Category: 75175-77-8

Some common heterocyclic compound, 75175-77-8, name is 3-(4-Fluorophenyl)-N,N-dimethylacrylamide, molecular formula is C11H12FNO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Quality Control of 3-(4-Fluorophenyl)-N,N-dimethylacrylamide

General procedure: Cyanothioacetamide (for X=S) (1.5 equiv) or cyanoacetamide (for X=O) (1.5 equiv) was added to a solution of the 1, 3-diones (for R4= -CF3 and -CH3) (1.0 equiv) or enaminones (for R4=H) (1.0 equiv) in ethanol in the presence of DABCO (1.0 equiv) at room temperature. The reaction mixture was stirred under reux for 3-6 h until complete conversion of the starting materials, as monitored by TLC. After cooled to room temperature, the solvent was evaporated under reduced pressure and the residue was neutralized with diluted hydrochloric acid (1 N) to precipitate the crude products. After filtrated and dried in vacuo, the product can be straight used for step d. Yield: 70-90%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 75175-77-8, its application will become more common.

Reference:
Article; Wang, Ning-Yu; Zuo, Wei-Qiong; Xu, Ying; Gao, Chao; Zeng, Xiu-Xiu; Zhang, Li-Dan; You, Xin-Yu; Peng, Cui-Ting; Shen, Yang; Yang, Sheng-Yong; Wei, Yu-Quan; Yu, Luo-Ting; Bioorganic and Medicinal Chemistry Letters; vol. 24; 6; (2014); p. 1581 – 1588;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Synthetic Route of 75175-77-8, These common heterocyclic compound, 75175-77-8, name is 3-(4-Fluorophenyl)-N,N-dimethylacrylamide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a solution of the appropriate enaminone 2a-i (5 mmol) in glacial acetic acid (15 mL), ethyl acetoacetate (5.5 mmol) and ammonium acetate (40 mmol) were added. The reaction mixture was heated under reflux for 5 h. After cooling and pouring into ice-water, the residue obtained was filtered and washed with petroleum ether then with water and finally crystallized from ethanol [41]. The yields of compounds 3a-i were 80%, 77%, 81%, 84%, 86%, 80%, 785, 76%, 83%, respectively.

The synthetic route of 75175-77-8 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Eldehna, Wagdy M.; Fares, Mohamed; Abdel-Aziz, Marwa M; Abdel-Aziz, Hatem A; Molecules; vol. 20; 5; (2015); p. 8800 – 8815;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 75175-77-8, name is 3-(4-Fluorophenyl)-N,N-dimethylacrylamide, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 3-(4-Fluorophenyl)-N,N-dimethylacrylamide

General procedure: The dihydro-6H-quinolin-5-one (3a-v) were synthesized based on aliterature method as following: aryl and heteroaryl methylketones(1a-k, 5.23 mmol) were treated with dimethylformamide-dimethylacetal(DMF-DMA) (20.92 mmol) in refluxing xylene for 7 h to form beta-enaminones (2a-k), and reacted with cyclohexane-1,3-dione/5,5-dimethylcyclohexane-1,3-dione (0.16 g, 1.2 mmol) ammonium acetate(2.0 mmol) in 2-propanol (5 mL) were added CeCl3·7H2O (0.2 mmol),NaI (0.2 mmol) and refluxed for 4 h (monitored by TLC). The reactionmixture was cooled to room temperature; a solid precipitate was filteredand washed with cold 2-propanol. The combined solvent wasevaporated, and the crude residue obtained was subjected to columnchromatography (hexane: ethyl acetate) to obtain dihydro-6H-quinolin-5-one derivatives (3a-v) as solids in very good yields.

According to the analysis of related databases, 75175-77-8, the application of this compound in the production field has become more and more popular.

Reference:
Article; Kantevari, Srinivas; Krishna, Vagolu Siva; Marvadi, Sandeep kumar; Sridhar, Balasubramanian; Srilakshmi Reshma, Rudraraju; Sriram, Dharmarajan; Surineni, Goverdhan; Bioorganic Chemistry; vol. 96; (2020);,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 75175-77-8, name is 3-(4-Fluorophenyl)-N,N-dimethylacrylamide, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of 3-(4-Fluorophenyl)-N,N-dimethylacrylamide

General procedure: A typical procedure: Amixture of beta-dimethylaminovynil ketone 1a-h (1.0 mmol, 0.175 g), ChCl:TsOH (1:2) (0.519 g), and 3-amino-5-methylthio-1H-1,2,4-triazole 2 (1.2 mmol, 0.156 g) was heated to120 C for 5 min.Water (10 mL) was added, and the resulting product(3) was extracted with chloroform (3 × 10 mL). The organic phaseswere dried over anhydrous Na2SO4 and the solvent was evaporateduntil totally dry in order to obtain the desired triazolopyrimidines(3a-h) in a pure form. The structure of compounds 3a-h was confirmedby 1H, 13C NMR spectroscopy, determination of their melting points, gaschromatography mass spectrometry (GC-MS), high-resolution massspectra (HRMS), and, FT-IR spectra. These data are available in theSupporting Information.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 75175-77-8.

Reference:
Article; Martins, Marcos A.P.; Paveglio, Guilherme C.; Munchen, Taiana S.; Meyer, Alexandre R.; Moreira, Dayse N.; Rodrigues, Leticia V.; Frizzo, Clarissa P.; Zanatta, Nilo; Bonacorso, Helio G.; Melo, Paola A.; Krzyzaniak, Sindy R.; Journal of Molecular Liquids; vol. 223; (2016); p. 934 – 938;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 75175-77-8 as follows. HPLC of Formula: C11H12FNO

General procedure: A mixture of compounds 11a-c (0.01 mol) with enaminones 12a-g {e.g., 3-(dimethylamino)-1-phenylprop-2-en-1-one (12a), 3-(dimethylamino)-1-(4-methylphenyl)prop-2-en-1-one (12b),3-(dimethylamino)-1-(4-methoxyphenyl)prop-2-en-1-one (12c), 1-(4-chlorophenyl)-3-(dimethyl-amino)prop-2-en-1-one (12d), 1-(4-bromophenyl)-3-(dimethylamino)prop-2-en-1-one (12e), 3-(dimethylamino)-1-(4-fluorophenyl)prop-2-en-1-one (12f) or 3-(dimethylamino)-1-(thiophen-2-yl)prop-2-en-1-one (12g)}(0.01 mol) in glacial acetic acid (25 mL), the reaction mixture was refluxed for 1 h and then left to cool.The solid product was filtered off, washed with ethanol, dried and finally recrystallized from DMF/H2Oto afford the corresponding pyrazolo[1,5-a]pyrimidine derivatives 18a-u.

According to the analysis of related databases, 75175-77-8, the application of this compound in the production field has become more and more popular.

Reference:
Article; El-Naggar, Mohamed; Hassan, Ashraf S.; Awad, Hanem M.; Mady, Mohamed F.; Molecules; vol. 23; 6; (2018);,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Application of 75175-77-8, These common heterocyclic compound, 75175-77-8, name is 3-(4-Fluorophenyl)-N,N-dimethylacrylamide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a solution of the appropriate enaminone 2a-i (5 mmol) in glacial acetic acid (15 mL), ethyl acetoacetate (5.5 mmol) and ammonium acetate (40 mmol) were added. The reaction mixture was heated under reflux for 5 h. After cooling and pouring into ice-water, the residue obtained was filtered and washed with petroleum ether then with water and finally crystallized from ethanol [41]. The yields of compounds 3a-i were 80%, 77%, 81%, 84%, 86%, 80%, 785, 76%, 83%, respectively.

The synthetic route of 75175-77-8 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Eldehna, Wagdy M.; Fares, Mohamed; Abdel-Aziz, Marwa M; Abdel-Aziz, Hatem A; Molecules; vol. 20; 5; (2015); p. 8800 – 8815;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 75175-77-8, name is 3-(4-Fluorophenyl)-N,N-dimethylacrylamide, This compound has unique chemical properties. The synthetic route is as follows., Application In Synthesis of 3-(4-Fluorophenyl)-N,N-dimethylacrylamide

General procedure: The dihydro-6H-quinolin-5-one (3a-v) were synthesized based on aliterature method as following: aryl and heteroaryl methylketones(1a-k, 5.23 mmol) were treated with dimethylformamide-dimethylacetal(DMF-DMA) (20.92 mmol) in refluxing xylene for 7 h to form beta-enaminones (2a-k), and reacted with cyclohexane-1,3-dione/5,5-dimethylcyclohexane-1,3-dione (0.16 g, 1.2 mmol) ammonium acetate(2.0 mmol) in 2-propanol (5 mL) were added CeCl3·7H2O (0.2 mmol),NaI (0.2 mmol) and refluxed for 4 h (monitored by TLC). The reactionmixture was cooled to room temperature; a solid precipitate was filteredand washed with cold 2-propanol. The combined solvent wasevaporated, and the crude residue obtained was subjected to columnchromatography (hexane: ethyl acetate) to obtain dihydro-6H-quinolin-5-one derivatives (3a-v) as solids in very good yields.

According to the analysis of related databases, 75175-77-8, the application of this compound in the production field has become more and more popular.

Reference:
Article; Kantevari, Srinivas; Krishna, Vagolu Siva; Marvadi, Sandeep kumar; Sridhar, Balasubramanian; Srilakshmi Reshma, Rudraraju; Sriram, Dharmarajan; Surineni, Goverdhan; Bioorganic Chemistry; vol. 96; (2020);,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 75175-77-8, name is 3-(4-Fluorophenyl)-N,N-dimethylacrylamide, This compound has unique chemical properties. The synthetic route is as follows., Application In Synthesis of 3-(4-Fluorophenyl)-N,N-dimethylacrylamide

General procedure: A typical procedure: Amixture of beta-dimethylaminovynil ketone 1a-h (1.0 mmol, 0.175 g), ChCl:TsOH (1:2) (0.519 g), and 3-amino-5-methylthio-1H-1,2,4-triazole 2 (1.2 mmol, 0.156 g) was heated to120 C for 5 min.Water (10 mL) was added, and the resulting product(3) was extracted with chloroform (3 × 10 mL). The organic phaseswere dried over anhydrous Na2SO4 and the solvent was evaporateduntil totally dry in order to obtain the desired triazolopyrimidines(3a-h) in a pure form. The structure of compounds 3a-h was confirmedby 1H, 13C NMR spectroscopy, determination of their melting points, gaschromatography mass spectrometry (GC-MS), high-resolution massspectra (HRMS), and, FT-IR spectra. These data are available in theSupporting Information.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 75175-77-8.

Reference:
Article; Martins, Marcos A.P.; Paveglio, Guilherme C.; Munchen, Taiana S.; Meyer, Alexandre R.; Moreira, Dayse N.; Rodrigues, Leticia V.; Frizzo, Clarissa P.; Zanatta, Nilo; Bonacorso, Helio G.; Melo, Paola A.; Krzyzaniak, Sindy R.; Journal of Molecular Liquids; vol. 223; (2016); p. 934 – 938;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Electric Literature of 75175-77-8, The chemical industry reduces the impact on the environment during synthesis 75175-77-8, name is 3-(4-Fluorophenyl)-N,N-dimethylacrylamide, I believe this compound will play a more active role in future production and life.

General procedure: Enaminones 1 (1.0 mmol), amines 2 (1.0 mmol), isatin 3 (1.0 mmol), p-xylene (10 ml), and trifluoroacetic acid (TFA) (0.2 ml) were charged into a 25 ml round-bottom flask, and the mixture was stirred at 130C for 20 min until the enaminones 1 were completely consumed. The mixture was cooled to room temperature, neutralized with a saturated solution of Na2CO3 to pH 8-9, and then EtOAc (30 ml¡Á2) was added. The organic phase was washed with water (20 ml), dried over Na2SO4, concentrated, and purified by flash column chromatography to afford pyrrolo[3,4-c]quinoline-1-one derivatives 4 in a 60-82% yield. The products were further identified by FTIR, NMR, and HRMS, and were found to be in good agreement with the assigned structures (see Supplementary data).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-(4-Fluorophenyl)-N,N-dimethylacrylamide, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Yu, Fu-Chao; Zhou, Bei; Xu, Hui; Li, Ya-Min; Lin, Jun; Yan, Sheng-Jiao; Shen, Yuehai; Tetrahedron; vol. 71; 7; (2015); p. 1036 – 1044;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Synthetic Route of 75175-77-8,Some common heterocyclic compound, 75175-77-8, name is 3-(4-Fluorophenyl)-N,N-dimethylacrylamide, molecular formula is C11H12FNO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: General procedure: A mixture of appropriately substituted arylmethyl ketone (4 mmol) and DMF-DMA (20 mmol)was refluxed for8-12 h and monitored by TLC. After complete consumption ofsubstituted methyl ketone, the mixture was subjected to rotaryevaporation under reduced pressure to remove the excess of DMFDMAand the liberated methanol. After that DMSO (6-8 mL) and 4-azidobenzenesulfonamide (4 mmol) were added to reactionmixture. After addition, reaction mixture was allowed to stir at 90C for 8-10 h in silicon oil bath. After completion, reaction mixturewas poured into water to afford required product (7a-7j). Crudeproduct thus obtained was recrystalized with ethanol.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-(4-Fluorophenyl)-N,N-dimethylacrylamide, its application will become more common.

Reference:
Article; Kumar, Rajiv; Vats, Lalit; Bua, Silvia; Supuran, Claudiu T.; Sharma, Pawan K.; European Journal of Medicinal Chemistry; vol. 155; (2018); p. 545 – 551;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics