Category: 72080-83-2

Reference of 72080-83-2, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 72080-83-2 as follows.

Example 27E Benzyl {3-[(8S,11S,14S)-17-(benzyloxy)-14-{[(benzaloxy)carbonyl]amino}-8-{[(2-{[(benzyloxy)carbonyl]amino}ethyl)amino]carbonyl}-5-methyl-10,13-dioxo-9,12-diazatricyclo[14.3.1.12,6]-henicosa-1(20),2(21),3,5,16,18-hexaen-11-yl]propyl}carbamate 25 mg (0.030 mmol) of the compound from Example 26E are suspended in DMF (2.0 ml) under argon at RT, and 18.0 mg (0.090 mmol) of benzyl(2-aminoethyl)carbamate, 8 mg (0.06 mmol) of N,N-diisopropylethylamine and 23 mg (0.060 mmol) of HATU are added. After 12 h at room temperature, 18.0 mg (0.090 mmol) of benzyl(2-aminoethyl)carbamate, 8 mg (0.06 mmol) of N,N-diisopropylethylamine and 23 mg (0.060 mmol) of HATU are again added, and the mixture is stirred at RT for 4 h. 50 ml of water are added, whereby the product precipitates in crystalline form. The product is filtered off, washed with water and stirred in 50 ml of acetonitrile:methanol. It is dried to constant weight in vacuo. Yield: 19 mg (62% of theory) LC-MS (method 2): Rt=2.90 min. MS (EI): m/z=989 [M+H]+

According to the analysis of related databases, 72080-83-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; AiCuris GmbH & Co. KG; US2007/99885; (2007); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 72080-83-2, name is Benzyl (2-aminoethyl)carbamate, A new synthetic method of this compound is introduced below., Quality Control of Benzyl (2-aminoethyl)carbamate

EDCI (260 mg, 1.35 mmol), HOBt (8 mg, 61 mumol) were added to a solution of diacid 12 (200 mg, 0.613 mmol) in CHCI3 (8 ml_) and the solution stirred for 5 minutes at room temperature. A solution of benzyl (2-aminoethyl)carbamate (262 mg, 1 .35 mmol) in CHCI3 (2 ml_) was added and the solution stirred at room temperature overnight. Water (25 ml_) was added and the aqueous phase extracted with EtOAc (3 * 30 ml_), the combined organic phases were washed with brine (1 * 30 ml_), dried (MgSO4) and the solvent removed to give a white resin. Analysis of the crude resin by 1H NMR spectroscopy indicated the presence of the desired compound, . purification by silica gel chromatography (EtOAc/Petrol 1 :1 ->; EtOAc/MeOH 9.5:0.5) gave diamide 13 (261 mg, 63%) as a white gum. umax (thin film/cm’1) 3341.8, 3067.4, 2926.3, 2855.1 , 1703.8, 1644.3, 1542.5, 1455.3, 1263.5, 1 145.6, 1034.5; deltaH (270 MHz, CDCI3) 7.56 (2H, br s, NH), 7.40 (1 H, br s, NH), 7.20 – 7.35 (10H, m), 6.00 (2H, br s, NH), 5.02 (4H, br s), 4.59 (1 H, t, J 4.7 Hz), 4.03 (1 H, d, J 4.8 Hz), 3.97 (1 H, d, J 4.8 Hz), 3.10 – 3.42 (8H, m), 2.45 – 2.60 (3H, m), 1.73 (1 H, d, J 10.0 Hz), 1.50 – 1.60 (2H, m, OCH2) 1.49 (1 H, d, J 10 Hz), 1.23 (10H, m), 0.85 (3H, m); deltac (67.5 MHz, CDCI3) 174.7, 172.6, 157.2 (x 2), 136.5, 128.6 (x 5), 128.2 (x 2), 128.1 (x 5), 104.0, 81 .6. 78.8, 66.9, 66.8, 46.6, 46.3, 44.0 (x 2), 40.7, 39.9, 39.7, 33.0, 32.1 , 31.9, 29.6, 29.3, 24.3, 22.7, 14.2; HRMS (+ve) Calcd for C37H5IN4O8 679.3701 [M+H] found 679.3724.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; DEAKIN UNIVERSITY; PFEFFER, Frederick; HENDERSON, Luke; LI, Jian; NATION, Roger; WO2010/99573; (2010); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 72080-83-2 as follows. Safety of Benzyl (2-aminoethyl)carbamate

General procedure: A mixture ofcompound 10 (0.15 g, 0.772 mmol), HOBt (0.23 g,1.70 mmol), EDCI (0.37 g, 1.93 mmol), benzoic acid(0.19 g, 1.54 mmol), and TEA (0.32 mL, 2.32 mmol) indry DMF (20 mL) was stirred at 80 C for 8 h. The mixturewas quenched with water (40 mL), then extracted withethyl acetate (3 x 40 mL). The combined organic layerextracts were washed with brine, dried over anhydrousMgSO4, filtered, and concentrated under reduced pressure.The residue was purified by flash column chromatography.The desired product was obtained as white solid (0.13 g,56.4 %).

According to the analysis of related databases, 72080-83-2, the application of this compound in the production field has become more and more popular.

Reference:
Article; Abdel-Maksoud, Mohammed S.; El-Gamal, Mohammed I.; Gamal El-Din, Mahmoud M.; Kwak, Seong-Shin; Kim, Hyun-Il; Oh, Chang-Hyun; Medicinal Chemistry Research; vol. 25; 5; (2016); p. 824 – 833;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Related Products of 72080-83-2, A common heterocyclic compound, 72080-83-2, name is Benzyl (2-aminoethyl)carbamate, molecular formula is C10H14N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

1-((Dimethylamino)(dimethyliminio)methyl)-1H-[1,2,3]triazolo[4,5-b]pyridine 3-oxide hexafluorophosphate(V) (HATU, 1.87 g, 4.92 mmol) and triethylamine (3.43 mL, 24.6 mmol) were subsequently added to a solution of (S)-22-(tert-butoxycarbonyl)-10,19,24-trioxo-39-sulfo-3,6,12,15-tetraoxa-9,18,23-triazanonatriacontanoic acid (4.5 mmol) in dry dichloromethane (40 mL). Triethylamine (1.82 mL, 13.1 mmol) was added to a suspension of (2-amino-ethyl)-carbamic acid benzyl ester hydrochloride (5, 1.93 g, 8.37 mmol) in dry dichloromethane (20 mL) and the resulting mixture was added to the above solution. The mixture was stirred overnight at room temperature. After 16 hours, another portion of 1-((dimethylamino)(dimethyliminio)methyl)-1H-[1,2,3]triazolo[4,5-b]pyridine 3-oxide hexafluorophosphate(V) (HATU, 0.38 g, 1 mmol), triethylamine (2.00 mL, 14.3 mmol) and (2-amino-ethyl)-carbamic acid benzyl ester hydrochloride (5, 0.40 g, 1.70 mmol) were added and the mixture was stirred for another 2 hours. The solution was washed with 1 M aqueous hydrochloric acid (2¡Á100 mL) and brine (50 mL), dried over anhydrous sodium sulfate and evaporated to dryness. Crude (S)-29-(tert-butoxycarbonyl)-3,8,17,26,31-pentaoxo-1-phenyl-2,10,13,19,22-pentaoxa-4,7,16,25,30-pentaazahexatetracontane-46-sulfonic acid (6) was used for the next step without further purification. (0579) Yield: quantitative (based on ELSD). (0580) LC-MS purity: 83% (ELSD). (0581) LC-MS Rt (Kinetex C18, 4.6 mm¡Á50 mm, acetonitrile/water 20:80 to 100:0+0.1% FA): 3.35 min. (0582) LC-MS m/z: 989.1 (M+H)+.

The synthetic route of 72080-83-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Novo Nordisk A/S; Gao, Xiang; Zhang, Xujia; Guan, Hongtao; Thoegersen, Henning; Sass-Oerum, Kristian; Iversen, Lars Fogh; Noergaard, Per; Joergensen, Sebastian Beck; Hansen, Kristian Tage; Wang, Yi; Frieboes, Kilian Waldemar Conde; Wieczorek, Birgit; (259 pag.)US2018/339057; (2018); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics