Category: 71432-55-8

Reference of tert-Butyl N,N’-diisopropylcarbamimidateIn 2022 ,《New rhodamines with changeable Π-conjugation for lengthening fluorescence wavelengths and imaging peroxynitrite》 appeared in Chem. The author of the article were Zhang, Haolin; Xu, Yanhui; Li, Hongyu; Shi, Wen; Li, Xiaohua; Ma, Huimin. The article conveys some information:

Rhodamines, a group of excellent fluorophores, have been widely used to design various fluorescent probes; however, their maximum emission wavelengths are relatively short for bioimaging. Herein, we report a new kind of rhodamine derivatives characterized by the dibenzo[1,4]oxazepine core, which can selectively react with peroxynitrite (ONOO-), generating oxazines with much longer anal. wavelengths. These derivatives are readily synthesized in one step via a similar Stieglitz rearrangement; the presence of the 1,4-oxazepine ring is confirmed by single-crystal X-ray. Most importantly, the derivative (ON-RB) from rhodamine B, upon reaction with ONOO-, releases the oxazine moiety that emits in the near-IR wavelength region. Using ON-RB, we have monitored the generation of ONOO- in macrophage-derived foam cells, revealing that ONOO- might be formed mainly in lipid droplets. The new chem. of the dibenzo[1,4]oxazepine ring formation, together with its specific reaction with ONOO-, may provide a convenient strategy to develop rhodamine-based probes with longer wavelengths. The experimental process involved the reaction of tert-Butyl N,N’-diisopropylcarbamimidate(cas: 71432-55-8Reference of tert-Butyl N,N’-diisopropylcarbamimidate)

tert-Butyl N,N’-diisopropylcarbamimidate(cas: 71432-55-8) belongs to anime. Amines have a free lone pair with which they can coordinate to metal centers. Amine–metal bonds are weaker because amines are incapable of backbonding, but they are still important for sensing applications.While stronger than hydrogen bonds, amine–metal bonds are still weaker than both covalent and ionic bonds.Reference of tert-Butyl N,N’-diisopropylcarbamimidate

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In 2019,Tetrahedron included an article by Zhou, Tianyi; Ringbeck, Benedikt; Schebb, Nils Helge; Scherkenbeck, Juergen. Computed Properties of C11H24N2O. The article was titled 《Isolation, total synthesis and quantification of caffeoylisocitric acid, a characteristic ingredient of the superfood amaranth》. The information in the text is summarized as follows:

Amaranth is regarded as a new “”super-vegetable”” in western countries, albeit it is consumed for centuries in Africa and Asia. In addition to common carotenoids, flavonoids and polyphenols, caffeoylisocitric acid has been described as amaranth type-specific secondary metabolite. Remarkably, nothing is known on biol. effects of this specific polyphenol. Here we detail a concise, diastereoselective synthesis of caffeoylisocitric acid (I), deuterium-labeling studies and a quant. determination of the caffeoylisocitric acid content of three different amaranth types.tert-Butyl N,N’-diisopropylcarbamimidate(cas: 71432-55-8Computed Properties of C11H24N2O) was used in this study.

tert-Butyl N,N’-diisopropylcarbamimidate(cas: 71432-55-8) belongs to anime. Primary amines having a tertiary alkyl group (R3CNH2) are difficult to prepare with most methods but are made industrially by the Ritter reaction. In this method a tertiary alcohol reacts with hydrogen cyanide (HCN) in the presence of a concentrated strong acid; a formamide, RNH―CHO, is formed first, which then undergoes hydrolysis.Computed Properties of C11H24N2O

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In 2017,Liu, Shourong; Zhao, Yanmei; He, Ruoyu; Kong, Limin; Xi, Jianjun; Sun, Jingjing; Shao, Yidan; Pan, Xuwang; Zhang, Jiankang; Zhuang, Rangxiao published 《Identification of novel N-acetylcysteine derivatives for the treatment of hepatocellular injury》.MedChemComm published the findings.Name: tert-Butyl N,N’-diisopropylcarbamimidate The information in the text is summarized as follows:

New anti-hepatocellular injury drugs with better curative effects and fewer side effects are urgently needed at present. In this study, a series of novel N-acetylcysteine (NAC) derivatives were designed, synthesized and biol. evaluated for their anti-hepatocellular injury activities against two different cell models. In the biol. evaluation against hydrogen peroxide (H2O2)-induced LO2 hepatocytes, half of the target compounds exhibited moderate to potent activities in improving the model cell viability, and two compounds (6a and 6b) displayed more potent activities in decreasing malondialdehyde (MDA) levels than the pos. control NAC. In further 4-acetamidophenol (APAP)-induced LO2 cell experiment, compounds 6a and 6b could not only improve the cell viability but also significantly reduce the secretion of MDA. Addnl., compound 6a displayed excellent Caco-2 permeability and oral bioavailability in rats. All these exptl. results suggested that compounds 6a and 6b could serve as potential lead mols. for further development of anti-hepatocellular injury drugs. The experimental process involved the reaction of tert-Butyl N,N’-diisopropylcarbamimidate(cas: 71432-55-8Name: tert-Butyl N,N’-diisopropylcarbamimidate)

tert-Butyl N,N’-diisopropylcarbamimidate(cas: 71432-55-8) belongs to anime. Many important products require amines as part of their syntheses. Methylamine is utilized in the production of the analgesic meperidine (trade name Demerol) and the photographic developer Metol (trademark), and dimethylamine is used in the synthesis of the antihistamine diphenhydramine (trade name Benadryl), the solvent dimethylformamide (DMF), and the rocket propellant 1,1-dimethylhydrazine. The synthesis of the insect repellent N,N-diethyl-m-toluamide (DEET) incorporates diethylamine while that of the synthetic fibre Kevlar requires aromatic amines.Name: tert-Butyl N,N’-diisopropylcarbamimidate

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In 2022,Pitcher, Noel P.; Harjani, Jitendra R.; Zhao, Yichao; Jin, Jianwen; Knight, Daniel R.; Li, Lucy; Putsathit, Papanin; Riley, Thomas V.; Carter, Glen P.; Baell, Jonathan B. published an article in ACS Omega. The title of the article was 《Development of 1,2,4-Oxadiazole Antimicrobial Agents to Treat Enteric Pathogens within the Gastrointestinal Tract》.Formula: C11H24N2O The author mentioned the following in the article:

Colonization of the gastrointestinal (GI) tract with pathogenic bacteria is an important risk factor for the development of certain potentially severe and life-threatening healthcare-associated infections, yet efforts to develop effective decolonization agents have been largely unsuccessful thus far. Herein, we report modification of the 1,2,4-oxadiazole class of antimicrobial compounds with poorly permeable functional groups in order to target bacterial pathogens within the GI tract. We have identified that the quaternary ammonium functionality of analog 26a (I) results in complete impermeability in Caco-2 cell monolayers while retaining activity against GI pathogens Clostridioides difficile and multidrug-resistant (MDR) Enterococcus faecium. Low compound recovery levels after oral administration in rats were observed, which suggests that the analogs may be susceptible to degradation or metabolism within the gut, highlighting a key area for optimization in future efforts. This study demonstrates that modified analogs of the 1,2,4-oxadiazole class may be potential leads for further development of colon-targeted antimicrobial agents. In addition to this study using tert-Butyl N,N’-diisopropylcarbamimidate, there are many other studies that have used tert-Butyl N,N’-diisopropylcarbamimidate(cas: 71432-55-8Formula: C11H24N2O) was used in this study.

tert-Butyl N,N’-diisopropylcarbamimidate(cas: 71432-55-8) belongs to anime. Milder oxidation, using reagents such as NaOCl, can remove four hydrogen atoms from primary amines of the type RCH2NH2 to form nitriles (R―C≡N), and oxidation with reagents such as MnO2 can remove two hydrogen atoms from secondary amines (R2CH―NHR′) to form imines (R2C=NR′). Tertiary amines can be oxidized to enamines (R2C=CHNR2) by a variety of reagents.Formula: C11H24N2O

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Product Details of 71432-55-8In 2014 ,《Enantioselective total synthesis of (-)-scabronine D》 was published in Heterocycles. The article was written by Kobayakawa, Yu; Nakada, Masahisa. The article contains the following contents:

An enantioselective total synthesis of (3aS,5aR,6R,9R,10aR)-8-[(benzoyloxy)methyl]-3,4,5,5a,6,9,10,10a-octahydro-6-hydroxy-5a-methyl-1-(1-methylethyl)-6,9-epoxycyclohept[e]indene-3a(2H)-carboxylic acid [(-)-scabronine D diterpenoid] a which contains bridged hemiacetal group is described. The synthesis of the target compound was achieved using an enantiopure intermediate which was previously reported for a total synthesis of scabronine G and scabronine A and (-)-episcabronine A. Because the advanced intermediate was found to be sensitive to basic reaction conditions, the C14 keto and C11 hydroxy groups had to be co-protected as Me acetal. In addition, both the C15 hydroxy and C17 carboxyl groups were too reactive to be chem. discriminated; hence, the carboxyl group once formed was protected as a tert-Bu ester for ensuring successful transformations. In the experimental materials used by the author, we found tert-Butyl N,N’-diisopropylcarbamimidate(cas: 71432-55-8Product Details of 71432-55-8)

tert-Butyl N,N’-diisopropylcarbamimidate(cas: 71432-55-8) belongs to anime. In organic chemistry, amines are compounds and functional groups that contain a basic nitrogen atom with a lone pair. Amines are formally derivatives of ammonia (NH3), wherein one or more hydrogen atoms have been replaced by a substituent such as an alkyl or aryl group (these may respectively be called alkylamines and arylamines; amines in which both types of substituent are attached to one nitrogen atom may be called alkylarylamines).Product Details of 71432-55-8

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In 2010,Yu, Shouyun; Ishida, Hiroshi; Juarez-Garcia, M. Elisa; Bode, Jeffrey W. published 《Unified synthesis of enantiopure β2h, β3h and β2,3-amino acids》.Chemical Science published the findings.Name: tert-Butyl N,N’-diisopropylcarbamimidate The information in the text is summarized as follows:

A single chiral auxiliary and synthetic route can be used for a three-step (cycloaddition, auxiliary removal and fragmentation) preparation of enantiopure β3h, β2h and β2,3-amino acids (>99% ee). This approach works for a wide variety of both natural and unnatural side chains, provides access to either enantiomeric form, and can be executed on a preparative scale without recourse to column chromatog. After reading the article, we found that the author used tert-Butyl N,N’-diisopropylcarbamimidate(cas: 71432-55-8Name: tert-Butyl N,N’-diisopropylcarbamimidate)

tert-Butyl N,N’-diisopropylcarbamimidate(cas: 71432-55-8) belongs to anime. Examples of direct uses of amines and their salts are as corrosion inhibitors in boilers and in lubricating oils (morpholine), as antioxidants for rubber and roofing asphalt (diarylamines), as stabilizers for cellulose nitrate explosives (diphenylamine), as protectants against damage from gamma radiation (diarylamines), as developers in photography (aromatic diamines), as flotation agents in mining, as anticling and waterproofing agents for textiles, as fabric softeners, in paper coating, and for solubilizing herbicides.Name: tert-Butyl N,N’-diisopropylcarbamimidate

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In 2015,Cameron, Alex; Fisher, Brendan; Fisk, Nicholas; Hummel, Jessica; White, Jonathan M.; Krenske, Elizabeth H.; Rizzacasa, Mark A. published 《Towards the Synthesis of Dihydrooxepino[4,3-b]pyrrole-Containing Natural Products via Cope Rearrangement of Vinyl Pyrrole Epoxides》.Organic Letters published the findings.Name: tert-Butyl N,N’-diisopropylcarbamimidate The information in the text is summarized as follows:

An approach to the dihydrooxepino[4,3-b]pyrrole core of diketopiperazine natural products which utilizes a vinyl pyrrole epoxide Cope rearrangement was investigated. It was found that an ester substituent on the epoxide was essential for the [3,3]-rearrangement to occur. D. functional calculations with M06-2X provided explanations for the effects of the pyrrole and ester groups on these rearrangements.tert-Butyl N,N’-diisopropylcarbamimidate(cas: 71432-55-8Name: tert-Butyl N,N’-diisopropylcarbamimidate) was used in this study.

tert-Butyl N,N’-diisopropylcarbamimidate(cas: 71432-55-8) belongs to anime. Large quantities of aliphatic amines are made synthetically. The most widely used industrial method is the reaction of alcohols with ammonia at a high temperature, catalyzed by metals or metal oxide catalysts (e.g., nickel or copper). Mixtures of primary, secondary, and tertiary amines are thereby produced.Name: tert-Butyl N,N’-diisopropylcarbamimidate

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In 2017,Ghatak, Tapas; Fridman, Natalia; Eisen, Moris S. published 《Actinide Complexes Possessing Six-Membered N-Heterocyclic Iminato Moieties: Synthesis and Reactivity》.Organometallics published the findings.Product Details of 71432-55-8 The information in the text is summarized as follows:

A novel class of ligand systems possessing a six-membered N-heterocyclic iminato [perimidin-2-iminato (PrRN where R = iso-Pr, cycloheptyl)] moiety is introduced. The complexation of these ligands with early actinides (An = Th and U) results in powerful catalysts [(PrRN)AnN{(SiMe3)2}3] (3-6)for exigent insertion of alcs. into carbodiimides to produce the corresponding isoureas in short reaction times with excellent yields. Exptl., thermodn., and kinetic data as well as the results of stoichiometric reactions provide cumulative evidence that support a plausible mechanism for the reaction.tert-Butyl N,N’-diisopropylcarbamimidate(cas: 71432-55-8Product Details of 71432-55-8) was used in this study.

tert-Butyl N,N’-diisopropylcarbamimidate(cas: 71432-55-8) belongs to anime. Reduction of nitro compounds, RNO2, by hydrogen or other reducing agents produces primary amines cleanly (i.e., without a mixture of products), but the method is mostly used for aromatic amines because of the limited availability of aliphatic nitro compounds. Reduction of nitriles and oximes (R2C=NOH) also yields primary amines.Product Details of 71432-55-8

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

《A Stereoselective Synthesis of (-)-Viridiofungin A Utilizing a TiCl4-Promoted Asymmetric Multicomponent Reaction》 was written by Ghosh, Arun K.; Kass, Jorden. Computed Properties of C11H24N2OThis research focused onviridiofungin A stereoselective synthesis multicomponent reaction. The article conveys some information:

A stereoselective synthesis of (-)-viridiofungin A is described. The convergent synthesis utilized a unique highly diastereoselective multicomponent reaction between optically active phenyldihydrofuran and an α-ketoester to provide two chiral centers including a quaternary carbon center in a single step. Other key steps include an acyloxycarbonium ion-mediated THF ring-opening reaction and a Julia-Kocienski olefination. In the experiment, the researchers used many compounds, for example, tert-Butyl N,N’-diisopropylcarbamimidate(cas: 71432-55-8Computed Properties of C11H24N2O)

tert-Butyl N,N’-diisopropylcarbamimidate(cas: 71432-55-8) belongs to anime. Amine, any member of a family of nitrogen-containing organic compounds that is derived, either in principle or in practice, from ammonia (NH3). Naturally occurring amines include the alkaloids, which are present in certain plants; the catecholamine neurotransmitters (i.e., dopamine, epinephrine, and norepinephrine); and a local chemical mediator, histamine, that occurs in most animal tissues.Computed Properties of C11H24N2O

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Safety of tert-Butyl N,N’-diisopropylcarbamimidateIn 2011 ,《(+)-Sorangicin A: evolution of a viable synthetic strategy》 was published in Tetrahedron. The article was written by Smith, Amos B. III; Dong, Shuzhi; Fox, Richard J.; Brenneman, Jehrod B.; Vanecko, John A.; Maegawa, Tomohiro. The article contains the following contents:

An effective, asym. total synthesis of the antibiotic (+)-sorangicin A has been achieved. Central to this venture was the development of first- and second-generation syntheses of the signature dioxabicyclo[3.2.1]octane core, the first featuring chemo- and stereoselective epoxide ring openings facilitated by a Co2(CO)6-alkyne complex, the second involving a KHMDS-promoted epoxide ring formation/opening cascade. Addnl. highlights include effective construction of the dihydro- and tetrahydropyran ring systems, resp., via a stereoselective conjugate addition/α-oxygenation protocol and a thioketalization/hydrostannane reduction sequence. Late-stage achievements entailed two Julia-Kocienski olefinations to unite three advanced fragments with high E-stereoselectivity, followed by a modified Stille protocol to introduce the Z,Z,E trienoate moiety, thereby completing the carbon skeleton. Mukaiyama macrolactonization, followed by carefully orchestrated Lewis and protic acid-promoted deprotections that suppressed isomerization and/or destruction of the sensitive (Z,Z,E)-trienoate linkage completed the first, and to date only, total synthesis of (+)-sorangicin A.tert-Butyl N,N’-diisopropylcarbamimidate(cas: 71432-55-8Safety of tert-Butyl N,N’-diisopropylcarbamimidate) was used in this study.

tert-Butyl N,N’-diisopropylcarbamimidate(cas: 71432-55-8) belongs to anime. Reduction of nitro compounds, RNO2, by hydrogen or other reducing agents produces primary amines cleanly (i.e., without a mixture of products), but the method is mostly used for aromatic amines because of the limited availability of aliphatic nitro compounds. Reduction of nitriles and oximes (R2C=NOH) also yields primary amines.Safety of tert-Butyl N,N’-diisopropylcarbamimidate

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics