Category: 7413-34-5

Binding of drugs to liposome-entrapped macromolecules prevents diffusion of drugs from liposomes in vitro and in vivo was written by Gregoriadis, Gregory;Davisson, Pamela J.;Scott, Susan. And the article was included in Biochemical Society Transactions in 1977.Computed Properties of C20H20N8Na2O5 This article mentions the following:

A technique is described to delay the diffusion of small-mol.-weight drugs from liposomes by binding the drugs to liposome-associated macromols. Melphalan [148-82-3] was bound to Na polyglutamate [26247-79-0] and incorporated into egg lecithin liposomes; after i.v. injection into rats, liposomal polyglutamate-bound melphalan was eliminated from the blood plasma at a much slower rate than free melphalan. Similar results were obtained for Na methotrexate [7413-34-5] bound to polyglutamate in egg lecithin liposomes, and for daunomycin [20830-81-3] bound to calf thymus DNA in egg lecithin liposomes. In the experiment, the researchers used many compounds, for example, Sodium (S)-2-(4-(((2,4-diaminopteridin-6-yl)methyl)(methyl)amino)benzamido)pentanedioate (cas: 7413-34-5Computed Properties of C20H20N8Na2O5).

Sodium (S)-2-(4-(((2,4-diaminopteridin-6-yl)methyl)(methyl)amino)benzamido)pentanedioate (cas: 7413-34-5) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.Computed Properties of C20H20N8Na2O5

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

The effect of immunosuppressive and anti-inflammatory drugs on monocyte function in vitro was written by Norris, David A.;Weston, William L.;Sams, W. Mitchell Jr.. And the article was included in Journal of Laboratory and Clinical Medicine in 1977.Formula: C20H20N8Na2O5 This article mentions the following:

Monocytes (MNL) cellular chemotaxis, bacterial killing and phagocytosis, and Oil Red O phagocytosis were studied in vitro in the presence of 8 anti-inflammatory or immunosuppressive drugs. Inhibition of Boyden Chamber migration of MNL’s in a MNL-lymphocyte mixture was achieved after 0.5 h incubation by 10-3 and 10-4 mol/L concentrations of chloroquine [54-05-7] (maximum inhibition 63%), dexamethasone [50-02-2] (58%), 6-mercaptopurine [50-44-2] (62%), Na methotrexate [7413-34-5] (66%) , and vinblastine [865-21-4] (100%). Bacterial killing was not significantly affected by any of the drugs studied. Bacterial phagocytosis was improved by vinblastine at 10-3 and 10-4M and by 6-mercaptopurine at 10-5M, but there was apparent interference with the assay at high drug concentrations Modification of the Oil Red O technique showed inhibitions of MNL phagocytosis by vinblastine at 10-3M (69% inhibition), chloroquine at 10-3M (49%), and mercaptopurine at 10-3M (32.5%). Cyclophosphamide [50-18-0], although reported to require hepatic conversion in vivo, may be partially activated in a lymphocyte-MNL mixture in vitro, producing a decrease in cell viability but no statistically significant impairment of MNL function. These results support direct inhibition of MNL cellular function as 1 of the mechanisms of the anti-inflammatory action of chloroquine, dexamethasone, methotrexate, 6-mercaptopurine, and vinblastine. In the experiment, the researchers used many compounds, for example, Sodium (S)-2-(4-(((2,4-diaminopteridin-6-yl)methyl)(methyl)amino)benzamido)pentanedioate (cas: 7413-34-5Formula: C20H20N8Na2O5).

Sodium (S)-2-(4-(((2,4-diaminopteridin-6-yl)methyl)(methyl)amino)benzamido)pentanedioate (cas: 7413-34-5) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds. Tertiary amides, with the important exception of N,N-dimethylformamide, exhibit low solubility in water. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.Formula: C20H20N8Na2O5

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Study on mutagenicity of daunomycin and methotrexate sodium by Ames test and SCE method was written by Zhao, Shou-Yun;Chiu, Hsin-Fang;Li, Chang-Pen;Chin, Shih-Chen;Fu, Shao-Min. And the article was included in Yichuan in 1981.Related Products of 7413-34-5 This article mentions the following:

Daunomycin (I) [20830-81-3] induced mutagenesis in histidine-deficient strains of Salmonella typhimurium, TA100 and especially TA 98 at concentrations of ≥2 μg/test; in contrast, Na methotrexate (II Na salt) [7413-34-5] did not induce mutagenesis in both strains. Similar observations were made when I and II were tested on human leukocytes by sister chromatid exchanges (SCE); I (10 μg/mL) stimulated SCE frequency, whereas II did not cause significant change in the frequency of SCE. The sensitivity of the SCE method was 1500-fold more sensitive than the other method in testing the mutagenicity of these drugs. In the experiment, the researchers used many compounds, for example, Sodium (S)-2-(4-(((2,4-diaminopteridin-6-yl)methyl)(methyl)amino)benzamido)pentanedioate (cas: 7413-34-5Related Products of 7413-34-5).

Sodium (S)-2-(4-(((2,4-diaminopteridin-6-yl)methyl)(methyl)amino)benzamido)pentanedioate (cas: 7413-34-5) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.Related Products of 7413-34-5

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics