Category: 730-25-6

Gas-chromatographic study of anilides of aliphatic carboxylic acids was written by Sharif’yanova, L. N.;Vigdergauz, M. S.. And the article was included in Zhurnal Analiticheskoi Khimii in 1981.Recommanded Product: N-(3,4-Dichlorophenyl)octanamide The following contents are mentioned in the article:

To develop methods of gas chromatog. anal. for 16 anilides, their retention indexes on 4 stationary phases were measured, sorption thermodn. functions calculated, and equations found which connect the logarithmic retention indexes with the mol. size. The methods developed were used to control the production of N-(4-methyl-3-chlorophenyl)propionamide. This study involved multiple reactions and reactants, such as N-(3,4-Dichlorophenyl)octanamide (cas: 730-25-6Recommanded Product: N-(3,4-Dichlorophenyl)octanamide).

N-(3,4-Dichlorophenyl)octanamide (cas: 730-25-6) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.Recommanded Product: N-(3,4-Dichlorophenyl)octanamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

The structure-activity relation in amides inhibiting photosynthesis was written by Hansch, Corwin;Deutsch, Edna W.. And the article was included in Biochimica et Biophysica Acta, Biophysics Including Photosynthesis in 1966.SDS of cas: 730-25-6 The following contents are mentioned in the article:

By using substituent constants and regression analysis, the effect of various substituents on several groups of Hill-reaction inhibitors were studied. The primary effect of substituents in altering the activity of a parent phenylcarbamate, anilide, or phenylurea was associated with the hydrophobic bonding power of the substituent. The stronger the function bound hydrophobically, the greater was its inhibitory power on the photosynthetic reaction in isolated chloroplasts. This study involved multiple reactions and reactants, such as N-(3,4-Dichlorophenyl)octanamide (cas: 730-25-6SDS of cas: 730-25-6).

N-(3,4-Dichlorophenyl)octanamide (cas: 730-25-6) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. The presence of the amide group –C(=O)N– is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cm−1. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.SDS of cas: 730-25-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Fatty acid amides and anilides. Syntheses and antimicrobial properties was written by Bistline, R. G. Jr.;Maurer, E. W.;Smith, F. D.;Linfield, W. M.. And the article was included in Journal of the American Oil Chemists’ Society in 1980.HPLC of Formula: 730-25-6 The following contents are mentioned in the article:

A series of fatty acid amides and anilides was prepared; a number of compounds in the series were highly active against gram pos. bacteria but ineffective against gram neg. organisms. The N,N-dimethyl- and N,N-diethylamides of C₁₂-C₁₄ fatty acids had minimal inhibitory concentration (MIC) values of 100 ppm or less. Substituted anilides of C₆-C₁₁ fatty acids were active when the following groups were attached to the aromatic ring: 3,4-dichloro, 3-nitro, 4-nitro, 5-nitro-2-hydroxy, 4-chloro-3-nitro, and 2-hydroxy-5-nitro. Some of these compounds had a MIC value of 0.1 ppm. Significantly, the presence of soap did not reduce the activity of these bacteriostats, whereas polysorbate 80 at high concentrations deactivated the compounds This study involved multiple reactions and reactants, such as N-(3,4-Dichlorophenyl)octanamide (cas: 730-25-6HPLC of Formula: 730-25-6).

N-(3,4-Dichlorophenyl)octanamide (cas: 730-25-6) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.HPLC of Formula: 730-25-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Inhibition of photochemical activity of isolated chloroplasts by acylanilides was written by Moreland, D. E.;Hill, K. L.. And the article was included in Weeds in 1963.Reference of 730-25-6 The following contents are mentioned in the article:

The effect of mono- and dichlorophenyl analogs of N-phenyl-2-methylpentanamide (I) and N-(3,4-dichlorophenyl) alkan-amides on the photolytic activity (Hill reaction) of chloroplasts isolated from turnip greens was studied. I inhibited the Hill reaction by 50% (I₅₀) at 4.5 × 10^-5M. Monochlorination in meta and para positions enhanced inhibition; ortho monochlorination negated inhibition. The N-(3,4-dichlorophenyl) analog was the most inhibitory of 6 dichlorinated isomers (I₅₀ = 5.8 × 10^-7M). The N-phenyl-N-(3,4-dichlorophenyl) analog, however, was less effective than unsubstituted I. Of the straight chain N-(3,4-dichlorophenyl) alkanamides, the propanamide was the most effective. 2-Methyl alkanamides were more effective than the corresponding straight-chain alkan-amides. Of these, N-(3,4-dichlorophenyl)-2-methylpropanamide was most effective. Kinetic studies indicate that both light and dark reactions are inhibited. This study involved multiple reactions and reactants, such as N-(3,4-Dichlorophenyl)octanamide (cas: 730-25-6Reference of 730-25-6).

N-(3,4-Dichlorophenyl)octanamide (cas: 730-25-6) belongs to amides. Compared to amines, amides are very weak bases and do not have clearly defined acid–base properties in water. On the other hand, amides are much stronger bases than esters, aldehydes, and ketones. As a result of interactions such as these, the water solubility of amides is greater than that of corresponding hydrocarbons. These hydrogen bonds are also have an important role in the secondary structure of proteins.Reference of 730-25-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Use of the hydrophobic substituent constant in a comparative molecular field analysis (CoMFA) on a set of anilides inhibiting the Hill reaction was written by Greco, G.;Novellino, E.;Pellecchia, M.;Silipo, C.;Vittoria, A.. And the article was included in SAR and QSAR in Environmental Research in 1993.Formula: C14H19Cl2NO The following contents are mentioned in the article:

The activity of a set of anilide inhibitors of the Hill reaction was modeled using the traditional Hansch approach and Comparative Mol. Field Anal. (CoMFA). In the “best” Hansch model the most relevant parameters were the hydrophobic constants associated to substituents at the 3- and 4-positions of the benzene ring (π₃ and π₄) and the B₁ Verloop’s parameter describing the “min. width” of the substituent attached to the carbonyl. Successively, a combined “Hansch-CoMFA” anal. was performed using as descriptors the steric field of the acyl substituents in conjunction with the π₃ and π₄ constants multiplied by proper weighting factors. The results of this latter type of anal. were significantly better than those obtained through the traditional Hansch approach. The predictive ability of the “Hansch-CoMFA” model was further tested by predicting the activity of a large number of anilides not included in the training set. The residuals of such predictions indicated that the Hansch-CoMFA model was characterized by higher predictive ability and confirmed the efficiency of such a 3D-QSAR method in handling shape-dependent factors. This study involved multiple reactions and reactants, such as N-(3,4-Dichlorophenyl)octanamide (cas: 730-25-6Formula: C14H19Cl2NO).

N-(3,4-Dichlorophenyl)octanamide (cas: 730-25-6) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.Formula: C14H19Cl2NO

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Antibacterially active substituted anilides of carboxylic and sulfonic acids was written by Linfield, Warner M.;Micich, Thomas J.;Montville, Thomas J.;Simon, John R.;Murray, Ermellina B.;Bistline, Raymond G. Jr.. And the article was included in Journal of Medicinal Chemistry in 1983.COA of Formula: C14H19Cl2NO The following contents are mentioned in the article:

Anilides of carboxylic and sulfonic acids were prepared and tested for antimicrobial activity. Although these anilides were ineffective against gram-neg. organisms, there was a good correlation between chem. structure and biol. activity against gram-pos. species. Both the nature and position of the benzene ring substituents and the length of the C side chain affected the activity and specificity of the compounds The highest activity was observed when the acyl or sulfuryl moiety had a C₇-C₉ side chain attached. The -CONH- and SO₂NH- bridging groups were equally effective. The attachment of COOH or COOCH₃ groups in the ω-position did not affect activity, but the substitution of the acidic proton of the sulfonamide group by an alkyl group rendered the compound inactive. Six compounds, which were substituted anilides of sulfonic acids, fatty acids, or the analagous α-methylene-substituted acids, were bacteriostatic at 10 ppm against Bacillus cereus, Staphylococcus aureus, Streptococcus faecalis, and Lactobacillus plantarum. One of these compounds, the 2-hydroxy-5-nitroanilide of α-methylenedecanoic acid, was bactericidal at 1 ppm. This study involved multiple reactions and reactants, such as N-(3,4-Dichlorophenyl)octanamide (cas: 730-25-6COA of Formula: C14H19Cl2NO).

N-(3,4-Dichlorophenyl)octanamide (cas: 730-25-6) belongs to amides. Compared to amines, amides are very weak bases and do not have clearly defined acid–base properties in water. On the other hand, amides are much stronger bases than esters, aldehydes, and ketones. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.COA of Formula: C14H19Cl2NO

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Fractionation of the photochemical systems of photosynthesis. I. Chlorophyll contents and photochemical activities of particles isolated from spinach chloroplasts was written by Anderson, Jan M.;Boardman, N. K.. And the article was included in Biochimica et Biophysica Acta, Biophysics Including Photosynthesis in 1966.Reference of 730-25-6 The following contents are mentioned in the article:

Spinach chloroplasts were fragmented by incubation with digitonin and the resulting chlorophyll-containing particles separated by differential centrifugation. Particles pelleted by forces of 1000 g and 10,000 g had a lower ratio of chlorophyll a/chlorophyll b (chl a/chl b) than the chloroplasts, whereas the smaller particles which either sedimented at 50,000-144,000 g or remained in the 144,000-g supernatant had higher ratios than the chloroplasts. Chl a/chl b ratios were usually determined spectrophotometrically in 80% acetone, but essentially the same ratios were obtained after transfer of the pigments to ether or after separation of the chlorophylls by thin-layer chromatography. The small particles were inactive in the Hill reaction, either with ferricyanide, trichloroindophenol, or NADP as oxidant, but they photoreduced NADP if provided with the electron-donor couple, Na ascorbate, and dichloroindophenol, and both ferredoxin and NADP reductase. The 1000-g and 10,000-g fractions showed Hill activity, but the rate of reduction of NADP in the presence of ferredoxin and NADP reductase was lower than the rates of reduction of ferricyanide and trichloroindophenol. The particles with the high chl a/chl b ratios appear to be representative of System I (the “long wavelength” system) of photosynthesis, whereas the 1000-g and 10,000-g fractions appear to be enriched in particles representative of System 2. Chloroplasts were also fragmented by Triton X-100 and Nonidet P-40; in contrast to the digiton treatment, the particles so obtained were photochem. inactive. This study involved multiple reactions and reactants, such as N-(3,4-Dichlorophenyl)octanamide (cas: 730-25-6Reference of 730-25-6).

N-(3,4-Dichlorophenyl)octanamide (cas: 730-25-6) belongs to amides. Compared to amines, amides are very weak bases and do not have clearly defined acid–base properties in water. On the other hand, amides are much stronger bases than esters, aldehydes, and ketones. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.Reference of 730-25-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Correlations between acidity of substituted phenylamides and inhibition of the Hill reaction was written by Camper, N. D.;Moreland, D. E.. And the article was included in Biochimica et Biophysica Acta, Biophysics Including Photosynthesis in 1965.COA of Formula: C14H19Cl2NO The following contents are mentioned in the article:

Relative acidities of substituted phenylamides were determined by potentiometric titration with 0.1N tetrabutylammonium hydroxide methoxide in BuNH₂ and expressed as half-neutralization potentials (HNP). The HNP values were correlated with inhibitory potency expressed against the Hill reaction. Of the phenylamide families studied, i.e., phenylureas, N-phenylcarbamates, and acylanilides, the phenylureas were the most acidic. Within each family, increased acidity was correlated with increased inhibition for the unchlorinated, 3- or 4-monochloro, and 3,4-dichloro derivatives, respectively. A peak occurred in the activity-acidity curve for various metasubstituted derivatives of 2-propyl N-phenylcarbamate which may be related to an optimum charge on the imino N required for high inhibitory activity. Variations in length of the side chain did not markedly affect the HNP. Substitution of an OH group for the imino H, replacement of the carbonyl O with a S atom, and chlorination and (or) unsaturation in the alkyl group increased acidity, but in general decreased inhibitory activity. A correlation between charge on the imino N and inhibition of the Hill reaction is apparent if considerations are restricted to a comparison of derivatives in which electronic rather than steric influences predominate. Steric influences are considered to control the fit, as well as the ease, with which the inhibitor approaches the active site. Electronic influences conceivably control chem. reactivity and binding of the inhibitor at the active center. This study involved multiple reactions and reactants, such as N-(3,4-Dichlorophenyl)octanamide (cas: 730-25-6COA of Formula: C14H19Cl2NO).

N-(3,4-Dichlorophenyl)octanamide (cas: 730-25-6) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.COA of Formula: C14H19Cl2NO

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Inhibitors of the Hill reaction was written by Good, Norman E.. And the article was included in Plant Physiology in 1961.Safety of N-(3,4-Dichlorophenyl)octanamide The following contents are mentioned in the article:

Compounds (147) of the general formula RNHC(X)R’ were studied as inhibitors of the reduction of ferricyanide by illuminated chloroplasts. The following were prepared (R, X, R’, and m.p. given): octyl, O, Me₂N, 27-8°; cyclohexyl, O, Me₂N, 156-7°; benzyl, O, Me₂N, 76-7°; and Ph, O. 2-methyl-1-propenyl, 127-9°. Similarly, 4-ClC₆H₄NHC(X)R'(X, R’, and m.p. given): O, Cl₂CH 137-8°; O Cl₃C, 127-8°; S, Et, 77-8°; O, 1-chloroethyl, 112°; O, 1,1-dichloroethyl, 94-5°; O, 2-methyl-1-propenyl, 121-2°; O, Me₃C, 148-9°; and S, 4-chloroanilino, 178-9°. Similarly, 3-ClC₆H₄NHC(X)R’; O, H, 55-6°; O, ClCH₂, 99-100°; O, Cl₃C, 101-2°; O, Pr, 45-6°; O, iso-Pr, 112°; O, 2-methyl-1-propenyl, 112-13°; O, Me₂N, 139-41°; and O, 4-chloro-3-butynoxy, 75-6°. Similarly, 2-ClC₆H₄NHC(X)R’: O, Cl₃C, 62°; O, 1-chloroethyl, 59°; O, Pr, 80°; O, iso-Pr, 93-4°; O, 2-methyl-2-propenyl, 88-9°; and O, Me₃C, 76. Similarly, 3,5-Cl₂C₆H₃NHC(X)R”: O, H, 127°; O, Cl₃C, 121-2°; O, Et, 118-20°; O, 2-chloroethyl, 97-8°; O, Pr, 85-6°; O, iso-Pr, 134-5°; O, 2-methyl-1-propenyl, 106-7°; and O, Me₂N, 163-5°. Similarly, 3,4-Cl₂C₆H₃NHC(X)R’: O, ClCH₂, 106-7°; O, Cl₃C, 124-6°; O, BrCH₂, 99-101°; O, 1,1-dichloroethyl, 110-12°; S, Et, 71-2°; O, 2-chloroethyl, 112-13°; O, 2-propenyl, 120-2°; O, Me₃C, 145-6°; O, sec-Bu, 112-13°; O, pentyl, 75-6°; O, heptyl, 42°; O, octyl, 69-70°; O, nonyl, 70-1°; O, Ph, 145-6°; O, 2-ClC₆H₄, 152-3°; O, 4-ClC₆H₄, 172-3°; O, 2,4-Cl₂C₆H₃, 156-7°; O, 3,4-Cl₂C₆H₃, 227-8°; O, cyclohexyl, 137-8°; O, benzyl, 132°; O, 3,4-dichlorobenzyl, 186-7°; O, PhOCH₂ 141-2°; O, 2,4-Cl₂C₆H₃OCH₂, 160-1°; O, 2-methyl-1-propenyl, 103°; O, 3-phenylpropyl, 74-5°; O, trans-2-naphthylmethyl, 157-8°; O, 1-naphthylmethyl, 170-2°; O, PrNH, 128-9°; O, BuNH, 121-2°; O, hexylamino, 104-5°; O, benzylamino, 171-2°; O, 2-hydroxylethylamino, 137-8°; O, Et₂N, 111-2; O, Pr₂ , 96-7°; O, iso-Pr₂N, 130-1°; O, piperidino, 172-3°; S, Et₂N, 95-6°; and S, EtNH, 114-15°. Similarly, iso-PrC(O)NHR: 2,3-Cl₂C₆H₃, 108-9°; 2,5-Cl₂C₆H₃, 137-9°; 2,4,5-Cl₃C₆H₂ 145-6°; 2,4,6-Cl₃C₆H₂, 151-2°; 2-MeOC₆H₄, 44°; 4-MeOC₆H₄, 109-11°; 4-O₂NC₆H₄, 167-9°; 3-O₂NC₆H₄, 93°; 3-chloro-4-methylphenyl, 146-7°; 2-methyl-3-chlorophenyl, 142-3°; 2-methyl-4-chlorophenyl, 163-4°; 3-nitro-4-methylphenyl, 106-7°; 1-naphthyl, 147-9°; 5,6,7,8-tetrahydro-2-naphthyl, 102°; 4-Me₂NC₆H₄, 157-8°; 2,6-dimethylphenyl, -; cyclohexyl, 116-17°; and benzyl, 91-2°. Generalizations: substitution on the 3-, 4-, or 5-positions of the benzene ring of the aniline derivatives by Cl, Br, MeO, or Me increased the inhibition. Other parts of the mol. being equal, the activity of the chloroanilides was in the decreasing order: 3,4; 3,5 and 3 and 4; unsubstituted and 2,4,5; 2,5 and 2,3; 2. p- and m-Nitro groups reduced activity slightly and p-dimethylamino reduced it greatly. The effects of modifying the acyl moiety of the anilides was too complex to classify. Polar groups reduced activity. N-Chloroacetyl-N-methylaniline, lacking an imino H, was barely inhibitory. The role of H bonding was uncertain. Substitutions on the aniline moiety which favor H bonding increased the effectiveness, but modification of the acyl moiety did not, since the imino H atoms of chloroacetyl and trichloroacetyl-3,4-dichloroaniline form bonds with carbonyl O to a very limited extent, although both were excellent inhibitors. The same was true of the triazines. This study involved multiple reactions and reactants, such as N-(3,4-Dichlorophenyl)octanamide (cas: 730-25-6Safety of N-(3,4-Dichlorophenyl)octanamide).

N-(3,4-Dichlorophenyl)octanamide (cas: 730-25-6) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.Safety of N-(3,4-Dichlorophenyl)octanamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics