Category: 71026-66-9

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 71026-66-9, name is tert-Butyl (4-aminophenyl)carbamate, A new synthetic method of this compound is introduced below., name: tert-Butyl (4-aminophenyl)carbamate

2,4-dichloro-5-nitropyrimidine (190 mg, 0.98 mmol) 6 mL of 1,4-dioxane was added,Placed in a 25 mL round bottom flask, Stirred at room temperature,(4-aminophenyl)Tert-butyl carbamate(200 mg, 0.96 mmol),N,N-diisopropylethylamine (137 mg, 1.06 mmol)Dissolved in 4 mL of 1,4-dioxane, Slowly added dropwise to the above reaction solution,After the addition was continued, the mixture was stirred at room temperature for about 1 hour,TLC to monitor the complete conversion of the reaction.Rotary Evaporation In addition to solvent,The crude product was separated by silica gel column chromatography (petroleum ether / ethyl acetate = 10: 1, v / v)To give 301 mg of tert-butyl (4- (2-chloro-5-nitropyrimidine-4-amino) phenyl)carbamate as an orange solid in 82% yield.

The synthetic route of 71026-66-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; East China University of Science and Technology; LI, HONGLIN; XU, YUFANG; CHEN, ZHUO; ZHAO, ZHENJIANG; LU, JIANKUN; SUN, DEHENG; YANG, YU; ZHOU, WEI; (29 pag.)CN106467540; (2017); A;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 71026-66-9, name is tert-Butyl (4-aminophenyl)carbamate, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C11H16N2O2

To a solution of N-Boc-p-phenylendiamine (53.7 mg, 0.258 mmol) inMeOH (5 mL), paraformaldehyde (37.4 mg) and sodium methoxide(67.4 mg, 1.248 mmol). The mixture was stirred for 11 h at reflux underan inert atmosphere. Then, the reaction mixture was reacted withNaBH4 (14.5 mg, 0.383 mmol) at room temperature and refluxed for anadditional 4 h. The mixture was concentrated in vacuo. The residue wasdissolved in saturated aqueous NH4Cl, was extracted with ethyl acetateand dried over Na2SO4. The solvent was concentrated in vacuo and waspurified by column chromatography on silica gel with Hexane: ethylacetate (7:3) to give N?-Boc-N-methyl-p-phenylendiamine as a yellowoil (45.7 mg, 80%). N?-Boc-N-methyl-p-phenylendiamine was dissolvedin 4M HCl/dioxane (500 muL) and stirred at room temperature for 2 h.The solvent was concentrated in vacuo and was dissolved in DMF(1 mL). This solution was added D-desthiobiotin (45.1 mg, 0.210 mmol),EDCI-HCl (41.1 mg, 0.214 mmol), HOBt (28.2 mg, 0.209 mmol) andDIEA (103.4 muL, 0.6 mmol). The mixture was stirred at room temperaturefor 15 h and was concentrated in vacuo. The residue was dissolvedin saturated aqueous NaHCO3, was extracted with ethyl acetate anddried over Na2SO4. Then, the residue was purified by preparative thinlayer chromatography with CH2Cl2_MeOH=10:1 to give 16 as a whitesolid (15.1 mg, 24%). 1H NMR (500 MHz, CD3OD) delta 7.29 (d, J=8.9 Hz, 2H), 6.61 (d, J=8.9 Hz, 2H), 3.86-3.80 (m, 1H), 3.74-3.70(m, 1H), 3.37 (s, 1H), 2.76 (s, 3H), 2.35 (t, J=7.5 Hz, 2H), 1.73 (quint,J=7.4 Hz, 2H), 1.56-1.34 (m, 6H), 1.12 (d, J=6.5 Hz, 3H); 13C NMR(125 MHz, CD3OD) delta 172.8, 164.8, 147.1, 128.2, 121.9, 112.3, 56.0,51.3, 36.2, 29.7, 28.3, 28.9, 25.8, 25.5, 14.2; FT-IR (neat) 3242, 3140,3067, 2925, 2855, 1691, 1652, 1602, 1517, 1430, 1401, 1376, 1347,1306, 1249, 1176, 1155, 1101, 1062 cm-1; Mp 85-87 C ; HRMS (ESI,positive): m/z calcd. for C17H26N4O2 [M+Na]+: 341.1948, found341.1945

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 71026-66-9.

Reference:
Article; Sato, Shinichi; Yoshida, Masaki; Hatano, Kensuke; Matsumura, Masaki; Nakamura, Hiroyuki; Bioorganic and Medicinal Chemistry; vol. 27; 6; (2019); p. 1110 – 1118;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Some common heterocyclic compound, 71026-66-9, name is tert-Butyl (4-aminophenyl)carbamate, molecular formula is C11H16N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C11H16N2O2

2,4-dichloro-5-nitro-pyrimidine (95 mg, 0.49 mmol) was placed into a 10 mL round bottom flask, 3 mL of 1,4-dioxane was added, and stirred at room temperature. Tert-butyl (4-aminophenyl) carbamate (100 mg, 0.48 mmol) and N,N-diisopropylethylamine (69 mg, 0.53 mmol) were dissolved in 2 mL of 1,4-dioxane. The resulting solution was added dropwise into the reaction solution as said above. Upon completion of addition, the resulting mixture was stirred at room temperature for 0.5 h, and TLC showed that the raw material was completely conversed. The solvent was removed by rotary evaporation, and the crude product was separated through silica gel column chromatography (petroleum ether/ethyl acetate=10:1, V/V) to obtain tert-butyl (4-(2-chloro-5-nitropyrimidyl-4-amino)-phenyl)carbamate as orange solids (144 mg, yield 82%). 1H NMR (400 MHz, DMSO-d6): delta 10.38 (s, 1H), 9.46 (s, 1H), 9.12 (s, 1H), 7.49 (d, J=8.6 Hz, 2H), 7.39 (d, J=8.6 Hz, 2H), 1.49 (s, 9H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 71026-66-9, its application will become more common.

Reference:
Patent; Li, Honglin; Xu, Yufang; Zhao, Zhenjiang; Liu, Xiaofeng; Zhou, Wei; Bai, Fang; Xue, Mengzhu; Zhang, Lei; Zhang, Youli; US2015/126508; (2015); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

71026-66-9, name is tert-Butyl (4-aminophenyl)carbamate, belongs to amides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: tert-Butyl (4-aminophenyl)carbamate

To a stirred solution of tert-butyl 4-aminophenylcarbamate(176 mg, 0.85 mmol) in 5 mL of THF was added phenyl 5-(l,3-difluoro-2- methylpropan-2-yl)isoxazol-3-ylcarbamate (250 mg, 0.85 mmol), DIEA (147 mL, 0.85 mmol), and DMAP (5.2 mg, 0.043 mmol). The resulting mixture was heated at 65 C for 90 min. LC-MS indicated that the reaction was complete. The organic solvent was removed under reduced pressure and the residue was purified with silica gel column chromatography, eluting with 0-50% EtOAc in hexanes, to give tert-butyl 4-(3-(5-(l,3-difluoro-2-methylpropan-2-yl)isoxazol-3-yl)ureido)phenylcarbamate (350 mg, 95%). LC-MS (ESI) m/z 411 (M + H)+.

The synthetic route of 71026-66-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; AMBIT BIOSCIENCES CORPORATION; LIU, Gang; WO2011/150198; (2011); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Some common heterocyclic compound, 71026-66-9, name is tert-Butyl (4-aminophenyl)carbamate, molecular formula is C11H16N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. HPLC of Formula: C11H16N2O2

General procedure: Mucohalic acid (1 eq) was added to a solution of 5:3 v/v dichloromethane/glacial acetic acid. Then, an amine (1 eq) was added, and the mixture was stirred for 10 min. To that mixture, sodium triacetoxyborohydride (3 eq) solution in 5:3 v/v dichloromethane and glacial acetic acid was added. The mixture was left to stir at room temperature for 24 h unless otherwise stated.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 71026-66-9, its application will become more common.

Reference:
Article; Almohaywi, Basmah; Taunk, Aditi; Wenholz, Daniel S.; Nizalapur, Shashidhar; Biswas, Nripendra N.; Ho, Kitty K. K.; Rice, Scott A.; Iskander, George; Black, David StC.; Griffith, Renate; Kumar, Naresh; Molecules; vol. 23; 5; (2018);,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Electric Literature of 71026-66-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 71026-66-9 name is tert-Butyl (4-aminophenyl)carbamate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: To a solution of 2-chloroethanesulfonyl chloride (1.56 g, 9.57 mmol) in THF (10 mL) was added dropwise N-methylaniline (989 mg, 9.23 mmol) followed by triethylamine (5 mL, 36 mmol) at 0 C. After stirring for 3 h, ethyl acetate was added, and the reaction mixture was washed with 3 M hydrochloric acid then brine, dried over magnesium sulfate, evaporated in vacuo to obtain 1.76 g (97%) of vinylsulfonamide 3a as a pale brown solid. The product was spectroscopically pure, and was used without further purification.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, tert-Butyl (4-aminophenyl)carbamate, and friends who are interested can also refer to it.

Reference:
Article; Kihara, Nobuhiro; Mitsuhashi, Yuji; Sato, Makoto; Hirose, Shun-Ichi; Goudo, Erika; Uzawa, Yoshinori; Shirai, Natsumi; Hamamoto, Sari; Iwasaki, Ryo; Fujioka, Akane; Tetrahedron Letters; vol. 57; 23; (2016); p. 2563 – 2566;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Synthetic Route of 71026-66-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 71026-66-9, name is tert-Butyl (4-aminophenyl)carbamate belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

The aldehyde (294 mg, 1.68 mmol, 1 eq. ) was added to a solution of aniline (350 mg, 1.68 mmol, 1 eq. ) and MGS04 (420 mg, 3.36 mmol, 2 eq. ) in 10 mL of toluene. The reaction mixture was stirred at 25 C for 12h, and the solvents were evaporated to give the imine (85%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, tert-Butyl (4-aminophenyl)carbamate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; CAREX S.A.; WO2004/72046; (2004); A2;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

71026-66-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 71026-66-9 name is tert-Butyl (4-aminophenyl)carbamate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

In a three-necked flask equipped with a thermometer and a dropping funnelAzobenzene-4,4′-dicarboxylic acid dichloride (25.0 g,81.4 mmol) and triethylamine (19.8 g, 195.4 mmol) were added, and 150 mL of dichloromethane was added. The solution was kept at 5 CAnd the mixture was dissolved in methylene chloride (100 mL)4- (N-tert-butoxycarbonylamino) aniline(37.3 g,179.1 mmol) was added, and the mixture was heated to room temperature and stirred for 6 hours. The reaction solution was added to water (250 mL), washed with pure water(300 mL). The organic layer was washed three times. The organic layer was dried over anhydrous magnesium sulfate, and the solvent was distilled off under reduced pressure to obtain the same(Yield 42.9 g, yield 81%)

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Jieenzhi Co., Ltd.; Jieenzhi Petrochemical Co., Ltd.; Teng Madaliang; Tian Cundianyang; Xiao Kouxiongerlang; Shan Neixiaohao; Jiu Tianlixiang; (145 pag.)CN104058993; (2017); B;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics