Category: 744183-20-8

Related Products of 744183-20-8, The chemical industry reduces the impact on the environment during synthesis 744183-20-8, name is tert-Butyl exo-3-amino-8-azabicyclo[3.2.1]octane-8-carboxylate, I believe this compound will play a more active role in future production and life.

To a mixture of the product of the previous step (1020 mg, 3.42 mmol) and tert25 butyl (1R,3s,55)-3-amino-8-azabicyclo[3.2.ljoctane-8-carboxylate (774 mg, 3.42 mmol)in DMSO (34.3 mL) was added DIPEA (1.787 mL, 10.26 mmol) at RT. The resultingmixture was stirred at 120 C for 19 h. Solvent was removed by rotary evaporation to give cmde product, which was purified by column chromatography to give the titlecompound as a brown solid (513 mg, 30.7% yield). (m/z): [M+Hj calcd for C25H34C1N503 488.24 found 488.2.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, tert-Butyl exo-3-amino-8-azabicyclo[3.2.1]octane-8-carboxylate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; THERAVANCE BIOPHARMA R&D IP, LLC; HUDSON, Ryan; KOZAK, Jennifer; FATHEREE, Paul R.; PODESTO, Dante D.; BRANDT, Gary E.L.; FLEURY, Melissa; BEAUSOLEIL, Anne-Marie; HUANG, Xiaojun; THALLADI, Venkat R.; (121 pag.)WO2016/191524; (2016); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Some common heterocyclic compound, 744183-20-8, name is tert-Butyl exo-3-amino-8-azabicyclo[3.2.1]octane-8-carboxylate, molecular formula is C12H22N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: tert-Butyl exo-3-amino-8-azabicyclo[3.2.1]octane-8-carboxylate

A solution of 5,7-dichloro-3-iodo-1,6-naphthyridine (7.0 g, 21.6 mol), DIPEA (5.6 g, 43.2 mmol) and tert-butyl (1R,3s,55)-3-amino-8-azabicyclo[3 .2.11 octane-8-carboxylate(5.8 g, 25.9 mmol) dissolved in NMP (70 mL) was heated at 110C for 3 h. The reaction mixture was purified by column chromatography (eluted with EtOAc:petroleum ether 0- 20 %) to give the title intermediate as ayellow solid (10.2 g, 91.8 % yield).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 744183-20-8, its application will become more common.

Reference:
Patent; THERAVANCE BIOPHARMA R&D IP, LLC; HUDSON, Ryan; KOZAK, Jennifer; FATHEREE, Paul R.; PODESTO, Dante D.; BRANDT, Gary E.L.; FLEURY, Melissa; BEAUSOLEIL, Anne-Marie; HUANG, Xiaojun; THALLADI, Venkat R.; (121 pag.)WO2016/191524; (2016); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics