Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 7341-96-0, name is Propiolamide, A new synthetic method of this compound is introduced below., HPLC of Formula: C3H3NO
Aimine (0.24 mmol)Rhodium acetate (0.0024 mmol) and molecular sieves (300 mg) were mixed in 10 mL single-necked vials,Oil pump for nitrogen ventilation,A 1 mL syringe was added with 1 mL of re-evaporated CH? Cl?Prepared as a mixed solution A and stirred at room temperature for 10 minutes.The aryl diazonium compound (0.2 mmol) and the amide compound (0.2 mmol) were dissolved in 1 mL of re-evaporated CH? Cl?Prepared into solution B. Solution B was added to the mixed solution A at 25 C with a syringe pump over 1 hour.Stirring for 3 to 12 hours, the reaction mixture is purified by column chromatography to obtain a pure product,Its structure as shown in equation (f)(2S, 3S) -3- (4-trifluoromethylphenyl) -3 – ((2-hydroxyphenyl) amino) -2-phenyl-2-propiolamide propionate,The yield was 70%Dr value is equal to 95: 5, HPLC purity is 97%.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; East China Normal University; Liu Shunying; Lei Ruirui; Jia Kaili; Wu Yong; Liu Donglan; Dong Suzhen; Hu Wenhao; (42 pag.)CN106831474; (2017); A;,
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