72791-76-5, The chemical industry reduces the impact on the environment during synthesis 72791-76-5, name is Benzyl bis(2-chloroethyl)carbamate, I believe this compound will play a more active role in future production and life.
2-phenylacetonitrile (5.000 g, 42.680 mmol) and sodium hydride (60.00%, 3.755 g, 93.897 mmol) was dissolved in N,N-dimethylformamide (100 mL) at 0 C and stirred for 30 minutes then benzyl bis(2-chloroethyl)carbamate (11.787 g, 42.680 mmol) was added thereto after further stirring at 60 C for 3 hours, the reaction was terminated by lowering the temperature to room temperature. The reaction mixture was poured into water and extracted with ethyl acetate. The organic layer was washed with a saturated aqueous sodium chloride solution, and water was removed with anhydrous magnesium sulfate, followed by filtration and concentration under reduced pressure. The concentrate was purified by column chromatography (SiO2, 40 g cartridge; ethyl acetate / hexane = 30% to 100%) and concentrated to give the title compound (7.500 g, 54.8%) as a white solid.
The chemical industry reduces the impact on the environment during synthesis Benzyl bis(2-chloroethyl)carbamate. I believe this compound will play a more active role in future production and life.
Reference:
Patent; Chong Kun Dang Co., Ltd.; Kim, Yoon Tae; Lee, Chang Sik; Oh, Jung Taek; Song, Hey Sung; Choe, Jin; Lee, Jae Young; (210 pag.)KR2017/43091; (2017); A;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics