Category: 711007-44-2

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 711007-44-2, name is 2,3-Diaminobenzamide belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. name: 2,3-Diaminobenzamide

General procedure: In a dark environment, a mixture of 2,3-diaminobenzamide(1.51 g, 10 mmol), PYTZ (20 mg), and ethanol (200 mL)was taken in an open pear-shaped bottle, stirred magneticallyat room temperature, and then aldehyde (10 mmol) wasadded slowly in 2 min. The bottle was exposed to visiblelight (Xenon, 10 A) under stirring condition. The reactionwas monitored by TLC. After the reaction completed, thereaction mixture was transferred to a three-neck bottle outsideof the photochemical reactor and air was introduced toensure that the intermediate was completely oxidized. Then,the solvent was evaporated in vacuum to 40 mL until thesolid appeared. The mixture was cooled down in an ice bathfor crystallization, filtration. The crude solid was recrystallizedfrom 25 mL ethanol (30 C) to get the target products.

The synthetic route of 711007-44-2 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Zhang, Li-Jie; Yang, Kang; Li, Chun-Yu; Sun, Ya-Quan; Chemical Papers; vol. 73; 11; (2019); p. 2697 – 2705;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 711007-44-2, name is 2,3-Diaminobenzamide, belongs to amides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 711007-44-2, Quality Control of 2,3-Diaminobenzamide

To a 100 ml three-neck flask was added 2,3-diaminobenzamide (3.2 g, 20 mmol), compound A (3.85 g, 22 mmol), sulfur powder (3.2 g, 100 mmol) was added, and stirred at 170 C. After 6 h, after cooling, 60 ml of methylene chloride was added and dissolved. The silicon gel was mixed and concentrated on a silica gel column. Chromatography on a silica gel column gave the desired product (C1) in a yield of 1.28 g (yield: 20%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2,3-Diaminobenzamide, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Shandong University Qilu Hospital; Tan Bingxu; (9 pag.)CN107556288; (2018); A;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 711007-44-2, name is 2,3-Diaminobenzamide, A new synthetic method of this compound is introduced below., SDS of cas: 711007-44-2

Example 1: Benzyl 3-(4-carbamoyl-lH-benzo[d]imidazol-2-yl)-3,4-dihydroisoquinoline-2- (lH)-carboxylate.[00147] Step-1: To a solution of 2-((benzyloxy)carbonyl)-l,2,3,4-tetrahydroisoquinoline-3- carboxylic acid (1.0 g, 3.21 mmol) in anhydrous DMF (20 ml) was added EDCHCl (1.85 g, 9.63 mmol), HOBt (681 mg, 5.05 mmol) and triethylamine (0.7 ml, 4.81 mmol) and the mixture was stirred at RT for 10 min. To this reaction mixture, 2,3-diaminobenzamide (606 mg, 4.01 mmol) was added and was stirred at RT over night. The reaction was poured in to water, stirred for 30 min and extracted with ethyl acetate. The organic layer was washed with brine and dried over anhydrous sodium sulfate and concentrated under vacuum to yield benzyl 3-(2-amino-3- carbomoylphenylcarbamoyl)-3,4-dihydroisoquinoline-2(lH)-carboxylate. MS (ES+): m/z 445.1 [M+H]+

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; ANGION BIOMEDICA CORP.; PANICKER, Bijoy; LIM, Dong, Sung; SMITH, David, E.; WO2011/2520; (2011); A2;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

711007-44-2, name is 2,3-Diaminobenzamide, belongs to amides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Quality Control of 2,3-Diaminobenzamide

A mixture of 2,3-diamino-benzamide (1,51 g, 10.0 mmoles) or a 2, 3-DIAMINO- (N-SUBSTITUTED)-BENZAMIDE (10.0 mmoles) and a suitable paramagnetic aldehyde (of general formula V) or dia- magnetic aldehyde (of general formula VI) (10.0 mol), and toluene-p-sulphonic acid monohydrate (95 mg, 0.5 mmoles) is refluxed in toluene (40 mL) or in an other appropriate solvent till all the starting compounds are consumed (4-6 hours) under Dean and Stark apparatus. Then the solvent is evaporated in vacuo, the residue dissolved in CHC13 (50 mL) or in some other halogenated solvent, and an appropriate oxidant such as acti- vated Mn02 (4.30 g, 50.0 mmoles) is added and the mixture is stirred and refluxed for about 6 hours. The mixture was fil- tered through Cellite, evaporated and the residue was purified by flash column chromatography (CHCl3/Et2O or CHC13/MEOH) or crystallization to give compound la or Ib (yield: 39-73 %)

The synthetic route of 711007-44-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; HIDEG, Kalman; KALAI, Tamas; SUeMEGI, Balazs; WO2004/96793; (2004); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Electric Literature of 711007-44-2, These common heterocyclic compound, 711007-44-2, name is 2,3-Diaminobenzamide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step-4: To a solution of 2-((benzyloxy)carbonyl)-3-methyl-l,2,3,4- tetrahydroisoquinoline-3-carboxylic acid (620 mg, 1.91 mmol) in anhydrous DMF (5 ml) was added EDCHCl (1.098 mg, 5.73 mmol), HOAt (390 mg, 2.87 mmol) and triethylamine (0.4 ml, 2.87 mmol) at RT and the mixture was stirred for 10 min. To this reaction mixture, 2,3- diaminobenzamide (346 mg, 2.29 mmol) was added and heated to 550C for 3 days. The reaction mixture was poured into ice cold water and stirred for 30 min. The precipitate formed was filtered and dried under vacuum and purified by preparative TLC using ethyl acetate as eluent to afford benzyl 3-((2-amino-3-carbamoylphenyl)carbamoyl)-3-methyl-3,4-dihydroisoquinoline- 2(lH)-carboxylate. MS (ES+): m/z 481.2 [M+ Na]+

The synthetic route of 711007-44-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ANGION BIOMEDICA CORP.; PANICKER, Bijoy; LIM, Dong, Sung; SMITH, David, E.; WO2011/2520; (2011); A2;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Electric Literature of 711007-44-2, These common heterocyclic compound, 711007-44-2, name is 2,3-Diaminobenzamide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Cbz-glycine (2.92 g, 13.89 mmol) and 120 mL of acetonitrile were added to a 250 mL reaction flask, stirred and dissolved, and CDI (2.57 g, 15.85 mmol) was slowly added, and reacted at 45 C for 1.5 hours. After the reaction of the material was monitored by TLC (dichloromethane:methanol = 10:1), Intermediate VII (2 g, 13.23 mmol) was added and reacted at 45 C for 4 hours. TLC (dichloromethane: methanol = 10:1) monitoringAfter the raw materials are reacted, a large amount of white solid is produced, suction filtered, and dried. It was added to a 100 mL reaction flask, 50 mL of glacial acetic acid was added, and the reaction was refluxed at 120 C. After the reaction of the material was monitored by TLC (dichloromethane:methanol = 10:1), the glacial acetic acid was concentrated under reduced pressure and dissolved in 100 mL of water.Extracted with ethyl acetate (100 mL ¡Á 2), and the organic layer was combined.Wash with saturated sodium chloride (150 mL) and dry over anhydrous sodium sulfate. Filtered off with suction, the filtrate was concentrated to give the crude product (VIII) 4.18g, yield 97.4%.

Statistics shows that 2,3-Diaminobenzamide is playing an increasingly important role. we look forward to future research findings about 711007-44-2.

Reference:
Patent; China Pharmaceutical University; Xu Yungen; Zhu Qihua; Ge Yiran; Li Hui; Zhang Guangxia; Wang Junwei; (21 pag.)CN109748923; (2019); A;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 711007-44-2, name is 2,3-Diaminobenzamide, belongs to amides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 711007-44-2, Product Details of 711007-44-2

Example 3: Benzyl 2-(4-carbamoyl-lH-benzo[d]imidazol-2-yl) indoline-1-carboxylate[00150] Step-1: To a solution of l-((benzyloxy)carbonyl)indoline-2-carboxylic acid (1.0 g, 3.37 mmol) in anhydrous DMF (20 ml) was added EDCHCl (1.93 g, 10.10 mmol), HOBt (681 mg, 5.05 mmol) and triethylamine (0.7 ml, 5.05 mmol) at RT and the mixture was stirred for 10 min. To this reaction mixture, 2,3-diaminobenzamide (635 mg, 4.20 mmol) was added and heated to 8O0C over night. The reaction mixture was poured into ice cold water and stirred for 30 min. The precipitate formed was filtered and dried under vacuum to yield benzyl 2-(2-amino- 3-carbamoylphenylcarbamoyl) indoline-1-carboxylate. MS (ES+): m/z 431.1 [M+H]+

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2,3-Diaminobenzamide, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ANGION BIOMEDICA CORP.; PANICKER, Bijoy; LIM, Dong, Sung; SMITH, David, E.; WO2011/2520; (2011); A2;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

The chemical industry reduces the impact on the environment during synthesis 711007-44-2, name is 2,3-Diaminobenzamide, I believe this compound will play a more active role in future production and life. 711007-44-2

General procedure: In a dark environment, a mixture of 2,3-diaminobenzamide(1.51 g, 10 mmol), PYTZ (20 mg), and ethanol (200 mL)was taken in an open pear-shaped bottle, stirred magneticallyat room temperature, and then aldehyde (10 mmol) wasadded slowly in 2 min. The bottle was exposed to visiblelight (Xenon, 10 A) under stirring condition. The reactionwas monitored by TLC. After the reaction completed, thereaction mixture was transferred to a three-neck bottle outsideof the photochemical reactor and air was introduced toensure that the intermediate was completely oxidized. Then,the solvent was evaporated in vacuum to 40 mL until thesolid appeared. The mixture was cooled down in an ice bathfor crystallization, filtration. The crude solid was recrystallizedfrom 25 mL ethanol (30 C) to get the target products.

The chemical industry reduces the impact on the environment during synthesis 711007-44-2. I believe this compound will play a more active role in future production and life.

Reference:
Article; Zhang, Li-Jie; Yang, Kang; Li, Chun-Yu; Sun, Ya-Quan; Chemical Papers; vol. 73; 11; (2019); p. 2697 – 2705;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

711007-44-2, Adding some certain compound to certain chemical reactions, such as: 711007-44-2, name is 2,3-Diaminobenzamide, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 711007-44-2.

To a 100 ml three-neck flask was added 2,3-diaminobenzamide (3.2 g, 20 mmol), compound C (4.47 g, 22 mmol), sulfur powder (3.2 g, 100 mmol) was added, and stirred at 170 C. After 6 h, after cooling, 60 ml of methylene chloride was added to dissolve, and the silica gel was mixed and concentrated on a silica gel column. Chromatography on a silica gel column afforded the target product (C3) 0.76 g (yield: 11%).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 711007-44-2.

Reference:
Patent; Shandong University Qilu Hospital; Tan Bingxu; (9 pag.)CN107556288; (2018); A;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

711007-44-2, These common heterocyclic compound, 711007-44-2, name is 2,3-Diaminobenzamide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Eine Loesung von 200 g (1,11 mol) 2,3-Diaminobenzoesaeureethylester in 1500 ml 1-Butanol wurde bei Raumtemperatur vorsichtig mit 400 ml Hydrazinhydrat versetzt. Die Mischung wurde 15 Stunden auf 100C erwaermt. Anschliessend wurde der Ansatz auf ein Drittel des Volumens eingeengt. Diese Loesung wurde langsam zu einer Suspension von ca. 200 g Raney-Nickel in 500 ml Wasser und 1000 ml Dimethylformamid getropft. Die Mischung wurde 2 Stunden auf 100C erwaermt. Nach Abkuehlen auf 10C wurde der Katalysator abgetrennt und das Filtrat im Vakuum eingeengt. Das so erhaltene Oel wurde in 500 ml Methanol geloest und mit Diethylether versetzt. Der Niederschlag wurde abgetrennt und das Filtrat erneut eingeengt. Eine Loesung des erhaltenen Oels in Methanol wurde unter Rueckfluss mit Chlorwasserstoff/iso-Propanol versetzt. Der beim Abkuehlen ausfallende Niederschlag wurde abgesaugt, mit Diethylether aufgeschlaemmt und erneut abgesaugt. Man erhielt 172,2 g des Produktes.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 711007-44-2.

Reference:
Patent; Abbott GmbH & Co. KG; EP1391457; (2004); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics