washed with brine, dried over Na2SO4, and concentrated in vacuo. The residue was purified by silica gel column chromatography (CHCl3) to give 47 (342 mg, 1.26 mmol, 46%) as a white solid.

The synthetic route of 758-96-3 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Ochiai, Koji; Takita, Satoshi; Eiraku, Tomohiko; Kojima, Akihiko; Iwase, Kazuhiko; Kishi, Tetsuya; Fukuchi, Kazunori; Yasue, Tokutaro; Adams, David R.; Allcock, Robert W.; Jiang, Zhong; Kohno, Yasushi; Bioorganic and Medicinal Chemistry; vol. 20; 5; (2012); p. 1644 – 1658;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

758-96-3, name is N,N-Dimethylpropionamide, belongs to amides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Application In Synthesis of N,N-Dimethylpropionamide

Scheme AStep a1a: compound A2 (N,N-2-trimethyl-3-oxopentanamide)32.1 ml (0.35 mol) phosphoryl trichloride (POCI3) were dissolved in 100 mL of toluene. 32.6 ml (0.3 mol) A , V-dimethylpropionamide (A1) (dissolved in 50 mL toluene) were added to the resulting solution under stirring under an inert gas atmosphere. The reaction mixture was heated to 80C for 6 h, allowed to cool to RT and stirred for another 12 h at RT. After evaporation of toluene under reduced pressure, the resulting mixture was stirred for 2 h. 100 mL toluene were then added, the resulting mixture was cooled to below 0C and icy water (100 mL) was added. Then, 24 g of solid NaOH, dissolved in water, were added to the mixture. After 1 h of stirring, 47.7 g Na2C03 as solid were added and the resulting mixture was stirred for 16 h at RT. The organic layer was separated, dried over MgS04 and distilled (0.8 bar, 78-82C). 10.8 g (46%) of A2 was obtained in form of a colorless solid.

The synthetic route of 758-96-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; GRUeNENTHAL GMBH; BUSCHMANN, Helmut, Heinrich; HOLENZ, Joerg; WO2011/157390; (2011); A2;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Synthetic Route of 758-96-3, The chemical industry reduces the impact on the environment during synthesis 758-96-3, name is N,N-Dimethylpropionamide, I believe this compound will play a more active role in future production and life.

General procedure: tert-Butyl acetate (0.14 mL; 1.0 mmol) was added to a solution of LDA (1.0 mmol) in 3 mL of dry THF at -78 C under argon atmosphere with stirring. After the solution was stirred for 10 min, a solution of vinyl sulfoxide 8 (71 mg; 0.2 mmol) in THF (1 mL) was added. The reaction mixture was stirred for 15 min and then reaction was quenched by adding saturated aq. NH4Cl. The whole mixture was extracted with CHCl3. The product was purified by silica gel column chromatography to afford adduct 9 (94 mg; 99%) as colorless oil.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, N,N-Dimethylpropionamide, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Satoh, Tsuyoshi; Awata, Yu; Kato, Yuichi; Ogata, Shingo; Ishigaki, Masashi; Sugiyama, Shimpei; Saitoh, Hideki; Tetrahedron; vol. 67; 6; (2011); p. 1102 – 1113;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Reference of 758-96-3, A common heterocyclic compound, 758-96-3, name is N,N-Dimethylpropionamide, molecular formula is C5H11NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step alb: compound A5 (3-(3-methoxyphenyl)-N,N,2-trimethyl-3-oxopropanamide)To 2,2,6,6-tetramethylpiperidine (17.5 g, 125 mmol) in 50 ml dry THF were added dropwise 72 ml (115 mmol) of a n-buthyllithium solution in n-hexane (1.6 M) at -30C. After 30 minutes of stirring, 5.0 g (50 mmol) Nu,Nu-dimethylpropionamide (A1) (dissolved in 50 mL dry THF) were added and the mixture was cooled to -70C and stirred for 1 h at this temperature. 22.5 g (125 mmol) ethyl-3-methoxybenzoate (dissolved in 30 mL dry THF) were slowly added dropwise and the resulting mixture was stirred for another 2 h at -70C. After the mixture had been allowed to warm to RT, it was hydrolyzed by employing a diluted aqueous solution of HCI (36 mL). The mixture was then washed with diethyl ether several times. The combined organic layers were dried over MgS04. The organic solvents were evaporated under reduced pressure and the remaining residue was dried in vacuo. CC (eluent: n-hexane/ethyl acetate (1 :4)) yielded 6.5 g (55%) of A5 in form of a colorless oil.

The synthetic route of 758-96-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; GRUeNENTHAL GMBH; BUSCHMANN, Helmut, Heinrich; HOLENZ, Joerg; WO2011/157390; (2011); A2;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 758-96-3 as follows. Computed Properties of C5H11NO

Weigh benzothiazole (0.5mmol, 67mg), K2S2O8 (2mmol, 0.54g) and Eosin Y (0.01mmol, 6.5mg) in a 25mL Schlenk reaction tube, and then add N, N-dimethylpropionamide (38mmol, 3.8g), placed under a 20W LED white light to react, stirred the reaction at room temperature, followed by TLC to monitor the progress of the reaction, the reaction was completed after 24 hours, the reaction solution was concentrated to remove the solvent, and the concentrated solution was separated by column chromatography (eluent Petroleum ether / ethyl acetate) in a volume ratio of 5: 1) to give a yellow oil, the derivative Ik. The yield was 66%.

According to the analysis of related databases, 758-96-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Zhejiang University of Technology; Weng Jianquan; Xu Wenxiu; Dai Xiaoqiang; Liu Xinghai; (11 pag.)CN110432282; (2019); A;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Reference of 758-96-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 758-96-3 name is N,N-Dimethylpropionamide, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Weigh 4-methylbenzothiazole (0.5mmol, 75mg), K2S2O8 (2mmol, 0.54g) and Eosin Y (0.01mmol, 6.5mg) in a 25mL Schlenk reaction tube,Then add N, N-dimethylpropionamide (38mmol, 3.8g), put it under the LED white light of 20W power to react, stir the reaction at room temperature, monitor the progress of the reaction with TLC, the reaction ends after 24h, and the reaction solution is concentrated The solvent was removed, and the concentrated solution was separated by column chromatography (eluent: petroleum ether / ethyl acetate with a volume ratio of 5: 1) to obtain a yellow oil, that is, the derivative Im. The yield was 72%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, N,N-Dimethylpropionamide, and friends who are interested can also refer to it.

Reference:
Patent; Zhejiang University of Technology; Weng Jianquan; Xu Wenxiu; Dai Xiaoqiang; Liu Xinghai; (11 pag.)CN110432282; (2019); A;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Electric Literature of 758-96-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 758-96-3 as follows.

General procedure: To a solution of 5-chloro-N-cyanothiophene-2-carboximidamide in CH3CN was added N,N-dimethylacetamide and POCl3. The mixture was stirred at 70 C overnight under N2. TLC showed starting material was consumed. The mixture was then poured into NaHCO3 (aq) carefully and the precipitate collected. The dried compound was taken to the next step without further purification.

According to the analysis of related databases, 758-96-3, the application of this compound in the production field has become more and more popular.

Reference:
Article; Hagen, Timothy J.; Mo, Xuesheng; Burgin, Alex B.; Fox III, David; Zhang, Zheng; Gurney, Mark E.; Bioorganic and Medicinal Chemistry Letters; vol. 24; 16; (2014); p. 4031 – 4034;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Application of 758-96-3, A common heterocyclic compound, 758-96-3, name is N,N-Dimethylpropionamide, molecular formula is C5H11NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

7-Methoxy-4-propionyl-2-trifluoromethylbenzo[b]thiophene To a solution of the compound of Example 37 (1.70 g) in THF (27 mL) was added an n-butyl lithium (1.58 mol/L hexane solution, 3.80 mL) at -78C, followed by stirring at the same temperature for 30 minutes, and then N,N-dimethyl propionamide (1.20 mL) was added thereto, followed by stirring at room temperature for 30 minutes. To the reaction liquid was added a saturated aqueous ammonium chloride solution, followed by extraction with ethyl acetate, the organic layer was washed with saturated brine and then dried over anhydrous magnesium sulfate, and the solvent was evaporated. The residue was purified by silica gel column chromatography (hexane:ethyl acetate=4: 1) to obtain the desired product (243 mg) as a white powder. EIMS (+): 288 [M]+, 1H NMR (CDCl3, 400 MHz): delta 1.27 (3H, t, J=7.3 Hz), 3.07 (2H, q, J=7.3 Hz), 4.09 (3H, s), 6.89 (1H, d, J=8.6 Hz), 8.05 (1H, d, J=8.6 Hz), 8.80 (1H, q, J=1.2 Hz).

The synthetic route of 758-96-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Kyorin Pharmaceutical Co., Ltd.; EP2168959; (2010); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 758-96-3, name is N,N-Dimethylpropionamide belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. HPLC of Formula: C5H11NO

Weigh 6-methoxybenzothiazole (0.5mmol, 83mg), K2S2O8 (2mmol, 0.54g) and Eosin Y (0.01mmol, 6.5mg) in a 25mL Schlenk reaction tube, and then add N, N-dimethyl Propionamide (38mmol, 3.8g) was placed under a 20W power LED white light to react. The reaction was stirred at room temperature. The progress of the reaction was monitored by TLC. The reaction was completed after 24 hours. The reaction solution was concentrated to remove the solvent. Separation (eluent: petroleum ether / ethyl acetate with a volume ratio of 5: 1) gave a yellow oil, namely the derivative Il. Yield: 74%.

The synthetic route of 758-96-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Zhejiang University of Technology; Weng Jianquan; Xu Wenxiu; Dai Xiaoqiang; Liu Xinghai; (11 pag.)CN110432282; (2019); A;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics