7326-73-0 Archives - Amides-buliding-blocks

24-Sep-2021 News Continuously updated synthesis method about 7326-73-0

The synthetic route of 3-(N,N-Dimethylsulfamoyl)benzoic acid has been constantly updated, and we look forward to future research findings.

These common heterocyclic compound, 7326-73-0, name is 3-(N,N-Dimethylsulfamoyl)benzoic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C9H11NO4S

To a mixture of HATU (36.25 mg, 95.35 pmol) and 3-(dimethylsulfamoyl)benzoic acid (20.04 mg, 87.40 pmol) in DCM (2.0 mL) was added DIPEA (41 .07 mg, 317.82 pmol) in one portion at 20 C under N2. The mixture was stirred at 20 C for 10 min. Then (2S)-2-amino-N-(4-phenylthiazol-2-yl)pentanamide (50.0 mg, 128.41 pmol, TFA salt) was added and the mixture was stirred at 20 C for 2 hours. The reaction mixture was concentrated under reduced pressure to give a residue. The residue was purified by prep-HPLC (TFA condition; column: Boston pH-lex 150*25 10 pm; mobile phase: [water (0.1 %TFA)- ACN]; B%: 57%-76%, 8 min) and lyophilized to give compound 17 as a white solid. 1 H NMR (400MHz, DMSO-de) d 12.52 (s, 1 H), 9.05 (d, J = 7.6 Hz, 1 H), 8.29-8.27 (m, 2H), 7.93-7.90 (m, 3H), 7.81 -7.79 (m, 1 H), 7.64 (s, 1 H), 7.54-7.39 (m, 2H), 7.38-7.27 (m, 1 H), 4.76-4.70 (m, 1 H), 2.68-2.65 (m, 6H), 1 .86-1 .83 (m, 2H), 1 .58-1 .31 (m, 2H), 0.96-0.92 (m, 3H) ppm. LCMS (ESI) m/z: [M+H]+ = 487.1. Chiral HPLC: Amycoat-MeOH(DEA)-40-7min-3mL, 2.022 min.

The synthetic route of 3-(N,N-Dimethylsulfamoyl)benzoic acid has been constantly updated, and we look forward to future research findings.

Reference:
Patent; FOGHORN THERAPEUTICS INC.; ANTHONY, Neville, John; MILLAN, David, Simon; VASWANI, Rishi, G.; SCHILLER, Shawn, E.R.; (239 pag.)WO2019/152437; (2019); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Some tips on C9H11NO4S

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-(N,N-Dimethylsulfamoyl)benzoic acid, other downstream synthetic routes, hurry up and to see.

Adding a certain compound to certain chemical reactions, such as: 7326-73-0, name is 3-(N,N-Dimethylsulfamoyl)benzoic acid, belongs to amides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 7326-73-0, name: 3-(N,N-Dimethylsulfamoyl)benzoic acid

To a solution of 3-(dimethylsulfamoyl)benzoic acid (75.72 mg, 330.31 pmol) in DCM (10 ml_) was added HATU (125.59 mg, 330.31 pmol) and DIPEA (155.24 mg, 1 .20 mmol). The solution was stirred for 10 min and then intermediate i-1 b (81 mg, 300.28 pmol) was added. The solution was stirred at 30 C for 12hr. The reaction solution was poured into water (50 ml_) and extracted with EtOAc (100 ml_). The organic layer was washed with brine (50 ml_), dried (Na2SC>4) and concentrated in vacuum. To the residue was added MeOH (20 ml_) and stirred for 20 min, a white solid was formed. The solid was filtered and dried in vacuum to give compound 13 as a white solid. LCMS (ESI) m/z: [M+H]+ = 444.9. 1 H NMR (400 MHz, DMSO-d6) d= 12.49 (s, 1 H), 9.32 (t, J=5.6 Hz, 1 H), 8.27-8.25 (m, 2H), 7.96-7.90 (m, 3H), 7.81 -7.80 (m, 1 H), 7.64 (s, 1 H), 7.46-7.42 (m, 2H), 7.33-7.30 (m, 1 H), 4.23 (d, J=5.6 Hz, 2H), 2.65 (s, 6H) ppm.

Continuously updated synthesis method about C9H11NO4S

The synthetic route of 3-(N,N-Dimethylsulfamoyl)benzoic acid has been constantly updated, and we look forward to future research findings.

Research on new synthetic routes about 7326-73-0

The synthetic route of 7326-73-0 has been constantly updated, and we look forward to future research findings.

7326-73-0, name is 3-(N,N-Dimethylsulfamoyl)benzoic acid, belongs to amides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: 3-(N,N-Dimethylsulfamoyl)benzoic acid

To a solution of 3-(dimethylsulfamoyl)benzoic acid (38.30 mg, 167.06 gmol) in DCM (1 .0 ml_) were added HATU (69.87 mg, 183.76 gmol), DIEA (64.77 mg, 501 .18 gmol, 87.30 gl_) and intermediate i- 45b (100 mg, 167.06 gmol). The reaction mixture was stirred at 20 C for 12 hours and then poured into water (2.0 ml_). The solution was extracted with EtOAc (2.0 ml_ * 3). The combined organic extracts were washed with brine (5.0 ml_), dried over Na2SC>4 and filtered. The filtrate was concentrated to give a residue. The residue was purified by column chromatography (S1O2. PE/EA=50/1 -1 /1 ) to give intermediate i-45c as a white solid. LCMS (ESI) m/z: [M+H]+ = 696.0 Chiral HPLC: OJ-3-MeOH(DEA)-60-7MIN-3ML-35T, 5.276min.

The synthetic route of 7326-73-0 has been constantly updated, and we look forward to future research findings.