Category: 75175-77-8

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 75175-77-8, name is 3-(4-Fluorophenyl)-N,N-dimethylacrylamide, A new synthetic method of this compound is introduced below., SDS of cas: 75175-77-8

General procedure: With a mixture of N,N-Dimethylenaminones 1 (1.0 mmol), isatins 2 (0.5 mmol), ammonium acetate 3 (1.0 mmol) in AcOH (1 mL) and EtOH-water (1:4) (5 mL), the reaction mixture was stirred at 80 C for 6 h until TLC indicated that the reaction was completed. The reaction mixture was allowed to cool to room temperature, neutralised with a saturated solution of Na2CO3 to pH 8-9, and then was extracted with ethyl acetate (2 ¡Á 30 mL). The organic phase was washed with water (20 mL) and the organic layer dried over Na2SO4, and concentrated under reduced pressure. The crude product was chromatographed onsilica gel (200-300 mesh) using a mixture of petroleum ether and ethyl acetate as eluent to afford the product 4.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Zhou, Pan; Hu, Biao; Lu, Lingling; Huang, Rong; Yu, Fuchao; Journal of Chemical Research; vol. 41; 9; (2017); p. 513 – 516;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 75175-77-8, name is 3-(4-Fluorophenyl)-N,N-dimethylacrylamide, belongs to amides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 75175-77-8, Recommanded Product: 75175-77-8

General procedure: Formamidine acetate (9.9 g, 0.096 mol) and sodium ethoxide(10.9 g, 0.16 mol) were dissolved in ethanol at 70 C for 1 h. Then2a-i was added in the reaction solution slowly, refluxed for15-20 h and monitored by TLC. The solution was concentratedin vacuum, the residue was resolved with dichloromethane(300 mL), washed with brine (60 mL), dried over anhydrousNa2SO4, and concentrated in vacuum to give the light yellowsolids 3a-i.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-(4-Fluorophenyl)-N,N-dimethylacrylamide, and friends who are interested can also refer to it.

Reference:
Article; Zhu, Wufu; Wang, Wenhui; Xu, Shan; Wang, Jianqiang; Tang, Qidong; Wu, Chunjiang; Zhao, Yanfang; Zheng, Pengwu; Bioorganic and Medicinal Chemistry; vol. 24; 8; (2016); p. 1749 – 1756;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Related Products of 75175-77-8, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 75175-77-8 as follows.

General procedure: In a 50 ml round-bottom flask, substituted enaminones (1 mmol), hydrazine hydrate (1.3 mmol) or phenyl hydrazine (1 mmol) and [crown ether MIm][HSO4] (20 mol%) were charged. The reaction mixture was stirred at 50 C under solvent-free conditions for 10-35 min. After completion of reaction (monitoredby TLC), the reaction mixture was extracted with ethyl acetate (2 9 10 ml). The extracted ethyl acetate was evaporated in a rotary evaporator and the desired product was isolated from the resultant mass by column chromatography (petether: ethyl acetate, 9.5: 0.5). Finally, the catalyst was recycled and used for thenext run.

According to the analysis of related databases, 75175-77-8, the application of this compound in the production field has become more and more popular.

Reference:
Article; Patil, Dayanand; Chandam, Dattatraya; Mulik, Abhijeet; Jagdale, Suryabala; Patil, Prasad; Deshmukh, Madhukar; Research on Chemical Intermediates; vol. 41; 9; (2015); p. 6843 – 6858;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 75175-77-8, name is 3-(4-Fluorophenyl)-N,N-dimethylacrylamide, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 75175-77-8

General procedure: N,N-Dimethylenaminones 1 (1.0 mmol), amines 2 (0.5mmol), PEG-400 (5 mL), oxone (1.2 eq) and trifluoroacetic acid (TFA) (0.2 mL) were charged into a 25 mL round-bottom flask, and the mixture was stirred at 120 oC for 20 min until the N,N-dimethyl enaminones1 were completely consumed. The mixture was cooled to room temperature,neutralized with a saturated solution of Na2CO3 to pH 8-9, and then EtOAc (30 mL ¡Á 2) were added. The organic phase was washed with water (20 mL), dried over Na2SO4, concentrated and purified by flash column chromatography to afford 1,4-DHPs 3 in a 50-72% yield.

According to the analysis of related databases, 75175-77-8, the application of this compound in the production field has become more and more popular.

Reference:
Article; Yu, Fu-Chao; Zhou, Bei; Xu, Hui; Chang, Kwen-Jen; Shen, Yuehai; Tetrahedron Letters; vol. 56; 6; (2015); p. 837 – 841;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics