Category: 7465-88-5

Mei, Yong-Kang published the artcilePhoto-Induced Construction of N-Aryl Amides by Fe Catalysis, Category: amides-buliding-blocks, the main research area is aryl amide preparation; methoxyamide arylboronic acid photo electrophilic amidation iron catalyst.

A photo-induced electrophilic amidation reaction with N-methoxyamides RC(O)NHOMe (R = Ph, 3-chlorophenyl, 2-thienyl, etc.) and arylboronic acids R1B(OH)2 (R1 = Ph, 3-bromophenyl, 3-thienyl, etc.) at low temperature using a simple iron salt as the catalyst precursor to N-aryl amides RC(O)NHR1 has been described. Initial mechanistic studies suggested that crucial amide radical species was involved.

European Journal of Organic Chemistry published new progress about Amidation (electrophilic). 7465-88-5 belongs to class amides-buliding-blocks, name is 4-Methoxy-N-phenylbenzamide, and the molecular formula is C14H13NO2, Category: amides-buliding-blocks.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Mkhonazi, Blessing D. published the artcilePalladium-Catalysed Reductive Aminocarbonylation of Aryl Bromides and Iodides with Nitroarenes, Application of 4-Methoxy-N-phenylbenzamide, the main research area is aryl amide preparation; nitroarene bromide aryl iodide palladium catalyzed reductive aminocarbonylation.

Herein, a palladium-catalyzed reductive aminocarbonylation of aryl bromides and iodides with nitroarenes to afford the resp. amides RC(O)NHR1 [R = Ph, 4-MeOC6H4, 3,5-diMeC6H3, etc.; R1 = Ph, 4-MeC6H4, 2-ClC6H4, etc.] was reported. The developed protocol employed Mo(CO)6 as a carbonyl source and a combination of Zn and TMSCl as co-reducing agents. For most substrates, the anticipated amide products were obtained in modest to high amide product yields.

SynOpen published new progress about Aminocarbonylation (reductive). 7465-88-5 belongs to class amides-buliding-blocks, name is 4-Methoxy-N-phenylbenzamide, and the molecular formula is C14H13NO2, Application of 4-Methoxy-N-phenylbenzamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Joseph, Devaneyan published the artcileMetal-free transamidation of benzoylpyrrolidin-2-one and amines under aqueous conditions, Recommanded Product: 4-Methoxy-N-phenylbenzamide, the main research area is benzoylpyrrolidinone benzoylpiperidinone benzoylazepanone amine transamidation green chem.

N-Acyl lactam amides, such as benzoylpyrrolidin-2-one, benzoylpiperidin-2-one, and benzoylazepan-2-one reacted with amines in the presence of DTBP and TBAI to afford the transamidated products in good yields. The reactions were conducted under aqueous conditions and good functional group tolerance was achieved. Both aliphatic and aromatic primary amines displayed good activity under metal-free conditions. A radical reaction pathway is proposed.

Organic & Biomolecular Chemistry published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 7465-88-5 belongs to class amides-buliding-blocks, name is 4-Methoxy-N-phenylbenzamide, and the molecular formula is C14H13NO2, Recommanded Product: 4-Methoxy-N-phenylbenzamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Lei, Peng published the artcileProtocol for Palladium/N-Heterocyclic Carbene-Catalyzed Suzuki-Miyaura Cross-Coupling of Amides by N-C(O) Activation, Quality Control of 7465-88-5, the main research area is diaryl ketone green preparation; amide arylboronic acid Suzuki Miyaura cross coupling palladium catalyst.

A protocol for the Suzuki-Miyaura cross-coupling of amides by selective N-C(O) bond activation catalyzed by com. available, air- and moisture-stable palladium/N-heterocyclic carbene (NHC) complexes was described to obtain diaryl ketones ArC(O)Ar1 [Ar = Ph, 2-MeC6H4, 4-MeOC6H4, 4-CO2MeC6H4; Ar1 = Ph, 2-MeC6H4, 4-MeC6H4, 4-MeOC6H4, 4-CO2MeC6H4]. The procedure described involved [Pd(IPr)(cin)Cl] [IPr = 2,6-(diisopropylphenyl)imidazol-2-ylidene, cin = cinnamyl] at 0.10 mol% at room temperature and was performed on decagram scale. Furthermore, a procedure for the synthesis of amide starting materials was accomplished via selective N- tert-butoxycarbonylation, which was the preferred method over N-acylation. The present protocol carried advantages of operational simplicity, com. availability of catalysts and excellent conversions at low catalyst loadings. The method was generally useful for activation of N-C(O) amide bonds in a broad spectrum of amide precursors. The protocol should facilitate the implementation of amide cross-coupling reactions.

Synthesis published new progress about Amides Role: RCT (Reactant), RACT (Reactant or Reagent). 7465-88-5 belongs to class amides-buliding-blocks, name is 4-Methoxy-N-phenylbenzamide, and the molecular formula is C14H13NO2, Quality Control of 7465-88-5.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Zhao, Rong published the artcileActivated charcoal supported copper nanoparticles: A readily available and inexpensive heterogeneous catalyst for the N-arylation of primary amides and lactams with aryl iodides, Recommanded Product: 4-Methoxy-N-phenylbenzamide, the main research area is aryl benzamide preparation; primary amide aryl iodide Goldberg reaction copper catalyst; lactam aryl iodide Goldberg reaction copper catalyst.

A novel heterogeneous copper catalyst has been developed by supporting copper nanoparticles on activated charcoal via in situ reducing copper(II) with aqueous hydrazine as reductant. The characterization of Cu/C catalyst showed that the Cu0 nano-particles were formed on the surface of charcoal. This catalyst displayed good catalytic activities toward the N-arylation of primary amides RC(O)NH2 (R = Ph, pyridin-3-yl, 3-nitrophenyl, etc.) and lactams such as 3-morpholinone, 2-azaspiro[4.5]decan-1-one, 2-pyridinone with aryl iodides 4-R1C6H4I (R1 = H, OMe, Ac, Br, NO2).

Tetrahedron published new progress about Amides Role: RCT (Reactant), RACT (Reactant or Reagent). 7465-88-5 belongs to class amides-buliding-blocks, name is 4-Methoxy-N-phenylbenzamide, and the molecular formula is C14H13NO2, Recommanded Product: 4-Methoxy-N-phenylbenzamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Song, Wangze published the artcileVisible Light-Induced Amide Bond Formation, Category: amides-buliding-blocks, the main research area is amide preparation green chem; thioacid aniline amide bond formation photoredox catalyst.

A metal-, base-, and additive-free amide bond formation reaction was developed under an organic photoredox catalyst. This green approach showed excellent functional selectivity without affecting other functional groups such as alcs., phenols, ethers, esters, halogens, or heterocycles. This method featured a broad substrate scope, good compatibility with water and air, and high yields (Category: amides-buliding-blocks.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Zhang, Guoqi published the artcileRedox-Noninnocent Ligand-Supported Vanadium Catalysts for the Chemoselective Reduction of C=X (X = O, N) Functionalities, Computed Properties of 7465-88-5, the main research area is vanadium ligand catalyst reduction ketone aldehyde imine ester carboxamide.

Catalysis is the second largest application for V after its use as an additive to improve steel production Mol. complexes of vanadium(V) are particularly useful and efficient catalysts for oxidation processes; however, their ability to catalyze reductive transformations has yet to be fully explored. Here the authors report the first examples of polar organic functionality reduction mediated by V. Open-shell VIII complexes that feature a π-radical monoanionic 2,2′:6′,2”-terpyridine ligand (Rtpy•)- functionalized at the 4′-position (R = (CH3)3SiCH2, Ph) catalyze mild and chemoselective hydroboration and hydrosilylation of functionalized ketones, aldehydes, imines, esters, and carboxamides with turnover numbers (TONs) of up to ∼1000 and turnover frequencies (TOFs) of up to ∼500 h-1. Computational evaluation of the precatalyst synthesis and activation revealed underappreciated complexity associated with the redox-active tpy chelate.

Journal of the American Chemical Society published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 7465-88-5 belongs to class amides-buliding-blocks, name is 4-Methoxy-N-phenylbenzamide, and the molecular formula is C14H13NO2, Computed Properties of 7465-88-5.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Xiong, Ni published the artcileMild Amide Synthesis Using Nitrobenzene under Neutral Conditions, Related Products of amides-buliding-blocks, the main research area is aryl aldehyde nitroarene iron catalyst photochem amidation; aryalkyl alc nitroarene iron catalyst photochem amidation; diaryl amide preparation.

In this report, a mild protocol for amide formation using the readily available nitroarenes as nitrogen sources and an inexpensive iron complex as a catalyst was described. Because of the use of the pH-neutral conditions and the avoidance of the strong oxidant or reductant, a wide range of aromatic and aliphatic aldehydes as well as nitroarenes with various functional groups could be tolerated well. A plausible mechanism was proposed based on the detailed studies, in which iron catalyst initiates the radical process and the solvent plays a key role as O-atom acceptor.

Organic Letters published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 7465-88-5 belongs to class amides-buliding-blocks, name is 4-Methoxy-N-phenylbenzamide, and the molecular formula is C14H13NO2, Related Products of amides-buliding-blocks.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Li, Qingyao published the artcilePhotomediated reductive coupling of nitroarenes with aldehydes for amide synthesis, Recommanded Product: 4-Methoxy-N-phenylbenzamide, the main research area is aryl amide preparation; aldehyde nitroarene reductive coupling photomediated hydrogen atom transfer catalysis.

In view of the widespread significance of amide functional groups in organic synthesis and pharmaceutical studies, an efficient and practical synthetic protocol that avoids the use of stoichiometric activating reagents or metallic reductants is highly desirable. A straight-forward pathway to access amides from abundant chem. feedstock would offer a strategic advantage in the synthesis of complex amides. Authors herein disclose a direct reductive amidation reaction using readily available aldehydes and nitroarenes enabled by photo-mediated hydrogen atom transfer catalysis. It avoids the use of metallic reductants and production of toxic chem. waste. While aldehydes represent a classic class of electrophilic synthons, the corresponding nucleophilic acyl radicals could be directly accessed by photo hydrogen atom transfer catalysis, enabling polarity inversion. Authors method provides an orthogonal strategy to conventional amide couplings, tolerating nucleophilic substituents such as free alcs. and sensitive functional groups to amines such as carbonyl or formyl groups. The synthetic utilization of this reductive amidation is demonstrated by the late-stage modification of complex biol. active mols. and direct access of drug mols. leflunomide and lidocaine.

Chemical Science published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 7465-88-5 belongs to class amides-buliding-blocks, name is 4-Methoxy-N-phenylbenzamide, and the molecular formula is C14H13NO2, Recommanded Product: 4-Methoxy-N-phenylbenzamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Singh, Ashmita published the artcileOxidative Amidation of Aldehydes with Amines Catalysed by Fe(II) – Hydride Complex and N- Heterocyclic Carbenes (NHC), Safety of 4-Methoxy-N-phenylbenzamide, the main research area is primary secondary amide preparation; aldehyde amine oxidative amidation iron catalyst NHC ligand.

Oxidative amidation reaction of aldehydes with amines, by tert Bu hydrogen peroxide in toluene was achieved. The reaction utilized the in situ generated catalyst produced by Fe(II) – hydride complex [FeH2(PPh3)4], and N-heterocyclic carbene (NHC) ligand. The catalytic system was found efficient for the synthesis of wide variety of mono and disubstituted amides.

ChemistrySelect published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 7465-88-5 belongs to class amides-buliding-blocks, name is 4-Methoxy-N-phenylbenzamide, and the molecular formula is C14H13NO2, Safety of 4-Methoxy-N-phenylbenzamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics