Category: 7465-88-5

Tang, Jing-Jing published the artcileVisible-Light-Promoted Iron-Catalyzed N-Arylation of Dioxazolones with Arylboronic Acids, Recommanded Product: 4-Methoxy-N-phenylbenzamide, the main research area is benzamide preparation; arylboronic acid dioxazolone arylation visible light iron catalyst.

Synthesis of benzamides ArC(O)NAr1 [Ar = Ph, 4-FC6H4, furan-2-yl, etc.; Ar1 = Ph, 4-MeC6H4, 4-BrC6H4, etc.] via visible-light-promoted iron salt-catalyzed N-arylation of arylboronic acids and bench-stable dioxazolones was achieved efficiently under external photosensitizer-free conditions. This reaction featured high reactivity, wide substrate scope, good functional group tolerance, simple operation procedure, and mild reaction conditions. Preliminary mechanistic investigations were conducted to support a radical pathway. This method may contribute to shift the paradigm of iron-catalyzed C-N bond construction and nitrene transfer chem.

ACS Catalysis published new progress about Arylation. 7465-88-5 belongs to class amides-buliding-blocks, name is 4-Methoxy-N-phenylbenzamide, and the molecular formula is C14H13NO2, Recommanded Product: 4-Methoxy-N-phenylbenzamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Song, Jia-Lin published the artcileRh(III)-Catalyzed N-Arylation of Alkyl Dioxazolones with Arylboronic Acids for the Synthesis of N-Aryl Amides, SDS of cas: 7465-88-5, the main research area is aryl amide preparation; alkyl dioxazolone aryl heterocyclic alkenyl boronic acid arylation amination.

Herein, a method for N-aryl amides preparation has been established through Rh(III)-catalyzed C(sp2)-N cross-coupling reactions of alkyl dioxazolones with arylboronic acids, heterocyclic boronic acid, and alkenyl boronic acid. This efficient and straightforward catalytic approach was featured with broad substrate scope (38 examples), good functional group compatibility, high yields (up to 99 %), and is suitable for late-stage modification of drug mol. structures. The possible mechanism hypothesis was also accomplished.

European Journal of Organic Chemistry published new progress about Amination. 7465-88-5 belongs to class amides-buliding-blocks, name is 4-Methoxy-N-phenylbenzamide, and the molecular formula is C14H13NO2, SDS of cas: 7465-88-5.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Liu, Xinwei published the artcileH2O2 -promoted C-C bond oxidative cleavage of β-O-4 lignin models to benzanilides using water as a solvent under metal-free conditions, Recommanded Product: 4-Methoxy-N-phenylbenzamide, the main research area is lignin model bond cleavage benzanilide hydrogen peroxide water solvent.

The production of aromatic compounds from lignin is an essential issue in the transformation of biomass. Herein, a simple method has been presented for the synthesis of benzanilides and phenols from aniline involving the oxidative cleavage of β-O-4 lignin models using H2O2 as an oxidizing agent without any metal catalysts and under relatively mild conditions.

Green Chemistry published new progress about Amidation. 7465-88-5 belongs to class amides-buliding-blocks, name is 4-Methoxy-N-phenylbenzamide, and the molecular formula is C14H13NO2, Recommanded Product: 4-Methoxy-N-phenylbenzamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Ghamari kargar, Pouya published the artcileA porous metal-organic framework (Ni-MOF): An efficient and recyclable catalyst for cascade oxidative amidation of alcohols by amines under ultrasound-irradiations, Application of 4-Methoxy-N-phenylbenzamide, the main research area is nickel metal organic framework surface area amidation green chem.

A novel and green protocol was developed for the synthesis of amides via the reaction of benzyl alcs. with amines in the presence of Ni-MOF named UoB-8 as catalyst. The morphol., structural, and physicochem. characteristics of the Ni-MOF were investigated by FT-IR, XRD, FESEM, EDX, TEM, BET, CHN and ICP analyses. The products were obtained in good to excellent yields, with short reaction times, under ultrasound irradiation (40 °C) in ethanol as solvent. In addition, low-cost catalyst was recovered and reused at least 5 times without detecting a noticeable reduction in efficiency.

Molecular Catalysis published new progress about Amidation. 7465-88-5 belongs to class amides-buliding-blocks, name is 4-Methoxy-N-phenylbenzamide, and the molecular formula is C14H13NO2, Application of 4-Methoxy-N-phenylbenzamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Li, Guangchen published the artcileHighly Chemoselective, Transition-Metal-Free Transamidation of Unactivated Amides and Direct Amidation of Alkyl Esters by N-C/O-C Cleavage, Recommanded Product: 4-Methoxy-N-phenylbenzamide, the main research area is chemoselective transamidation unactivated amide amidation alkyl ester.

The amide bond is one of the most fundamental functional groups in chem. and biol. and plays a central role in numerous processes harnessed to streamline the synthesis of key pharmaceutical and industrial mols. Although the synthesis of amides is one of the most frequently performed reactions by academic and industrial scientists, the direct transamidation of tertiary amides is challenging due to unfavorable kinetic and thermodn. contributions of the process. Herein, we report the first general, mild, and highly chemoselective method for transamidation of unactivated tertiary amides by a direct acyl N-C bond cleavage with non-nucleophilic amines. This operationally simple method is performed in the absence of transition metals and operates under unusually mild reaction conditions. In this context, we further describe the direct amidation of abundant alkyl esters to afford amide bonds with exquisite selectivity by acyl C-O bond cleavage. The utility of this process is showcased by a broad scope of the method, including various sensitive functional groups, late-stage modification, and the synthesis of drug mols. (>80 examples). Remarkable selectivity toward different functional groups and within different amide and ester electrophiles that is not feasible using existing methods was observed Extensive exptl. and computational studies were conducted to provide insight into the mechanism and the origins of high selectivity. We further present a series of guidelines to predict the reactivity of amides and esters in the synthesis of valuable amide bonds by this user-friendly process. In light of the importance of the amide bond in organic synthesis and major practical advantages of this method, the study opens up new opportunities in the synthesis of pivotal amide bonds in a broad range of chem. contexts.

Journal of the American Chemical Society published new progress about Amidation. 7465-88-5 belongs to class amides-buliding-blocks, name is 4-Methoxy-N-phenylbenzamide, and the molecular formula is C14H13NO2, Recommanded Product: 4-Methoxy-N-phenylbenzamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Fu, Zhengqiang published the artcileManganese Catalyzed Direct Amidation of Esters with Amines, Computed Properties of 7465-88-5, the main research area is amide preparation; ester amine amidation manganese catalyst.

The transition metal catalyzed amide bond forming reaction of esters with amines has been developed as an advanced approach for overcoming the shortcomings of traditional methods. The broad scope of substrates in transition metal catalyzed amidations remains a challenge. Here, a manganese(I)-catalyzed method for the direct synthesis of amides from a various number of esters and amines is reported with unprecedented substrate scope using a low catalyst loading. A wide range of aromatic, aliphatic, and heterocyclic esters, even in fatty acid esters, reacted with a diverse range of primary aryl amines, primary alkyl amines, and secondary alkyl amines to form amides. It is noteworthy that this approach provides the first example of the transition metal catalyzed amide bond forming reaction from fatty acid esters and amines. The acid-base mechanism for the manganese(I)-catalyzed direct amidation of esters with amines was elucidated by DFT calculations

Journal of Organic Chemistry published new progress about Amidation. 7465-88-5 belongs to class amides-buliding-blocks, name is 4-Methoxy-N-phenylbenzamide, and the molecular formula is C14H13NO2, Computed Properties of 7465-88-5.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Ke, Fang published the artcileElectrochemical N-acylation synthesis of amides under aqueous conditions, Formula: C14H13NO2, the main research area is amide chemoselective preparation; carboxylic acid amine electrochem acylation.

An electrochem. N-acylation of carboxylic acids with amines was reported for the synthesis of amides I [R1 = H, 4-CN, 2-I, etc.; R2 = H, 4-Me, 4-Cl, etc.]. The sustainable TBAB electrocatalysis proceeded with excellent chemoselectivity and positional selectivity, and with ample scope, allowing electrochem. N-acylation under mild reaction conditions at room temperature in water. Moreover, the synthetic utility of the current method was demonstrated by the synthesis of melatonin.

Green Chemistry published new progress about Acylation. 7465-88-5 belongs to class amides-buliding-blocks, name is 4-Methoxy-N-phenylbenzamide, and the molecular formula is C14H13NO2, Formula: C14H13NO2.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Exner, Jessica published the artcileElectronic effects in profluorescent benzotriazinyl radicals: a combined experimental and theoretical study, HPLC of Formula: 7465-88-5, the main research area is profluorescent benzotriazinyl radical preparation styryl trapping product; absorption photoluminescence EPR g factor quantum chem calculation.

The synthesis, photophys. characterization, and quantum chem. calculations of a series of benzotriazinyl radicals I (R1, R2, R3 = H, OMe, CN) and their styryl radical trapping products II are presented. The benzotriazinyl radicals are non-luminescent but surprisingly the corresponding styryl radical trapping products exhibit high fluorescence quantum yields (up to 60% in some cases), making them highly valuable probes or labels. Addnl., the influence of the substitution pattern on the optical properties of the radical trapping products was observed exptl. and interpreted by means of quantum chem. calculations Specific substitution patterns showed a bathochromic shift compared to the unsubstituted compound Computationally, it was shown that this substitution pattern leads to a stronger energetic stabilization of the LUMO than the HOMO. Anal. of the influence of the substitution pattern on the optical properties showed a bathochromic shift in several examples, which was interpreted by means of quantum chem. calculations

Physical Chemistry Chemical Physics published new progress about Absorption spectra. 7465-88-5 belongs to class amides-buliding-blocks, name is 4-Methoxy-N-phenylbenzamide, and the molecular formula is C14H13NO2, HPLC of Formula: 7465-88-5.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Kadam, Abhishek A. published the artcileNi-Catalyzed Three-Component Alkene Carboacylation Initiated by Amide C-N Bond Activation, Computed Properties of 7465-88-5, the main research area is alkene amide tetraarylborate nickel catalyst chemoselective diastereoselective carboacylation; functionalized ketone stereoselective preparation.

The nickel-catalyzed intermol. carboacylation of alkenes with amides and tetraarylborates is presented. Bicyclic alkenes are readily functionalized with a variety of N-benzoyl-N-phenylbenzamides and triarylboranes, which are generated in situ from the corresponding tetraarylborates, to synthesize ketone products in up to 91% yield. Preliminary mechanistic studies suggest that migratory insertion precedes transmetalation and that reductive elimination is the turnover-limiting step. These reactions occur with excellent chemoselectivity and diastereoselectivity in the absence of a directing/chelating group and further demonstrate amides as practical acyl electrophiles for alkene dicarbofunctionalization reactions.

ACS Catalysis published new progress about Acylation catalysts. 7465-88-5 belongs to class amides-buliding-blocks, name is 4-Methoxy-N-phenylbenzamide, and the molecular formula is C14H13NO2, Computed Properties of 7465-88-5.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Chen, Dianpeng published the artcileExternal Reductant-Free Palladium-Catalyzed Reductive Insertion of Isocyanide: Synthesis of Polysubstituted Pyrroles and Its Applications as a Cysteine Probe, SDS of cas: 7465-88-5, the main research area is palladium catalyst insertion isocyanide polysubstituted pyrrole preparation cysteine determination.

An unprecedented route is described for the synthesis of 2-amino-4-cyanopyrrole derivatives via palladium-catalyzed reductive isocyanide insertion of alkynyl imines. In the reactions, no external reductant was added and isocyanide plays a dual role as both a C1 synthon for imidoylation and a cyano source for cyanation. Mechanism studies suggest a [4 + 1] cycloaddition, an isocyanide insertion, β-carbon elimination, and palladium hydride-based reduction are involved. Moreover, the application of 2-amine-4-cyanopyrroles as a cysteine probe is realized to detect cysteine.

Organic Letters published new progress about Cycloaddition reaction. 7465-88-5 belongs to class amides-buliding-blocks, name is 4-Methoxy-N-phenylbenzamide, and the molecular formula is C14H13NO2, SDS of cas: 7465-88-5.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics