Category: 7465-88-5

Zhi, Peng published the artcileVilsmeier-Haack reagent mediated synthetic transformations with an immobilized iridium complex photoredox catalyst, Name: 4-Methoxy-N-phenylbenzamide, the main research area is immobilized iridium complex photocatalyst Vilsmeier Haack reagent in situ; amide synthesis Vilsmeier Haack reagent in situ photoredox catalyst; nitrile synthesis Vilsmeier Haack reagent in situ photoredox catalyst; anhydride synthesis Vilsmeier Haack reagent in situ photoredox catalyst.

An immobilized iridium complex photocatalyst Ir(ppy)2(PDVB-py) was synthesized by immobilization of the iridium complex onto the nanoporous vinylpyridine-divinylbenzene copolymer (PDVB-py). Its application for the synthesis of amides, nitriles, and anhydrides was reported via reactions under the action of the visible-light-driven in situ generated Vilsmeier-Haack reagent from CBr4 in DMF. The results showed that this heterogeneous photocatalyst has extremely high activity and excellent stability to be recycled five times.

New Journal of Chemistry published new progress about Acetamides Role: SPN (Synthetic Preparation), PREP (Preparation). 7465-88-5 belongs to class amides-buliding-blocks, name is 4-Methoxy-N-phenylbenzamide, and the molecular formula is C14H13NO2, Name: 4-Methoxy-N-phenylbenzamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Joseph, Devaneyan published the artcileReaction of Amide and Sodium Azide for the Synthesis of Acyl Azide, Urea, and Iminophosphorane, Product Details of C14H13NO2, the main research area is acyl azide sym aromatic urea iminophosphorane preparation; amide sodium azide phosphine substitution Curtius rearrangement.

Amides reacted with NaN3 to give the acyl azides in DMF at 25°C and produce the sym. ureas in THF/H2O at 80°C via the sequential reaction of acyl substitution and Curtius rearrangement. All acyl azides were also obtained from the secondary amides via sequential reaction of p-toluenesulfonyl chloride and NaN3. In addition, keto-stabilized iminophosphoranes were prepared from a one-pot reaction of amides, NaN3, and phosphines.

Organic Letters published new progress about Acyl azides Role: SPN (Synthetic Preparation), PREP (Preparation). 7465-88-5 belongs to class amides-buliding-blocks, name is 4-Methoxy-N-phenylbenzamide, and the molecular formula is C14H13NO2, Product Details of C14H13NO2.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Rahman, Mahbubur Md. published the artcileMetal-Free Transamidation of Secondary Amides by N-C Cleavage, Application of 4-Methoxy-N-phenylbenzamide, the main research area is secondary amide transamidation nitrogen carbon bond cleavage.

Transamidation reactions represent a fundamental chem. process involving conversion of one amide functional group into another. Herein, the authors report a facile, highly chemoselective method for transamidation of N-tert-butoxycarbonylation (N-Boc) activated secondary amides that proceeds under exceedingly mild conditions in the absence of any additives. Because this reaction was performed in the absence of metals, oxidants, or reductants, the reaction tolerates a large number of useful functionalities. The reaction is compatible with diverse amides and nucleophilic amines, affording the transamidation products in excellent yields through direct nucleophilic addition to the amide bond. The utility of this methodol. is highlighted in the synthesis of Tigan, a com. antiemetic, directly from the amide bond. The authors expect that this new metal-free transamidation will have broad implications for the development of new transformations involving direct nucleophilic addition to the amide bond as a key step.

Journal of Organic Chemistry published new progress about Amides, secondary Role: RCT (Reactant), RACT (Reactant or Reagent). 7465-88-5 belongs to class amides-buliding-blocks, name is 4-Methoxy-N-phenylbenzamide, and the molecular formula is C14H13NO2, Application of 4-Methoxy-N-phenylbenzamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Jat, Jawahar L. published the artcileMetal-free synthesis of secondary amides using N-Boc-O-tosylhydroxylamine as nitrogen source via Beckmann rearrangement, Computed Properties of 7465-88-5, the main research area is ketone tertbutyloxycarbonyl tosylhydroxylamine Beckmann rearrangement; secondary amide preparation.

Herein, the first direct method for the synthesis of secondary amides from ketones via the Beckmann rearrangement using N-Boc-O-tosylhydroxylamine (TsONHBoc) as the aminating agent was reported. This reagent was expected to play a dual role, first in the formation of the activated oxime intermediate, and then via facilitation of the amide formation as a Bronsted acid by the tosylic acid byproduct. The metal and additive-free one-step method progresses in TFE solvent through the in situ generation of the primary amine reagent (TsONH2), and produces a water-soluble byproduct.

New Journal of Chemistry published new progress about Amides, secondary Role: SPN (Synthetic Preparation), PREP (Preparation). 7465-88-5 belongs to class amides-buliding-blocks, name is 4-Methoxy-N-phenylbenzamide, and the molecular formula is C14H13NO2, Computed Properties of 7465-88-5.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Swetha, Sathyendran published the artcileAn Umpolung Route to Amides from α-Aminonitriles under Metal-Free Conditions, Related Products of amides-buliding-blocks, the main research area is secondary tertiary amide preparation umpolung; aminonitrile decyanation.

A metal-free, base-mediated decyanation of α-aminonitriles has been developed to synthesize secondary and tertiary amides using O2 or air as an amide oxygen source. Radical scavenging studies disclosed that the cleavage of C-CN bond may proceed via an anionic pathway. The practicality of the work was also demonstrated through an in situ generated α-aminonitriles from corresponding aldehydes and amines to afford amides. The important features of this work include broad functional group compatibility, 41% to 89% product yields, gram-scale synthesis of 2° and 3° amides, broad substrate scope, and an umpolung strategy.

Advanced Synthesis & Catalysis published new progress about Amides, secondary Role: SPN (Synthetic Preparation), PREP (Preparation). 7465-88-5 belongs to class amides-buliding-blocks, name is 4-Methoxy-N-phenylbenzamide, and the molecular formula is C14H13NO2, Related Products of amides-buliding-blocks.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Chandra, Dinesh published the artcileDirect synthesis of secondary amides from ketones through Beckmann rearrangement using O-(mesitylsulfonyl)hydroxylamine, Category: amides-buliding-blocks, the main research area is mesitylsulfonyl hydroxylamine preparation ketone Beckmann rearrangement; secondary amide preparation.

A highly efficient direct method for the preparation of secondary amides and lactams from ketones using O-(mesitylsulfonyl)hydroxylamine (MSH) was developed. The reactions proceeded rapidly at room temperature under mild condition without requiring any additive and tolerate multiple functional groups. A simple aqueous work-up often furnished the products in excellent yield with high purity.

Tetrahedron Letters published new progress about Amides, secondary Role: SPN (Synthetic Preparation), PREP (Preparation). 7465-88-5 belongs to class amides-buliding-blocks, name is 4-Methoxy-N-phenylbenzamide, and the molecular formula is C14H13NO2, Category: amides-buliding-blocks.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Bai, Jin published the artcileVisible-Light Carbon Nitride-Catalyzed Aerobic Cyclization of Thiobenzanilides under Ambient Air Conditions, Safety of 4-Methoxy-N-phenylbenzamide, the main research area is thiobenzanilide cyclization carbon nitride catalyst photochem; benzothiazole preparation.

A metal-free heterogeneous photocatalysis has been developed for the synthesis of benzothiazoles via intramol. C-H functionalization/C-S bond formation of thiobenzanilides by inexpensive graphitic carbon nitride (g-C3N4) under visible-light irradiation This reaction provides access to a broad range of 2-substituted benzothiazoles in high yields under an air atm. at room temperature without addition of a strong base or organic oxidizing reagents. In addition, the catalyst was found to be stable and reusable after five reaction cycles.

Organic Letters published new progress about Anilides Role: SPN (Synthetic Preparation), PREP (Preparation) (thio). 7465-88-5 belongs to class amides-buliding-blocks, name is 4-Methoxy-N-phenylbenzamide, and the molecular formula is C14H13NO2, Safety of 4-Methoxy-N-phenylbenzamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Adegboyega, Abdullahi K. published the artcileReaction of Dioxazolones with Boronic Acids: Copper-Mediated Synthesis of N-Aryl Amides via N-Acyl Nitrenes, HPLC of Formula: 7465-88-5, the main research area is aryl amide preparation; dioxazolone boronic acid copper mediated reaction.

Dioxazolones, as direct amide sources, have been used with boronic acids in the presence of copper(I) chloride to access N-aryl amides at room temperature The versatility of the developed reaction is proven by ample scope having a wide range of functional group tolerance. The reaction optimization conditions revealed that a fluorine additive demonstrated improved reactivity toward the intended transformation. The addition of triphenylphosphine resulted in N-acyl iminophosphorane, suggesting the involvement of an N-acyl nitrene intermediate.

Organic Letters published new progress about Aromatic amides Role: SPN (Synthetic Preparation), PREP (Preparation). 7465-88-5 belongs to class amides-buliding-blocks, name is 4-Methoxy-N-phenylbenzamide, and the molecular formula is C14H13NO2, HPLC of Formula: 7465-88-5.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Zhou, Zijun published the artcilePhotoinduced Transition-Metal-Free Chan-Evans-Lam-Type Coupling: Dual Photoexcitation Mode with Halide Anion Effect, Product Details of C14H13NO2, the main research area is photoinduced transition metal free Chan Evans Lam type coupling.

Herein, we report a photoinduced transition-metal-free C(aryl)-N bond formation between 2,4,6-tri(aryl)boroxines or arylboronic acids as an aryl source and 1,4,2-dioxazol-5-ones (dioxazolones) as an amide coupling partner. Chloride anion, either generated in situ by photodissociation of chlorinated solvent mols. or added sep. as an additive, was found to play a critical cooperative role, thereby giving convenient access to a wide range of synthetically versatile N-arylamides under mild photo conditions. The synthetic virtue of this transition-metal-free Chan-Evans-Lam-type coupling was demonstrated by large-scale reactions, synthesis of 15N-labeled arylamides, and applicability toward biol. relevant compounds On the basis of mechanistic investigations, two distinctive photoexcitations are proposed to function in the current process, in which the first excitation involving chloro-boron adduct facilitates the transition-metal-free activation of dioxazolones by single electron transfer (SET), and the second one enables the otherwise-inoperative 1,2-aryl migration of the thus-formed N-chloroamido-borate adduct.

Journal of the American Chemical Society published new progress about Boroxins Role: RCT (Reactant), RACT (Reactant or Reagent). 7465-88-5 belongs to class amides-buliding-blocks, name is 4-Methoxy-N-phenylbenzamide, and the molecular formula is C14H13NO2, Product Details of C14H13NO2.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Zuo, Dongxu published the artcileHighly Chemoselective Transamidation of Unactivated Tertiary Amides by Electrophilic N-C(O) Activation by Amide-to-Acyl Iodide Re-routing, Category: amides-buliding-blocks, the main research area is tertiary amide transamidation cooperative catalysis chemoselective; Acyl Iodides; Amides; Cooperative Catalysis; N−C(O) Activation; Transamidation.

The challenging transamidation of unactivated tertiary amides has been accomplished via cooperative acid/iodide catalysis. Most crucially, the method provides a novel manifold to re-route the reactivity of unactivated N,N-dialkyl amides through reactive acyl iodide intermediates, thus reverting the classical order of reactivity of carboxylic acid derivatives This method provides a direct route to amide-to-amide bond interconversion with excellent chemoselectivity using equivalent amounts of amines. The combination of acid and iodide has been identified as the essential factor to activate the amide C-N bond through electrophilic catalytic activation, enabling the production of new desired transamidated products with wide substrate scope of both unactivated amides and amines, including late-stage functionalization of complex APIs (>80 examples). Authors anticipate that this powerful activation mode of unactivated amide bonds will find broad-ranging applications in chem. synthesis.

Angewandte Chemie, International Edition published new progress about Bond activation catalysts (N-C(O) activation). 7465-88-5 belongs to class amides-buliding-blocks, name is 4-Methoxy-N-phenylbenzamide, and the molecular formula is C14H13NO2, Category: amides-buliding-blocks.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics