In an article, author is Zhang, Xu, once mentioned the application of 74-79-3, Application In Synthesis of L-Arginine, Name is L-Arginine, molecular formula is C6H14N4O2, molecular weight is 174.2, MDL number is MFCD00002635, category is amides-buliding-blocks. Now introduce a scientific discovery about this category.
The combination of multistage mass spectrometry experiments employing the distonic radical approach together with DFT calculations are used to examine addition of the N-methyl-pyridinium-4-yl radical cation (gamma-NMP) to iso(thio)cyanates in the gas-phase. The type of products formed depend on the nature of the iso(thio)cyanate: (1) hydrogen atom abstraction occurs for alkyl isocyanates; (2) aryl isocyanates undergo radical-ipso substitution; (3) radical attack occurs at the C=C bond of allyl isocyanate; (4) radical attack occurs at the C=S bond of isothiocyanates to generate S adducts of gamma-NMP and isonitriles. DFT calculations provide insight into the reactivity differences of these heterocumulenes towards the electrophilic C-centered gamma-distonic radical cations. Translation of these gas phase results to the solution phase were hampered by dominating radical recombination reactions which appear to be favoured over the radical-iso(thio)cyanate reactions.
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Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics