Adding a certain compound to certain chemical reactions, such as: 72594-62-8, name is tert-Butyl naphthalen-1-ylcarbamate, belongs to amides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 72594-62-8, Product Details of 72594-62-8
General procedure: Under argon, to a solution of N-Boc-1-naphthylamine (1a) or 1-naphthyl-N-pivalamide (1b) (2.2 mmol) in dry Et2O (15 mL) at -20 C, t-BuLi in pentane (4.6 mmol) was added dropwise. The reaction mixture was stirred at this temperature for 2 h. Next, to the solution of lithiated species was added dropwise at -20 C, a solution of an appropriate electrophile (ethyl chloroformate, 2.2 mmol) in dry Et2O (10 mL). Then, the mixture was allowed to warm to room temperature and was stirred under these conditions for 2 h. After this time, to the reaction mixture a saturated solution of NH4Cl (20 mL) was added and was stirred for 0.5 h. The water layer was separated and extracted subsequently with Et2O (3¡Á20 mL). The organic phase was dried over MgSO4 and concentrated till dryness. The crude material was separated by flash chromatography.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, tert-Butyl naphthalen-1-ylcarbamate, and friends who are interested can also refer to it.
Reference:
Article; Nowak, Monika; Malinowski, Zbigniew; Jo?wiak, Andrzej; Fornal, Emilia; B?aszczyk, Alina; Kontek, Renata; Tetrahedron; vol. 70; 34; (2014); p. 5153 – 5160;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics